Experiences Of Non-Traditional Female College Students With Bipolar Disorder

Background: Although research has been done on many aspects of bipolar disorder, research has not examined the individual living experiences of college students with bipolar disorder. Research looks at the Methods: In-depth interviews were used to learn the details of the experience of attending college with bipolar disorder. Three volunteers came forward to be interviewed. They had a bipolar disorder diagnosis, and are current students at a southern university. Questions focused on the lived experience of being a student with bipolar disorder, and probing questions were used to learn more about each participant’s particular experience. The first two interviews had primary codes applied, then secondary codes, then themes. The third interview was done to confirm or repute the results of the first two interviews Results: The results of this study found three major themes throughout the three participants’ interviews. The first theme was ‘supports’, which included categories of medication and treatments; family, co-worker, and church support systems; disability accommodations; mania as a support; and ideas the participants had that could further help students. The second theme was ‘barriers’, which included categories of suicidal thoughts and actions, stigma and judgment, the difficulty involved in diagnosing and treating bipolar disorder, and ideas from the participants on things that do not help them to have success in school. The third theme, “It’s part of who I am” focuses on the fact that bipolar disorder has contributed to who they are as people at this stage in their life. Categories for this theme include grades, school as therapy, choosing where to live, staying away from campus, “It’s part of who I am”, and “at the beginning it’s just about accepting it”. Conclusion: Occupational therapists can help clients with bipolar disorder become aware of and access accommodation services in higher education, when that client has a goal of successfully attending college. Occupational therapists can also advocate for a larger role on college campuses to help students with bipolar disorder through group intervention and to help them with medication management

The Presence of Cross Education within the Body- An Evaluation of Contralateral Grip Strength

Please enjoy Volume 5, Issue 1 of the JSMAHS. In this issue you will find Professional and under graduate research abstracts, case reports, and critically appraised topics. Thank you for viewing this 5th Annual OATA Special Edition

Delayed diagnosis of cystic fibrosis associated with R117H on a background of 7T polythymidine tract at intron 8

AbstractWe report late diagnoses of cystic fibrosis (CF) in two men aged 61 and 65 years. At the time of presentation, both patients had significant pulmonary disease. In each case two CFTR gene mutations were identified, including R117H on a background of a poly T genotype of 7T/9T. Patients with two identified CFTR mutations which include the R117H/7T anomaly should be followed up routinely as they remain susceptible to severe lung disease

Present and future pharmacotherapeutic agents in heart failure: an evolving paradigm

Many conditions culminate in heart failure (HF), a multi-organ systemic syndrome with an intrinsically poor prognosis. Pharmacotherapeutic agents that correct neurohormonal dysregulation and haemodynamic instability have occupied the forefront of developments within the treatment of HF in the past. Indeed, multiple trials aimed to validate these agents in the 1980s and early 1990s, resulting in a large and robust evidence-base supporting their use clinically. An established treatment paradigm now exists for the treatment of HF with reduced ejection fraction (HFrEF), but there have been very few notable developments in recent years. HF remains a significant health concern with an increasing incidence as the population ages. We may indeed be entering the surgical era for HF treatment, but these therapies remain expensive and inaccessible to many. Newer pharmacotherapeutic agents are slowly emerging, many targeting alternative therapeutic pathways, but with mixed results. Metabolic modulation and manipulation of the nitrate/nitrite/nitric oxide pathway have shown promise and could provide the answers to fill the therapeutic gap between medical interventions and surgery, but further definitive trials are warranted. We review the significant evidence base behind the current medical treatments for HFrEF, the physiology of metabolic impairment in HF, and discuss two promising novel agents, perhexiline and nitrite

Effects of a twelve-week exercise intervention on subsequent compensatory behaviours in adolescent girls: an exploratory study

This is an accepted manuscript of an article published by Human Kinetics Publishers Inc. in Pediatric Exercise Science on 19/07/2019, available online: https://doi.org/10.1123/pes.2019-0012 The accepted version of the publication may differ from the final published version.Purpose: Chronic exercise programmes can induce adaptive compensatory behavioural responses through increased energy intake (EI) and/or decreased free-living physical activity in adults. These responses can negate the benefits of an exercise-induced energy deficit; however, it is unclear whether young people experience similar responses. This study examined whether exercise-induced compensation occurs in adolescent girls. Methods: Twenty-three adolescent girls, heterogeneous for weight status, completed the study. Eleven, 13-year-old adolescent girls completed a twelve-week supervised exercise intervention (EX). Twelve body size matched girls comprised the non-exercise control group (CON). Body composition, EI, free-living energy expenditure (EE) and peak oxygen uptake (V ̇O_2) were measured repeatedly over the intervention. Results: Laboratory EI (EX: 9027, 9610, 9243 kJd-1 and CON: 9953, 9770, 10052 kJd-1 at 0, 12 and 18 weeks respectively) (ES = 0.26, P = 0.46) and free living EI (EX: 7288, 6412, 5273, 4916 kJd-1 and CON: 7227, 7128, 6470, 6337 kJd-1 at 0, 6, 12 and 18 weeks respectively) (ES ≤ 0.26, P = 0.90) did not change significantly over time and were similar between groups across the duration of the study. Free-living EE was higher in EX than CON (13295 vs. 12115 kJd-1, ES ≥ 0.88, P ≥ 0.16), but no significant condition by time interactions were observed (P ≥ 0.17). Conclusion: The current findings indicate that compensatory changes in EI and EE behaviours did not occur at a group level within a small cohort of adolescent girls. However, analysis at the individual level highlights large inter-individual variability in behaviours, which suggest a larger study may be prudent to extend this initial exploratory research

The Early Effects of Rapid Androgen Deprivation on Human Prostate Cancer.

