103 research outputs found
A Comparative Study of Anxiety, Pain and Maternal-fetal Attachment between Women who became Pregnant after Infertility Treatment and became Pregnant Naturally
- Publication venue
- 'Korean Society of Women Health Nursing'
- Publication date
- 01/06/2016
- Field of study
PURPOSE: This study was a comparative study to understand the levels of anxiety, pain and maternal-fetal attachment between women who became pregnant after infertility treatment and became pregnant naturally.
METHODS: This study used a comparative survey design. Data were collected by 50 couples of natural pregnancy and of who became pregnant after infertility treatment who visited delivery room in C Medical hospital, Seoul. These couples were to have first baby, and cervix dilatation of women was less than 3 cm regardless of diagnosis.
RESULTS: The score of anxiety of infertile women was significantly higher than that of naturally pregnant women; however, that of spouses showed no difference. The pain score for infertile women was significantly higher in both the active and transition phases. Pain scores that reported by their spouses did not show differences in either phase. The score of maternal-fetal attachment showed no difference between two groups of women.
CONCLUSION: The result showed the importance of nursing intervention to reduce women's anxiety and pain, through both antenatal-childbirth education programs and assertive nursing interventions. It is necessary to develop and evaluate new intervention which would be more effective for reducing pain and anxiety for couples who became pregnant after infertility treatment
Prevalence and Correlates of Depressive Symptoms among North Korean Defectors Living in South Korea for More than One Year
- Author
- Abbey
- Bauer
- Becker
- Bong-Hee Jeon
- Bora Yoo
- Chang-In Lee
- Cho
- Cho
- Cho
- Database center for North Korean human rights
- Duk-Soo Kim
- Eksi
- Eun-Kyung Jwa
- Felsman
- Furnham
- Goldberg
- Gong-Guy
- Han
- Hanul Chong
- Hauff
- Hauff
- Hong
- Jaehwan Chung
- Jang
- Jeon
- Jeon
- Jeon
- Jeon
- Jeon
- Joon-Hyuk Park
- Jun-Hwa Lee
- Kim
- Kim
- Laban
- Lee
- Lee
- Lee
- Lin
- Meinhardt
- Mi-Jeong Yang
- Mi-Yeul Hyun
- Min-Ho Bae
- Ministry of Unification Republic of Korea
- Ministry of Unification Republic of Korea
- Moon-Doo Kim
- Na-Ri Kim
- Nwadior
- Priebe
- Radloff
- Roh
- Rumbaut
- Sanghee Kim
- Seong-Chul Hong
- Tousignant
- Yang
- Young-Sook Kwak
- Šikić
- Publication venue
- Korean Neuropsychiatric Association
- Publication date
- 01/01/2009
- Field of study
Dietary phytochemicals, HDAC inhibition, and DNA damage/repair defects in cancer cells
- Author
- A Ahmad
- A Baschnagel
- A Brunet
- A Codina
- A Herman-Antosiewicz
- A Ito
- A Kaidi
- A Kimura
- A Link
- A Mai
- A Mangerich
- A Saha
- A Scuto
- A Sekhavat
- A Taddei
- A Tyagi
- A Tyagi
- AA Goodarzi
- AA Powolny
- AC Goulet
- AG Kazantsev
- AL Hilchie
- AR Amin
- AS Azmi
- AV Lichtenstein
- B Delage
- B Du
- B Pajak
- B Schwer
- B Sobhian
- B Wang
- BA Tamburini
- BB Aggarwal
- BG Cosio
- BG Cosio
- BG Cosio
- BH Lv
- C Bonnesen
- C Cazaux
- C Conti
- C Giommarelli
- C Sanmartín
- CC Chen
- CD Davis
- CD Heinen
- CE Redon
- CJ Lord
- CR Regenbrecht
- CS Chen
- CT Brew
- D Beher
- D Chirnomas
- D Palmieri
- D Rossetto
- D Vauzour
- D Vieyra
- D Xiao
- D Xiao
- D Yu
- DA Barbie
- DL Hatfield
- DL Rowe
- DO Moon
- DR Schmidt
- DS Yu
- E Sekine-Suzuki
- EL Putiri
- EP Rogakou
- EP Rogakou
- ER Jang
- F Kassie
- F Kassie
- F Kassie
- FL Büchner
- FV Rassool
- G Bar-Sela
- G Boily
- G Bora-Tatar
- G Chen
- G Eot-Houllier
- G Eot-Houllier
- G Lopez
- G Ouyang
- G Zupkovitz
- GD Kao
- GD Kim
- GL Wolff
- GX Li
- H Andelová
- H Ding
- H Ide
- H Kang
- H Ling
- H Nian
- H Nian
- H Nian
- H Ogiwara
- H Vaziri
- H Wang
- H Xiao
- H Xiao
- H Zeng
- H Zeng
- HC Wang
- HF Lu
- HF Wang
- HY Leung
- I Soerjomataram
- IA Ismail
- IC Weaver
- IC Weaver
- IM Ward
- IP Pogribny
- J Antosiewicz
- J Cao
- J Epstein
- J Essers
- J Ford
- J Huang
- J Jeong
- J Kang
- J Kotsopoulos
- J Luo
- J Steevens
- J Tan
- J Wang
- J Yuan
- J Zain
- J Zhao
- JA Palacios
- JC Purrucker
- JC Purrucker
- JD Clarke
- JD Clarke
- JD Hayes
- JF Kurland
- JG Wood
- JH Lee
- JH Lee
- JH Petrini
- JI Lee
- JS Lee
- JV Higdon
- K Aquilano
- K Balasubramanyam
- K Balasubramanyam
- K Camphausen
- K Camphausen
- K Doyle
- K Ito
- K Ozaki
- K Sebova
- K Vanhees
- KA Ahmad
- KC Choi
- KC Cuneo
- KC Liu
- KJ Auborn
- KK Bhakat
- KK Meja
- KL Chang
- KM Dhandapani
- KM Miller
- KT Howitz
- L Geng
- L Kai
- L Mi
- L Ye
- L Yi
- LA Anderson
- LA Poirier
- LC Clark
- LG Wang
- LH Wang
- M Athar
- M Entin-Meer
- M Iciek
- M Kaur
- M Ming
- M Namdar
- M Pandey
- M Podhorecka
- M Rusin
- M Suganuma
- M Uhl
- M Wu
- MA Kato
- MA Lea
- MA Lea
- MA Lea
- MA Lea
- MB Scher
- MC Motta
- MC Myzak
- MC Myzak
- MC Myzak
- MF Ullah
- MG Marcu
- MK Kim
- MS Kim
- MS Tsai
- MZ Fang
- N Ayoub
- N Ayoub
- N Bhatnagar
- N Druesne-Pecollo
- N Hail Jr
- N Kikuno
- N Kothapalli
- N Sriram
- N Xiang
- N Yamashita
- N Zhou
- NJ Krogan
- NJ Krogan
- OH Krämer
- P Chi
- P Gallinari
- P Guha
- P Pettazzoni
- P Rajendran
- P Rajendran
- P Sestili
- PA Jeggo
- PA Marks
- PC Fong
- PE Miller
- PL Jones
- Q Zhu
- R Di Micco
- R Hu
- R Malik
- R Plummer
- R Ruotolo
- R Sharma
- R Ye
- R Ye
- R Zhang
- RA Izzard
- RA McCord
- RH Dashwood
- RH Dashwood
- RH Wang
- RH Wang
- RI Tennen
- RI Yarden
- RJ Shiau
- RP Sahu
- RP Sahu
- RR Rosato
- RS Murugan
- RT Utley
- RV Priyadarsini
- RW Johnstone
- S Adimoolam
- S Balasubramanian
- S Banerjee
- S Basak
- S Batra
- S Bhaskara
- S Bhaskara
- S Burma
- S Caito
- S Chung
- S Fan
- S Fu
- S Ishii
- S Katiyar
- S Kotian
- S Leone
- S Lev-Ari
- S Milutinovic
- S Mueller
- S Padhye
- S Someya
- S Sukumari-Ramesh
- SA Gatz
- SK Kachhap
- SM Hadi
- SM Meeran
- SM Meeran
- SS Lin
- SV Singh
- T Chen
- T Robert
- T Toyoizumi
- T Vaissière
- T Yamamori
- T Yamamoto
- TT Paul
- V Basile
- V Nandakumar
- VS Konkimalla
- W Fan
- W Jiang
- W Shi
- WJ Lee
- WJ Lee
- WS Xu
- X Liu
- X Ma
- X Shen
- Y Chen
- Y Hu
- Y Ji
- Y Li
- Y Li
- Y Li
- Y Li
- Y Qi
- Y Sun
- Y Sun
- Y Sun
- Y Tominaga
- Y Wu
- Y Zhang
- Y Ziv
- YN Gopal
- YN Gopal
- Z Ji
- Z Yuan
- Publication venue
- BioMed Central
- Publication date
- 01/01/2011
- Field of study
Genomic instability is a common feature of cancer etiology. This provides an avenue for therapeutic intervention, since cancer cells are more susceptible than normal cells to DNA damaging agents. However, there is growing evidence that the epigenetic mechanisms that impact DNA methylation and histone status also contribute to genomic instability. The DNA damage response, for example, is modulated by the acetylation status of histone and non-histone proteins, and by the opposing activities of histone acetyltransferase and histone deacetylase (HDAC) enzymes. Many HDACs overexpressed in cancer cells have been implicated in protecting such cells from genotoxic insults. Thus, HDAC inhibitors, in addition to unsilencing tumor suppressor genes, also can silence DNA repair pathways, inactivate non-histone proteins that are required for DNA stability, and induce reactive oxygen species and DNA double-strand breaks. This review summarizes how dietary phytochemicals that affect the epigenome also can trigger DNA damage and repair mechanisms. Where such data is available, examples are cited from studies in vitro and in vivo of polyphenols, organosulfur/organoselenium compounds, indoles, sesquiterpene lactones, and miscellaneous agents such as anacardic acid. Finally, by virtue of their genetic and epigenetic mechanisms, cancer chemopreventive agents are being redefined as chemo- or radio-sensitizers. A sustained DNA damage response coupled with insufficient repair may be a pivotal mechanism for apoptosis induction in cancer cells exposed to dietary phytochemicals. Future research, including appropriate clinical investigation, should clarify these emerging concepts in the context of both genetic and epigenetic mechanisms dysregulated in cancer, and the pros and cons of specific dietary intervention strategies
