Diagnostic Challenges of SAPHO Syndrome

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ANALISI DI NUOVI MARCATORI CELLULARI E MOLECOLARI PER LA SPONDILITE ANCHILOSANTE

Objective. Here we investigated spontaneous and induced osteoclastogenesis in peripheral blood mononuclear cells (PBMCs) from ankylosing spondylitis (AS) patients, in order to explore the relation between osteoclastogenesis and disease activity. In addition, in order to explore functional characteristics of AS osteoclasts (OCs), we tested their susceptibility to undergo apoptosis investigating their response to Emblica officinalis plant extracts, previously characterized by us as apoptotic inducer in OCs. Methods. PBMCs from healthy individuals and AS patients were cultured with or without osteoclastogenic inducers, stained for tartrate-resistant acid phosphatase (TRAP), and immunostained for Bcl-XL, Survivin and Bim proteins. After treatment with E. officinalis extracts, OCs were subjected to TUNEL test for measuring apoptosis. Disease activity was measured by Ankylosing Spondylitis Disease Actvity Score-CRP (ASDAS-CRP) and magnetic resonance imaging. Results. We found that PBMCs from AS are more susceptible to spontaneous osteoclastogenesis than the PBMCs from control samples, and that the osteoclastogenic potential was significantly associated with high ASDAS among AS patients with bone marrow edema. In addition, after treatment with E. officinalis extracts normal OCs underwent apoptosis, but OCs from AS patients showed a strong resistance to apoptotic stimulus. We found that OCs from AS patients, unlike OCs from healthy individuals, express high levels of survival signals including Bcl-XL and Survivin, but do not express Bim proapoptotic protein. Conclusion. Our data demonstrate that AS OCs present qualitative peculiarities: this may help in identifying an effective strategy to prevent bone changes in AS

ANALISI DI NUOVI MARCATORI CELLULARI E MOLECOLARI PER LA SPONDILITE ANCHILOSANTE

Objective. Here we investigated spontaneous and induced osteoclastogenesis in peripheral blood mononuclear cells (PBMCs) from ankylosing spondylitis (AS) patients, in order to explore the relation between osteoclastogenesis and disease activity. In addition, in order to explore functional characteristics of AS osteoclasts (OCs), we tested their susceptibility to undergo apoptosis investigating their response to Emblica officinalis plant extracts, previously characterized by us as apoptotic inducer in OCs. Methods. PBMCs from healthy individuals and AS patients were cultured with or without osteoclastogenic inducers, stained for tartrate-resistant acid phosphatase (TRAP), and immunostained for Bcl-XL, Survivin and Bim proteins. After treatment with E. officinalis extracts, OCs were subjected to TUNEL test for measuring apoptosis. Disease activity was measured by Ankylosing Spondylitis Disease Actvity Score-CRP (ASDAS-CRP) and magnetic resonance imaging. Results. We found that PBMCs from AS are more susceptible to spontaneous osteoclastogenesis than the PBMCs from control samples, and that the osteoclastogenic potential was significantly associated with high ASDAS among AS patients with bone marrow edema. In addition, after treatment with E. officinalis extracts normal OCs underwent apoptosis, but OCs from AS patients showed a strong resistance to apoptotic stimulus. We found that OCs from AS patients, unlike OCs from healthy individuals, express high levels of survival signals including Bcl-XL and Survivin, but do not express Bim proapoptotic protein. Conclusion. Our data demonstrate that AS OCs present qualitative peculiarities: this may help in identifying an effective strategy to prevent bone changes in AS

IC5063: AGN driven outflow of warm and cold gas

We present new ATCA 17- and 24-GHz radio images and ESO-NTT optical spectra of the radio-loud Seyfert galaxy IC5063, the first galaxy in which a fast (~ 600 km/s) outflow of neutral hydrogen was discovered. The new radio data confirm the triple radio structure with a central core and two resolved radio lobes. This implies that the previously detected fast outflow of neutral gas is occurring off-nucleus, near a radio lobe about 0.5 kpc from the core. The ionised gas shows complex kinematics in the region co-spatial with the radio emission. Broad and blueshifted (~ 500 km/s) emission is observed in the region of the radio lobe, at the same location as the blueshifted HI absorption. The velocity of the ionised outflow is similar to the one found in HI. The first order correspondence between the radio and optical properties suggests that the outflow is driven by the interaction between the radio jet and the ISM. Despite the high outflow velocities, no evidence is found for the ionisation of the gas being due to fast shocks in the region of the outflow, indicating that photoionisation from the AGN is likely to be the dominant ionisation mechanism. The outflow rate of the warm (ionised) gas is small compared to that of the cold gas. The mass outflow rate associated with the HI is in the same range as for ``mild'' starburst-driven superwinds in ULIRGs. However, in IC5063, the AGN-driven outflow appears to be limited to the inner kpc region of the galaxy. The kinetic power associated with the HI outflow is a small fraction (a few x 10^-4) of the Eddington luminosity of the galaxy but is a significant fraction (~ 0.1) of the nuclear bolometric luminosity. In IC5063, the outflows may have sufficient kinetic power to have a significant impact on the evolution of the ISM in the host galaxy.Comment: Accepted for publication in A&A, 11 pages, 8 figure

