RXJ0848.6+4453: The Evolution of Galaxy Sizes and Stellar Populations in a z=1.27 Cluster

RXJ0848.6+4453 (Lynx W) at redshift 1.27 is part of the Lynx Supercluster of galaxies. Our analysis of stellar populations and star formation history in the cluster covers 24 members and is based on deep optical spectroscopy from Gemini North and imaging data from HST. Focusing on the 13 bulge-dominated galaxies for which we can determine central velocity dispersions, we find that these show a smaller evolution of sizes and velocity dispersions than reported for field galaxies and galaxies in poorer clusters. The galaxies in RXJ0848.6+4453 populate the Fundamental Plane similar to that found for lower redshift clusters with a zero point offset corresponding to an epoch of last star formation at z_form= 1.95+-0.2. The spectra of the galaxies in RXJ0848.6+4453 are dominated by young stellar populations at all galaxy masses and in many cases show emission indicating low level on-going star formation. The average age of the young stellar populations (estimated from H-zeta) is consistent with a major star formation episode 1-2 Gyr prior, which in turn agrees with z_form=1.95. Galaxies dominated by young stellar populations are distributed throughout the cluster. We speculate that low level star formation has not yet been fully quenched in the center of this cluster may be because the cluster is significantly poorer than other clusters previously studied at similar redshifts, which appear to have very little on-going star formation in their centers.Comment: Accepted for publication in Astronomical Journal. High-resolution figures available from the first author by reques

The Fundamental Plane in RX J0142.0+2131: a galaxy cluster merger at z=0.28

We present the Fundamental Plane (FP) in the z = 0.28 cluster of galaxies RX J0142.0+2131. There is no evidence for a difference in the slope of the FP when compared with the Coma cluster, although the internal scatter is larger. On average, stellar populations in RX J0142.0+2131 have rest-frame V-band mass-to-light ratios (M/L_V) 0.29+-0.03 dex lower than in Coma. This is significantly lower than expected for a passively-evolving cluster formed at z_f=2. Lenticular galaxies have lower average M/L_V and a distribution of M/L_V with larger scatter than ellipticals. Lower mass-to-light ratios are not due to recent star formation: our previous spectroscopic observations of RX J0142.0+2131 E/S0 galaxies showed no evidence for significant star-formation within the past ~4 Gyr. However, cluster members have enhanced alpha-element abundance ratios, which may act to decrease M/L_V. The increased scatter in the RX J0142.0+2131 FP reflects a large scatter in M/L_V implying that galaxies have undergone bursts of star formation over a range of epochs. The seven easternmost cluster galaxies, including the second brightest member, have M/L_V consistent with passive evolution and z_f = 2. We speculate that RX J0142.0+2131 is a cluster-cluster merger where the galaxies to the east are yet to fall into the main cluster body or have not experienced star formation as a result of the merger.Comment: 4 pages, 2 figures, accepted for publication in ApJ Letter

Spectroscopy of Low Surface Brightness Galaxies with the Hobby-Eberly Telescope

We have obtained low resolution spectra of nineteen red and blue low surface brightness galaxies, using the Marcario Low Resolution Spectrograph on the 9.2m Hobby-Eberly Telescope. These galaxies form a very heterogeneous class, whose spectra qualitatively resemble those of high surface brightness galaxies covering the full range of spectra seen in galaxies of Hubble types from E to Irr. We use a combination of emission line (EW(Halpha), NII/Halpha) and absorption line (Mgb, Hbeta, ) based diagnostics to investigate the star-formation and chemical enrichment histories of these galaxies. These are diverse, with some galaxies having low metallicity and very young mean stellar ages, and other galaxies showing old, super-solar metallicity stellar populations. In contrast with some previous studies which found a strong trend of decreasing metallicity with decreasing central surface brightness, we find a population of galaxies with low surface brightness and near-solar metallicity. Correlations between several of the gas phase and stellar population age and metallicity indicators are used to place contraints on plausible evolutionary scenarios for LSB galaxies. The redshift range spanned by these galaxies is broad, with radial velocities from 3400 km/s to more than 65000 km/s. A subset of the sample galaxies have published HI redshifts and gas masses based on observations with the Arecibo 305m single-dish radio telescope, which place these galaxies far off of the mean Tully-Fisher relation. Our new optical redshifts do not agree with the published HI redshifts for these galaxies. Most of the discrepancies can be explained by beam confusion in the Arecibo observations, causing erroneous HI detections for some of the galaxies.Comment: 31 pages, 12 figures, 7 tables. Uses emulateapj5.sty and onecolfloat5.sty, which are included. Accepted for publication in the Astronomical Journa

Expertise in research integration and implementation for tackling complex problems: when is it needed, where can it be found and how can it be strengthened?

© 2020, The Author(s). Expertise in research integration and implementation is an essential but often overlooked component of tackling complex societal and environmental problems. We focus on expertise relevant to any complex problem, especially contributory expertise, divided into ‘knowing-that’ and ‘knowing-how.’ We also deal with interactional expertise and the fact that much expertise is tacit. We explore three questions. First, in examining ‘when is expertise in research integration and implementation required?,’ we review tasks essential (a) to developing more comprehensive understandings of complex problems, plus possible ways to address them, and (b) for supporting implementation of those understandings into government policy, community practice, business and social innovation, or other initiatives. Second, in considering ‘where can expertise in research integration and implementation currently be found?,’ we describe three realms: (a) specific approaches, including interdisciplinarity, transdisciplinarity, systems thinking and sustainability science; (b) case-based experience that is independent of these specific approaches; and (c) research examining elements of integration and implementation, specifically considering unknowns and fostering innovation. We highlight examples of expertise in each realm and demonstrate how fragmentation currently precludes clear identification of research integration and implementation expertise. Third, in exploring ‘what is required to strengthen expertise in research integration and implementation?,’ we propose building a knowledge bank. We delve into three key challenges: compiling existing expertise, indexing and organising the expertise to make it widely accessible, and understanding and overcoming the core reasons for the existing fragmentation. A growing knowledge bank of expertise in research integration and implementation on the one hand, and accumulating success in addressing complex societal and environmental problems on the other, will form a virtuous cycle so that each strengthens the other. Building a coalition of researchers and institutions will ensure this expertise and its application are valued and sustained