Ultra-Rare Genetic Variation in the Epilepsies : A Whole-Exome Sequencing Study of 17,606 Individuals
- Author
- Abbott LE
- Achtyes ED
- Afawi Z
- Andrade DM
- Annesi G
- Arslan M
- Auce P
- Auvinen P
- Azevedo MH
- Bahlo M
- Balestrini S
- Barišić N
- Bass N
- Bauer J
- Baum LW
- Baykan B
- Bebek N
- Becker F
- Bellows ST
- Bennett CA
- Berkovic SF
- Bianchini C
- Bisulli F
- Blackwood D
- Blatt I
- Borggräfe I
- Braatz V
- Brockmann K
- Bromet EJ
- Buckley PF
- Buono RJ
- Burgess R
- Byrnes A
- Caglayan SH
- Canafoglia L
- Canavati C
- Carvalho CB
- Castellotti B
- Cavalleri GL
- Cerrato F
- Cherny SS
- Chung S-K
- Churchhouse C
- Ciullo V
- Cossette P
- Cotsapas C
- Daly MJ
- De Jonghe P
- Delanty N
- Dennig D
- Depondt C
- Devinsky O
- Dhindsa RS
- Dixon-Salazar T
- Dlugos DJ
- Doccini V
- Doherty CP
- El-Naggar H
- Elger CE
- Ellis CA
- Fanous AH
- Feng Y-CA
- Ferraro TN
- Franceschetti S
- French JA
- Freyer C
- Gabriel SB
- Gagliardi M
- Gallati S
- Gambardella A
- Gili T
- Goldstein DB
- Granata T
- Guerrini R
- Gundogdu-Eken A
- Gupta N
- Hakonarson H
- Haryanyan G
- Hegde M
- Heinzen EL
- Helbig I
- Helbig KL
- Hengsbach C
- Heyne H
- Howrigan DP
- Häusler M
- Iacomino M
- Inoue Y
- Johns EMC
- Johnson MR
- Johnstone M
- Kamalakaran S
- Kanaan M
- Kara B
- Kesim Y
- Khankhanian P
- King C
- Klein KM
- Kluger G
- Knake S
- Knowles JA
- Korczyn AD
- Korinthenberg R
- Kotov R
- Kousiappa I
- Krause R
- Krestel H
- Krey I
- Kunz WS
- Kurlemann G
- Kurlemann G
- Kuzniecky RI
- Kwan P
- Kälviäinen R
- Labate A
- Lal D
- Lander ES
- Laššuthová P
- Lehesjoki A-E
- Lehrer DS
- Lemke JR
- Lerche H
- Leu C
- Licchetta L
- Linnankivi T
- Lo W
- Lowenstein DH
- Lui CHT
- Macciardi F
- Macdonald A
- Madeleyn R
- Madia F
- Maisch AF
- Malaspina D
- Mancardi MM
- Manna L
- Marder SR
- Marini C
- Marson AG
- May P
- Mayer T
- McCarroll SA
- McCormack M
- McIntosh A
- McKenna K
- McQuillin A
- Medeiros H
- Mei D
- Minardi R
- Mo K
- Montomoli M
- Morley CP
- Mountier E
- Muhle H
- Müller-Schlüter K
- Neale BM
- O’Brien TJ
- Palotie A
- Papacostas SS
- Parrini E
- Pato CN
- Pato MT
- Pendziwiat M
- Perkins DO
- Petrovski S
- Pickrell WO
- Pippucci T
- Piras F
- Piras F
- Poduri A
- Powell R
- Privitera M
- Rademacher A
- Rademacher M
- Rapaport MH
- Rau S
- Rees MI
- Regan BM
- Reif A
- Reif PS
- Rosenow F
- Saarela A
- Sadleir LG
- Sadoway TR
- Salman B
- Salpietro V
- Schachter S
- Schankin CJ
- Scheffer IE
- Schneider N
- Schreiber H
- Schubert-Bast S
- Schulze-Bonhage A
- Sedláčková L
- Shain C
- Sham PC
- Shiedley BR
- Shilling H
- Shukralla A
- Sills GJ
- Singh T
- Sisodiya SM
- Sobell JL
- Solomonson M
- Spalletta G
- Sperling MR
- Stamberger H
- Stanley KE
- Steinhoff BJ
- Stephani U
- Stewart R
- Stipa C
- Striano P
- Suzuki T
- Tanteles GA
- Tashman K
- Tinuper P
- Todaro M
- Topaloglu P
- Tumiene B
- Turkdogan D
- Uğur-İşeri S
- Van Baalen A
- Vari MS
- Vetro A
- Vlčková M
- Von Spiczak S
- Watts N
- Weber YG
- Weckhuysen D
- Weckhuysen S
- Wolking S
- Yamakawa K
- Yapıcı Z
- Yis U
- Yücesan E
- Zagaglia S
- Zara F
- Zsurka G
- Özkara Ç
- Štěrbová K
- Publication venue
- Publication date
- 01/01/2019
- Field of study
Sequencing-based studies have identified novel risk genes associated with severe epilepsies and revealed an excess of rare deleterious variation in less-severe forms of epilepsy. To identify the shared and distinct ultra-rare genetic risk factors for different types of epilepsies, we performed a whole-exome sequencing (WES) analysis of 9,170 epilepsy-affected individuals and 8,436 controls of European ancestry. We focused on three phenotypic groups: severe developmental and epileptic encephalopathies (DEEs), genetic generalized epilepsy (GGE), and non-acquired focal epilepsy (NAFE). We observed that compared to controls, individuals with any type of epilepsy carried an excess of ultra-rare, deleterious variants in constrained genes and in genes previously associated with epilepsy; we saw the strongest enrichment in individuals with DEEs and the least strong in individuals with NAFE. Moreover, we found that inhibitory GABA(A) receptor genes were enriched for missense variants across all three classes of epilepsy, whereas no enrichment was seen in excitatory receptor genes. The larger gene groups for the GABAergic pathway or cation channels also showed a significant mutational burden in DEEs and GGE. Although no single gene surpassed exome-wide significance among individuals with GGE or NAFE, highly constrained genes and genes encoding ion channels were among the lead associations; such genes included CACNAIG, EEF1A2, and GABRG2 for GGE and LGI1, TRIM3, and GABRG2 for NAFE. Our study, the largest epilepsy WES study to date, confirms a convergence in the genetics of severe and less-severe epilepsies associated with ultra-rare coding variation, and it highlights a ubiquitous role for GABAergic inhibition in epilepsy etiology.Peer reviewe
Global, regional, and national burden of stroke and its risk factors, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019
- Author
- Abady GG
- Abbasi-Kangevari M
- Abbasifard M
- Abd-Allah F
- Abedi V
- Abu-Rmeileh NM
- Abualhasan A
- Abushouk A
- Adebayo OM
- Agarwal G
- Agasthi P
- Ahinkorah BO
- Ahmad S
- Ahmadi S
- Aji B
- Akbarpour S
- Akinyemi RO
- Al Hamad H
- Al Montasir A
- Al-Raddadi RM
- Alahdab F
- Alif SM
- Alipour V
- Aljunid SM
- Almustanyir S
- Alvis-Guzman N
- Ancuceanu R
- Anderlini D
- Anderson JA
- Ansar A
- Antonazzo IC
- Arabloo J
- Arnlov J
- Artanti KD
- Aryan Z
- Asgari S
- Ashraf T
- Athar M
- Atreya A
- Ausloos M
- Bach XT
- Baig AA
- Baltatu OC
- Banach M
- Barboza MA
- Barker-Collo SL
- Barnighausen TW
- Barone MTU
- Basu S
- Bazmandegan G
- Beghi E
- Beheshti M
- Bejot Y
- Bell AW
- Bennett DA
- Bensenor IM
- Bezabhe WM
- Bezabih YM
- Bhagavathula AS
- Bhardwaj P
- Bhattacharyya K
- Bijani A
- Bikbov B
- Bin Zaman S
- Birhanu MM
- Bisignano C
- Boloor A
- Bonny A
- Brauer M
- Brenner H
- Bryazka D
- Butt ZA
- Campos-Nonato IR
- Cantu-Brito C
- Carrero JJ
- Castaneda-Orjuela CA
- Catapano AL
- Chakraborty PA
- Charan J
- Choudhari SG
- Chowdhury EK
- Chu D-T
- Chung S-C
- Colozza D
- Costa VM
- Costanzo S
- Criqui MH
- D'Amico E
- Dadras O
- Dagnew B
- Dai X
- Dalal K
- Damasceno AAM
- Dandona L
- Dandona R
- Davletov K
- De La Cruz-Gongora V
- Desai R
- Dhamnetiya D
- Dharmaratne SD
- Dhimal M
- Dhimal ML
- Diaz D
- Dichgans M
- Dokova K
- dos Santos FLC
- Doshi R
- Douiri A
- Duncan BB
- Eftekharzadeh S
- Ekholuenetale M
- El Nahas N
- El-Jaafary S
- Elgendy IY
- Elhadi M
- Endres M
- Endries AY
- Erku DA
- Faraon EJA
- Farooque U