Numerical simulations on the relative importance of starbursts and AGN in ultra-luminous infrared galaxies

We investigate the relative importance of starbursts and AGN in nuclear activities of ultra-luminous infrared galaxies (ULIRGs) based on chemodynamical simulations combined with spectrophotometric synthesis codes. We numerically investigate both the gas accretion rates (m_acc) onto super massive black holes (SMBHs) and the star formation rates (m_sf) in ULIRGs formed by gas-rich galaxy mergers and thereby discuss what powers ULIRGs. Our principal results, which can be tested against observations, are as follows. (1) ULIRGs powered by AGN can be formed by major merging between luminous, gas-rich disk galaxies with prominent bulges containing SMBHs, owing to the efficient gas fuelling m_acc > 1 M_sun/yr of the SMBH. AGN in these ULIRGs can be surrounded by compact poststarburst stellar populations (e.g., A-type stars). (2) ULIRGs powered by starbursts with m_sf ~ 100 M_sun/yr can be formed by merging between gas-rich disk galaxies with small bulges having the bulge-to-disk-ratio (f_b) as small as 0.1. (3) The relative importance of starbursts and AGN can depend on physical properties of merger progenitor disks, such as f_b, gas mass fraction, and total masses. For example, more massive galaxy mergers are more likely to become AGN-dominated ULIRGs. (4) For most models, major mergers can become ULIRGs, powered either by starbursts or by AGN, only when the two bulges finally merge. Interacting disk galaxies can become ULIRGs with well separated two cores (> 20kpc) at their pericenter when they are very massive and have small bulges. (5) Irrespective of the choice of model, interacting/merging galaxies show the highest accretion rates onto the central SMBHs, and the resultant rapid growth of the SMBHs occur when their star formation rates are very high.Comment: 18 pages, 15 figures (f1.jpg for color figure of figure 1), accepted in MNRA

The properties of the stellar populations in ULIRGs II: the star formation histories and evolution

This is the second of two papers presenting a detailed long-slit spectroscopic study of the stellar populations in a sample of 36 ULIRGs. In the previous paper we presented the sample, the data and the spectral synthesis modelling while in this paper, we carry out a detailed analysis of the modelling results. We find that the star formation histories of ULIRGs are complex, with at least two epochs of star formation activity and that the charcteristic timescale of the star formation acivity is <100Myr. These results are consistent with models that predict an epoch of enhanced star formation coinciding with the first pass of the merging nuclei, along with a further, more intense, episode of star formation occurring as the nuclei finally merge together. It is also found that the young stellar populations (YSPs) tend to be younger and more reddened in the nuclear regions of the galaxies. This is in good agreement with the merger simulations, which predict that the bulk of the star formation activity in the final stages of mergers will occur in the nuclear regions of the merging galaxies. In addition, our results show that ULIRGs have total stellar masses that are similar to, or smaller than, the break of the galaxy mass function (m* = 1.4 x 10^{11} Msolar). Finally, we find no significant differences between the ages of the YSP in ULIRGs with and without optically detected Seyfert nuclei, nor between those with warm and cool mid- to far-IR colours. While this results do not entirely rule out the idea that cool ULIRGs with HII/LINER spectra evolve into warm ULIRGs with Seyfert-like spectra, it is clear that the AGN activity in local Seyfert-like ULIRGs has not been triggered a substantial period (>=100 Myr) after the major merger-induced starbursts in the nuclear regions.Comment: Accepted for publication in MNRAS. The paper contains 16 pages, 6 figures and 7 table

Adaptive optics imaging and optical spectroscopy of a multiple merger in a luminous infrared galaxy

(abridged) We present near-infrared (NIR) adaptive optics imaging obtained with VLT/NACO and optical spectroscopy from the Southern African Large Telescope (SALT) of a luminous infrared galaxy (LIRG) IRAS 19115-2124. These data are combined with archival HST imaging and Spitzer imaging and spectroscopy, allowing us to study this disturbed interacting/merging galaxy, dubbed the Bird, in extraordinary detail. In particular, the data reveal a triple system where the LIRG phenomenon is dominated by the smallest of the components. One nucleus is a regular barred spiral with significant rotation, while another is highly disturbed with a surface brightness distribution intermediate to that of disk and bulge systems, and hints of remaining arm/bar structure. We derive dynamical masses in the range 3-7x10^10 M_solar for both. The third component appears to be a 1-2x10^10 M_solar mass irregular galaxy. The total system exhibits HII galaxy-like optical line ratios and strengths, and no evidence for AGN activity is found from optical or mid-infrared data. The star formation rate is estimated to be 190 M_solar/yr. We search for SNe, super star clusters, and detect 100-300 km/s outflowing gas from the Bird. Overall, the Bird shows kinematic, dynamical, and emission line properties typical for cool ultra luminous IR galaxies. However, the interesting features setting it apart for future studies are its triple merger nature, and the location of its star formation peak - the strongest star formation does not come from the two major K-band nuclei, but from the third irregular component. Aided by simulations, we discuss scenarios where the irregular component is on its first high-speed encounter with the more massive components.Comment: 24 pages, 16 figures. Accepted MNRAS version, minor corrections only, references added. Higher resolution version (1.3MB) is available from http://www.saao.ac.za/~petri/bird/ulirg_bird_highres_vaisanen_v2.pd

