Interactively exploring supply and demand in the UK independent music scene

We present an exploratory data mining tool useful for finding patterns in the geographic distribution of independent UK-based music artists. Our system is interactive, highly intuitive, and entirely browser-based, meaning it can be used without any additional software installations from any device. The target audiences are artists, other music professionals, and the general public. Potential uses of our software include highlighting discrepancies in supply and demand of specific music genres in different parts of the country, and identifying at a glance which areas have the highest densities of independent music artists

The state of the Martian climate

60°N was +2.0°C, relative to the 1981–2010 average value (Fig. 5.1). This marks a new high for the record. The average annual surface air temperature (SAT) anomaly for 2016 for land stations north of starting in 1900, and is a significant increase over the previous highest value of +1.2°C, which was observed in 2007, 2011, and 2015. Average global annual temperatures also showed record values in 2015 and 2016. Currently, the Arctic is warming at more than twice the rate of lower latitudes

Visualization and Identification of IL-7 Producing Cells in Reporter Mice

Interleukin-7 (IL-7) is required for lymphocyte development and homeostasis although the actual sites of IL-7 production have never been clearly identified. We produced a bacterial artificial chromosome (BAC) transgenic mouse expressing ECFP in the Il7 locus. The construct lacked a signal peptide and ECFP (enhanced cyan fluorescent protein ) accumulated inside IL-7-producing stromal cells in thoracic thymus, cervical thymus and bone marrow. In thymus, an extensive reticular network of IL-7-containing processes extended from cortical and medullary epithelial cells, closely contacting thymocytes. Central memory CD8 T cells, which require IL-7 and home to bone marrow, physically associated with IL-7-producing cells as we demonstrate by intravital imaging

Visualization and Identification of IL-7 Producing Cells in Reporter Mice

Interleukin-7 (IL-7) is required for lymphocyte development and homeostasis although the actual sites of IL-7 production have never been clearly identified. We produced a bacterial artificial chromosome (BAC) transgenic mouse expressing ECFP in the Il7 locus. The construct lacked a signal peptide and ECFP (enhanced cyan fluorescent protein ) accumulated inside IL-7-producing stromal cells in thoracic thymus, cervical thymus and bone marrow. In thymus, an extensive reticular network of IL-7-containing processes extended from cortical and medullary epithelial cells, closely contacting thymocytes. Central memory CD8 T cells, which require IL-7 and home to bone marrow, physically associated with IL-7-producing cells as we demonstrate by intravital imaging

At the bottom of the differential diagnosis list: unusual causes of pediatric hypertension

Hypertension affects 1–5% of children and adolescents, and the incidence has been increasing in association with obesity. However, secondary causes of hypertension such as renal parenchymal diseases, congenital abnormalities and renovascular disorders still remain the leading cause of pediatric hypertension, particularly in children under 12 years old. Other less common causes of hypertension in children and adolescents, including immobilization, burns, illicit and prescription drugs, dietary supplements, genetic disorders, and tumors will be addressed in this review

