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Elective Cancer Surgery in COVID-19-Free Surgical Pathways During the SARS-CoV-2 Pandemic: An International, Multicenter, Comparative Cohort Study.

Author: Aawsaj Y.
Abad Gurumeta A.
Abad-Motos A.
Abate E.
Abatini C.
Abbadessa F.
Abbas A. M.
Abbassi-Ghadi N.
Abbott D.
Abbott T.
Abd Elazeem H. A. S.
Abdalla M.
Abdallah M.
Abdel Al S.
Abdel Jalil R.
Abdeldayem H.
Abdelkader Salama I.
Abdelkarem M. M.
Abdelkarim M.
Abdelmajeed A.
Abdelrahman A.
Abdelrahman S.
Abdelsamed A.
Abdou M.
Abdulkareem A.
Abdulwahed E.
Abdur-Rahman L.
Abel M. K.
Abellan M.
Aboelkassem Ibrahim A.
Abosamak N. E.
Abou Chaar M. K.
Abou-Khalil J.
Abouassi A.
Aboulkassem H.
Abreu Da Silva A.
Abu J.
Abu Za'nouneh F. J.
Abu-Nayla I.
Abubakar A.
Acebes Garcia F.
Achalandabaso Boira M.
Acher A.
Acrich E.
Adamina M.
Adamoli L.
Addae-Boateng E.
Aderombi A.
Adeyeye A.
Adiamah A.
Adishesh M.
Agapov M.
Aggarwal A.
Aghayeva A.
Agilinko J.
Agnes A.
Agostini C.
Agoston P.
Agrawal A.
Agresta F.
Aguado H.
Aguilar Gonzalez M.
Aguzzoli L.
Ahad S.
Ahmadi N.
Ahmeidat A.
Ahn J. H.
Aiken T.
Aime A.
Ajlan A.
Akalin M.
Akaydin E.
Akeel N.
Akgor U.
Akhtar M. A.
Akhter Rahman M. M.
Akilli H.
Akin E.
Akkour K.
Akmenkalne L.
Al Abdallah M.
Al Awwad S.
Al Habes H.
Al Maadany F. S.
Al Raddadi R.
Al-Habib A.
Al-Habsi R.
Al-Ishaq Z.
Al-Khayal K.
Al-Masri M.
Al-Mohammad A.
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Al-Najjar H.
Al-Omishy H.
Al-Sarireh B.
AL-Sayed M.
Al-Tamimi Y.
Alaa S.
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Aladeojebi A.
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Alanbuki A.
Alatar A.
Alawneh F.
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Albertsmeier M.
Albi Martin B.
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Publication venue: J Clin Oncol
Publication date: 01/01/2020
Field of study

PURPOSE: As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19-free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway. PATIENTS AND METHODS: This international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19-free surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation). RESULTS: Of 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19-free surgical pathways. Patients who underwent surgery within COVID-19-free surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19-free surgical pathways (2.2% v 4.9%; adjusted odds ratio [aOR], 0.62; 95% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1/2), propensity score-matched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rate was also lower in COVID-19-free surgical pathways (2.1% v 3.6%; aOR, 0.53; 95% CI, 0.36 to 0.76). CONCLUSION: Within available resources, dedicated COVID-19-free surgical pathways should be established to provide safe elective cancer surgery during current and before future SARS-CoV-2 outbreaks

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Elective cancer surgery in COVID-19-free surgical pathways during the SARS-CoV-2 pandemic: An international, multicenter, comparative cohort study

Author: Aawsaj Y.
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Abad-Motos A.
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Whelan P.
Whisker L.
Whitehall E.
Whitmore H.
Wilkin R.
Wilkins A.
Williams G.
Williams J.
Williams K.
Williams M. A.
Williams T.
Williamson K.
Wilson M.
Wimberger P.
Wimmer A.
Winnand P.
Winter D.
Winter S.
Wolfer S.
Wong M. P. K.
Wong S.
Wong W. J.
Woodham A.
Woodun H.
Worku D.
Wright G.
Wullschleger M.
Wustrack R.
Xenaki S.
Xu M. J.
Xyda S. E.
Xynos E.
Yahaya A. S.
Yanez C.
Yang W.
Yassin N.
Ye G.
Yesantharao P.
Yesilyurt D.
Yetkin G.
Yiallourou A.
Yildirim A.
Yildiz A.
Ying Y.
Yip V.
Yordanov S.
Young R.
Yousof E. A.
Youssef A.
Youssef M.
Yuksel E.
Yurttas C.
Zacharoulis D.
Zafar S. N.
Zakai D.
Zakaria A. D.
Zakaria R.
Zakaria Z.
Zambelli M. F.
Zambon M.
Zamora L.
Zamvar V.
Zani S.
Zanotti S.
Zanus G.
Zapardiel I.
Zarabini A. G.
Zatecky J.
Zegarac M.
Zelic M.
Zeller N.
Zengin A. K.
Zerbib P.
Zervas K.
Zese M.
Zhang H.
Zivanovic M.
Zivkovic M.
Zizzo M.
Zografos C.
Zonta S.
Zorrilla Ortuzar J.
Zourntou S.
Zouzoulas D.
Zubaidi A.
Zullo A.
Publication venue: 'American Society of Clinical Oncology (ASCO)'
Publication date: 01/01/2021
Field of study

