Uso de sustancias psicoactivas entre estudiantes universitários

El objetivo del estudio fue identificar el perfil del uso de sustancias psicoactivas entre estudiantes de Ciencias Biológicas, Educación Física, Enfermería, Fisioterapia, Farmacia, Odontología y Nutrición. Se trata de un estudio transversal, cuantitativo, exploratorio y descriptivo, con 567 estudiantes. Los datos fueron recolectados por medio de un cuestionario y analizados a través de la estadística descriptiva. En los resultados, se constató que el 11,6% de los estudiantes nunca experimentó el consumo de sustancias psicoactivas. Las drogas prevalentemente consumidas fueron: alcohol (n = 501), tabaco (n = 161), marihuana (n = 115) y cocaína (n = 26). Se concluye que el consumo de sustancias psicoactivas entre los estudiantes es un problema y que debe ser enfrentado a través de acciones preventivas y de reducción de daños.The objective of this study was to identify the profile of use of psychoactive substances among students of Biological Sciences, Physical Education, Nursing, Physiotherapy, Pharmacy, Dentistry and Nutrition courses. It was a cross - sectional, quantitative, exploratory and descriptive study with 567 students. Data were collected through a questionnaire and analyzed through descriptive statistics. In the results, it was found that 11.6% of students had never tried psychoactive substances in their lives. The most prevalent drugs among university students were alcohol (n = 501), tobacco (n = 161), marijuana (n = 115), and cocaine (n = 26). The result led to the conclusion that consumption of psychoactive substances among students is a problem that must be faced through the implementation of preventive and harm reduction actions.O objetivo do estudo foi identificar o perfil do uso de substâncias psicoativas entre estudantes dos cursos de Ciências Biológicas, Educação Física, Enfermagem, Fisioterapia, Farmácia, Odontologia e Nutrição. Trata-se de estudo transversal, quantitativo, exploratório e descritivo, com 567 estudantes. Os dados foram coletados por meio de um questionário e analisados através da estatística descritiva. Nos resultados, verificou-se que 11,6% dos estudantes nunca experimentaram substâncias psicoativas na vida. As drogas mais prevalentes entre os universitários foram o álcool (n=501), tabaco (n=161), maconha (n=115) e cocaína (n=26). Conclui-se que o consumo de substâncias psicoativas entre os estudantes é problema que deve ser enfrentado através da implantação de ações preventivas e de redução de danos

The use of radiofrequency for hepatocellular carcinoma ablation : an update review and perspectives

The World Health Organization classifies liver cancer among the five types of cancer with highest death rates in the world. Among the current methods available for the treatment of liver cancer, there is the resection of hepatic tissue and the radiofrequency ablation of the tumor. Even though resection presents the best results, only 10% to 15% of the affected patients may eligible for this procedure. On the other hand, the radiofrequency ablation encompasses a larger scope of patients and provides a non-invasive method when compared to resection. There is research with sufficient evidence to allow the transposition of this concept to new technological paradigms, which would yield a more effective ablation process, i.e.: generating enough volumetric necrosis for complete regression of the tumor, leading to a high survival rate of patients. These technological paradigms encompass aspects of operability, innovation and of theoretical framework. In terms of operability, there is the use of better imaging sources to aid the healthcare professional in the positioning of electrodes; in terms of innovation, there are new technologies such as the use of optical fiber microsensors and metallic magnetic nanoparticles to increase the efficiency of the process; in terms of theoretical framework, there is the development of more precise mathematical models that would expand the possibilities of application and increase its effectiveness. These new challenges are new possibilities that may reshape the concept and the use of radiofrequency ablation as it is currently known

ELEMENTOS PARA O ENSINO DE DANÇA: APRECIAÇÃO, COMPOSIÇÃO, IMPROVISAÇÃO E TÉCNICA.

INTRODUÇÃO: Este ensaio apresenta e discuti quatro elementos balizadores para uma proposta de ensino de dança, quais sejam: a técnica, a improvisação, a composição e a apreciação. Buscando dialogar com a produção científica e artística a respeito destes elementos e suas relações com a pedagogia de dança. DESENVOLVIMENTO: Tendo em vista a profundidade conceitual que estes elementos adquiriram tanto na produção acadêmico-científica como também na arte contemporânea, o objetivo deste trabalho é trazer à tona o debate da importância de o ensino de dança ultrapassar as pedagogias reprodutivistas e espontaneístas. CONCLUSÃO: Dançar não é apenas decorar e executar passos previamente estabelecidos, é preciso compreender a dança como um sistema de criação capaz de impulsionar uma capacidade questionadora e reveladora direcionada ao desenvolvimento do autoconhecimento, da autonomia expressiva e da criatividade humana

ANÁLISE DOS IMPACTOS SOCIOAMBIENTAIS A PARTIR DA APLICAÇÃO DA MATRIZ CHECK LIST E OBSERVAÇÃO DIRETA: O CASO DO BOSQUE RODRIGUES ALVES