State of the climate in 2018

In 2018, the dominant greenhouse gases released into Earth’s atmosphere—carbon dioxide, methane, and nitrous oxide—continued their increase. The annual global average carbon dioxide concentration at Earth’s surface was 407.4 ± 0.1 ppm, the highest in the modern instrumental record and in ice core records dating back 800 000 years. Combined, greenhouse gases and several halogenated gases contribute just over 3 W m−2 to radiative forcing and represent a nearly 43% increase since 1990. Carbon dioxide is responsible for about 65% of this radiative forcing. With a weak La Niña in early 2018 transitioning to a weak El Niño by the year’s end, the global surface (land and ocean) temperature was the fourth highest on record, with only 2015 through 2017 being warmer. Several European countries reported record high annual temperatures. There were also more high, and fewer low, temperature extremes than in nearly all of the 68-year extremes record. Madagascar recorded a record daily temperature of 40.5°C in Morondava in March, while South Korea set its record high of 41.0°C in August in Hongcheon. Nawabshah, Pakistan, recorded its highest temperature of 50.2°C, which may be a new daily world record for April. Globally, the annual lower troposphere temperature was third to seventh highest, depending on the dataset analyzed. The lower stratospheric temperature was approximately fifth lowest. The 2018 Arctic land surface temperature was 1.2°C above the 1981–2010 average, tying for third highest in the 118-year record, following 2016 and 2017. June’s Arctic snow cover extent was almost half of what it was 35 years ago. Across Greenland, however, regional summer temperatures were generally below or near average. Additionally, a satellite survey of 47 glaciers in Greenland indicated a net increase in area for the first time since records began in 1999. Increasing permafrost temperatures were reported at most observation sites in the Arctic, with the overall increase of 0.1°–0.2°C between 2017 and 2018 being comparable to the highest rate of warming ever observed in the region. On 17 March, Arctic sea ice extent marked the second smallest annual maximum in the 38-year record, larger than only 2017. The minimum extent in 2018 was reached on 19 September and again on 23 September, tying 2008 and 2010 for the sixth lowest extent on record. The 23 September date tied 1997 as the latest sea ice minimum date on record. First-year ice now dominates the ice cover, comprising 77% of the March 2018 ice pack compared to 55% during the 1980s. Because thinner, younger ice is more vulnerable to melting out in summer, this shift in sea ice age has contributed to the decreasing trend in minimum ice extent. Regionally, Bering Sea ice extent was at record lows for almost the entire 2017/18 ice season. For the Antarctic continent as a whole, 2018 was warmer than average. On the highest points of the Antarctic Plateau, the automatic weather station Relay (74°S) broke or tied six monthly temperature records throughout the year, with August breaking its record by nearly 8°C. However, cool conditions in the western Bellingshausen Sea and Amundsen Sea sector contributed to a low melt season overall for 2017/18. High SSTs contributed to low summer sea ice extent in the Ross and Weddell Seas in 2018, underpinning the second lowest Antarctic summer minimum sea ice extent on record. Despite conducive conditions for its formation, the ozone hole at its maximum extent in September was near the 2000–18 mean, likely due to an ongoing slow decline in stratospheric chlorine monoxide concentration. Across the oceans, globally averaged SST decreased slightly since the record El Niño year of 2016 but was still far above the climatological mean. On average, SST is increasing at a rate of 0.10° ± 0.01°C decade−1 since 1950. The warming appeared largest in the tropical Indian Ocean and smallest in the North Pacific. The deeper ocean continues to warm year after year. For the seventh consecutive year, global annual mean sea level became the highest in the 26-year record, rising to 81 mm above the 1993 average. As anticipated in a warming climate, the hydrological cycle over the ocean is accelerating: dry regions are becoming drier and wet regions rainier. Closer to the equator, 95 named tropical storms were observed during 2018, well above the 1981–2010 average of 82. Eleven tropical cyclones reached Saffir–Simpson scale Category 5 intensity. North Atlantic Major Hurricane Michael’s landfall intensity of 140 kt was the fourth strongest for any continental U.S. hurricane landfall in the 168-year record. Michael caused more than 30 fatalities and $25 billion (U.S. dollars) in damages. In the western North Pacific, Super Typhoon Mangkhut led to 160 fatalities and$6 billion (U.S. dollars) in damages across the Philippines, Hong Kong, Macau, mainland China, Guam, and the Northern Mariana Islands. Tropical Storm Son-Tinh was responsible for 170 fatalities in Vietnam and Laos. Nearly all the islands of Micronesia experienced at least moderate impacts from various tropical cyclones. Across land, many areas around the globe received copious precipitation, notable at different time scales. Rodrigues and Réunion Island near southern Africa each reported their third wettest year on record. In Hawaii, 1262 mm precipitation at Waipā Gardens (Kauai) on 14–15 April set a new U.S. record for 24-h precipitation. In Brazil, the city of Belo Horizonte received nearly 75 mm of rain in just 20 minutes, nearly half its monthly average. Globally, fire activity during 2018 was the lowest since the start of the record in 1997, with a combined burned area of about 500 million hectares. This reinforced the long-term downward trend in fire emissions driven by changes in land use in frequently burning savannas. However, wildfires burned 3.5 million hectares across the United States, well above the 2000–10 average of 2.7 million hectares. Combined, U.S. wildfire damages for the 2017 and 2018 wildfire seasons exceeded $40 billion (U.S. dollars)