PURPOSE As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19–free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway. PATIENTS AND METHODS This international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19–free surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation). RESULTS Of 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19–free surgical pathways. Patients who underwent surgery within COVID-19–free surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19–free surgical pathways (2.2% v 4.9%; adjusted odds ratio [aOR], 0.62; 95% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1/2), propensity score–matched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rate was also lower in COVID-19–free surgical pathways (2.1% v 3.6%; aOR, 0.53; 95% CI, 0.36 to 0.76). CONCLUSION Within available resources, dedicated COVID-19–free surgical pathways should be established to provide safe elective cancer surgery during current and before future SARS-CoV-2 outbreaks

Archivio istituzionale della Ricerca - Università degli Studi di Parma

Regulatory T Cells and Profile of FOXP3 Isoforms Expression in Peripheral Blood of Patients with Myelodysplastic Syndromes

Author: Alexander N. Mitin
Almira D. Donetskova
Galina A. Dudina
Marina M. Litvina
Sergey A. Polyakov
Tatiana A. Mitina
Publication venue: 'Hindawi Limited'
Publication date: 01/01/2018
Field of study

We have investigated the frequencies of regulatory T cells and the level of FOXP3 isoforms expression in peripheral blood of patients with myelodysplastic syndromes and found the significant reduction of regulatory T cells at all stages of the disease. At the same time in untreated patients, we observed the shift in the FOXP3 isoforms expression profile towards the full-length molecule possibly due to inflammation. Based on the already known information about the potentially higher functional activity of FOXP3 molecule lacking exon 2, we have also hypothesized that our finding may explain the high risk of autoimmune disorders in this disease

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Regulatory T Cells and Profile of FOXP3 Isoforms Expression in Peripheral Blood of Patients with Myelodysplastic Syndromes

Author: Alexander N. Mitin
Almira D. Donetskova
Galina A. Dudina
Marina M. Litvina
Sergey A. Polyakov
Tatiana A. Mitina
Publication venue: 'Hindawi Limited'
Publication date
Field of study

Crossref

Physiological and Functional Effects of Dominant Active TCRα Expression in Transgenic Mice

Author: Alexander N. Mitin
Alexandra V. Bruter
Almira D. Donetskova
Anastasiia A. Kalinina
Dmitry B. Kazansky
Elena E. Antoshina
Lubov S. Trukhanova
Ludmila M. Khromykh
Margarita F. Nikonova
Maria A. Zamkova
Marina M. Litvina
Nadezda A. Persiyantseva
Nina I. Sharova
Rustam Kh. Ziganshin
Tatiana G. Gorkova
Victoria V. Komogorova
Yulia Yu. Silaeva
Publication venue: 'MDPI AG'
Publication date: 01/03/2023
Field of study

A T cell receptor (TCR) consists of α- and β-chains. Accumulating evidence suggests that some TCRs possess chain centricity, i.e., either of the hemi-chains can dominate in antigen recognition and dictate the TCR’s specificity. The introduction of TCRα/β into naive lymphocytes generates antigen-specific T cells that are ready to perform their functions. Transgenesis of the dominant active TCRα creates transgenic animals with improved anti-tumor immune control, and adoptive immunotherapy with TCRα-transduced T cells provides resistance to infections. However, the potential detrimental effects of the dominant hemi-chain TCR’s expression in transgenic animals have not been well investigated. Here, we analyzed, in detail, the functional status of the immune system of recently generated 1D1a transgenic mice expressing the dominant active TCRα specific to the H2-Kb molecule. In their age dynamics, neither autoimmunity due to the random pairing of transgenic TCRα with endogenous TCRβ variants nor significant disturbances in systemic homeostasis were detected in these mice. Although the specific immune response was considerably enhanced in 1D1a mice, responses to third-party alloantigens were not compromised, indicating that the expression of dominant active TCRα did not limit immune reactivity in transgenic mice. Our data suggest that TCRα transgene expression could delay thymic involution and maintain TCRβ repertoire diversity in old transgenic mice. The detected changes in the systemic homeostasis in 1D1a transgenic mice, which are minor and primarily transient, may indicate variations in the ontogeny of wild-type and transgenic mouse lines

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Delaying surgery for patients with a previous SARS-CoV-2 infection

