The run of ourselves: Shame, guilt and confession in post-Celtic Tiger Irish media

This article examines the emergence of the themes of shame and guilt in Irish print and broadcast media in the wake of Ireland’s 2008 economic collapse. It considers how the potential search for explanation of the crisis as a manifestation of unregulated banking and development sectors was displaced onto a confessional discursive pattern in which emphasis was placed on rampant borrowing and consumption as reflective of collective narcissism and acquisitive greed. Hence the logic that ‘hubris’ led inevitably to a national fall from grace and the corresponding resurgence of postcolonial shame; and the interplay between cultural nationalist and neoliberal discourses of redemption through confession of guilt and disciplinary self-regulation as the purging of excess

Transmission of Yellow Fever Vaccine Virus Through Blood Transfusion and Organ Transplantation in the USA in 2021: Report of an Investigation

BACKGROUND: In 2021, four patients who had received solid organ transplants in the USA developed encephalitis beginning 2-6 weeks after transplantation from a common organ donor. We describe an investigation into the cause of encephalitis in these patients. METHODS: From Nov 7, 2021, to Feb 24, 2022, we conducted a public health investigation involving 15 agencies and medical centres in the USA. We tested various specimens (blood, cerebrospinal fluid, intraocular fluid, serum, and tissues) from the organ donor and recipients by serology, RT-PCR, immunohistochemistry, metagenomic next-generation sequencing, and host gene expression, and conducted a traceback of blood transfusions received by the organ donor. FINDINGS: We identified one read from yellow fever virus in cerebrospinal fluid from the recipient of a kidney using metagenomic next-generation sequencing. Recent infection with yellow fever virus was confirmed in all four organ recipients by identification of yellow fever virus RNA consistent with the 17D vaccine strain in brain tissue from one recipient and seroconversion after transplantation in three recipients. Two patients recovered and two patients had no neurological recovery and died. 3 days before organ procurement, the organ donor received a blood transfusion from a donor who had received a yellow fever vaccine 6 days before blood donation. INTERPRETATION: This investigation substantiates the use of metagenomic next-generation sequencing for the broad-based detection of rare or unexpected pathogens. Health-care workers providing vaccinations should inform patients of the need to defer blood donation for at least 2 weeks after receiving a yellow fever vaccine. Despite mitigation strategies and safety interventions, a low risk of transfusion-transmitted infections remains. FUNDING: US Centers for Disease Control and Prevention (CDC), the Biomedical Advanced Research and Development Authority, and the CDC Epidemiology and Laboratory Capacity Cooperative Agreement for Infectious Diseases

Predicting age from cortical structure across the lifespan

Despite inter-individual differences in cortical structure, cross-sectional and longitudinal studies have demonstrated a large degree of population-level consistency in age-related differences in brain morphology. The present study assessed how accurately an individual’s age could be predicted by estimates of cortical morphology, comparing a variety of structural measures, including thickness, gyrification, and fractal dimensionality. Structural measures were calculated across up to seven different parcellation approaches, ranging from 1 region to 1000 regions. The age-prediction framework was trained using morphological measures obtained from T1-weighted MRI volumes collected from multiple sites, yielding a training dataset of 1056 healthy adults, aged 18-97. Age predictions were calculated using a machine-learning approach that incorporated non-linear differences over the lifespan. In two independent, held-out test samples, age predictions had a median error of 6-7 years. Age predictions were best when using a combination of cortical metrics, both thickness and fractal dimensionality. Overall, the results reveal that age-related differences in brain structure are systematic enough to enable reliable age prediction based on metrics of cortical morphology

Migration, Masculinity and the Fugitive State of Mind in the Irish Emigrant Footballer Autobiography: the Case of Paul McGrath

The ‘confessional’ autobiography has become a popular variant of professional football autobiography in Britain. Co-written ‘autobiographies’ by prominent former emigrant Irish or Irish descended international footballers have featured prominently in this sub-genre.  Their ‘confessions’ of alcoholism, gambling, infidelity, irresponsibility towards partners or dependents, or underlying ontological insecurity might be seen as an insightful engagement with their lives as male footballers in Britain.  However, focusing on two autobiographies of Paul McGrath, and reading these ‘troubled’ accounts using psychoanalytic perspectives on sport, migration and masculinity, it is argued that they are contradictory texts which embody a peculiar variation on the emigrant “fugitive state of mind” (Davar, 1996), both approximating and deferring mature, reflexive engagement with the social and cultural construction of identity, allowing them to occupy a liminal but discontent imaginary space in which adolescent masculinity can be indefinitely extended.   The homosocial world of men’s professional football is a key factor in this