The androgen receptor (AR) is the dominant growth factor in prostate cancer (PCa). Therefore, understanding how ARs regulate the human transcriptome is of paramount importance. The early effects of castration on human PCa have not previously been studied 27 patients medically castrated with degarelix 7 d before radical prostatectomy. We used mass spectrometry, immunohistochemistry, and gene expression array (validated by reverse transcription-polymerase chain reaction) to compare resected tumour with matched, controlled, untreated PCa tissue. All patients had levels of serum androgen, with reduced levels of intraprostatic androgen at prostatectomy. We observed differential expression of known androgen-regulated genes (TMPRSS2, KLK3, CAMKK2, FKBP5). We identified 749 genes downregulated and 908 genes upregulated following castration. AR regulation of α-methylacyl-CoA racemase expression and three other genes (FAM129A, RAB27A, and KIAA0101) was confirmed. Upregulation of oestrogen receptor 1 (ESR1) expression was observed in malignant epithelia and was associated with differential expression of ESR1-regulated genes and correlated with proliferation (Ki-67 expression).We thank CRUK, The NIHR, The Academy of Medical Sciences(RG:63397) and the National Cancer Research Prostate Cancer: Mechanisms of Progression and Treatment (ProMPT) collaborative (G0500966/75466), Hutchison Whampoa Limited, the Human Research Tissue Bank (Addenbrooke’s Hospital, supported by the NIHR Cambridge BRC), and Cancer Research UK

The genomic evolution of human prostate cancer.

Prostate cancers are highly prevalent in the developed world, with inheritable risk contributing appreciably to tumour development. Genomic heterogeneity within individual prostate glands and between patients derives predominantly from structural variants and copy-number aberrations. Subtypes of prostate cancers are being delineated through the increasing use of next-generation sequencing, but these subtypes are yet to be used to guide the prognosis or therapeutic strategy. Herein, we review our current knowledge of the mutational landscape of human prostate cancer, describing what is known of the common mutations underpinning its development. We evaluate recurrent prostate-specific mutations prior to discussing the mutational events that are shared both in prostate cancer and across multiple cancer types. From these data, we construct a putative overview of the genomic evolution of human prostate cancer

Early oxygen uptake recovery following exercise testing in children with chronic chest diseases.

addresses: Children's Health and Exercise Research Centre, School of Sport and Health Sciences, University of Exeter, Exeter, Devon, UK.types: Journal Article; Research Support, Non-U.S. Gov'tThis is the author's post-print version of an article published in Pediatric Pulmonology, 2009, Vol. 44, Issue 5, pp. 480 – 488. Copyright © Wiley-Blackwell 2009. The definitive version is available at www3.interscience.wiley.comThe value of exercise testing as an objective measure of disease severity in patients with chronic chest diseases (CCD) is becoming increasingly recognized. The aim of this study was to investigate changes in oxygen uptake (VO2) during early recovery following maximal cardiopulmonary exercise testing (CPXT) in relation to functional capacity and markers of disease severity. Twenty-seven children with CCD (age 12.7 +/- 3.1 years; 17 female) [19 children with Cystic fibrosis (CF) (age 13.4 +/- 3.1 years; 10 female) and 8 with other stable non-CF chest diseases (NON-CF) (age 11.1 +/- 2.2 years; 7 female)] and 27 healthy controls (age 13.2 +/- 3.3 years; 17 female) underwent CPXT on a cycle ergometer. On-line respiratory gas analysis measured VO2 before and during CPXT to peak VO2) (VO2(peak)), and during the first 10 min of recovery. Early VO2 recovery was quantified by the time (sec) to reach 50% of the VO2 (peak) value. Early VO2 recovery was correlated against spirometry [forced expiratory volume in 1 sec (FEV(1)) and forced expiratory flow between 25% and 75% of the forced vital capacity (FEF(25-75))] and aerobic fitness (VO2)(peak)) as a measure of functional capacity. Disease severity was graded in the CF patients by the Shwachman score (SS). Compared to controls, children with CCD demonstrated a significantly reduced VO2(peak) (P = 0.011), FEV(1) (P < 0.001), FEF(25-75) (P < 0.001), and a significantly prolonged early (VO2) recovery (P = 0.024). In the CF patients the SS was significantly correlated with early VO2 recovery (r = -0.63, P = 0.004), FEV(1) (r = 0.72, P = 0.001), and FEF(25-75) (r = 0.57, P = 0.011). In the children with CCD, FEV(1), FEF(25-75), and BMI were not significantly correlated with VO2(peak) or early VO2 recovery. Lung function does not necessarily reflect aerobic fitness and the ability to recover from exercise in these patients. A significant relationship was found between VO2(peak) and early VO2 recovery (r = -0.39, P = 0.044) in the children with CCD, showing that a greater aerobic fitness corresponded with a faster recovery