Author: A A Ali Karar
A A Kerawala
A A Marra
A Abad Gurumeta
A Abad-Motos
A Abdelmajeed
A Abdelrahman
A Abdelsamed
A Abdulkareem
A Aboelkassem Ibrahim
A Abouassi
A Abreu da Silva
A Abubakar
A Acher
A Aderombi
A Adeyeye
A Adiamah
A Aggarwal
A Aghayeva
A Agnes
A Agrawal
A Ahmeidat
A Aimé
A Ajlan
A Al-Habib
A Al-Mohammad
A Al-Mukhtar
A Aladeojebi
A Alamri
A Alanbuki
A Alatar
A Alburakan
A Alfaro-Goldaracena
A Alhamed
A Alhefdhi
A Almeciga
A Almeida
A Alomair
A Alonso Poza
A Alsaif
A Anastasi
A Antic
A Anzak
A Aprile
A Arminio
A Arulanantham
A Askari
A Asqalan
A Athanasiou
A Ayhan
A Ayman
A Ayubi
A Azizi
A B Martins
A Bacon
A Baker
A Balakrishnan
A Bandiera
A Banerjee
A Barrabe
A Beamish
A Bellacci
A Belli
A Belvedere
A Benkabbou
A Bhalla
A Bhangu
A Billè
A Bin Nasser
A Biondi
A Blatt
A Blazquez Martin
A Boddy
A Bokhari
A Bondurri
A Boulton
A Boutall
A Branquinho
A Brunelli
A Brunt
A Bruscino
A Budacan
A Burahee
A Böttcher
A C Almeida
A C Deus
A C Roslani
A C Soares
A C Vieira Paiva Lopes
A Caiado
A Camillo
A Canas-Martinez
A Cano
A Carabias
A Chandock
A Charalabopoulos
A Che Jusoh
A Chebaro
A Chessa
A Chiappini
A Chitul
A Choudhry
A Chowdhury
A Colquhoun
A Conesa
A Cordova
A Costanzi
A Cotoia
A Cotter
A Crichton
A Cuadrado-García
A Currie
A Cvetkovic
A D Bueno Cañones
A D Rajgor
A D Zakaria
A D'Amore
A D'Urso
A Daly
A Davies
A Day
A De Gea Rico
A De Manzoni Garberini
A De Pablo García-Cuenca
A De Troia
A De Virgilio
A Dehal
A Desai
A Di Bartolomeo
A Di Bella
A Di Somma
A Diamantis
A Doyle
A Durrani
A E Arikan
A E Sherif
A Eastmond
A El Ouahabi
A Elawad
A Eldaly
A Elhamshary
A Esposito
A Esteban
A Ezanno
A Fadzli
A Fagotti
A Fancellu
A Farsi
A Faustino
A Fazenda
A Fernández-López
A Ferrero
A Ferrés
A Fiorini
A Fisher
A Fletcher
A Fowler
A Fox
A Frampton
A Frankel
A Frati
A Freitas
A Frena
A Fuson
A G Carta
A G Zarabini
A Gabre-Kidan
A Gagliano
A Gainza
A Gatti
A Gattolin
A Gaunt
A Geddes
A Gegúndez Simón
A Ghanbari
A Ghannam
A Giaglaras
A Gianni
A Giblin
A Gillis
A Gklavas
A Glencer
A Gomes da Costa
A Gori
A Goyal
A Gronchi
A Gueutier
A Guglielmi
A Guimarães
A Gupta
A Gutierrez Calvo
A Gvaramadze
A Gómez-Pedraza
A H Hussain
A H Khan
A Habeeb
A Hainsworth
A Hamad
A Hannah
A Hanson
A Harky
A Hasenburg
A Hawkins
A Haynes
A Haynes
A Henry
A Herman
A Hernández Gutierrez
A Heuer
A Hmedat
A Hogan
A Hunt
A I Gutiérrez Fernández
A I Kilani
A I Soriano
A I Tercero-Uribe
A Ibrahim
A Ionescu
A Jah
A Jain
A Jamal
A Jibril
A Jiménez
A Joshi
A Jotic
A K Ali
A K Andrade
A K Lala
A K Scafa
A K Zengin
A Kahn
A Kamocka
A Kanatas
A Kappenberger
A Karamarkovic
A Karim
A Kattakayam
A Kaufmann
A Kawai
A Kent
A Khajuria
A Khan
A Khoja
A Kirk
A Kisiel
A Kler
A Kocataş
A Koh
A Kolias
A Kollàr
A Kolusarı
A Kourdouli
A Kouyoumdjian
A Kredan
A Kumar
A Königsrainer
A L De Oliveira López
A L Ebbehøj
A L Picardo
A Laforest
A Lagares
A Laios
A Laird
A Landaluce-Olavarria
A Lanzon
A Larentzakis
A Lauretta
A Lim
A Loayza
A Loehrer
A Lopez Abad
A Louvrier
A Lovece
A Lowery
A Lyons
A Lázaro
A López Campillo
A M Abbas
A M Baietti
A M Castaño-Leon
A M Correia
A M Lacy
A M Majbar
A M Minaya Bravo
A M Ntziovara
A M Pathanki
A M Perrone
A M Scanu
A Macchi
A Madhavan
A Madkhali
A Maffioli
A Maffuz-Aziz
A Maghrabi
A Maiga
A Majkowska
A Mansuri
A Mantevas
A Marano
A Marchbank
A Marco Garrido
A Margalit
A Martin-Ucar
A Martinez German
A Marçal
A Mashat
A Maw
A McCanny
A Mccarthy
A McLennan
A McMillan
A Melo
A Menon
A Merchan
A Merdrignac
A Miljković
A Millan
A Mingoli
A Minicozzi
A Mirabella
A Modabber
A Mohammad
A Moro
A Morris
A Morsi
A Morton
A Mosca
A Moumen
A Muratore
A Mustafa
A N Sanli
A Nabil
A Nakas
A Nawawi
A Nobre Pinto
A Nogués
A Oar
A Oliveira
A Osorio
A Otero
A Ovaitt
A P Ferreira Pinto
A P Pezzuto
A Parello
A Parente
A Parseliunas
A Patel
A Patel
A Paunovic
A Pearce
A Pereira
A Pereira-Neves
A Peryt
A Petrillo
A Piras
A Pisani Ceretti
A Pisanu
A Polydorou
A Popoola
A Porcu
A Provozina
A Pucar
A Pérez Núñez
A Qasem
A Quennell
A Qureshi
A Ramachandran
A Ramos Bonilla
A Ramwell
A Ribeiro
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A Robinson
A Robson
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A Rodrigues
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A Rogers
A Rogers
A Romero de Diego
A Rowcroft
A Ruivo
A Ruiz Escobar
A Ruzzenente
A S Bodla
A S Coonar
A S Crugnale
A S Memon
A S Mohamed Sidek
A S Yahaya
A Sabry
A Sachdeva
A Sagnotta
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A Salamah
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A Saleem
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A Samir Abdelaal
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A Santoro
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A Saratziotis
A Sarin
A Sayasneh
A Scalabre
A Schache
A Seguin-Givelet
A Seleim
A Sgrò
A Shabana
A Sharkey
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A Sheel
A Shenfine
A Sherif
A Shuwayyah
A Singh
A Soares
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A Spinelli
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A Stanimirovic
A Stavroglou
A Stefanovic
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A Subocius
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A Sutherland
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A Sánchez-Pernaute
A Taddei
A Taibi
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A Tang
A Tedde
A Thomas
A Thompson
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A Townson
A Trivic
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A Turnbull
