thurnauer: vt and vi, to paint in the second person

In these paintings, visual and verbal languages provide us with different maps of the same territory; and Thurnauer’s hybridized representations argue that the world can only be rendered through a dialogue, an interlocution of different forms, genres, media. We approach her work, not as viewers whose function is predicated through a gaze regulated according to the distorting demands of consumption or control, but as readers engaged in a critical activity seeing around the edges of historically produced versions of the self

Mass Illuminations:Jennings, Madge, Rimbaud and the 'Popular' Prose Poem

The importance of the Mass-Observation social research project to post-war British literature can be traced to the founding involvement of two poets, Humphrey Jennings and Charles Madge. Their experimentation with the possibility of a prose-based poetry in the mid-Thirties has already been linked to the example of Surrealism. Here, it is argued that they were also strongly influenced by Rimbaud’s Une Saison en Enfer (1873) and Illuminations (1872-74). Madge’s prose poem ‘Bourgeois News’ uses textual collage to create a Rimbaldian vision of the ‘parade sauvage’ of late imperial Britain, which strikingly anticipates the work of more recent British prose poets such as Rod Mengham and Tony Lopez. In conclusion, archival evidence is used to support the hypothesis that Madge composed an anoymous news article, influenced by his reading of Rimbaud, as an illustration of his belief that newspapers contained the potential for a revolutionary new form of ‘popular poetry’

The sadism of the author or the masochism of the reader?

The symposium giving rise to this collection and the thriving of the B.S. Johnson Society both indicate that there is something exceptional going on with the literary and academic community’s relationship with this author, something we (collectively) still haven’t quite fathomed. In order to attempt to identify the source of Johnson’s fascination, I want to discuss the author-reader relationship as it comes into focus in his novels since, implicitly and explicitly, this is a recurring issue in academic studies of Johnson’s work (see White 2011)

Dityrosine cross-links are present in alzheimer's disease-derived Tau Oligomers and Paired Helical Filaments (PHF) which Promotes the stability of the PHF-core Tau (297–391) in vitro

A characteristic hallmark of Alzheimer's Disease (AD) is the pathological aggregation and deposition of tau into paired helical filaments (PHF) in neurofibrillary tangles (NFTs). Oxidative stress is an early event during AD pathogenesis and is associated with tau-mediated AD pathology. Oxidative environments can result in the formation of covalent dityrosine crosslinks that can increase protein stability and insolubility. Dityrosine cross-linking has been shown in Aβ plaques in AD and α-synuclein aggregates in Lewy bodies in ex vivo tissue sections, and this modification may increase the insolubility of these aggregates and their resistance to degradation. Using the PHF-core tau fragment (residues 297 – 391) as a model, we have previously demonstrated that dityrosine formation traps tau assemblies to reduce further elongation. However, it is unknown whether dityrosine crosslinks are found in tau deposits in vivo in AD and its relevance to disease mechanism is unclear. Here, using transmission electron microscope (TEM) double immunogold-labelling, we reveal that neurofibrillary NFTs in AD are heavily decorated with dityrosine crosslinks alongside tau. Single immunogold-labelling TEM and fluorescence spectroscopy revealed the presence of dityrosine on AD brain-derived tau oligomers and fibrils. Using the tau (297–391) PHF-core fragment as a model, we further showed that prefibrillar tau species are more amenable to dityrosine crosslinking than tau fibrils. Dityrosine formation results in heat and SDS stability of oxidised prefibrillar and fibrillar tau assemblies. This finding has implications for understanding the mechanism governing the insolubility and toxicity of tau assemblies in vivo

Telemediations

Postprin

Poems

SMITTEN, THE STO

Investigating early-stage protein misfolding of Abeta and tau in neurodegenerative diseases

EMBARGOED - expected end date 03.05.202