- Farzadfar F
- Feigin VL
- Feroze AH
- Filip I
- Fischer F
- Flood D
- Gad MM
- Gaidhane S
- Gela JD
- Ghashghaee A
- Gheshlagh RG
- Ghith N
- Ghozali G
- Ghozy S
- Gialluisi A
- Giampaoli S
- Giang TV
- Gilani SA
- Gill PS
- Gnedovskaya E
- Golechha M
- Goulart AC
- Guo Y
- Gupta R
- Gupta VB
- Gupta VK
- Gyanwali P
- Hafezi-Nejad N
- Hamidi S
- Hanif A
- Hankey GJ
- Hanson SW
- Hargono A
- Hashi A
- Hassan TS
- Hassen HY
- Havmoeller RJ
- Hay S
- Hayat K
- Hegazy M
- Herteliu C
- Holla R
- Hostiuc S
- Househ M
- Huang J
- Humayun A
- Hwang B-F
- Iacoviello L
- Iavicoli I
- Ibitoye SE
- Ilesanmi OS
- Ilic IM
- Ilic MD
- Iqbal U
- Irvani SSN
- Islam SMS
- Ismail NE
- Iso H
- Isola G
- Iwagami M
- Jabbari SHY
- Jacob L
- Jain V
- Jang S-I
- Jayapal SK
- Jayaram S
- Jayawardena R
- Jeemon P
- Jha RP
- Johnson CO
- Johnson WD
- Jonas JB
- Jonasson JM
- Joseph N
- Jozwiak JJ
- Jurisson M
- Kalani R
- Kalhor R
- Kalkonde Y
- Kamath A
- Kamiab Z
- Kan FP
- Kanchan T
- Kandel H
- Kandel SN
- Karch A
- Katoto PDMC
- Kayode GA
- Keshavarz P
- Khader YS
- Khan EA
- Khan IA
- Khan M
- Khan MAB
- Khatib MN
- Khubchandani J
- Kim GR
- Kim MS
- Kim YJ
- Kisa A
- Kisa S
- Kivimaki M
- Kolte D
- Koolivand A
- Koyanagi A
- Krishan K
- Krishnamoorthy V
- Krishnamurthi R
- Kumar GA
- Kusuma D
- La Vecchia C
- Lacey B
- Lak HM
- Lallukka T
- Lasrado S
- Lavados PM
- Laxminarayana SLK
- Leonardi M
- Li B
- Li S
- Lin H
- Lin R-T
- Linh GV
- Liu X
- Lo WD
- Lorkowski S
- Lucchetti G
- Magnani FG
- Mahajan PB
- Majeed A
- Makki A
- Malekzadeh R
- Malik AA
- Manafi N
- Mansournia MA
- Mantovani LG
- Martini S
- Mazzaglia G
- Mehndiratta MM
- Menezes RG
- Meretoja A
- Mersha AG
- Miazgowski B
- Miazgowski T
- Michalek IM
- Mirrakhimov EM
- Moghaddam SS
- Mohammad Y
- Mohammadian-Hafshejani A
- Mohammed S
- Mokdad AH
- Mokhayeri Y
- Molokhia M
- Moni MA
- Moradzadeh R
- Morawska L
- Morze J
- Murray CJL
- Muruet W
- Musa KI
- Nagarajan AJ
- Naghavi M
- Nascimento BR
- Negoi RI
- Norrving B
- Noubiap JJ
- Nwatah VE
- Oancea B
- Odukoya OO
- Olagunju AT
- Orru H
- Owolabi MO
- Padubidri JR
- Pana A
- Parekh T
- Park E-C
- Pathak M
- Peres MFP
- Perianayagam A
- Piradov MA
- Podder V
- Polinder S
- Postma MJ
- Pourshams A
- Radfar A
- Rafiei A
- Raggi A
- Rahim F
- Rahimi-Movaghar V
- Rahman M
- Rahman MA
- Rahmani AM
- Rajai N
- Ranasinghe P
- Rao CR
- Rao SJ
- Rathi P
- Rawaf DL
- Rawaf S
- Razek HMAE
- Reitsma MB
- Renjith V
- Renzaho AMN
- Rezapour A
- Rodriguez JAB
- Roever L
- Romoli M
- Roth GA
- Rynkiewicz A
- Sacco S
- Sadeghi M
- Sahebkar A
- Saif-Ur-Rahman K
- Salah R
- Salih YA
- Salman RA-S
- Samaei M
- Samy AM
- Santos IS
- Santric-Milicevic MM
- Sarrafzadegan N
- Sathian B
- Sattin D
- Saute RL
- Schiavolin S
- Schlaich MP
- Schmidt MI
- Schutte AE
- Sepanlou SG
- Seylani A
- Sha F
- Shahabi S
- Shaikh MA
- Shannawaz M
- Shawon MSR
- Sheikh A
- Sheikhbahaei S
- Shibuya K
- Siabani S
- Silva DAS
- Singh JA
- Singh JK
- Skryabin VY
- Skryabina AA
- Sobaih BH
- Stark BA
- Stortecky S
- Stranges S
- Swamy SN
- Tadesse EG
- Tahbaz SV
- Tarigan IU
- Temsah M-H
- Teuschl Y
- Thrift AG
- Tonelli M
- Tovani-Palone MR
- Trang HN
- Tripathi M
- Truong-Minh P
- Tsegaye GW
- Ullah A
- Unim B
- Unnikrishnan B
- Vakilian A
- Vasankari TJ
- Venketasubramanian N
- Vervoort D
- Vo B
- Volovici V
- Vosoughi K
- Wafa HA
- Waheed Y
- Wang Y
- Wijeratne T
- Winkler AS
- Wolfe CDA
- Woodward M
- Wu JH
- Xu X
- Yadav L
- Yadollahpour A
- Yamagishi K
- Yatsuya H
- Yonemoto N
- Yu C
- Yunusa I
- Zaman MS
- Zamanian M
- Zand R
- Zandifar A
- Zastrozhin MS
- Zastrozhina A
- Zhang Y
- Zhang Z-J
- Zhong C
- Zuniga YMH
- Publication venue
- ELSEVIER SCIENCE INC
- Publication date
- 01/10/2021
- Field of study
Background:
Regularly updated data on stroke and its pathological types, including data on their incidence, prevalence, mortality, disability, risk factors, and epidemiological trends, are important for evidence-based stroke care planning and resource allocation. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) aims to provide a standardised and comprehensive measurement of these metrics at global, regional, and national levels.
Methods:
We applied GBD 2019 analytical tools to calculate stroke incidence, prevalence, mortality, disability-adjusted life-years (DALYs), and the population attributable fraction (PAF) of DALYs (with corresponding 95% uncertainty intervals [UIs]) associated with 19 risk factors, for 204 countries and territories from 1990 to 2019. These estimates were provided for ischaemic stroke, intracerebral haemorrhage, subarachnoid haemorrhage, and all strokes combined, and stratified by sex, age group, and World Bank country income level.
Findings:
In 2019, there were 12·2 million (95% UI 11·0–13·6) incident cases of stroke, 101 million (93·2–111) prevalent cases of stroke, 143 million (133–153) DALYs due to stroke, and 6·55 million (6·00–7·02) deaths from stroke. Globally, stroke remained the second-leading cause of death (11·6% [10·8–12·2] of total deaths) and the third-leading cause of death and disability combined (5·7% [5·1–6·2] of total DALYs) in 2019. From 1990 to 2019, the absolute number of incident strokes increased by 70·0% (67·0–73·0), prevalent strokes increased by 85·0% (83·0–88·0), deaths from stroke increased by 43·0% (31·0–55·0), and DALYs due to stroke increased by 32·0% (22·0–42·0). During the same period, age-standardised rates of stroke incidence decreased by 17·0% (15·0–18·0), mortality decreased by 36·0% (31·0–42·0), prevalence decreased by 6·0% (5·0–7·0), and DALYs decreased by 36·0% (31·0–42·0). However, among people younger than 70 years, prevalence rates increased by 22·0% (21·0–24·0) and incidence rates increased by 15·0% (12·0–18·0). In 2019, the age-standardised stroke-related mortality rate was 3·6 (3·5–3·8) times higher in the World Bank low-income group than in the World Bank high-income group, and the age-standardised stroke-related DALY rate was 3·7 (3·5–3·9) times higher in the low-income group than the high-income group. Ischaemic stroke constituted 62·4% of all incident strokes in 2019 (7·63 million [6·57–8·96]), while intracerebral haemorrhage constituted 27·9% (3·41 million [2·97–3·91]) and subarachnoid haemorrhage constituted 9·7% (1·18 million [1·01–1·39]). In 2019, the five leading risk factors for stroke were high systolic blood pressure (contributing to 79·6 million [67·7–90·8] DALYs or 55·5% [48·2–62·0] of total stroke DALYs), high body-mass index (34·9 million [22·3–48·6] DALYs or 24·3% [15·7–33·2]), high fasting plasma glucose (28·9 million [19·8–41·5] DALYs or 20·2% [13·8–29·1]), ambient particulate matter pollution (28·7 million [23·4–33·4] DALYs or 20·1% [16·6–23·0]), and smoking (25·3 million [22·6–28·2] DALYs or 17·6% [16·4–19·0]).
Interpretation:
The annual number of strokes and deaths due to stroke increased substantially from 1990 to 2019, despite substantial reductions in age-standardised rates, particularly among people older than 70 years. The highest age-standardised stroke-related mortality and DALY rates were in the World Bank low-income group. The fastest-growing risk factor for stroke between 1990 and 2019 was high body-mass index. Without urgent implementation of effective primary prevention strategies, the stroke burden will probably continue to grow across the world, particularly in low-income countries.
