COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study

Background: The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms. Methods: International, prospective observational study of 60 109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms. Results: ‘Typical’ symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (≤ 18 years: 69, 48, 23; 85%), older adults (≥ 70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each P < 0.001). The most common atypical presentations under 60 years of age were nausea and vomiting and abdominal pain, and over 60 years was confusion. Regression models showed significant differences in symptoms with sex, age and country. Interpretation: This international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men

NF Z76-041-1: Norme de description pour l'éducation en France - Partie 1 : Description des ressources pédagogiques (NoDEfr-1)

International audienceCe document spécifie la norme française de description pour l'éducation partie 1 : description des ressources (NoDEfr-1) . Cette norme est définie comme un profil d'application de la norme internationale ISO/IEC 19788 Information technology - Learning, education and training - Metadata for learning resources / Technologies de l'information - Apprentissage, éducation et formation - Métadonnées pour ressources d'apprentissage. Elle repose sur différentes parties de cette norme (plus particulièrement les parties 1, 2, 4, 5, 7, 8, 9, 11)

NF Z76-041-1: Norme de description pour l'éducation en France - Partie 1 : Description des ressources pédagogiques (NoDEfr-1)

International audienceCe document spécifie la norme française de description pour l'éducation partie 1 : description des ressources (NoDEfr-1) . Cette norme est définie comme un profil d'application de la norme internationale ISO/IEC 19788 Information technology - Learning, education and training - Metadata for learning resources / Technologies de l'information - Apprentissage, éducation et formation - Métadonnées pour ressources d'apprentissage. Elle repose sur différentes parties de cette norme (plus particulièrement les parties 1, 2, 4, 5, 7, 8, 9, 11)

A combination of cyclophosphamide and interleukin-2 allows CD4+ T cells converted to Tregs to control scurfy syndrome

International audienceAbstract Immunodysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome is caused by mutations in forkhead box P3 (FOXP3), which lead to the loss of function of regulatory T cells (Tregs) and the development of autoimmune manifestations early in life. The selective induction of a Treg program in autologous CD4+ T cells by FOXP3 gene transfer is a promising approach for curing IPEX. We have established a novel in vivo assay of Treg functionality, based on adoptive transfer of these cells into scurfy mice (an animal model of IPEX) and a combination of cyclophosphamide (Cy) conditioning and interleukin-2 (IL-2) treatment. This model highlighted the possibility of rescuing scurfy disease after the latter’s onset. By using this in vivo model and an optimized lentiviral vector expressing human Foxp3 and, as a reporter, a truncated form of the low-affinity nerve growth factor receptor (ΔLNGFR), we demonstrated that the adoptive transfer of FOXP3-transduced scurfy CD4+ T cells enabled the long-term rescue of scurfy autoimmune disease. The efficiency was similar to that seen with wild-type Tregs. After in vivo expansion, the converted CD4FOXP3 cells recapitulated the transcriptomic core signature for Tregs. These findings demonstrate that FOXP3 expression converts CD4+ T cells into functional Tregs capable of controlling severe autoimmune disease

Rapport du programme de recherche SEMIPAR - Secret militaire et participation en matière nucléaire

Le projet Secret Militaire et Participation en matière nucléaire (SEMIPAR) s'est achevé en 2012. Il s'agissait d'une étude de 3 ans confiée en 2009 au Centre de Recherche et d'Etude en Droit et Science Politique (CREDESPO) de l'Université de Bourgogne par le ministère de l'Environnement (programme Concertation, décision, environnement) afin de répondre aux problématiques suivantes : - Peut-on apporter des réponses aux conflits nés de la confrontation entre obligations stratégiques liées au secret de la défense nationale, environnement et territoire et - Comment concilier les exigences liées au droit à l'information, au secret de la défense nationale et à la participation

Rapport du programme de recherche SEMIPAR - Secret militaire et participation en matière nucléaire

Le projet Secret Militaire et Participation en matière nucléaire (SEMIPAR) s'est achevé en 2012. Il s'agissait d'une étude de 3 ans confiée en 2009 au Centre de Recherche et d'Etude en Droit et Science Politique (CREDESPO) de l'Université de Bourgogne par le ministère de l'Environnement (programme Concertation, décision, environnement) afin de répondre aux problématiques suivantes : - Peut-on apporter des réponses aux conflits nés de la confrontation entre obligations stratégiques liées au secret de la défense nationale, environnement et territoire et - Comment concilier les exigences liées au droit à l'information, au secret de la défense nationale et à la participation

Poetic or Humorous Text Generation: Jam Event at PFIA2022

International audienceIn this paper, we describe the organization and the results of a Jam event on computational creativity at a major French national conference in AI PFIA2022. During this Jam event, participants were challenged by the task of humor or poetry generation using a number of resources and corpus

Poetic or Humorous Text Generation: Jam Event at PFIA2022

International audienceIn this paper, we describe the organization and the results of a Jam event on computational creativity at a major French national conference in AI PFIA2022. During this Jam event, participants were challenged by the task of humor or poetry generation using a number of resources and corpus