Home Visiting Services for Refugee, Immigrant, Migrant, and Dual Language Learner Families

Thousands of refugees and asylum seekers come to the United States each year to escape humanitarian crises in their home countries. Some face hurdles to accessing services, including language barriers, incomplete documentation, and ineligibility for public programs. Immigrant families often face similar barriers while also fearing deportation or other unintended consequences if they seek help. Home visiting services can support refugee and immigrant families in engaging with others, coping with trauma, and accessing community resources and services. Access to services, in turn, may help offset concerns such as food and housing insecurity and negative health and educational outcomes.This brief produced spotlights five home visiting programs using innovative, strengths-based practices to reach and serve refugee, immigrant, migrant, and dual language learner families

Kids Share 2022: Report on Federal Expenditures on Children through 2021 and Future Projections

Public spending on children represents an effort to invest in the nation's future. Investments supporting children's healthy development and human potential can promote their well-being and help them grow into the next generation of adults and workers, leading to a stronger workforce and economy.To inform policymakers, children's advocates, and the general public about how public funds are spent on children, this 16th edition of the annual Kids' Share report provides an updated analysis of federal expenditures on children from 1960 to 2021. It also offers an updated view of public expenditures made in response to the ongoing COVID-19 pandemic. Projections of federal expenditures on children through 2032 give a sense of how budget priorities are scheduled to unfold over the longer term under current law

Inflammation, insulin resistance, and diabetes-mendelian randomization using CRP haplotypes points upstream

Background Raised C-reactive protein (CRP) is a risk factor for type 2 diabetes. According to the Mendelian randomization method, the association is likely to be causal if genetic variants that affect CRP level are associated with markers of diabetes development and diabetes. Our objective was to examine the nature of the association between CRP phenotype and diabetes development using CRP haplotypes as instrumental variables. Methods and Findings We genotyped three tagging SNPs (CRP + 2302G > A; CRP + 1444T > C; CRP + 4899T > G) in the CRP gene and measured serum CRP in 5,274 men and women at mean ages 49 and 61 y (Whitehall II Study). Homeostasis model assessment-insulin resistance (HOMA-IR) and hemoglobin A1c (HbA1c) were measured at age 61 y. Diabetes was ascertained by glucose tolerance test and self-report. Common major haplotypes were strongly associated with serum CRP levels, but unrelated to obesity, blood pressure, and socioeconomic position, which may confound the association between CRP and diabetes risk. Serum CRP was associated with these potential confounding factors. After adjustment for age and sex, baseline serum CRP was associated with incident diabetes (hazard ratio = 1.39 [95% confidence interval 1.29-1.51], HOMA-IR, and HbA1c, but the associations were considerably attenuated on adjustment for potential confounding factors. In contrast, CRP haplotypes were not associated with HOMA-IR or HbA1c (p=0.52-0.92). The associations of CRP with HOMA-IR and HbA1c were all null when examined using instrumental variables analysis, with genetic variants as the instrument for serum CRP. Instrumental variables estimates differed from the directly observed associations (p=0.007-0.11). Pooled analysis of CRP haplotypes and diabetes in Whitehall II and Northwick Park Heart Study II produced null findings (p=0.25-0.88). Analyses based on the Wellcome Trust Case Control Consortium (1,923 diabetes cases, 2,932 controls) using three SNPs in tight linkage disequilibrium with our tagging SNPs also demonstrated null associations. Conclusions Observed associations between serum CRP and insulin resistance, glycemia, and diabetes are likely to be noncausal. Inflammation may play a causal role via upstream effectors rather than the downstream marker CRP

La imagen y la narrativa como herramientas para el abordaje psicosocial en escenarios de violencia. Bogotá, Colombia y Manila, Filipinas