Funding:
Bill & Melinda Gates Foundation
A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)
- Author
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- Ibañes PG
- Ibsen M
- Idei M
- Idei M
- Idone FA
- Iesu E
- Iesu E
- Iglesias-Santiago A
- Ignacio ML
- Iida A
- Iijima H
- Ilan R
- Ilyina V
- Imanaka H
- Inaloo S
- Ince C
- Iotti GA
- Iotti GA
- Iotti GA
- IPREA Study Group
- Irazabal JM
- Irazabal JM
- Ishimatsu S
- Itenov TS
- Iwamoto M
- Izawa M
- Izdes S
- Jaber S
- Jacky A
- Jacobs FM
- Jacques T
- Jaffal K
- Jamali S
- Jang BH
- Janotka M
- Janotka M
- Janotka M
- Jansen D
- Jansen N
- Japan Septic Disseminated Intravascular Coagulation (JSEPTIC DIC) study group
- Jardim JJ
- Jardim M
- Jareño A
- Javadpour S
- Jayasinghe S
- Jean-Baptiste S
- Jean-Baptiste S
- Jensen AE
- Jensen JU
- Jeon YD
- Jeon YD
- Jeong IY
- Jeong IY
- Jeong WY
- Jeong WY
- Jian Z
- Jiao LR
- Jibaja M
- Jimenez-Herrera MF
- Jiménez GJ
- Jo YH
- Joachim J
- Jochmans S
- John G
- Jonas M
- Jonas M
- Jonas M
- Jones C
- Joshi R
- Joshi V
- Jovaisa T
- JSEPTIC (Japanese Society of Education for Physicians and Trainees in Intensive Care) Clinical Trial Group
- Juan WC
- Juanas CA
- Judickas S
- Juez A
- Juliarena A
- Jun IG
- Jun IG
- Jung K
- Jung KW
- Junior JM
- Kaczirek K
- Kaese S
- Kalani N
- Kalenka A
- Kalfon P
- Kamali E
- Kaminsky GE
- Kaneko M
- Kang M
- Kang M
- Kang PL
- Kang PL
- Kang PL
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- Kang Y
- Kao KC
- Kappler F
- Kara A
- Karachi F
- Karanjia N
- Karbing DS
- Karsten E
- Kasdan H
- Kashiya S
- Kashyap R
- Katabami K
- Katabami K
- Katabami K
- Katabami K
- Katira BH
- Kavanagh BP
- Kawamura N
- Kawano S
- Kay FU
- Kayaaslan B
- Kayambu G
- Kazutoshi F
- Ke MW
- Ke MW
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- Keep J
- Keller E
- Kellner F
- Kelly JM
- Kenardy J
- Keough E
- Kerhuel L
- Kerr C
- Kezyte G
- Khadjibaev A
- Khaliq W
- Khine H
- Kim DJ
- Kim HJ
- Kim JM
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- Kim KS
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- Kim MH
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- Kim W
- Kimmoun A
- King HS
- Kinnear J
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- Kirakli C
- Kirca H
- Kirman M
- Kirwan CJ
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- Klapsing P
- Klaus DA
- Kleinpell R
- Kluge S
- Knafelj R
- Knight LD
- Ko JI
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- Kobayashi A
- Koco E
- Kodate A
- Kodate A
- Kodate A
- Kokkini S
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- Komuro T
- Kondili E
- Kongpolprom N
- Kooner G
- Kostalas M
- Kosuk ME
- Kotsopoulos A
- Kou PS
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- Kovacikova L
- Kox M
- Kraegpoeth A
- Krenn CG
- Krishna B
- Kristof J
- Kruger A
- Kruger A
- Krüger A
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- Kubik M
- Kubota K
- Kuebler WM
- Kulaga EV
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- Kumari BK
- Kumbamu A
- Kunze-Szikszay N
- Kurmukov IA
- Kurth T
- Kurtz P
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- Kwon HM
- Kwon HM
- Kwon WY
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- Kye YC
- Kyle UG
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- Labaune MA
- Labra C
- Lacerda P
- Laerkner E
- Lafaurie M
- Lafuente E
- Lagonidis D
- Lagos R
- Lahmer T
- Lai CC
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- Latini R
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- Latorre J
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- Lichtenstein D
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- Lin KC
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- Lischinsky A
- Lissonde F
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- Liu CP
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- Liu D
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- Llorente B
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- Lopez-Gude MJ
- Lorini L
- Lortat-Jacob B
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- Lotay R
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- Lukaszewicz AC
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- Macrì M
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- Maistry N
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- Staszewsky L
- Stauffert N
- Stella A
- Stephens T
- Stiphout C
- Stocchetti N
- Stocchetti N
- Stougianni M
- Street H
- Stretti F
- Struijs A
- Stubbs C
- Stubbs C
- Student Research Committee - Shiraz University of Medical Sciences
- Stümpfle R
- Stümpfle R
- Su F
- Su L
- Su PL
- Su PL
- Suchomel P
- Suh GJ
- Suh GJ
- Suh GJ
- Suh GY
- Suh JW
- Sullivan E
- Sun WZ
- Sun XM
- Sung D
- Suwanpasu S
- Suzuki S
- Suzuki T
- Swart M
- Sy O
- Sydow K
- Sylla P
- Sáez VC
- Sánchez B
- Sánchez B
- Sánchez EC
- Sánchez MJ
- Sánchez MJ
- Sánchez MJ
- Sánchez MJ
- Sánchez MJ
- Sánchez MJ
- Sánchez PC
- Sánchez PC
- Sánchez-Elvira LA
- Tabatabaei HR
- Tabei SH
- Taccone F
- Taccone FS
- Taccone FS
- Taccone FS
- Taccone FS
- Taccone FS
- Taccone FS
- Taccone FS
- Taggu A
- Taggu A
- Takahashi H
- Takaki S
- Takaki S
- Takeda M
- Takeda M
- Takei T
- Takei T
- Talan L
- Tamura T
- Tanaka H
- Tanaka S
- Tanaka S
- Tane N
- Tang KB
- Tang LK
- Tapia A
- Tapponnier R
- Tapponnier R
- Tapponnier R
- Tarabrin O
- Tarabrin P
- Tavazzi G
- Tavazzi G
- Teboul JL
- Telli S
- Temprano-Gómez I
- Tena SA
- Tencé N
- Terzi N
- Terzi N
- Terzi N
- Terzi N
- Thabut G
- Thabut G
- Theodorakopoulou M
- Thies P
- Thilakasiri MC
- Thomas B
- Thompson E
- Thévenin D
- Tiainen M
- Timsit JF
- Tirkkonen J
- Tirumala S
- Tjepkema-Cloostermans MC
- Tobar M
- Tofiño AL
- Toh CH
- Tokyo Womens Medical University
- Tomas E
- Tomas E
- Tomic I
- Tominaga N
- Tomás MA
- Tonelotto BF
- Tonetti T
- Tonetti T
- Topcu L
- Tormos P
- Torner MM
- Torner MM
- Torrance HD
- Torrent RL
- Torrent RL
- Torres A
- Torres E
- Torres JC
- Torriglia F
- Torriglia F
- Torriglia F
- Torsvik M
- Tosi F
- Touratier S
- Touw HR
- Toval S
- Tran N
- Trapp O
- Travierso C
- Travieso PM
- Traynor T
- Trefler S
- Trenado J
- Trenado J
- Treso-Geira M
- Trifan B
- Triulzi F
- Troeltzsch M
- Troncoso I
- Trouiller P
- Tseng CJ
- Tsirigotis P
- Tsukahara K
- Tsunano Y
- Tsunoda M
- Tsunoda M
- Tsutui T
- Tucci MR
- Tudor BA
- Tuinman PR
- Tullo L
- Turel M
- Turon R
- Twisk JW
- Törnblom S
- Ugawa T
- Ujike Y
- Ulla DV
- Ullman A
- Unal M
- Urbanaviciute I
- Uriona S
- Urli T
- Usón MC
- Vaahersalo J
- Vaara S
- Vaid N
- Vakalos A
- Valbuena BL
- Valbuena BL
- Valeiras-Valero A
- Vallecoccia MS
- Vallejo-Báez J
- Vallverdu M
- Vallverdu M
- Vallverdú I
- Vallés J
- van den Boogaard M
- van der Heiden ES
- van der Hoeven JG
- van der Hoeven JG
- van der Voort PH
- van Galen T
- van Ieperen SN
- Van Logten T
- van Nes M
- van Putten MJ
- van Thiel RJ
- van Wijk A
- Vandijck D
- Vaneker I
- Vanhuyse F
- Vaporidi K
- Vaquerizo C
- Varas GM
- Varas JL
- Varea MM
- Vargiolu A
- Varma A
- Varpula T
- Vatsik MV
- Vazquez D
- Vedage D
- Vega LM
- Veigas P
- Vela JL
- Velasquez T
- Venkatesan K
- Venn R
- Venn R
- Venot M
- Venrdramin A
- Ventura-Rosado A
- Vergani G
- Verginella F
- Verhaeghe R
- Verhage R
- Vermeir P
- Veronesi M
- Vezzani A
- Vezzani A
- Vianna G
- Viciana R
- Vidal A
- Vidal MV
- Vidal MV
- Viegas E
- Vieillard-Baron A
- Vieira JE
- Viera MA
- Viera MA
- Vigne C
- Villa G
- Villa P
- Villalba D
- Villamizar PR
- Villamizar PR
- Villanova M
- Villard I
- Villarreal E
- Villarreal E
- Vincent B
- Vincent JL
- Vincent JL
- Vincent JL
- Vincent JL
- Vincent JL
- Vincent JL
- Vincent JL
- Vinje LJ
- Vinsonneau C
- Vitaller S
- Vittone F
- Vogelaers D
- Voiriot G
- Volker T
- Volta CA
- Volta CA
- Vondrakova D
- Vondrakova D
- Vondrakova D
- Vong LV
- Vourli S
- Vrettou C
- Vucic M
- Vázquez CF
- Vázquez CF
- Wada T
- Wada T
- Wada T
- Wada T
- Waldauf P
- Wand S
- Wang CH
- Wang H
- Wann SR
- Wann SR
- Wann SR
- Wann SR
- Wathanawatthu T
- Wee S
- Welte T
- Welters I
- Wetz A
- Weyer CM
- White C
- Wiesner O
- Wijayatilake DS
- Wildenberg L
- Wilks M
- Wilson ME
- WIND study group
- WIND study group
- WIND study group
- Winder-Rhodes S
- Witter T
- Wolf M
- Wolff M
- Wong Y
- Wood B
- Wood CA
- Wood D
- Wood M
- Wray J
- Xie Z
- Xini A
- Xini A
- Xiol EA
- Xu M
- Yager T
- Yaguchi A
- Yaguchi A
- Yamaguchi O
- Yamaguchi O
- Yamaguchi Y
- Yamaguchi Y
- Yamamoto H
- Yamamoto N
- Yaman G
- Yamashita K
- Yamazaki A
- Yan WW
- Yan WW
- Yang JH
- Yang JS
- Yang YL
- Yasuda H
- Yatabe T
- Yebenes JC
- Yeh YC
- Yemets H
- Yergaliyeva A
- Yılmaz G
- Yilmazer F
- Yodice P
- Yokoyama M
- Yonis H
- Yonis H
- Yonis H
- Yoon SZ
- Yoruk F
- Yoshida K
- Yoshida T
- Yoshida T
- Yoshida T
- Yoshida T
- Yoshihiro S
- Yoshitake E
- You KM
- Youn AM
- Young A
- Yu KM
- Yumoto T
- Yuzawa J
- Yuzawa J
- Zabaletta WJ
- Zabini D
- Zahorec M
- Zaien I
- Zakynthinos S
- Zanello M
- Zani D
- Zarantonello F
- Zayas B
- Zepeda EM
- Zeroual N
- Zerva L
- Zhang J
- Zhou JC
- Zhou JC
- Zhou JX
- Zhovnir V
- Zibandah N
- Zijlstra F
- Zimmerman J
- Zogheib E
- Zogheib E
- Zogheib E
- Zullino V
- Zwaag J
- Zýková I
- Álvarez JT
- Álvarez-Lerma F
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Meeting abstrac
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.
