Spleen rupture in a case of untreated Plasmodium vivax infection

We report the unique case of a 19-yearold nonimmune patient with Plasmodium vivax monoinfection, confirmed by PCR in the peripheral blood and in the spleen section, who was splenectomized due to spleen rupture two days prior to the diagnosis and treatment of the malarial infection. Microscopic analyses evidenced white pulp expansion and a diffuse hypercellularity in the splenic red pulp, with intense proliferating plasmablasts in the subcapsular and perivascular compartments as well as large numbers of intact P. vivax-infected reticulocytes in the cords, in the absence of other concomitant infectious diseases. To our knowledge, this is the first full detailed immunohistopathological characterization of a nontreated P. vivax-infected spleen

The SOPHIE search for northern extrasolar planets. V. Follow-up of ELODIE candidates: Jupiter-analogs around Sun-like stars

We present radial-velocity measurements obtained in a programs underway to search for extrasolar planets with the spectrograph SOPHIE at the 1.93-m telescope of the Haute-Provence Observatory. Targets were selected from catalogs observed with ELODIE, mounted previously at the telescope, in order to detect long-period planets with an extended database close to 15 years. Two new Jupiter-analog candidates are reported to orbit the bright stars HD150706 and HD222155 in 16.1 and 10.9 yr at 6.7 (+4.0,-1.4) and 5.1(+0.6,-0.7) AU and to have minimum masses of 2.71 (+1.44,-0.66) and 1.90 (+0.67,-0.53) M_Jup, respectively. Using the measurements from ELODIE and SOPHIE, we refine the parameters of the long-period planets HD154345b and HD89307b, and publish the first reliable orbit for HD24040b. This last companion has a minimum mass of 4.01 +/- 0.49 M_Jup orbiting its star in 10.0 yr at 4.92 +/- 0.38 AU. Moreover, the data provide evidence of a third bound object in the HD24040 system. With a surrounding dust debris disk, HD150706 is an active G0 dwarf for which we partially corrected the effect of the stellar spot on the SOPHIE radial-velocities. HD222155 is an inactive G2V star. On the basis of the previous findings of Lovis and collaborators and since no significant correlation between the radial-velocity variations and the activity index are found in the SOPHIE data, these variations are not expected to be only due to stellar magnetic cycles. Finally, we discuss the main properties of this new population of long-period Jupiter-mass planets, which for the moment, consists of fewer than 20 candidates. These stars are preferential targets either for direct-imaging or astrometry follow-up to constrain the system parameters and for higher precision radial-velocity to search for lower mass planets, aiming to find a Solar System twin.Comment: accepted for publication in Astronomy & Astrophysic

Essential features of responsible governance of agricultural biotechnology

Agricultural biotechnology continues to generate considerable controversy. We argue that to address this controversy, serious changes to governance are needed. The new wave of genomic tools and products (e.g., CRISPR, gene drives, RNAi, synthetic biology, and genetically modified [GM] insects and fish), provide a particularly useful opportunity to reflect on and revise agricultural biotechnology governance. In response, we present five essential features to advance more socially responsible forms of governance. In presenting these, we hope to stimulate further debate and action towards improved forms of governance, particularly as these new genomic tools and products continue to emerge

The global governance of human cloning: the case of UNESCO

Since Dolly the Sheep was cloned in 1996, the question of whether human reproductive cloning should be banned or pursued has been the subject of international debate. Feelings run strong on both sides. In 2005, the United Nations adopted its Declaration on Human Cloning to try to deal with the issue. The declaration is ambiguously worded, prohibiting “all forms of human cloning inasmuch as they are incompatible with human dignity and the protection of human life”. It received only ambivalent support from UN member states. Given this unsatisfactory outcome, in 2008 UNESCO (the United Nations Educational, Scientific and Cultural Organization) set up a Working Group to investigate the possibility of a legally binding convention to ban human reproductive cloning. The Working Group was made up of members of the International Bioethics Committee, established in 1993 as part of UNESCO’s Bioethics Programme. It found that the lack of clarity in international law is unhelpful for those states yet to formulate national regulations or policies on human cloning. Despite this, member states of UNESCO resisted the idea of a convention for several years. This changed in 2015, but there has been no practical progress on the issue. Drawing on official records and first-hand observations at bioethics meetings, this article examines the human cloning debate at UNESCO from 2008 onwards, thus building on and advancing current scholarship by applying recent ideas on global governance to an empirical case. It concludes that, although human reproductive cloning is a challenging subject, establishing a robust global governance framework in this area may be possible via an alternative deliberative format, based on knowledge sharing and feasibility testing rather than the interest-based bargaining that is common to intergovernmental organizations and involving a wide range of stakeholders. This article is published as part of a collection on global governance

Communicating climate change: conduits, content, and consensus

Climate change has been the subject of increasing efforts by scientists to understand its causes and implications; it has been of growing interest to policymakers, international bodies, and a variety of nongovernment organizations; and it has attracted varied amounts of attention from traditional and, increasingly, online media. These developments have been aligned with shifts in the nature of climate change communication, with changes in how researchers study it and how a variety of actors try to influence it. This article situates the theory and practice of climate change communication within developments that have taken place since we first reviewed the field in 2009. These include the rise of new social media conduits for communication, research, and practice aimed at fine tuning communication content, and the rise to prominence of scientific consensus as part of that content. We focus in particular on continuing tensions between a focus on the part of communicators to inform the public and more dialogic strategies of public engagement. We also consider the tension between efforts to promote consensus and certainty in climate science and approaches that attempt to engage with uncertainty more fully. We explore the lessons to be learnt from climate communication since 2009, highlighting how the field remains haunted by the deficit model of science communication. Finally, we point to more fruitful future directions for climate change communication, including more participatory models that acknowledge, rather than ignore, residual uncertainties in climate science in order to stimulate debate and deliberation