A Urbani
A Urbieta
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A Vallance
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A Varazzani
A Vazquez Fernandez
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A Vieira
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A Wilkins
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A Woodham
A Y Azzam
A Yiallourou
A Yıldırım
A Yildiz
A Youssef
A Zubaidi
A Zullo
A Älgå
Abd Elazeem Has
Abhinav Tiwari
Abigail Vallance
Adesoji Ademuyiwa
Adesoji O Ademuyiwa
Adrian Marchbank
Ahmad Qureshi
Akshay Patel
Alan McNeill
Alessandro Brunelli
Alessandro Gronchi
Alex Alamri
Alex Wilkins
Alexandra Colquhoun
Alexis P Arnaud
Aman S Coonar
Amanpreet Brar
Ana Minaya-Bravo
Ana Minaya-Bravo
Ana Minaya-Bravo
Ana Minaya-Bravo
Anant Desai
Anant Desai
Andreas A Schnitzbauer
Andreas K Demetriades
Andrew G Schache
Andrew Knight
Andrew Loehrer
Andrew Schache
Andrey Litvin
Aneel A Bhangu
Aneel A Bhangu
Aneel Bhangu
Angelos Kolias
Angelos Kolias
Anna Fagotti
Antonino Spinelli
Antonio Ramos-De la Medina
April C Roslani
Arda Isik
Arnav Agarwal
B A Fahey
B Al-Sarireh
B Albi Martin
B Alhassan
B Ayub
B B Ozmen
B Baca
B Bakmaz
B Banky
B Barmayehvar
B Barrat
B Bartalucci
B Bozkırlı
B Brown
B Caimari
B Challacombe
B Chumbinho
B Cimenoglu
B Cirillo
B Citgez
B Collard
B Costeira
B Cros
B Davidson
B De Andrés Asenjo
B De Simone
B Devauchelle
B Dias
B Diéguez
B Díaz-Feijoo
B El Ahmadi
B Gil Ibañez
B Giray
B Gricks
B Griffiths
B Grotenhuis
B Gális
B Göksoy
B J Mehigan
B Jayasankar
B Johnston
B Kajmaković
B Keeler
B Kidane
B Knowles
B Kocer
B Kotlar
B Kovacevic
B Lamb
B Le Roy
B Lieske
B Malgras
B Manku
B Mantoglu
B Martin-Perez
B McAree
B Narice
B Nunez-Garcia
B Patrício
B Pramodana
B Pérez-Saborido
B Rai
B S Kamera
B S Ong
B Seeliger
B Sheu
B Soyak
B Steel
B Swinson
B Tadic
B Thakur
B Ugarte-Sierra
B Vieira
B Vieira
B Wadham
Bandara Gbk
Benjamin Lamb
Brett E Dawson
Brittany K Bankhead-Kendall
C A Espinosa
C A Guariglia
C Abatini
C Agostini
C Allemand
C Alurralde
C Anthoulakis
C Arican
C Ashmore
C Aydin
C Azevedo
C B Kulle
C Baker
C Baldi
C Barry
C Barry
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C Baía
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C Bergamini
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C C Foo
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C Eiriz Fernandez
C Evans
C Evans
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C F Feo
C Ferreira
C Ferron
C Fitzgerald
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C Frattaruolo
C Freyschlag
C G Gil
C G Mitrofan
C Gambacciani
C Gan
C Gaskill
C Gemmell
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C Riley
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C Roy
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C S Betz
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C Sarre
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C Smith
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C Teh
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C Torres Arcos
C Tugmen
C Underwood
C Uras
C Uras
C V Feo
C Vera Mansilla
C Verberne
C W Chan
C Walker
C West
C Y Tang
C Yurttas
C Yánez
C Zografos
Carlos Jose Perez Rivera
Chai Akw
Chetan Khatri
Chris Bretherton
Christian Freyschlag
Christina Fotopoulou
Cioffi Spb
Conor S Jones
Constantine Halkias
Costa Mjma
D A Raptis
D Abbott
D Alazawi
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D Barker
D Bekele
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D M Donati
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D Parker
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D Phan
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D R Sarma
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D Raveendran
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D Shrestha
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D T María Dolores
D Tartaglia
D Tatsis
D Tham
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D Thompson
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D Tsolakidis
D Vatansever
D Veiga
D Velickovic
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D Vervoort
D Vijayan
D Vimalachandran
D W Kjaer
D Walker
D Ward
D Watson
D West
D Winter
D Worku
D Yeşilyurt
D Z Khan
D Zacharoulis
D Zakai
D Zouzoulas
D Öfner
Dale Vimalachandran
Dale Vimalchandran
Daniel Cox
Daniel M Fountain
Daoud Chaudhry
David Moszkowicz
Dejan Radenkovic
Dennis Mazingi
Derek Alderson
Dhruv Ghosh
Dinesh Thekinkattil
Dmitri Nepogodiev
Dmitri Nepogodiev
Duane Wedderburn
E A Yousof
E Abate
E Abdulwahed
E Acrich
E Addae-Boateng
E Akaydin
E Akin
E Alshareea
E Alvarez
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E Artigues
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E Athanasakis
E Aytac
E Badellino
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E Baldini
E Balik
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E Bertolani
E Bonci
E Boyd
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E Brian
E Brunocilla
E C Ong
E C Osterberg
E Cassinotti
E Chan
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E Elsey
E Espin-Basany
E Essam
E Esteban Agustí
E Etchill
E Felli
E Fiori
E Foley
E Francone
E G Lunghi
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Publication venue: 'Wiley'
Publication date: 01/01/2020
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Preoperative nasopharyngeal swab testing and postoperative pulmonary complications in patients undergoing elective surgery during the SARS-CoV-2 pandemic.