O Trabalho tem como objetivo avaliar os impactos ocasionados pelo turismo em Belém, mais precisamente no Bosque Rodrigues Alves Jardim Zoobotânico da Amazônia, onde foi realizada a pesquisa de campo, buscou-se verificar por meio da pesquisa qualitativa, como ocorre os impactos negativos e positivos da atividade turística no âmbito cultural socioambiental e econômico no Bosque, além do turismo ser uma atividade propulsora de emprego e renda movimentando a esfera local, a metodologia aplicada foi a pesquisa de campo e bibliográfica, e aplicação e preenchimento do indicador para análise de impactos socioambientais, a matriz check-list, buscou-se apresentar sobre a caracterização da área de estudo, expor o resumo dos resultados, o problema apresentado, e o diagnóstico, foram identificados os impactos do turismo no local, com isso foi exposto no trabalho a análise dos resultados com a atividade turística contribuindo de maneira positiva dentro da área verde

Nucleoplasmic calcium buffering sensitizes human squamous cell carcinoma to anticancer therapy

Submitted by Nuzia Santos ([email protected]) on 2014-02-19T16:27:35Z No. of bitstreams: 1 Methylation of ASC, a Pro-apoptotic Gene Associates with NALP1, Inhibits Apoptosis in Human Colon Cancer - JCST-04-131.pdf.pdf: 2490709 bytes, checksum: 37241b1945fb96047c2b5565a08b9671 (MD5)Made available in DSpace on 2014-02-19T16:27:35Z (GMT). No. of bitstreams: 1 Methylation of ASC, a Pro-apoptotic Gene Associates with NALP1, Inhibits Apoptosis in Human Colon Cancer - JCST-04-131.pdf.pdf: 2490709 bytes, checksum: 37241b1945fb96047c2b5565a08b9671 (MD5) Previous issue date: 2012Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, BrazilSão Francisco Radiotherapy Institute. Belo Horizonte, MG, BrazilSão Francisco Radiotherapy Institute. Belo Horizonte, MG, BrazilSão Francisco Radiotherapy Institute. Belo Horizonte, MG, BrazilSão Francisco Radiotherapy Institute. Belo Horizonte, MG, BrazilFederal University of Vales do Jequitinhonha and Mucurí. Diamantina,MG, BrazilNational Laboratory of Biosciences. Campinas, SP, BrazilNational Laboratory of Biosciences. Campinas, SP, BrazilFederal University of Minas Gerais. Department of Biochemistry and Immunology. Belo Horizonte, MG, BrazilFederal University of Minas Gerais. Department of Biochemistry and Immunology. Belo Horizonte, MG, BrazilFederal University of Minas Gerais. School of Engineering. Belo Horizonte, MG, BrazilFederal University of Minas Gerais. Department of Biochemistry and Immunology. Belo Horizonte, MG, BrazilFederal University of Minas Gerais. Department of Physiology and Biophysics. Belo Horizonte, MG, BrazilFederal University of Minas Gerais. Department of Physiology and Biophysics. Belo Horizonte, MG, BrazilRené Rachou Research Center. Belo Horizonte,MG, BrazilFederal University of Minas Gerais. Department of Biochemistry and Immunology. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. René Rachou Research Center. Belo Horizonte, MG, BrazilFederal University of Minas Gerais. Department of Physiology and Biophysics. Belo Horizonte, MG, Brazil/Howard Hughes Medical Institute. USABackground: Calcium (Ca2+) signaling within the nucleus is known to play a crucial role in cell proliferation. The aim of this study was to investigate whether nuclear Ca2+ buffering could improve the antitumor effect of X-rays therapy on Human Squamous Cell Carcinoma (HSCC). Methods: For these purpose, we developed an experimental protocol that simulated clinical radiotherapy and prevented bystander effects of irradiation. HSCC, A431 cell line, was submitted to 10Gy cumulative X-rays therapy alone (XR Cd 10Gy) or in association with the strategy that selectively buffer nuclear Ca 2+ (Ca 2+ n) signaling. Results: Upon Ca 2+ n buffering, A431 cell proliferation rate decreased significantly as compared to control. Cell cycle analysis showed that association of Ca2+ n buffering with XR Cd 10Gy increased the percentage of A431 cells at G 2 /M and did not increase nuclear/mitochondrial DNA damages. Nonetheless, Ca 2+ n buffering prevented the increase of the radioresistance-related biomarker ADAM-17 expression and EGFR activation induced by irradiation. Furthermore, the association therapy almost completely abolished cell survival fraction even using approximately half of the X-rays cumulative dose Conclusions: Nuclear Ca 2+ buffering sensitizes human squamous cell carcinoma to X - rays irradiation treatment