- Author
- Abdel-Aziz AK
- Abdelfatah S
- Abdellatif M
- Abdoli A
- Abel S
- Abeliovich H
- Abildgaard MH
- Abudu YP
- Acevedo-Arozena A
- Adamopoulos IE
- Adeli K
- Adolph TE
- Adornetto A
- Aflaki E
- Agam G
- Agarwal A
- Aggarwal BB
- Agnello M
- Agostinis P
- Agrewala JN
- Agrotis A
- Aguilar PV
- Ahmad ST
- Ahmed ZM
- Ahumada-Castro U
- Aits S
- Aizawa S
- Akkoc Y
- Akoumianaki T
- Akpinar HA
- Al-Abd AM
- Al-Akra L
- Al-Gharaibeh A
- Alaoui-Jamali MA
- Alberti S
- Alcocer-Gómez E
- Alessandri C
- Ali M
- Alim Al-Bari MA
- Aliwaini S
- Alizadeh J
- Almacellas E
- Almasan A
- Alonso A
- Alonso GD
- Altan-Bonnet N
- Altieri DC
- Alves da Costa C
- Alves S
- Alzaharna MM
- Amadio M
- Amantini C
- Amaral C
- Ambrosio S
- Amer AO
- Ammanathan V
- An Z
- Andersen SU
- Andrabi SA
- Andrade-Silva M
- Andres AM
- Angelini S
- Ann D
- Anozie UC
- Ansari MY
- Antas P
- Antebi A
- Antón Z
- Anwar T
- Apetoh L
- Apostolova N
- Araki T
- Araki Y
- Arasaki K
- Araya J
- Araújo WL
- Arden C
- Arguelles S
- Arias E
- Arikkath J
- Arimoto H
- Ariosa AR
- Armstrong-James D
- Arnauné-Pelloquin L
- Aroca A
- Arroyo DS
- Arsov I
- Artero R
- Arévalo M-A
- Asaro DML
- Aschner M
- Ashrafizadeh M
- Ashur-Fabian O
- Atanasov AG
- Au AK
- Auberger P
- Auner HW
- Aurelian L
- Autelli R
- Avagliano L
- Aveic S
- Aveleira CA
- Avin-Wittenberg T
- Aydin Y
- Ayton S
- Ayyadevara S
- Azzopardi M
- Baba M
- Backer JM
- Backues SK
- Bae D-H
- Bae O-N
- Bae SH
- Baehrecke EH
- Baek A
- Baek S-H
- Baek SH
- Bagetta G
- Bagniewska-Zadworna A
- Bai H
- Bai J
- Bai X
- Bai Y
- Bairagi N
- Baksi S
- Balazadeh S
- Balbi T
- Baldari CT
- Balduini W
- Ballabio A
- Ballester M
- Balzan R
- Bandopadhyay R
- Banerjee S
- Banerjee S
- Bao Y
- Baptista MS
- Baracca A
- Barbati C
- Bargiela A
- Barilà D
- Barlow PG
- Barmada SJ
- Barreiro E
- Barreto GE
- Bartek J
- Bartel B
- Bartolome A
- Barve GR
- Basagoudanavar SH
- Bassham DC
- Bast RC
- Basu A
- Batoko H
- Batten I
- Baulieu EE
- Baumgarner BL
- Bayry J
- Beale R
- Beau I
- Beaumatin F
- Bechara LRG
- Beck GR
- Beers MF
- Begun J
- Behl C
- Behrends C
- Behrens GMN
- Bei R
- Bejarano E
- Bel S
- Belaid A
- Belgareh-Touzé N
- Bellarosa C
- Belleudi F
- Bello-Morales R
- Belló Pérez M
- Beltran JSDO
- Beltran S
- Benbrook DM
- Bendorius M
- Benitez BA
- Benito-Cuesta I
- Bensalem J
- Berchtold MW
- Berezowska S
- Bergamaschi D
- Bergami M
- Bergmann A
- Berliocchi L
- Berlioz-Torrent C
- Bernard A
- Berthoux L
- Besirli CG
- Besteiro S
- Betin VM
- Beyaert R
- Bezbradica JS
- Bhaskar K
- Bhatia-Kissova I
- Bhattacharya R
- Bhattacharya S
- Bhattacharyya S
- Bhuiyan MS
- Bhutia SK
- Bi L
- Bi X
- Biden TJ
- Bijian K
- Billes VA
- Binart N
- Bincoletto C
- Birgisdottir AB
- Bjorkoy G
- Blanco G
- Blas-Garcia A
- Blasiak J
- Blomgran R
- Blomgren K
- Blum JS
- Boada-Romero E
- Boban M
- Boesze-Battaglia K
- Boeuf P
- Boland B
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- Bonaldo P
- Bonam SR
- Bonfili L
- Bonifacino JS
- Boone BA
- Bootman MD
- Bordi M
- Borner C
- Bornhauser BC
- Borthakur G
- Bosch J
- Bose S
- Botana LM
- Botas J
- Boulanger CM
- Boulton ME
- Bourdenx M
- Bourgeois B
- Bourke NM
- Bousquet G
- Boya P
- Bozhkov PV
- Bozi LHM
- Bozkurt TO
- Brackney DE
- Brand-Saberi B
- Brandts CH
- Braun RJ
- Braus GH
- Bravo-Sagua R
- Bravo-San Pedro JM
- Brest P
- Bringer M-A
- Briones-Herrera A
- Broaddus VC
- Brodersen P
- Brodsky JL
- Brody SL
- Bronson PG
- Bronstein JM
- Brown CN
- Brown RE
- Brum PC
- Brumell JH
- Brunetti-Pierri N
- Bruno D
- Bryson-Richardson RJ
- Bucci C
- Buch S
- Buchan JR
- Buchrieser C
- Buckingham EM
- Budak H
- Budini M
- Bueno M
- Buitrago-Molina LE
- Bultynck G
- Burada F
- Buraschi S
- Burgoyne JR
- Burón MI
- Bustos V
- Butturini E
- Byrd A
- Bánréti Á
- Büttner S
- Cabas I
- Cabrera-Benitez S
- Cadwell K
- Cai J
- Cai L
- Cai Q
- Cairó M
- Calbet JA
- Caldwell GA
- Caldwell KA
- Call JA
- Calvani R
- Calvo AC
- Calvo-Rubio Barrera M
- Camara NO
- Camonis JH
- Camougrand N
- Campanella M
- Campbell EM
- Campbell-Valois F-X
- Campello S
- Campesi I
- Campos JC
- Camuzard O
- Cancino J
- Candido de Almeida D
- Canesi L
- Caniggia I
- Canonico B
- Cantí C
- Cao B
- Caraglia M
- Caramés B
- Carchman EH
- Cardenal-Muñoz E
- Cardenas C
- Cardenas L
- Cardoso SM
- Carew JS
- Carle GF
- Carleton G
- Carloni S
- Carmona-Gutierrez D
- Carneiro LA
- Carnevali O
- Carosi JM
- Carra S
- Carrier A
- Carrier L
- Carroll B
- Carter AB
- Carvalho AN
- Casanova M
- Casas C
- Casas J
- Cassioli C
- Castillo EF
- Castillo K
- Castillo-Lluva S
- Castoldi F
- Castori M
- Castro AF
- Castro-Caldas M
- Castro-Hernandez J
- Castro-Obregon S
- Catz SD
- Cavadas C
- Cavaliere F
- Cavallini G
- Cavinato M
- Cayuela ML
- Cebollada Rica P
- Cecarini V
- Cecconi F
- Cechowska-Pasko M
- Cenci S
- Ceperuelo-Mallafré V
- Cerqueira JJ
- Cerutti JM
- Cervia D
- Cetintas VB
- Cetrullo S
- Chae H-J
- Chagin AS
- Chai C-Y
- Chakrabarti G
- Chakrabarti O
- Chakraborty T
- Chakraborty T
- Chami M
- Chamilos G
- Chan DW
- Chan ED
- Chan EYW
- Chan H
- Chan HH
- Chan HYE
- Chan MTV
- Chan YS
- Chandra PK
- Chang C
- Chang C-P
- Chang H-C
- Chang K
- Chao J
- Chapman T
- Charlet-Berguerand N
- Chatterjee S
- Chaube SK
- Chaudhary A
- Chauhan S
- Chaum E
- Checler F
- Cheetham ME
- Chen C-S
- Chen G-C
- Chen J-F
- Chen L
- Chen L
- Chen LL
- Chen M
- Chen M-K
- Chen N
- Chen Q
- Chen R-H
- Chen S
- Chen W
- Chen W
- Chen X
- Chen X-M
- Chen X-W
- Chen Y
- Chen Y
- Chen Y
- Chen Y-G
- Chen Y-J
- Chen Y-Q
- Chen Z
- Chen Z
- Chen Z
- Chen Z-H
- Chen ZJ
- Chen ZS
- Cheng H
- Cheng J
- Cheng S-Y
- Cheng W
- Cheng X
- Cheng X-T
- Cheng Y
- Cheng Z
- Cheong H
- Cheong JK
- Chernyak BV
- Cherry S
- Cheung CFR
- Cheung CHA
- Cheung K-H
- Chevet E
- Chi RJ
- Chiang AKS
- Chiaradonna F
- Chiarelli R
- Chiariello M
- Chica N
- Chiocca S
- Chiong M
- Chiou S-H
- Chiramel AI
- Chiurchiù V
- Cho D-H
- Choe S-K
- Choi AMK
- Choi ME
- Choudhury KR
- Chow NS
- Chu CT
- Chua JJE
- Chua JP
- Chung H
- Chung KP
- Chung S
- Chung S-H
- Chung Y-L
- Cianfanelli V
- Ciechomska IA
- Cifuentes M
- Cinque L
- Cirak S
- Cirone M
- Clague MJ
- Clarke R
- Clementi E
- Coccia EM
- Codogno P
- Cohen E
- Cohen MM
- Colasanti T
- Colasuonno F
- Colbert RA
- Colell A
- Coll NS
- Collins MO
- Colombo MI
- Colón-Ramos DA
- Combaret L
- Comincini S
- Cominetti MR
- Consiglio A
- Conte A
- Conti F
- Contu VR
- Cookson MR
- Coombs KM
- Coppens I
- Corasaniti MT
- Cordes N
- Corkery DP
- Cortese K
- Costa MDC
- Costantino S
- Costelli P
- Coto-Montes A
- Crack PJ
- Crespo JL
- Criollo A
- Crippa V
- Cristofani R
- Csizmadia T
- Cuadrado A
- Cui B
- Cui J
- Cui Y
- Cui Y
- Culetto E
- Cumino AC
- Cybulsky AV
- Czaja MJ
- Czuczwar SJ
- D'Adamo S
- D'Amelio M
- D'Arcangelo D
- D'Lugos AC
- D'Orazi G
- da Silva JA
- Dafsari HS
- Dagda RK
- Dagdas Y
- Daglia M
- Dai X
- Dai Y
- Dai Y
- Dal Col J
- Dalhaimer P
- Dalla Valle L
- Dallenga T
- Dalmasso G
- Damme M
- Dando I
- Dantuma NP
- Darling AL
- Das H
- Dasarathy S
- Dasari SK
- Dash S
- Daumke O
- Dauphinee AN
- Davies JS
- Davis RJ
- Davis T
- Dayalan Naidu S
- De Amicis F
- De Bosscher K
- De Felice F
- De Franceschi L
- De Leonibus C
- de Mattos Barbosa MG
- De Meyer GRY
- De Milito A
- De Nunzio C
- De Palma C
- De Santi M
- De Virgilio C
- De Zio D
- Debnath J
- DeBosch BJ
- Decuypere J-P
- Deehan MA
- Deflorian G
- DeGregori J
- Dehay B
- Del Rio G
- Delaney JR
- Delbridge LMD
- Delorme-Axford E
- Delpino MV
- Demarchi F
- Dembitz V
- Demers ND
- Deng H
- Deng Z
- Dengjel J
- Dent P
- Denton D
- DePamphilis ML
- Der CJ
- Deretic V
- Descoteaux A
- Devis L
- Devkota S
- Devuyst O
- Dewson G
- Dharmasivam M
- Dhiman R
- di Bernardo D
- Di Cristina M
- Di Domenico F
- Di Fazio P
- Di Fonzo A
- Di Guardo G
- Di Guglielmo GM
- Di Leo L
- Di Malta C
- Di Nardo A
- Di Rienzo M
- Di Sano F
- Diallinas G
- Diao J
- Diaz-Araya G
- Dickinson JM
- Diederich M
- Dieudé M
- Dikic I
- Ding S
- Ding W-X
- Dini L
- Dinic M
- Dinić J
- Dinkova-Kostova AT
- Dionne MS
- Distler JHW
- Diwan A