Author: Aawsaj Y
Abad Gurumeta A
Abad-Motos A
Abate E
Abatini C
Abbadessa F
Abbas AM
Abbassi-Ghadi N
Abbott D
Abbott T
Abbott TEF
Abd Elazeem HAS
Abdalla M
Abdallah M
Abdelaal SA
Abdeldayem H
Abdelkarem MM
Abdelkarim M
Abdelmajeed A
Abdelrahman A
Abdelrahman S
Abdelsamed A
Abdou M
Abdulkareem A
Abdulwahed E
Abdur-Rahman L
Abel MK
Abellan M
Abosamak NE
Abou Chaar MK
Abou-Khalil J
Abouassi A
Aboulkassem H
Abreu da Silva A
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Agnes A
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Ahmeidat A
Ahn JH
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Akin E
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Al Habes H
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Al-Mohammad A
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Alazawi D
Albertsmeier M
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Aldecoa Ansorregui I
Alderson D
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Almeida JI
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Alonso Poza A
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Alshammari S
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Alshaygy I
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Althobaiti W
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Antonopoulou MI
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Aremu I
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Athanasakis E
Athanasiou A
Athayde Nemesio R
Atherton R
Athwal R
Atici DS
Atta R
Attia D
Augestad KM
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Avci EK
Avlund T
Awad S
Ayasra F
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Ayasra Y
Aydin C
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Ayman A
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Azamat IF
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Azizeldine MG
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Azzam AY
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Baca B
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Baena Sanfeliu E
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Bagraith K
Baia C
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Bajomo O
Baker A
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Balasubramanian I
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Balik E
Ballabio M
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Ballouhey Q
Baloyiannis I
Bambina F
Ban VS
Bandara GBK
Bandiera A
Bandovas JP
Banerjee A
Bankhead-Kendall BK
Bankhead-Kendall BK
Banky B
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Baptista VH
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Bashir Y
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Becerra Garcia FC
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Belcher E
Belia F
Belkhadir ZH
Bellacci A
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Bellora P
Belluco C
Beltramini GA
Beltran de Heredia J
Belvedere A
Benavides Buleje JA
Benkabbou A
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Benson O
Benson RA
Benson RA
Bergamini C
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Betz CS
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Bezede C
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Bhangu A
Bhangu AA
Bhangu AA
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Bhatti MI
Biala M
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Bianchini M
Bianco F
Bianco F
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Bichoo R
Biel JR
Bigay K
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Bille A
Bin Nasser A
Bin Traiki T
Biondi A
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Blanco-Colino R
Blanco-Colino R
Blas Laina JL
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Bolt J
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Bravo Infante R
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Bromage S
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Buarque IL
Budacan A
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Bueno Canones AD
Buerba GA
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Burahee A
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Cabezudo Noguera SF
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Cagigal Ortega EP
Cagigas Fernandez C
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Caiado A
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Caina Ruiz R
Caird S
Cairncross L
Caja Vivancos P
Cakmak G
Calabro M
Callanan D
Calvo Espino P
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Camillo' A
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Campagnaro T
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Campbell W
Campisi G
Canas-Martinez A
Candiani M
Candotti G
Canhoto C
Cano A
Cano-Valderrama O
Canonico G
Canotilho R
Cantalejo Diaz M
Cao H
Capelli P
Capezzuoli L
Capitan-Morales L
Capizzi V
Capoglu R
Capolupo GT
Carabias A
Caram EL
Carannante F
Carcoforo P
Cardoso N
Cardoso P
Caricato M
Carrano FM
Carrasco Prats M
Carroll P
Carta AG
Carter J
Caruana EJ
Caruana EJ
Caruana EJ
Caruso J
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Cassinotti E
Castano-Leon AM
Castillejos-Molina RA
Catala Bauset JC
Catarzi L
Cato LD
Cavaleiro S
Cavalle Busquets P
