424 research outputs found
Acquired trichostasis in postoperative site: a case report
This is an Open Access article distributed under the terms of the Creative Commons Attribution Licens
Cluster-formation in the Rosette molecular cloud at the junctions of filaments
For many years feedback processes generated by OB-stars in molecular clouds,
including expanding ionization fronts, stellar winds, or UV-radiation, have
been proposed to trigger subsequent star formation. However, hydrodynamic
models including radiation and gravity show that UV-illumination has little or
no impact on the global dynamical evolution of the cloud. The Rosette molecular
cloud, irradiated by the NGC2244 cluster, is a template region for triggered
star-formation, and we investigated its spatial and density structure by
applying a curvelet analysis, a filament-tracing algorithm (DisPerSE), and
probability density functions (PDFs) on Herschel column density maps, obtained
within the HOBYS key program. The analysis reveals not only the filamentary
structure of the cloud but also that all known infrared clusters except one lie
at junctions of filaments, as predicted by turbulence simulations. The PDFs of
sub-regions in the cloud show systematic differences. The two UV-exposed
regions have a double-peaked PDF we interprete as caused by shock compression.
The deviations of the PDF from the log-normal shape typically associated with
low- and high-mass star-forming regions at Av~3-4m and 8-10m, respectively, are
found here within the very same cloud. This shows that there is no fundamental
difference in the density structure of low- and high-mass star-forming regions.
We conclude that star-formation in Rosette - and probably in high-mass
star-forming clouds in general - is not globally triggered by the impact of
UV-radiation. Moreover, star formation takes place in filaments that arose from
the primordial turbulent structure built up during the formation of the cloud.
Clusters form at filament mergers, but star formation can be locally induced in
the direct interaction zone between an expanding HII--region and the molecular
cloud.Comment: A&A Letter, in pres
Mosaicism for combined tetrasomy of chromosomes 8 and 18 in a dysmorphic child: A result of failed tetraploidy correction?
<p>Abstract</p> <p>Background</p> <p>Mosaic whole-chromosome tetrasomy has not previously been described as a cause of fetal malformations.</p> <p>Case presentation</p> <p>In a markedly dysmorphic child with heart malformations and developmental delay, CGH analysis of newborn blood DNA suggested a 50% dose increase of chromosomes 8 and 18, despite a normal standard karyotype investigation. Subsequent FISH analysis revealed leukocytes with four chromosomes 8 and four chromosomes 18. The child's phenotype had resemblance to both mosaic trisomy 8 and mosaic trisomy 18. The double tetrasomy was caused by mitotic malsegregation of all four chromatids of both chromosome pairs. A possible origin of such an error is incomplete correction of a tetraploid state resulting from failed cytokinesis or mitotic slippage during early embryonic development.</p> <p>Conclusion</p> <p>This unique case suggests that embryonic cells may have a mechanism for tetraploidy correction that involves mitotic pairing of homologous chromosomes.</p
HPV infection and immunochemical detection of cell-cycle markers in verrucous carcinoma of the penis
Penile verrucous carcinoma is a rare disease and little is known of its aetiology or pathogenesis. In this study we examined cell-cycle proteins expression and correlation with human papillomavirus infection in a series of 15 pure penile verrucous carcinomas from a single centre. Of 148 penile tumours, 15 (10%) were diagnosed as pure verrucous carcinomas. The expression of the cell-cycle-associated proteins p53, p21, RB, p16INK4A and Ki67 were examined by immunohistochemistry. Human papillomavirus infection was determined by polymerase chain reaction to identify a wide range of virus types. The expression of p16INK4A and Ki67 was significantly lower in verrucous carcinoma than in usual type squamous cell carcinoma, whereas the expression of p53, p21 and RB was not significantly different. p53 showed basal expression in contrast to usual type squamous cell carcinoma. Human papillomavirus infection was present in only 3 out of 13 verrucous carcinomas. Unique low-risk, high-risk and mixed viral infections were observed in each of the three cases. In conclusion, lower levels of p16INK4A and Ki67 expressions differentiate penile verrucous carcinoma from usual type squamous cell carcinoma. The low Ki67 index reflects the slow-growing nature of verrucous tumours. The low level of p16INK4A expression and human papillomavirus detection suggests that penile verrucous carcinoma pathogenesis is unrelated to human papillomavirus infection and the oncogenes and tumour suppressor genes classically altered by virus infection.Peer reviewedFinal Accepted Versio
First-principles calculation of the band offset at BaO/BaTiO and SrO/SrTiO interfaces
We report first-principles density-functional pseudopotential calculations on
the atomic structures, electronic properties, and band offsets of BaO/BaTiO
and SrO/SrTiO nanosized heterojunctions grown on top of a silicon
substrate. The density of states at the junction does not reveal any electronic
induced interface states. A dominant perovskite character is found at the
interface layer. The tunability of the band offset with the strain conditions
imposed by the substrate is studied. Using previously reported theoretical data
available for Si/SrO, Si/BaO and BaTiO/SrRuO interfaces we
extrapolate a value for the band alignments along the whole gate stacks of
technological interest: Si/SrO/SrTiO and Si/BaO/BaTiO/SrRuO
heterostructures.Comment: 12 pages, 6 figures, submitted to Phys. Rev.