- Dixon IMC
- Djavaheri-Mergny M
- Dobrinski I
- Dobrovinskaya O
- Dobrowolski R
- Dobson RCJ
- Dokmeci Emre S
- Donadelli M
- Dong B
- Dong X
- Dong XC
- Dong Z
- Dorn Ii GW
- Dotsch V
- Dou H
- Dou J
- Dowaidar M
- Dridi S
- Drucker L
- du Toit A
- Du A
- Du C
- Du G
- Du H-N
- Du L-L
- Duan S-B
- Duan X
- Duarte SP
- Dubrovska A
- Dunlop EA
- Dupont N
- Durán RV
- Dwarakanath BS
- Dyshlovoy SA
- Dávila VA
- Díaz-Laviada I
- Ebrahimi-Fakhari D
- Eckhart L
- Edelstein CL
- Efferth T
- Eftekharpour E
- Eichinger L
- Eid N
- Eisenberg T
- Eissa NT
- Eissa S
- Ejarque M
- El Andaloussi A
- El-Hage N
- El-Naggar S
- El-Shafey ES
- Eleuteri AM
- Elgendy M
- Eliopoulos AG
- Elizalde MM
- Elks PM
- Elsasser H-P
- Elsherbiny ES
- Emerling BM
- Emre NCT
- Eng CH
- Engedal N
- Engelbrecht A-M
- Engelsen AST
- Enserink JM
- Escalante R
- Esclatine A
- Escobar-Henriques M
- Eskelinen E-L
- Espert L
- Eusebio M-O
- Fabrias G
- Fabrizi C
- Facchiano A
- Facchiano F
- Fadeel B
- Fader C
- Faesen AC
- Fairlie WD
- Falcó A
- Falkenburger BH
- Fan D
- Fan J
- Fan Y
- Fang EF
- Fang Y
- Fang Y
- Fanto M
- Farfel-Becker T
- Faure M
- Fazeli G
- Fedele AO
- Feldman AM
- Feng D
- Feng J
- Feng L
- Feng W
- Feng Y
- Feng Y
- Fenz Araujo T
- Ferguson TA
- Fernandez-Checa JC
- Fernie AR
- Fernández ÁF
- Fernández-Veledo S
- Ferrante AW
- Ferraresi A
- Ferrari MF
- Ferreira JCB
- Ferro-Novick S
- Figueras A
- Filadi R
- Filigheddu N
- Filippi-Chiela E
- Filomeni G
- Fimia GM
- Fineschi V
- Finetti F
- Finkbeiner S
- Fisher EA
- Fisher PB
- Flamigni F
- Fliesler SJ
- Flo TH
- Florance I
- Florey O
- Florio T
- Fodor E
- Follo C
- Fon EA
- Forlino A
- Fornai F
- Fortini P
- Fracassi A
- Fraldi A
- Franco B
- Franco R
- Franconi F
- Frankel LB
- Friedman SL
- Fröhlich LF
- Frühbeck G
- Fuentes JM
- Fujiki Y
- Fujita N
- Fujiwara Y
- Fukuda M
- Fulda S
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- Álvarez ÉMC
- Ávalos Y
- Önal G
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- Čolić M
- Đokić J
- Žerovnik E
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field
Global burden of 369 diseases and injuries in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019
- Author
- Abbafati C
- Abbas KM
- Abbasi M
- Abbasi-Kangevari M
- Abbasifard M
- Abbastabar H
- Abd El Razek HM
- Abd El Razek MM
- Abd-Allah F
- Abdelalim A
- Abdollahi M
- Abdollahpour I
- Abdulkader RS
- Abdullah KH
- Abedi A
- Abedi P
- Abegaz KH
- Abolhassani H
- Abosetugn AE
- Aboyans V
- Abrams EM
- Abreu LG
- Abrigo MRM
- Abu Haimed AK
- Abu-Gharbieh E
- Abu-Raddad LJ
- Abualhasan A
- Abushouk AI
- Acebedo A
- Ackerman IN
- Adabi M
- Adair T
- Adamu AA
- Adebayo OM
- Adedeji IA
- Adekanmbi V
- Adelson JD
- Adeoye AM
- Adetokunboh OO
- Adham D
- Advani SM
- Afarideh M
- Afshari M
- Afshin A
- Agardh EE
- Agarwal G
- Agasthi P
- Agesa KM
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- Aghamir SMK
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- Ahmadi A
- Ahmadi K
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- Ahmadpour E
- Ahmed MB
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- Akalu TY
- Akinyemi RO
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- Al-Mekhlafi HM
- Al-Raddadi RM
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- Alanezi FM
- Alanzi TM
- Albertson SB
- Alcalde-Rabanal JE
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- Alemu BW
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- Alhassan RK
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- Tessema ZT
- Thakur B
- Thankappan KR
- Thapar R
- Thomas N
- Thomson AM
- Thrift AG
- Thurston GD
- Titova MV
- Tlou B
- Tohidinik HR
- Tonelli M
- Topor-Madry R
- Topouzis F
- Toroudi HP
- Torre AE
- Touvier M
- Tovani-Palone MR
- Traini E
- Tran BX
- Travillian R
- Trias-Llimos S
- Troeger CE
- Truelsen TC
- Tsai AC
- Tsatsakis A
- Tyrovolas S
- Uddin R
- Ullah I
- Ullah S
- Umeokonkwo CD
- Undurraga EA
- Unnikrishnan B
- Upadhyay E
- Uthman OA
- Vacante M
- Vaicekonyte R
- Vakilian A
- Valdez PR
- Valli A
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- Vardavas C
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- Vasankari TJ
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- Vasseghian Y
- Veisani Y
- Velasquez IM
- Venketasubramanian N
- Vidale S
- Violante FS
- Vlassov V
- Vollset SE
- Vongpradith A
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- Vujcic IS
- Vukovic A
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- Waheed Y
- Wallin MT
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- Weiss DJ
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- Werdecker A
- West JJ
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- Whisnant JL
- Whiteford HA
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- Wickramasinghe ND
- Wiens KE
- Wijeratne T
- Wilner LB
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- Wiysonge CS
- Wojtyniak B
- Woldu G
- Wolfe CDA
- Wondmeneh TG
- Wondmieneh AB
- Wool EE
- Wozniak SS
- Wu A-M
- Wu C
- Wu J
- Wunrow HY
- Xie Y
- Xu G
- Xu R
- Yadgir S
- Yamada T
- Yamagishi K
- Yaminfirooz M
- Yano Y
- Yaya S
- Yazdi-Feyzabadi V
- Yearwood JA
- Yeheyis TY
- Yeshitila YG
- Yilgwan CS
- Yilma MT
- Yip P
- Yonemoto N
- Yoon S-J
- York HW
- Younis MZ
- Younker TP
- Yousefi B
- Yousefi Z
- Yousefifard M
- Yousefinezhadi T
- Yousuf AY
- Yu C
- Yu Y
- Yuan C-W
- Yuce D
- Yusefzadeh H
- Zadey S
- Zahabi SS
- Zaidi SS
- Zaki L
- Zaki MES
- Zakzuk J
- Zamani M
- Zamanian M
- Zandian H
- Zangeneh A
- Zarafshan H
- Zastrozhin MS
- Zewdie KA
- Zhang J
- Zhang Y
- Zhang Z-J
- Zhao JT
- Zhao X-JG
- Zhao Y
- Zheleva B
- Zheng P
- Zhou M
- Zhu C
- Ziapour A
- Zimsen SRM
- Zlavog BS
- Zodpey S
- Publication venue
- 'Elsevier BV'
- Publication date
- 17/10/2020
- Field of study
Five insights from the Global Burden of Disease Study 2019
- Author
- Abbafati C
- Abbas KM
- Abbasi M
- Abbasi-Kangevari M
- Abbasifard M
- Abbastabar H
- Abd El Razek HM
- Abd El Razek MM
- Abd-Allah F
- Abdelalim A
- Abdollahi M
- Abdollahpour I
- Abdulkader RS
- Abdullah KH
- Abedi A
- Abedi P
- Abegaz KH
- Abolhassani H
- Abosetugn AE
- Aboyans V
- Abrams EM
- Abreu LG
- Abrigo MRM
- Abu Haimed AK
- Abu-Gharbieh E
- Abu-Raddad LJ
- Abualhasan A
- Abushouk AI
- Acebedo A
- Ackerman IN
- Adabi M
- Adair T
- Adamu AA
- Adebayo OM
- Adedeji IA
- Adekanmbi V
- Adelson JD
- Adeoye AM
- Adetokunboh OO
- Adham D
- Advani SM
- Afarideh M
- Afshari M
- Afshin A
- Agardh EE
- Agarwal G
- Agasthi P
- Agesa KM
- Aghaali M
- Aghamir SMK
- Agrawal A
- Ahmad T
- Ahmadi A
- Ahmadi K
- Ahmadi M
- Ahmadieh H
- Ahmadpour E
- Ahmed MB
- Aji B
- Akalu TY
- Akinyemi RO
- Akinyemiju T
- Akombi B
- Akunna CJ
- Al-Aly Z
- Al-Mekhlafi HM
- Al-Raddadi RM
- Alahdab F
- Alam K
- Alam N
- Alam S
- Alam T
- Alanezi FM
- Alanzi TM
- Albertson SB
- Alcalde-Rabanal JE
- Alema NM
- Alemu BW
- Alemu YM
- Alhabib KF
- Alhassan RK
- Ali M
- Ali S
- Alicandro G
- Alijanzadeh M
- Alinia C
- Alipour V
- Alizade H
- Aljunid SM
- Alla F
- Allebeck P
- Almadi MAH
- Almasi A
- Almasi-Hashiani A
- Almasri NA
- Almulhim AM
- Alonso J
- Altirkawi KA
- Alumran AK
- Alvis-Guzman N
- Alvis-Zakzuk NJ
- Amare AT
- Amare B
- Amini S
- Amini-Rarani M
- Aminorroaya A
- Amiri F
- Amit AML
- Amugsi DA
- Amul GGH
- Anbesu EW
- Ancuceanu R
- Anderlini D
- Anderson JA
- Andrei CL
- Andrei T
- Androudi S
- Angus C
- Anjomshoa M
- Ansari F
- Ansari I
- Ansari-Moghaddam A
- Antonazzo IC
- Antonio CAT
- Antony CM
- Antriyandarti E
- Anvari D
- Anwer R
- Appiah SCY
- Arab-Zozani M
- Arabloo J
- Aravkin AY
- Arba AAK
- Aremu O
- Ariani F
- Aripov T
- Armoon B
- Arnlov J
- Arowosegbe OO
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- Arzani A
- Asaad M
- Asadi-Aliabadi M
- Asadi-Pooya AA
- Asgari S
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- Ashbaugh C
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- Atnafu DD
- Atout MMW
- Atre SR
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- Avokpaho EFGA
- Ayano G
- Ayanore MA
- Aynalem GL
- Aynalem YA
- Ayza MA