Cayetano Paniagua L
Cazador Labat M
Cecchini L
Cecconello I
Cecire J
Celebi F
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Cellerino P
Cenciarelli S
Ceranic M
Ceretti PA
Cervellera M
Cervera I
Ceyhan GO
Chaar M
Chai AKW
Chakib O
Chakrabortee S
Challacombe B
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Chan CW
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Chandock A
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Charlton G
Chase T
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Chaudhry D
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Chavarrias N
Chebaro A
Checcucci C
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Chen L
Chen S
Chern H
Chessa A
Cheung LK
Chevallay M
Chew D
Chia Z
Chiappini A
Chiarella V
Chiarugi M
Chidambaram S
Chiesa-Estomba CM
Chiozza M
Chitul A
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Choi D
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Chong L
Choolani Bhojwani E
Choong P
Chopra S
Choudhry A
Choudhury J
Chouillard E
Chowdhry MF
Chowdhury A
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Christensen P
Christensen P
Christidis P
Christoforidis D
Christou C
Chrysos E
Chu F
Chumbinho B
Chung E
Cianflocca D
Ciccarone F
Cicerchia PM
Cimenoglu B
Cintas Catena J
Cioffi SPB
Ciofic E
Cipriani R
Cirillo B
Cirocchi N
Cisternino G
Citgez B
Citterio D
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Clifford R
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Cocozza E
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Coffey JC
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Colino M
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Colledan M
Collera P
Colletti G
Collins C
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Colombari RC
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Colquhoun A
Combellack T
Comini LV
Conesa A
Confalonieri M
Conlon K
Connelly T
Connolly EM
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Conti L
Conti L
Contis I
Cool P
Coonar AS
Coonar AS
Cope D
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Correia de Sa T
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Corte Real J
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Cosimelli M
Cossu ML
Costa Santos D
Costa M
Costa MJMA
Costanzi A
Costeira B
Costigan F
Cotoia A
Cotsoglou C
Cotte E
Cotter A
Cottu P
Coughlin P
Cox D
Coza I
Cozza V
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Cribb G
Crichton A
Cristian D
Cros B
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Cuadrado-Garcia A
Cukier M
Cullinane C
Cullivan O
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Cunha MF
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D'Amore A
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D'Angelo G
D'Ugo D
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D'Urso A
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Daiko H
Dainius E
Dakpe S
Daliya P
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Davidson B
Davidson GH
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Davies RJ
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Dawson BE
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De Andres Olabarria U
De Barros J
De Berardinis R
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De Cicco R
De Crescenzo E
De Graaff M
De Iaco P
De la Hoz Rodriguez A
De la Rosa Abaroa MA
De Lacy FB
De Miguel Ardevines MDC
De Nardi P
De Oliveira Lopez AL
De Pablo Garcia-Cuenca A
De Palma G
De Pastena M
De Simone B
De Simone V
de Solorzano Aurusa OFJ
De Sousa X
De Toma G
De Troia A
De Vincenti R
De Virgilio A
Dehal A
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Del Valle E
Delgado Fernandez J
Deligiannidis D
Delimpalta C
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Delrio P
Demetriades AK
Demir H
Demirhan R
Demyttenaere S
Denet C
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Depalma N
Derkaoui Hassani F
Derksen T
Desai A
Desai A
Desai A
Desio M
Deus AC
Devauchelle B
Devezas V
Devine M
Di Bartolomeo A
Di Bella A
Di Candido F
Di Chiara F
Di Franco G
Di Giuseppe M
Di Martino C
Di Martino M
Di Marzo F
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Di Somma A
Di Taranto G
Diamantis A
Dias B
Diaz Del Gobbo R
Diaz Pena P
Diaz Perez D
Diaz-Feijoo B
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Diez-Valladares L
Dijan E
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Dincer HA
Distler M
Divya GS
Dixon J
Djurisic I
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Domingues JC
Dominguez I
Dominguez-Rosado I
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Donati DM
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Donohue C
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Doyle A
Drake T
Drake TM
Drubay V
Duchalais E
Dudi-Venkata NN
Duff S
Dulgeroglu O
Dumitra S
Dumitra S
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Dunning J
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Duque-Mallen V
Duran Ballesteros M
Duran-Valles F
Durrani A
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Dwidar O
Dzamic Z
Dziakova J
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Eastmond A
Ebbehoj AL
Economopoulou P
Edmond M
Edmondson R
Edwards J
Edwards J
Edwards JG
Efthimiou M
Egan R
Egbeare D