The sociodemographic patterning of drinking and binge drinking in Estonia, Latvia, Lithuania and Finland, 1994–2002
An Empirical Explanation of the Speed-Distance Effect
Understanding motion perception continues to be the subject of much debate, a central challenge being to account for why the speeds and directions seen accord with neither the physical movements of objects nor their projected movements on the retina. Here we investigate the varied perceptions of speed that occur when stimuli moving across the retina traverse different projected distances (the speed-distance effect). By analyzing a database of moving objects projected onto an image plane we show that this phenomenology can be quantitatively accounted for by the frequency of occurrence of image speeds generated by perspective transformation. These results indicate that speed-distance effects are determined empirically from accumulated past experience with the relationship between image speeds and moving objects
Expected Performance of the ATLAS Experiment - Detector, Trigger and Physics
A detailed study is presented of the expected performance of the ATLAS
detector. The reconstruction of tracks, leptons, photons, missing energy and
jets is investigated, together with the performance of b-tagging and the
trigger. The physics potential for a variety of interesting physics processes,
within the Standard Model and beyond, is examined. The study comprises a series
of notes based on simulations of the detector and physics processes, with
particular emphasis given to the data expected from the first years of
operation of the LHC at CERN
Compliance to advanced trauma life support protocols in adult trauma patients in the acute setting
A census of dense cores in the Aquila cloud complex: SPIRE/PACS observations from the <i>Herschel</i> Gould Belt survey
We present and discuss the results of the Gould Belt survey (HGBS) observations in an ~11 area of the Aquila molecular cloud complex at ~ 260 pc, imaged with the SPIRE and PACS photometric cameras in parallel mode from to . Using the multi-scale, multi-wavelength source extraction algorithm , we identify a complete sample of starless dense cores and embedded (Class 0-I) protostars in this region, and analyze their global properties and spatial distributions. We find a total of 651 starless cores, ~60% ± 10% of which are gravitationally bound prestellar cores, and they will likely form stars in the future. We also detect 58 protostellar cores. The core mass function (CMF) derived for the large population of prestellar cores is very similar in shape to the stellar initial mass function (IMF), confirming earlier findings on a much stronger statistical basis and supporting the view that there is a close physical link between the stellar IMF and the prestellar CMF. The global shift in mass scale observed between the CMF and the IMF is consistent with a typical star formation efficiency of ~40% at the level of an individual core. By comparing the numbers of starless cores in various density bins to the number of young stellar objects (YSOs), we estimate that the lifetime of prestellar cores is ~1 Myr, which is typically ~4 times longer than the core free-fall time, and that it decreases with average core density. We find a strong correlation between the spatial distribution of prestellar cores and the densest filaments observed in the Aquila complex. About 90% of the -identified prestellar cores are located above a background column density corresponding to ~ 7, and ~75% of them lie within filamentary structures with supercritical masses per unit length ≳16 . These findings support a picture wherein the cores making up the peak of the CMF (and probably responsible for the base of the IMF) result primarily from the gravitational fragmentation of marginally supercritical filaments. Given that filaments appear to dominate the mass budget of dense gas at , our findings also suggest that the physics of prestellar core formation within filaments is responsible for a characteristic “efficiency” ~ for the star formation process in dense gas
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