- Azari S
- Azarian G
- Azene ZN
- Azhar G
- Azzopardi PS
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- Badawi A
- Badiye AD
- Bagherzadeh M
- Bagli E
- Bahrami MA
- Baig AA
- Bairwa M
- Bakhshaei MH
- Bakhtiari A
- Bakkannavar SM
- Balachandran A
- Balakrishnan S
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- Balassyano S
- Baldasseroni A
- Bali AO
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- Ballew SH
- Balzi D
- Banach M
- Bandpei MAM
- Banerjee SK
- Banik PC
- Bannick MS
- Bante AB
- Bante SA
- Baraki AG
- Barboza MA
- Barker-Collo SL
- Barnighausen TW
- Barrero LH
- Barthelemy CM
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- Bhutta ZA
- Bibi S
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- Bijani A
- Bikbov B
- Bilano V
- Bin Sayeed MS
- Bin Zaman S
- Biondi A
- Birihane BM
- Bisanzio D
- Bisignano C
- Biswas RK
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- Bjorge T
- Bockarie MJ
- Bohlouli S
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- Breitborde NJK
- Breitner S
- Brenner H
- Breusov AV
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- Briko AN
- Briko NI
- Britton GB
- Brugha T
- Bryazka D
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- Burkart K
- Burnett RT
- Busse R
- Butt ZA
- Caetano dos Santos FL
- Cahill LE
- Cahuana-Hurtado L
- Cai T
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- Camera LA
- Campos-Nonato IR
- Cao J
- Car J
- Car LT
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- Carrero JJ
- Carvalho F
- Castaldelli-Maia JM
- Castaneda-Orjuela CA
- Castelpietra G
- Castle CD
- Castro E
- Castro F
- Catala-Lopez F
- Causey K
- Cederroth CR
- Cercy KM
- Cerin E
- Chalek J
- Chandan JS
- Chang AR
- Chang AY
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- Charan J
- Charlson FJ
- Chattu VK
- Chaturvedi S
- Cherbuin N
- Chimed-Ochir O
- Chin KL
- Chirinos-Caceres JL
- Cho DY
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- Christensen H
- Chu D-T
- Chung MT
- Chung S-C
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- Classen TKD
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- Compton K
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- Cowie BC
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- Crowe CS
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- Cunningham M
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- da Silva DD
- Dahlawi SMA
- Dai H
- Dai H
- Damasceno AAM
- Damiani G
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- Daneshpajouhnejad P
- Dangel WJ
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- Darshan BB
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- Dean FE
- DeCleene NK
- Deen A
- Defo BK
- Degenhardt L
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- Dellavalle RP
- Demeke FM
- Demoz GT
- Demsie DG
- Denova-Gutierrez E
- Dereje ND
- Deribe K
- Dervenis N
- Desai R
- Desalew A
- Dessie GA
- Deuba K
- Dharmaratne SD
- Dhungana GP
- Dianatinasab M
- Diaz D
- Dichgans M
- Didarloo A
- Dingels ZV
- Dippenaar IN
- Dirac MA
- Djalalinia S
- Do HT
- Dokova K
- Doku DT
- Dolecek C
- Dolgert AJ
- Dorostkar F
- Doshi CP
- Doshi PP
- Doshmangir L
- Douiri A
- Doxey MC
- Doyle KE
- Driscoll TR
- Dubljanin E
- Dunachie SJ
- Duncan BB
- Duraes AR
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- Ebrahimi H
- Edvardsson D
- Effiong A
- Ehrlich JR
- El Nahas N
- El Sayed I
- El Tantawi M
- El-Jaafary SI
- Elbarazi I
- Elgendy IY
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- Elsharkawy A
- Elyazar IRF
- Emamian MH
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- Erskine HE
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- Eskandarieh S
- Esmaeilnejad S
- Esmaeilzadeh F
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- Etisso AE
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- Fanzo J
- Farag T
- Farahmand M
- Faraj A
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- Faridnia R
- Farinha CSES
- Farioli A
- Faris PS
- Faro A
- Faruque M
- Farzadfar F
- Fattahi N
- Fazaeli AA
- Fazlzadeh M
- Feigin VL
- Feldman R
- Fereshtehnejad S-M
- Fernandes E
- Ferrara G
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- Ferrari AJ
- Ferreira ML
- Feyissa GT
- Filip I
- Fischer F
- Fisher JL
- Fitzgerald R
- Flohr C
- Flor LS
- Foigt NA
- Folayan MO
- Fomenkov AA
- Force LM
- Fornari C
- Forooshani ZSD
- Foroutan M
- Fox JT
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- Frank TD
- Franklin RC
- Freitas M
- Fu W
- Fukumoto T
- Fukutaki K
- Fuller JE
- Fullman N
- Furtado JM
- Gad MM
- Gaidhane AM
- Gakidou E
- Galles NC
- Gallus S
- Gamkrelidze A
- Garcia-Basteiro AL
- Gardner WM
- Geberemariyam BS
- Gebrehiwot AM
- Gebremedhin KB
- Gebremeskel GG
- Gebremeskel LG
- Gebresillassie BM
- Gebreslassie AAAA
- Gela JD
- Geramo YCD
- Geremew A
- Gesesew HA
- Gething PW
- Gezae KE
- Ghadimi M
- Ghadiri K
- Ghaffarifar F
- Ghafourifard M
- Ghajar A
- Ghamari F
- Ghashghaee A
- Ghiasvand H
- Ghith N
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- Guled RA
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- Jayatilleke AU
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- Publication venue
- Publication date
- 01/01/2020
- Field of study
The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 provides a rules-based synthesis of the available evidence on levels and trends in health outcomes, a diverse set of risk factors, and health system responses. GBD 2019 covered 204 countries and territories, as well as first administrative level disaggregations for 22 countries, from 1990 to 2019. Because GBD is highly standardised and comprehensive, spanning both fatal and non-fatal outcomes, and uses a mutually exclusive and collectively exhaustive list of hierarchical disease and injury causes, the study provides a powerful basis for detailed and broad insights on global health trends and emerging challenges. GBD 2019 incorporates data from 281 586 sources and provides more than 3.5 billion estimates of health outcome and health system measures of interest for global, national, and subnational policy dialogue. All GBD estimates are publicly available and adhere to the Guidelines on Accurate and Transparent Health Estimate Reporting. From this vast amount of information, five key insights that are important for health, social, and economic development strategies have been distilled. These insights are subject to the many limitations outlined in each of the component GBD capstone papers.Peer reviewe
Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors
- Author
- Abdellaoui Abdel
- Abramova Liliya
- Adams Mark
- Adams Mark J.
- Adan Roger A. H.
- Adolfsson Rolf
- Adolfsson Rolf
- Adorjan Kristina
- Agartz Ingrid
- Agartz Ingrid
- Agerbo Esben
- Agerbo Esben
- Agerbo Esben
- Aguayo Samuel
- Ahuja Sunil
- Air Tracy M.
- Air Tracy M.
- Al Eissa Mariam
- Albani Diego
- Alda Martin
- Alda Martin
- Alfredsson Lars
- Alfredsson Lars
- Alfredsson Lars
- Alliey-Rodriguez Ney
- Als Thomas D.
- Andlauer Till F. M.
- Ando Tetsuya
- Andreassen Ole A.
- Andreassen Ole A.
- Andreassen Ole A.
- Anjorin Adebayo
- Anjorin Adebayo
- Antilla Verneri
- Antoniou Anastasia
- Appadurai Vivek
- Argyres Dean P.
- Arolt Volker
- Artigas Maria Soler
- Aschauer Harald
- Ashley-Koch Allison E.
- Aslan Mihaela
- Awasthi Swapnil
- Awasthi Swapnil
- Awasthi Swapnil
- Azevedo M. Helena
- Babadjanova Gulja
- Bacanu Silviu-Alin
- Backlund Lena
- Baek Ji Hyun
- Baker Jessica H.
- Ballas Zuhair
- Bass Nicholas
- Bass Nicholas
- Bau Claiton H. D.
- Bauer Michael
- Baune Bernhard T.
- Baune Bernhard T.
- Baune Bernhard T.
- Beckham Jean
- Beckham Jean
- Beckham Jean C.
- Beekman Aartjan T. F.
- Beins Eva C.
- Bellivier Frank
- Bellivier Frank
- Bencko Vladimir
- Bengesser Susanne
- Bergen Andrew W.
- Bergen Andrew W.
- Bergen Sarah E.
- Berger Klaus
- Berger Klaus
- Berrettini Wade H.
- Berrettini Wade H.
- Berrettini Wade H.
- Bhushan Sujata
- Biernacka Joanna M.
- Biernacka Joanna M.
- Bigdeli Tim B.
- Bigdeli Tim B.
- Bigdeli Tim B.