Egbuchulem IK
Egoroff N
Eiriz Fernandez C
El Aamrani M
El Abbadi N
El Ahmadi B
El Bouazizi Y
El Ouahabi A
El-sayed I
Elawad A
Elayyan M
Elazzazy E
Elbe P
Eldaly A
Elena GDCR
ElFiky M
Elghazaly MS
Elhadi M
Elhamshary A
Elhoseiny M
Elhusseini M
Elkadi H
Elkaffas SMMM
Elkhayat H
Elliott JA
Elliott M
Ellojli I
Elmoslemany T
Elnemr M
Elqasabi MS
Elsey E
Elshaer M
Elsherbini I
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Emile S
Emiroglu M
Emmanuel K
Emslie K
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Ensenat Nora J
Ergun S
Erol T
Escartin J
Escobar P
Escola D
ESCP ESC
Esene I
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Eskander P
Eskinazi D
Espin-Basany E
Espino Segura-Illa M
Espinosa CA
Espitalier F
Esposito A
Esposito G
Essam E
Essangri H
Estaire Gomez M
Esteban Agusti E
Esteban Sinovas O
Esteban A
Etchill E
Ethunandan M
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Evans C
Evans C
Evans J
Evans JP
Evans JP
Evans RPT
Evans S
Eveno C
Evoy D
Eweda M
Ezanno A
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Fabregas N
Fadzli A
Fagotti A
Fagotti A
Fahey BA
Fahim M
Fahmawee T
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Falcon GM
Fambrini M
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Fancellu A
Faria CS
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Farma J
Farnesi F
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Farre Font R
Farrell R
Farsi A
Fasanmade K
Fathi NQ
Faulkner G
Faustino A
Fayed Y
Fazenda A
Fearon N
Federico P
Federico PNS
Fehervari M
Felli E
Fenton M
Feo CF
Feo CV
Fernandes U
Fernandes V
Fernandez Bernabe P
Fernandez Camunas A
Fernandez Pablos FJ
Fernandez Rodriguez P
Fernandez M
Fernandez PV
Fernandez-Lopez A
Fernando D
Ferrari F
Ferrari M
Ferrario L
Ferraz I
Ferreira Pinto AP
Ferreira C
Ferreli F
Ferrero A
Ferrero S
Ferres A
Ferron C
Fidalgo H
Fidelis L
Figari M
Figueiredo de Barros I
Findlay L
Finnegan L
Fiore M
Fiore M
Fiore M
Fiore M
Fiori E
Fiorini A
Firat N
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Fitzgerald C
Fitzgerald JE
Fitzjohn H
Flamey N
Flavin M
Fleming C
Fleming D
Fleming J
Fletcher A
Flindall I
Flores Clotet R
Foley D
Foley E
Folli S
Fong R
Fonseca F
Fonsi GB
Fontana M
Fontana T
Foo CC
Ford S
Ford S
Ford S
Fordington S
Forouhi P
Fortuna L
Fossett R
Fotopoulou C
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Foulkes R
Fountain D
Fountain DM
Fowler A
Fowler G
Fox A
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Fragulidis G
Frampton A
Franco G
Francone E
Frankel A
Franken J
Frantzeskou K
Franza M
Fraser L
Fraser S
Frasson M
Frati A
Frattaruolo C
Fregatti P
Freitas A
Frena A
Freyschlag C
Freyschlag C
Freystaetter K
Frias L
Frio F
Frisoni T
Fritzmann J
Frongia F
Fruscio R
Fu H
Fujiwara K
Fuks D
Fulginiti SF
Fullmer T
Furbetta N
Fusai G
Fusetti S
Fuson A
Futaba K
Futaba K
Fuwa O
Gabre-Kidan A
Gabre-Kidan A
Gacic S
Gagliano A
Gagliardi F
Gahunia S
Gaino F
Gainza A
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Gala T
Galindo Jara P
Galis B
Gallagher K
Gallagher T
Galliamov E
Gallo G
Gallo G
Gallo G
Galun D
Galvao D
Gambacciani C
Gan C
Gananadha S
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Gani J
Ganly I
Ganly I
Garberini DMA
Garces Garcia R
Garces-Albir M
Garcia Alonso M
Garcia Egea J
Garcia Escudero D
Garcia Gutierrez JJ
Garcia Perez D
Garcia Perez JM
Garcia Pineda V
Garcia Porcel VJ
Garcia Rico E
Garcia Romero E
Garcia Santos EP
Garcia Senorans PM
Garcia Septiem J
Garcia Soria V
Garcia Villayzan JE
Garcia JS
Garcia PM
Garcia-Conde M
Garcia-Loarte Gomez E
Garcia-Moreno Nisa F
Garcia-Quijada J
Garcia-Sancho Tellez L
Garfinkle R
Garmanova T
Garmanova T
Garrett W
Garrido R
Garrido S
Gascon Ferrer I
Gash K
Gaskill C
Gasparini G
Gata V
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Gattolin A
Gaunt A
Gauri N
Gavalda Pellice MGP
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Gegundez Simon A
Gelarda E
Gemmell C
Gemmill E
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Gennaro M
Gentilli S
Georgiades F
Geraghty J
Gerchunoff JI
Geretto P
Ghallab I
Ghaly G
Ghamgh R
Ghanbari A
Ghanem R
Ghannam A
Ghazali N
Ghebre R
Ghedan S
Ghitulescu G
Ghosh D
Ghufoor K
Ghunaim M
Giacometti M
Giaglaras A
Gialamas E
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Giblin A
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Ginesu GC
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Giralt Lopez de Sagredo J
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Giuliani G
Gkekas I
Gklavas A
Gkrinia E
Glasbey JC
Glasbey JC
Glasbey JC
Glasbey JC
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Glencer A
GlobalPaedSurg
GlobalSurg
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Gomes GMA
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Gomez Diaz CJ
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Gomez Latorre L
Gomez Portugal PE
Gomez Ruiz M
Gomez Sanz T
Gomez P
Gomez-Pedraza A
Gomez-Rosado J
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Gonzalez Garcia JA
Gonzalez Sanchez JJ
Gonzalez Valverde FM
Gonzalez AM
Gonzalez J
Gonzalez-Gonzalez E
Gonzalez-Nicolas Trebol MT
Goodrum S
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Publication venue: Br J Surg
Publication date: 11/11/2020
Field of study