NEOTROPICAL CARNIVORES: a data set on carnivore distribution in the Neotropics

Mammalian carnivores are considered a key group in maintaining ecological health and can indicate potential ecological integrity in landscapes where they occur. Carnivores also hold high conservation value and their habitat requirements can guide management and conservation plans. The order Carnivora has 84 species from 8 families in the Neotropical region: Canidae; Felidae; Mephitidae; Mustelidae; Otariidae; Phocidae; Procyonidae; and Ursidae. Herein, we include published and unpublished data on native terrestrial Neotropical carnivores (Canidae; Felidae; Mephitidae; Mustelidae; Procyonidae; and Ursidae). NEOTROPICAL CARNIVORES is a publicly available data set that includes 99,605 data entries from 35,511 unique georeferenced coordinates. Detection/non-detection and quantitative data were obtained from 1818 to 2018 by researchers, governmental agencies, non-governmental organizations, and private consultants. Data were collected using several methods including camera trapping, museum collections, roadkill, line transect, and opportunistic records. Literature (peer-reviewed and grey literature) from Portuguese, Spanish and English were incorporated in this compilation. Most of the data set consists of detection data entries (n = 79,343; 79.7%) but also includes non-detection data (n = 20,262; 20.3%). Of those, 43.3% also include count data (n = 43,151). The information available in NEOTROPICAL CARNIVORES will contribute to macroecological, ecological, and conservation questions in multiple spatio-temporal perspectives. As carnivores play key roles in trophic interactions, a better understanding of their distribution and habitat requirements are essential to establish conservation management plans and safeguard the future ecological health of Neotropical ecosystems. Our data paper, combined with other large-scale data sets, has great potential to clarify species distribution and related ecological processes within the Neotropics. There are no copyright restrictions and no restriction for using data from this data paper, as long as the data paper is cited as the source of the information used. We also request that users inform us of how they intend to use the data

Characterisation of microbial attack on archaeological bone

As part of an EU funded project to investigate the factors influencing bone preservation in the archaeological record, more than 250 bones from 41 archaeological sites in five countries spanning four climatic regions were studied for diagenetic alteration. Sites were selected to cover a range of environmental conditions and archaeological contexts. Microscopic and physical (mercury intrusion porosimetry) analyses of these bones revealed that the majority (68%) had suffered microbial attack. Furthermore, significant differences were found between animal and human bone in both the state of preservation and the type of microbial attack present. These differences in preservation might result from differences in early taphonomy of the bones. © 2003 Elsevier Science Ltd. All rights reserved

Núcleos de Ensino da Unesp: artigos 2008

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq

Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, observational study

Background: Up to 30% of hospitalised patients with COVID-19 require advanced respiratory support, including high-flow nasal cannulas (HFNC), non-invasive mechanical ventilation (NIV), or invasive mechanical ventilation (IMV). We aimed to describe the clinical characteristics, outcomes and risk factors for failing non-invasive respiratory support in patients treated with severe COVID-19 during the first two years of the pandemic in high-income countries (HICs) and low middle-income countries (LMICs). Methods: This is a multinational, multicentre, prospective cohort study embedded in the ISARIC-WHO COVID-19 Clinical Characterisation Protocol. Patients with laboratory-confirmed SARS-CoV-2 infection who required hospital admission were recruited prospectively. Patients treated with HFNC, NIV, or IMV within the first 24 h of hospital admission were included in this study. Descriptive statistics, random forest, and logistic regression analyses were used to describe clinical characteristics and compare clinical outcomes among patients treated with the different types of advanced respiratory support. Results: A total of 66,565 patients were included in this study. Overall, 82.6% of patients were treated in HIC, and 40.6% were admitted to the hospital during the first pandemic wave. During the first 24 h after hospital admission, patients in HICs were more frequently treated with HFNC (48.0%), followed by NIV (38.6%) and IMV (13.4%). In contrast, patients admitted in lower- and middle-income countries (LMICs) were less frequently treated with HFNC (16.1%) and the majority received IMV (59.1%). The failure rate of non-invasive respiratory support (i.e. HFNC or NIV) was 15.5%, of which 71.2% were from HIC and 28.8% from LMIC. The variables most strongly associated with non-invasive ventilation failure, defined as progression to IMV, were high leukocyte counts at hospital admission (OR [95%CI]; 5.86 [4.83-7.10]), treatment in an LMIC (OR [95%CI]; 2.04 [1.97-2.11]), and tachypnoea at hospital admission (OR [95%CI]; 1.16 [1.14-1.18]). Patients who failed HFNC/NIV had a higher 28-day fatality ratio (OR [95%CI]; 1.27 [1.25-1.30]). Conclusions: In the present international cohort, the most frequently used advanced respiratory support was the HFNC. However, IMV was used more often in LMIC. Higher leucocyte count, tachypnoea, and treatment in LMIC were risk factors for HFNC/NIV failure. HFNC/NIV failure was related to worse clinical outcomes, such as 28-day mortality. Trial registration This is a prospective observational study; therefore, no health care interventions were applied to participants, and trial registration is not applicable