La violencia es el espejo de la realidad en la que vivimos. Colombia la ha experimentado por más de 70 años por medio de masacres, torturas, secuestros, desplazamiento, violencia intrafamiliar, sexual, etc. Éste trabajo analiza el relato de Alfredo Campo un hombre indígena víctima de la violencia armada que tuvo que salir desplazado de su comunidad en el departamento del Cauca. De acuerdo con lo anterior se formulan preguntas de tipo circular, reflexivo y estratégico que ayudan a ejercitar la forma de preguntar, obteniendo respuestas que sean útiles para la intervención psicosocial. Seguidamente, se reflexiona y se proponen tres estrategias frente al Caso de otra comunidad denominada Peñas Coloradas, un colectivo de personas que crearon un pueblo desde cero y que fueron víctimas de la incursión armada y el hostigamiento militar del Ejército Nacional. Para finalizar, se presenta aquí un informe analítico desde un ejercicio práctico por medio de la herramienta foto voz realizado en cuatro localidades de Bogotá que son: Puente Aranda, Engativá, Fontibón y Ciudad Bolívar. Así mismo, el ejercicio de la foto intervención se realizó en Manila capital de Filipinas. Desde la posición de las estudiantes se reflexiona sobre la intervención y los beneficios que tiene esta herramienta para visibilizar no solo el impacto negativo que dejan los eventos violentos, sino también las dinámicas de transformación positiva que son el resultado del afrontamiento de estas comunidades a las situaciones adversas.Violence is the mirror of the reality in which we live. Colombia has experienced it for more than 70 years through massacres, torture, kidnappings, displacement, domestic and sexual violence, etc. This work analyzes the story of Alfredo Campo, an indigenous man victim of armed violence who had to be displaced from his community in the department of Cauca. In accordance with the above, circular, reflective and strategic questions are formulated that help to exercise the way of asking, obtaining answers that are useful for psychosocial intervention. Next, three strategies are reflected on and proposed regarding the Case of another community called Peñas Coloradas, a group of people who created a town from scratch and who were victims of the armed incursion and military harassment of the National Army Finally, an analytical report is presented here from a practical exercise through the voice photo tool carried out in four locations in the city of Bogotá, which are: Puente Aranda, Engativá, Fontibón and Ciudad Bolívar. Likewise, the photo intervention exercise was carried out in the city of Manila, the capital of the Philippines. From the position of the students, they reflect on the intervention and the benefits of this tool, where it was possible to make visible not only the negative impact left by violent events, but also the dynamics of positive transformation that are the result of coping with these communities. to adverse situations

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.

Multiple sclerosis is a common disease of the central nervous system in which the interplay between inflammatory and neurodegenerative processes typically results in intermittent neurological disturbance followed by progressive accumulation of disability. Epidemiological studies have shown that genetic factors are primarily responsible for the substantially increased frequency of the disease seen in the relatives of affected individuals, and systematic attempts to identify linkage in multiplex families have confirmed that variation within the major histocompatibility complex (MHC) exerts the greatest individual effect on risk. Modestly powered genome-wide association studies (GWAS) have enabled more than 20 additional risk loci to be identified and have shown that multiple variants exerting modest individual effects have a key role in disease susceptibility. Most of the genetic architecture underlying susceptibility to the disease remains to be defined and is anticipated to require the analysis of sample sizes that are beyond the numbers currently available to individual research groups. In a collaborative GWAS involving 9,772 cases of European descent collected by 23 research groups working in 15 different countries, we have replicated almost all of the previously suggested associations and identified at least a further 29 novel susceptibility loci. Within the MHC we have refined the identity of the HLA-DRB1 risk alleles and confirmed that variation in the HLA-A gene underlies the independent protective effect attributable to the class I region. Immunologically relevant genes are significantly overrepresented among those mapping close to the identified loci and particularly implicate T-helper-cell differentiation in the pathogenesis of multiple sclerosis

Exome-wide analysis of rare coding variation identifies novel associations with COPD and airflow limitation in MOCS3, IFIT3 and SERPINA12.