Echoes from Ancient Supernovae in the Large Magellanic Cloud

In principle, the light from historical supernovae could still be visible as scattered-light echoes even centuries later. However, while echoes have been discovered around some nearby extragalactic supernovae well after the explosion, targeted searches have not recovered any echoes in the regions of historical Galactic supernovae. The discovery of echoes can allow us to pinpoint the supernova event both in position and age and, most importantly, allow us to acquire spectra of the echo light to type the supernova centuries after the direct light from the explosion first reached the Earth. Here we report on the discovery of three faint new variable surface brightness complexes with high apparent proper motion pointing back to well-defined positions in the Large Magellanic Cloud (LMC). These positions correspond to three of the six smallest (and likely youngest) previously catalogued supernova remnants, and are believed to be due to thermonuclear (Type Ia) supernovae. Using the distance and proper motions of these echo arcs, we estimate ages of 610 and 410 yr for the echoes #2 and #3.Comment: 13 pages, 3 figures, 1 table. PDF format. Note: This paper has been accepted by Nature for publication as a letter. It is embargoed for discussion in the popular press until publication in Natur

The Urokinase Receptor (uPAR) Facilitates Clearance of Borrelia burgdorferi

The causative agent of Lyme borreliosis, the spirochete Borrelia burgdorferi, has been shown to induce expression of the urokinase receptor (uPAR); however, the role of uPAR in the immune response against Borrelia has never been investigated. uPAR not only acts as a proteinase receptor, but can also, dependently or independently of ligation to uPA, directly affect leukocyte function. We here demonstrate that uPAR is upregulated on murine and human leukocytes upon exposure to B. burgdorferi both in vitro as well as in vivo. Notably, B. burgdorferi-inoculated C57BL/6 uPAR knock-out mice harbored significantly higher Borrelia numbers compared to WT controls. This was associated with impaired phagocytotic capacity of B. burgdorferi by uPAR knock-out leukocytes in vitro. B. burgdorferi numbers in vivo, and phagocytotic capacity in vitro, were unaltered in uPA, tPA (low fibrinolytic activity) and PAI-1 (high fibrinolytic activity) knock-out mice compared to WT controls. Strikingly, in uPAR knock-out mice partially backcrossed to a B. burgdorferi susceptible C3H/HeN background, higher B. burgdorferi numbers were associated with more severe carditis and increased local TLR2 and IL-1β mRNA expression. In conclusion, in B. burgdorferi infection, uPAR is required for phagocytosis and adequate eradication of the spirochete from the heart by a mechanism that is independent of binding of uPAR to uPA or its role in the fibrinolytic system

Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the FADS locus

: Identifying genetic determinants of reproductive success may highlight mechanisms underlying fertility and identify alleles under present-day selection. Using data in 785,604 individuals of European ancestry, we identified 43 genomic loci associated with either number of children ever born (NEB) or childlessness. These loci span diverse aspects of reproductive biology, including puberty timing, age at first birth, sex hormone regulation, endometriosis and age at menopause. Missense variants in ARHGAP27 were associated with higher NEB but shorter reproductive lifespan, suggesting a trade-off at this locus between reproductive ageing and intensity. Other genes implicated by coding variants include PIK3IP1, ZFP82 and LRP4, and our results suggest a new role for the melanocortin 1 receptor (MC1R) in reproductive biology. As NEB is one component of evolutionary fitness, our identified associations indicate loci under present-day natural selection. Integration with data from historical selection scans highlighted an allele in the FADS1/2 gene locus that has been under selection for thousands of years and remains so today. Collectively, our findings demonstrate that a broad range of biological mechanisms contribute to reproductive success

Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits

Few genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution to obesity-related traits. Here, we use GWAS data from 51,080 current smokers and 190,178 nonsmokers (87% European descent) to identify loci influencing BMI and central adiposity, measured as waist circumference and waist-to-hip ratio both adjusted for BMI. We identify 23 novel genetic loci, and 9 loci with convincing evidence of gene-smoking interaction (GxSMK) on obesity-related traits. We show consistent direction of effect for all identified loci and significance for 18 novel and for 5 interaction loci in an independent study sample. These loci highlight novel biological functions, including response to oxidative stress, addictive behaviour, and regulatory functions emphasizing the importance of accounting for environment in genetic analyses. Our results suggest that tobacco smoking may alter the genetic susceptibility to overall adiposity and body fat distribution.Peer reviewe

Genome-wide analysis identifies 12 loci influencing human reproductive behavior.

The genetic architecture of human reproductive behavior-age at first birth (AFB) and number of children ever born (NEB)-has a strong relationship with fitness, human development, infertility and risk of neuropsychiatric disorders. However, very few genetic loci have been identified, and the underlying mechanisms of AFB and NEB are poorly understood. We report a large genome-wide association study of both sexes including 251,151 individuals for AFB and 343,072 individuals for NEB. We identified 12 independent loci that are significantly associated with AFB and/or NEB in a SNP-based genome-wide association study and 4 additional loci associated in a gene-based effort. These loci harbor genes that are likely to have a role, either directly or by affecting non-local gene expression, in human reproduction and infertility, thereby increasing understanding of these complex traits