- Binder Elisabeth B.
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- Birgegård Andreas
- Birner Armin
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- Boden Joseph M.
- Boehm Ilka
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- Boks Marco P.
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- Boomsma Dorret I.
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- Boyko Edward
- Braff David L.
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- Breeling James
- Breen Gerome
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- Brewer Jessica V.
- Brophy Mary T.
- Brum Murielle
- Brumpton Ben M.
- Brunkhorst-Kanaan Nathalie
- Bryant Richard
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- Buehren Katharina
- Bulik Cynthia M.
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- Byrne Enda M.
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- Bøen Erlend
- Børglum Anders D.
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- Børte Sigrid
- Cahn Wiepke
- Cai Na
- Cairns Murray
- Campos Adrian I.
- Carlberg Laura
- Carr Vaughan J.
- Carter Bruce W.
- Casas Miguel
- Casas Miquel
- Cassina Matteo
- Castelao Enrique
- Castelao Enrique
- Catts Stanley
- Cervantes Pablo
- Cervilla Jorge A.
- Chang Kyong-Mi
- Chang Xiao
- Charney Alexander W.
- Chaumette Boris
- Chen Hsi-Chung
- Chen Wei J.
- Cho Kelly
- Cho Kelly
- Christensen Jane Hvarregaard
- Cichon Sven
- Cichon Sven
- Cichon Sven
- Cichon Sven
- Clarke Toni-Kim
- Clarke Toni-Kim
- Clementi Maurizio
- Cohen David
- Coleman Jonathan R. I.
- Coleman Jonathan R. I.
- Coleman Jonathan R. I.
- Coleman Jonathan R. I.
- Colodro-Conde Lucía
- Cone Roger D.
- Connor Todd
- Constans Joseph
- Coombes Brandon
- Coon Hilary
- Corvin Aiden
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- Courtet Philippe
- Couvy-Duchesne Baptiste
- Craddock Nicholas
- Craddock Nicholas
- Craddock Nick
- Craig David
- Crawford Gregory E.
- Crawford Steven
- Crawford Steven
- Crivelli Silvia
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- Cruceanu Cristiana
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- Czerski Piotr M.
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- Dedoussis George
- Degenhardt Franziska
- Degenhardt Franziska
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- Degortes Daniela
- Dellitalia Louis
- Demontis Ditte
- Dennis Michelle F.
- Depaulo J. Raymond
- DePaulo J. Raymond
- der Auwera Sandra Van
- Derks Eske M.
- DeSocio Janiece E.
- Di Florio Arianna
- DiBlasi Emily
- Dick Danielle M.
- Dietl Lydie
- Dikeos Dimitris
- Dikeos Dimitris
- Dina Christian
- Direk Nese
- Djurovic Srdjan
- Djurovic Srdjan
- Dmitrzak-Weglarz Monika
- Do Nhan
- Dobbyn Amanda L.
- Docherty Anna R.
- Dolan Conor V.
- Domenici Enrico
- Domschke Katharina
- Douzenis Athanassios
- Drange Ole Kristian
- Duncan Laramie E.
- Dunn Erin C.
- Duriez Philibert
- Edenberg Howard J.
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- Edwards Alexis C.
- Egberts Karin
- Ehrlich Stefan
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- Elvsåshagen Torbjørn
- Erlangsen Annette
- Escaramís Geòrgia
- Escott-Price Valentina
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- Esko Tõnu
- Esko Tõnu
- Esko Tõnu
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- Espeseth Thomas
- Estivill Xavier
- Etain Bruno
- Fanous Ayman H.
- Farmer Anne
- Favaro Angela
- Fayad Joseph
- Ferentinos Panagiotis
- Fernández-Aranda Fernando
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- Ferrier I. Nicol
- Fichter Manfred M.
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- Frei Oleksandr
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- Fullerton Janice M.
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- Föcker Manuel
- Gaddy Melinda
- Gade Katrin
- Galfalvy Hanga
- Gallinger Steven
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- Gaziano J. Michael
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- Gelernter Joel
- Gelernter Joel
- Gershon Elliot S.
- Gibson Gretchen
- Giegling Ina
- Giegling Ina
- Gill Michael
- Giuranna Johanna
- Giusti-Rodríquez Paola
- Gizer Ian R.
- Glatt Stephen J.
- Godschalk Michael
- Goes Fernando S.
- Goes Fernando S.
- Gonidakis Fragiskos
- Gordon Scott
- Gordon Scott D.
- Gordon Scott D.
- Gordon-Smith Katherine
- Gorwood Philip
- Gorwood Philip
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- Grabe Hans J.
- Greco Jennifer
- Green Melissa J.
- Green Melissa J.
- Greenwood Tiffany A.
- Grevet Eugenio H.
- Grigoroiu-Serbanescu Maria
- Grigoroiu-Serbanescu Maria
- Grove Jakob
- Grove Jakob
- Grove Jakob
- Guillaume Sébastien
- Guo Yiran
- Guo Yiran
- Gupta Samir
- Gutierrez Blanca
- Gutierrez Salvador
- Guzman-Parra Jose
- Guzman-Parra José
- Ha Kyooseob
- Hafferty Jonathan D.
- Hagenaars Saskia P.
- Hakonarson Hakon
- Hakonarson Hakon
- Hall Lynsey S.
- Halmi Katherine A.
- Halmi Katherine A.
- Hamilton Steven P.
- Hamilton Steven P.
- Hammer Kimberly
- Hamner Mark
- Hamshere Marian L.
- Hanscombe Ken B.
- Hansen Christine Søholm
- Hansen Christine Søholm
- Hansen Thomas F.
- Haraldsson Magnus
- Harley John
- Hartmann Annette
- Harvey Phillip D.
- Hassan Kiadeh Farnush Farhadi
- Hatzikotoulas Konstantinos
- Hauser Elizabeth
- Hauser Elizabeth R.
- Hauser Joanna
- Hauser Joanna
- Hauser Joanna
- Hauser Michael A.
- Hautzinger Martin
- Hayward Caroline
- Heath Andrew C.
- Hebebrand Johannes
- Heilbronner Urs
- Heilmann-Heimbach Stefanie
- Helder Sietske G.
- Hellgren Dennis
- Henders Anjali K.
- Henskens Frans
- Herms Stefan
- Herms Stefan
- Herms Stefan
- Herpertz-Dahlmann Beate
- Herzog Wolfgang
- Hickie Ian B.
- Hillert Jan
- Hinney Anke
- Hishimoto Akitoyo
- Hoffmann Per
- Hoffmann Per
- Hoffmann Per
- Holmans Peter A.
- Homuth Georg
- Hong Kyung Sue
- Horn Carsten
- Horwood L. John
- Hottenga Jouke-Jan
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- Hougaard David M.
- Hougaard David M.
- Howard David M.
- Huang Grant
- Huckins Laura
- Huckins Laura M.
- Hudson James I.
- Huffman Jennifer E.
- Hultman Christina M.
- Humphries Donald E.
- Hung Adriana
- HUNT All-In Psychiatry
- Huq Mostaqul
- Hurley Robin
- Hveem Kristian
- Hwu Hai-Gwo
- Hübel Christopher
- Ikeda Masashi
- Imgart Hartmut
- Inoko Hidetoshi
- Iruvanti Pran
- Ising Marcus
- Ising Marcus
- Ivins Douglas
- Iwata Nakao
- Jablensky Assen V.
- Jacobson Daniel
- Jacono Frank
- Jain Sonia
- Jamain Stéphane
- Jamain Stéphane
- Janout Vladimir
- Jansen Rick
- Jhala Darshana
- Jiménez-Murcia Susana
- Jiménez-Murcia Susana
- Johnson Craig
- Johnson Craig
- Johnson Jessica S.
- Jones Ian
- Jones Ian
- Jones Ian
- Jones Lisa A.
- Jones Lisa A.
- Jones Lisa A.
- Jonsson Lina
- Jordan Jennifer
- Jorgenson Eric
- Julià Antonio
- Jungkunz Martin
- Kahn René S.
- Kahn René S.
- Kalman Janos L.
- Kalsi Gursharan
- Kamatani Yoichiro
- Kaminsky Laurence
- Kaminská Deborah
- Kamitaki Nolan
- Kang JooEun
- Kaplan Allan S.
- Kaplan Allan S.
- Kaprio Jaakko
- Karhunen Leila
- Karwautz Andreas
- Kas Martien J. H.
- Kay Yang Jessica Mei
- Kaye Walter H.
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- Yao Shuyang
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- Yilmaz Zeynep
- Young Allan H.
- Young Hannah
- Zablocki Clement J.
- Zai Clement C.
- Zandi Peter P.
- Zeggini Eleftheria
- Zerwas Stephanie
- Zhang Futao
- Zhao Hongyu
- Zhou Hang
- Zillich Lea
- Zillich Lea
- Zipfel Stephan
- Zwart John-Anker
- Świątkowska Beata
- Świątkowska Beata
- Świątkowska Beata
- Publication venue
- Publication date
- 01/01/2021
- Field of study
Background Suicide is a leading cause of death worldwide, and nonfatal suicide attempts, which occur far more frequently, are a major source of disability and social and economic burden. Both have substantial genetic etiology, which is partially shared and partially distinct from that of related psychiatric disorders. Methods We conducted a genome-wide association study (GWAS) of 29,782 suicide attempt (SA) cases and 519,961 controls in the International Suicide Genetics Consortium (ISGC). The GWAS of SA was conditioned on psychiatric disorders using GWAS summary statistics via multitrait-based conditional and joint analysis, to remove genetic effects on SA mediated by psychiatric disorders. We investigated the shared and divergent genetic architectures of SA, psychiatric disorders, and other known risk factors. Results Two loci reached genome-wide significance for SA: the major histocompatibility complex and an intergenic locus on chromosome 7, the latter of which remained associated with SA after conditioning on psychiatric disorders and replicated in an independent cohort from the Million Veteran Program. This locus has been implicated in risk-taking behavior, smoking, and insomnia. SA showed strong genetic correlation with psychiatric disorders, particularly major depression, and also with smoking, pain, risk-taking behavior, sleep disturbances, lower educational attainment, reproductive traits, lower socioeconomic status, and poorer general health. After conditioning on psychiatric disorders, the genetic correlations between SA and psychiatric disorders decreased, whereas those with nonpsychiatric traits remained largely unchanged. Conclusions Our results identify a risk locus that contributes more strongly to SA than other phenotypes and suggest a shared underlying biology between SA and known risk factors that is not mediated by psychiatric disorders.Peer reviewe
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