Several regions of the genome have shown to be associated with COPD in genome-wide association studies of common variants.To determine rare and potentially functional single nucleotide polymorphisms (SNPs) associated with the risk of COPD and severity of airflow limitation.3226 current or former smokers of European ancestry with lung function measures indicative of Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2 COPD or worse were genotyped using an exome array. An analysis of risk of COPD was carried out using ever smoking controls (n=4784). Associations with %predicted FEV1 were tested in cases. We followed-up signals of interest (p<10(-5)) in independent samples from a subset of the UK Biobank population and also undertook a more powerful discovery study by meta-analysing the exome array data and UK Biobank data for variants represented on both arrays.Among the associated variants were two in regions previously unreported for COPD; a low frequency non-synonymous SNP in MOCS3 (rs7269297, pdiscovery=3.08×10(-6), preplication=0.019) and a rare SNP in IFIT3, which emerged in the meta-analysis (rs140549288, pmeta=8.56×10(-6)). In the meta-analysis of % predicted FEV1 in cases, the strongest association was shown for a splice variant in a previously unreported region, SERPINA12 (rs140198372, pmeta=5.72×10(-6)). We also confirmed previously reported associations with COPD risk at MMP12, HHIP, GPR126 and CHRNA5. No associations in novel regions reached a stringent exome-wide significance threshold (p<3.7×10(-7)).This study identified several associations with the risk of COPD and severity of airflow limitation, including novel regions MOCS3, IFIT3 and SERPINA12, which warrant further study

MiR-137-derived polygenic risk: effects on cognitive performance in patients with schizophrenia and controls

Variants at microRNA-137 (MIR137), one of the most strongly associated schizophrenia risk loci identified to date, have been associated with poorer cognitive performance. As microRNA-137 is known to regulate the expression of ~1900 other genes, including several that are independently associated with schizophrenia, we tested whether this gene set was also associated with variation in cognitive performance. Our analysis was based on an empirically derived list of genes whose expression was altered by manipulation of MIR137 expression. This list was cross-referenced with genome-wide schizophrenia association data to construct individual polygenic scores. We then tested, in a sample of 808 patients and 192 controls, whether these risk scores were associated with altered performance on cognitive functions known to be affected in schizophrenia. A subgroup of healthy participants also underwent functional imaging during memory (n=108) and face processing tasks (n=83). Increased polygenic risk within the empirically derived miR-137 regulated gene score was associated with significantly lower performance on intelligence quotient, working memory and episodic memory. These effects were observed most clearly at a polygenic threshold of P=0.05, although significant results were observed at all three thresholds analyzed. This association was found independently for the gene set as a whole, excluding the schizophrenia-associated MIR137 SNP itself. Analysis of the spatial working memory fMRI task further suggested that increased risk score (thresholded at P=10−5) was significantly associated with increased activation of the right inferior occipital gyrus. In conclusion, these data are consistent with emerging evidence that MIR137 associated risk for schizophrenia may relate to its broader downstream genetic effects

Parma consensus statement on metabolic disruptors

A multidisciplinary group of experts gathered in Parma Italy for a workshop hosted by the University of Parma, May 16–18, 2014 to address concerns about the potential relationship between environmental metabolic disrupting chemicals, obesity and related metabolic disorders. The objectives of the workshop were to: 1. Review findings related to the role of environmental chemicals, referred to as “metabolic disruptors”, in obesity and metabolic syndrome with special attention to recent discoveries from animal model and epidemiology studies; 2. Identify conclusions that could be drawn with confidence from existing animal and human data; 3. Develop predictions based on current data; and 4. Identify critical knowledge gaps and areas of uncertainty. The consensus statements are intended to aid in expanding understanding of the role of metabolic disruptors in the obesity and metabolic disease epidemics, to move the field forward by assessing the current state of the science and to identify research needs on the role of environmental chemical exposures in these diseases. We propose broadening the definition of obesogens to that of metabolic disruptors, to encompass chemicals that play a role in altered susceptibility to obesity, diabetes and related metabolic disorders including metabolic syndrome

Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins

Statins effectively lower LDL cholesterol levels in large studies and the observed interindividual response variability may be partially explained by genetic variation. Here we perform a pharmacogenetic meta-analysis of genome-wide association studies (GWAS) in studies addressing the LDL cholesterol response to statins, including up to 18,596 statin-treated subjects. We validate the most promising signals in a further 22,318 statin recipients and identify two loci, SORT1/CELSR2/PSRC1 and SLCO1B1, not previously identified in GWAS. Moreover, we confirm the previously described associations with APOE and LPA. Our findings advance the understanding of the pharmacogenetic architecture of statin response