BACKGROUND: Surgical services are preparing to scale up in areas affected by COVID-19. This study aimed to evaluate the association between preoperative SARS-CoV-2 testing and postoperative pulmonary complications in patients undergoing elective cancer surgery. METHODS: This international cohort study included adult patients undergoing elective surgery for cancer in areas affected by SARS-CoV-2 up to 19 April 2020. Patients suspected of SARS-CoV-2 infection before operation were excluded. The primary outcome measure was postoperative pulmonary complications at 30 days after surgery. Preoperative testing strategies were adjusted for confounding using mixed-effects models. RESULTS: Of 8784 patients (432 hospitals, 53 countries), 2303 patients (26.2 per cent) underwent preoperative testing: 1458 (16.6 per cent) had a swab test, 521 (5.9 per cent) CT only, and 324 (3.7 per cent) swab and CT. Pulmonary complications occurred in 3.9 per cent, whereas SARS-CoV-2 infection was confirmed in 2.6 per cent. After risk adjustment, having at least one negative preoperative nasopharyngeal swab test (adjusted odds ratio 0.68, 95 per cent confidence interval 0.68 to 0.98; P = 0.040) was associated with a lower rate of pulmonary complications. Swab testing was beneficial before major surgery and in areas with a high 14-day SARS-CoV-2 case notification rate, but not before minor surgery or in low-risk areas. To prevent one pulmonary complication, the number needed to swab test before major or minor surgery was 18 and 48 respectively in high-risk areas, and 73 and 387 in low-risk areas. CONCLUSION: Preoperative nasopharyngeal swab testing was beneficial before major surgery and in high SARS-CoV-2 risk areas. There was no proven benefit of swab testing before minor surgery in low-risk areas

Ezid

Crossref

AIR Universita degli studi di Milano

UCL Discovery

eScholarship - University of California

Archivio istituzionale della ricerca - Alma Mater Studiorum Università di Bologna

Apollo (Cambridge)

Bern Open Repository and Information System (BORIS)

Queen Mary Research Online

White Rose Research Online

Archivio istituzionale della ricerca - Università di Palermo