High intensity neutrino oscillation facilities in Europe

The EUROnu project has studied three possible options for future, high intensity neutrino oscillation facilities in Europe. The first is a Super Beam, in which the neutrinos come from the decay of pions created by bombarding targets with a 4 MW proton beam from the CERN High Power Superconducting Proton Linac. The far detector for this facility is the 500 kt MEMPHYS water Cherenkov, located in the Fréjus tunnel. The second facility is the Neutrino Factory, in which the neutrinos come from the decay of μ+ and μ− beams in a storage ring. The far detector in this case is a 100 kt magnetized iron neutrino detector at a baseline of 2000 km. The third option is a Beta Beam, in which the neutrinos come from the decay of beta emitting isotopes, in particular He6 and Ne18, also stored in a ring. The far detector is also the MEMPHYS detector in the Fréjus tunnel. EUROnu has undertaken conceptual designs of these facilities and studied the performance of the detectors. Based on this, it has determined the physics reach of each facility, in particular for the measurement of CP violation in the lepton sector, and estimated the cost of construction. These have demonstrated that the best facility to build is the Neutrino Factory. However, if a powerful proton driver is constructed for another purpose or if the MEMPHYS detector is built for astroparticle physics, the Super Beam also becomes very attractive

Rapid ethical assessment on informed consent content and procedure in Hintalo-Wajirat, Northern Ethiopia: a qualitative study

Background Informed consent is a key component of bio-medical research involving human participants. However, obtaining informed consent is challenging in low literacy and resource limited settings. Rapid Ethical Assessment (REA) can be used to contextualize and simplify consent information within a given study community. The current study aimed to explore the effects of social, cultural, and religious factors during informed consent process on a proposed HPV-serotype prevalence study. Methodology A qualitative community-based REA was conducted in Adigudom and Mynebri Kebeles, Northern Ethiopia, from July to August 2013. Data were collected by a multi-disciplinary team using open ended questions concerning informed consent components in relation to the parent study. The team conducted one-to-one In-Depth Interviews (IDI) and Focus Group Discussions (FGDs) with key informants and community members to collect data based on the themes of the study. Tape recorded data were transcribed in Tigrigna and then translated into English. Data were categorized and thematically analyzed using open coding and content analysis based on pre-defined themes. Results The REA study revealed a number of socio-cultural issues relevant to the proposed study. Low community awareness about health research, participant rights and cervical cancer were documented. Giving a vaginal sample for testing was considered to be highly embarrassing, whereas giving a blood sample made participants worry that they might be given a result without the possibility of treatment. Verbal consent was preferred to written consent for the proposed study. Conclusion This rapid ethical assessment disclosed important socio-cultural issues which might act as barriers to informed decision making. The findings were important for contextual modification of the Information Sheet, and to guide the best consent process for the proposed study. Both are likely to have enabled participants to understand the informed consent better and consequently to comply with the study

Ethics and ‘fracking’: A review of (the limited) moral thought on shale gas development

Whilst claims about the ethicality of shale gas development via hydraulic fracturing (‘fracking’) are commonplace in everyday discourse, little scholarly attention has been afforded explicitly to this aspect of unconventional fossil fuel extraction. The limited research that speaks to ethical considerations largely describes ethical concerns associated with development – extremely few claims in research literature make an ethical case for development. The most common ethical concerns cited in research stem from issues of distributive justice, with procedural justice, the precautionary principle, exposure to involuntary risks, rights-based arguments, and changes in community character and way of life as next most common. Additional research hints implicitly at ethical dilemmas associated with shale gas development, but does not openly identify these issues as having moral implications. Many ethical considerations relate closely to concerns about water quality and the volume/supply of water available for other purposes. The limited scholarship in this area reveals the import of understanding the ways in which ethics permeate thoughts about shale gas development for designing policy that responds to constituent needs and concerns. Even more limited than research on ethical claims in association with shale gas development is well-reasoned scholarship that analyses the extent to which ethical claims about development are well justified and philosophically justifiable. A comprehensive and systematic analysis of the range of ethical claims potentially relevant to shale gas development and their usefulness for informing policy on this topic would contribute greatly to informed decision-making on this controversial issue – something that science alone cannot achieve

Engendering harm: a critique of sex selection for 'family balancing'

The most benign rationale for sex-selection is deemed to be “family balancing.” On this view, provided the sex-distribution of an existing offspring group is “unbalanced,” one may legitimately use reproductive technologies to select the sex of the next child. I present four novel concerns with granting “family balancing” as a justification for sex-selection: (a) families or family subsets should not be subject to medicalization; (b) sex selection for “family balancing” entrenches heteronormativity, inflicting harm in at least three specific ways; (c) the logic of affirmative action is appropriated; (d) the moral mandate of reproductive autonomy is misused. I conclude that the harms caused by “family balancing” are sufficiently substantive to over-ride any claim arising from a supposed right to sex selection as an instantiation of procreative autonomy