Radio Sources in Low-Luminosity Active Galactic Nuclei. III. "AGNs" in a Distance-Limited Sample of "LLAGNs"

(abbreviated): This paper presents the results of a high resolution radio imaging survey of all known (96) low-luminosity active galactic nuclei (LLAGNs) at D<19Mpc. We find that almost half of all LINERs and low-luminosity Seyferts have flat-spectrum radio cores when observed at 150mas resolution. Higher (2mas) resolution observations of a flux-limited subsample have provided a 100% (16 of 16) detection rate of pc-scale radio cores, with implied brightness temperatures > 10^8 K. The five LLAGNs with the highest core radio fluxes also have pc-scale `jets.' Compact radio cores are almost exclusively found in massive ellipticals and in type1 nuclei. The core radio power is correlated with the nuclear optical `broad' Halpha luminosity, the nuclear optical `narrow' emission line luminosity and width, and with the galaxy luminosity. In these correlations LLAGNs fall close to the low-luminosity extrapolations of more powerful AGNs. About half of all LLAGNs with multiple epoch data show significant inter-year radio variability. Investigation of a sample of ~150 nearby bright galaxies, most of them LLAGNs, shows that the nuclear (<150mas size) radio power is strongly correlated with both the black hole mass and the galaxy bulge luminosity; linear regression fits to all ~150 galaxies give: log P(2cm) = 1.31 log M_blackhole + 8.77 and log P(2cm) = 1.89 log L_B(bulge) - 0.17. Low accretion rates are implied in both advection- and jet-type models. In brief, all evidence points towards the presence of accreting massive black holes in a large fraction, perhaps all, of LLAGNs.Comment: to appear in A&

Extreme Starbursts in the Local Universe

The "Extreme starbursts in the local universe" workshop was held at the Insituto de Astrofisica de Andalucia in Granada, Spain on 21-25 June 2010. Bearing in mind the advent of a new generation of facilities such as JWST, Herschel, ALMA, eVLA and eMerlin, the aim of the workshop was to bring together observers and theorists to review the latest results. The purpose of the workshop was to address the following issues: what are the main modes of triggering extreme starbursts in the local Universe? How efficiently are stars formed in extreme starbursts? What are the star formation histories of local starburst galaxies? How well do the theoretical simulations model the observations? What can we learn about starbursts in the distant Universe through studies of their local counterparts? How important is the role of extreme starbursts in the hierarchical assembly of galaxies? How are extreme starbursts related to the triggering of AGN in the nuclei of galaxies? Overall, 41 talks and 4 posters with their corresponding 10 minutes short talks were presented during the workshop. In addition, the workshop was designed with emphasis on discussions, and therefore, there were 6 discussion sessions of up to one hour during the workshop. Here is presented a summary of the purposes of the workshop as well as a compilation of the abstracts corresponding to each of the presentations. The summary and conclusions of the workshop along with a description of the future prospects by Sylvain Veilleux can be found in the last section of this document. A photo of the assistants is included.Comment: worksho

Radio Sources in Low-Luminosity Active Galactic Nuclei.IV. Radio Luminosity Function, Importance of Jet Power, and Radio Properties of the Complete Palomar Sample

We present the completed results of a high resolution radio imaging survey of all (~200) low-luminosity active galactic nuclei (LLAGNs) and AGNs in the Palomar Spectroscopic Sample. The high incidences of pc-scale radio nuclei, with T(brightness) >=10^7 K, and sub-parsec jets argue for accreting black holes in >=50% of all LINERs and low-luminosity Seyferts; there is no evidence against all LLAGNs being mini-AGNs. The radio luminosity function (RLF) of Palomar Sample LLAGNs and AGNs extends three orders of magnitude below, and is continuous with, that of `classical' AGNs. We find marginal evidence for a low-power turnover in the RLF; nevertheless LLAGNs are responsible for a significant fraction of present day mass accretion. Adopting the jet model of Falcke & Biermann, we show that the accretion energy output in LLAGNs is dominated by the energy in the observed jets rather than the radiated bolometric luminosity. The Palomar LLAGNs and AGNs follow the same scaling between jet power and narrow line region (NLR) luminosity as the pc to kpc jets in powerful radio galaxies. Eddington ratios of <= 10^{-1} - 10^{-5} are implied in jet models of the radio emission. We find evidence that, in analogy to Galactic black hole candidates, LINERs are in a `low/hard' state (gas poor nuclei, low Eddington ratio, ability to launch collimated jets) while low-luminosity Seyferts are in a `high' state (gas rich nuclei, higher Eddington ratio, less likely to launch collimated jets). The jets are energetically more significant than supernovae in the LLAGN host galaxies, and are potentially able to deposit sufficient energy into the innermost parsecs to significantly slow the gas supply to the accretion disk.Comment: Results and content same as pervious submission; language and wording updated for clarity. To appear in A&