Estimating land surface evaporation: a review of methods using remotely sensed surface temperature data

This paper reviews methods for estimating evaporation from landscapes, regions and larger geographic extents, with remotely sensed surface temperatures, and highlights uncertainties and limitations associated with those estimation methods. Particular attention is given to the validation of such approaches against ground based flux measurements. An assessment of some 30 published validations shows an average root mean squared error value of about 50 W m⁻² and relative errors of 15–30%. The comparison also shows that more complex physical and analytical methods are not necessarily more accurate than empirical and statistical approaches. While some of the methods were developed for specific land covers (e.g. irrigation areas only) we also review methods developed for other disciplines, such as hydrology and meteorology, where continuous estimates in space and in time are needed, thereby focusing on physical and analytical methods as empirical methods are usually limited by in situ training data. This review also provides a discussion of temporal and spatial scaling issues associated with the use of thermal remote sensing for estimating evaporation. Improved temporal scaling procedures are required to extrapolate instantaneous estimates to daily and longer time periods and gap-filling procedures are needed when temporal scaling is affected by intermittent satellite coverage. It is also noted that analysis of multi-resolution data from different satellite/sensor systems (i.e. data fusion) will assist in the development of spatial scaling and aggregation approaches, and that several biological processes need to be better characterized in many current land surface models

Numerical simulations of flow-topography interaction using unstructured grids

Eddies and jets are important components of global ocean momentum and heat budgets but are typically unresolved in low resolution global climate models. Herein, they are evaluated with an idealised model set–up that incorporates barotropic flow, past a cylinder on a β –plane. The flow dynamics are a function of two non–dimensional numbers: the Reynolds number and the [Symbol appears here. To view, please open pdf attachment] –parameter. The model used, Fluidity–ICOM, utilises unstructured meshes and a new stable mixed discontinuous/continuous finite element pair (P1DGP2). Unstructured meshes decrease the computational cost; the simulations using a non–uniform unstructured mesh had approximately 40% fewer nodes and ran at twice the speed of a uniform structured mesh for a comparable drag coefficient (Cd). The validation of Fluidity–ICOM was performed for a range of Reynolds numbers (0:0 < Re [Mathematical symbol appears here. To view, please open pdf attachment] 3 x 10[to the power of six]) and the percentage difference between published and Fluidity–ICOM values of Cd was found to be less than 10% for the regimes where the dynamics are essentially two–dimensional. The validation highlighted two important considerations: the position of the lateral domain boundary and the boundary mesh resolution. The wake structure for a moderate Reynolds number (1000) and [Symbol appears here. To view, please open pdf attachment] –parameter (75) changed significantly between coarse and fine boundary resolutions. The former was comprised of a double jet structure and the latter a single jet in the lee of the cylinder. This study demonstrated that resolving the frictional boundary layer dynamics is crucially important, as they substantially impact on the downstream flow. Evaluation of the single jet structure for a large parameter space [Mathematical formula appears here. To view, please open pdf attachment] revealed the presence of interfacial Rossby waves with both eastward and westward propagation with respect to the mean flow. The Rossby wave occurred due to the presence of a strong staircase gradient in absolute vorticity. As the Reynolds number increased for a fixed [Symbol appears here. To view, please open pdf attachment] –parameter, the presence of a stronger shear resulted in a faster phase speed of the Rossby wave and a stronger mean–flow. This parameter–space also showed a large dependence on drag to the [Symbol appears here. To view, please open pdf attachment] –parameter. Overall, this study has implications for the Gulf Stream separation and for understanding the interaction of the Antarctic Circumpolar Current (ACC) with topography.EThOS - Electronic Theses Online ServiceGBUnited Kingdo