The Therapeutic Potential of the Stem Cell Secretome for Spinal Cord Repair : A Systematic Review and Meta-Analysis

Acknowledgments: We would like to thank Drs Ya-Tzu Chen (Taipei Veterans General Hospital), May-Jywan Tsai (Taipei Veterans General Hospital), Kenji Kanekiyo (Aino University) and Yi Ren (Florida State University) for responding to our requests for clarification on their studies. We would also like to thank Dr Jack Rivers-Auty (University of Tasmania) for his advice on statistical analysis. Funding: This work was supported by Graham and Pam Dixon and the Scottish Rugby Union.Peer reviewedPublisher PD

A systematic review and meta-analysis of thigmotactic behaviour in the open field test in rodent models associated with persistent pain

Thigmotaxis is an innate predator avoidance behaviour of rodents. To gain insight into how injury and disease models, and analgesic drug treatments affect thigmotaxis, we performed a systematic review and meta-analysis of studies that assessed thigmotaxis in the open field test. Systematic searches were conducted of 3 databases in October 2020, March and August 2022. Study design characteristics and experimental data were extracted and analysed using a random-effects meta-analysis. We also assessed the correlation between thigmotaxis and stimulus-evoked limb withdrawal. This review included the meta-analysis of 165 studies We report thigmotaxis was increased in injury and disease models associated with persistent pain and this increase was attenuated by analgesic drug treatments in both rat and mouse experiments. Its usefulness, however, may be limited in certain injury and disease models because our analysis suggested that thigmotaxis may be associated with the locomotor function. We also conducted subgroup analyses and meta-regression, but our findings on sources of heterogeneity are inconclusive because analyses were limited by insufficient available data. It was difficult to assess internal validity because reporting of methodological quality measures was poor, therefore, the studies have an unclear risk of bias. The correlation between time in the centre (type of a thigmotactic metric) and types of stimulus-evoked limb withdrawal was inconsistent. Therefore, stimulus-evoked and ethologically relevant behavioural paradigms should be viewed as two separate entities as they are conceptually and methodologically different from each other

Advanced UVOIR Mirror Technology Development (AMTD) for Very Large Space Telescopes

ASTRO2010 Decadal Survey stated that an advanced large-aperture ultraviolet, optical, near-infrared (UVOIR) telescope is required to enable the next generation of compelling astrophysics and exoplanet science; and, that present technology is not mature enough to affordably build and launch any potential UVOIR mission concept. AMTD is the start of a multiyear effort to develop, demonstrate and mature critical technologies to TRL-6 by 2018 so that a viable flight mission can be proposed to the 2020 Decadal Review. AMTD builds on the state of art (SOA) defined by over 30 years of monolithic & segmented ground & space-telescope mirror technology to mature six key technologies: (1) Large-Aperture, Low Areal Density, High Stiffness Mirror Substrates: Both (4 to 8 m) monolithic and (8 to 16 m) segmented primary mirrors require larger, thicker, and stiffer substrates. (2) Support System: Large-aperture mirrors require large support systems to ensure that they survive launch and deploy on orbit in a stress-free and undistorted shape. (3) Mid/High Spatial Frequency Figure Error: Very smooth mirror is critical for producing high-quality point spread function (PSF) for high contrast imaging. (4) Segment Edges: The quality of segment edges impacts PSF for high-contrast imaging applications, contributes to stray light noise, and affects total collecting aperture. (5) Segment to Segment Gap Phasing: Segment phasing is critical for producing high-quality temporally-stable PSF. (6) Integrated Model Validation: On-orbit performance is driven by mechanical & thermal stability. Compliance cannot be 100% tested, but relies on modeling. AMTD is pursuing multiple design paths to provide the science community with options to enable either large aperture monolithic or segmented mirrors with clear engineering metrics traceable to science requirements

Marine pelagic ecosystems: the West Antarctic Peninsula

The marine ecosystem of the West Antarctic Peninsula (WAP) extends from the Bellingshausen Sea to the northern tip of the peninsula and from the mostly glaciated coast across the continental shelf to the shelf break in the west. The glacially sculpted coastline along the peninsula is highly convoluted and characterized by deep embayments that are often interconnected by channels that facilitate transport of heat and nutrients into the shelf domain. The ecosystem is divided into three subregions, the continental slope, shelf and coastal regions, each with unique ocean dynamics, water mass and biological distributions. The WAP shelf lies within the Antarctic Sea Ice Zone (SIZ) and like other SIZs, the WAP system is very productive, supporting large stocks of marine mammals, birds and the Antarctic krill, Euphausia superba. Ecosystem dynamics is dominated by the seasonal and interannual variation in sea ice extent and retreat. The Antarctic Peninsula is one among the most rapidly warming regions on Earth, having experienced a 28C increase in the annual mean temperature and a 68C rise in the mean winter temperature since 1950. Delivery of heat from the Antarctic Circumpolar Current has increased significantly in the past decade, sufficient to drive to a 0.68C warming of the upper 300 m of shelf water. In the past 50 years and continuing in the twenty-first century, the warm, moist maritime climate of the northern WAP has been migrating south, displacing the once dominant cold, dry continental Antarctic climate and causing multi-level responses in the marine ecosystem. Ecosystem responses to the regional warming include increased heat transport, decreased sea ice extent and duration, local declines in icedependent Ade´lie penguins, increase in ice-tolerant gentoo and chinstrap penguins, alterations in phytoplankton and zooplankton community composition and changes in krill recruitment, abundance and availability to predators. The climate/ecological gradients extending along theWAPand the presence of monitoring systems, field stations and long-term research programmes make the region an invaluable observatory of climate change and marine ecosystem response

Altimetry for the future: Building on 25 years of progress

In 2018 we celebrated 25 years of development of radar altimetry, and the progress achieved by this methodology in the fields of global and coastal oceanography, hydrology, geodesy and cryospheric sciences. Many symbolic major events have celebrated these developments, e.g., in Venice, Italy, the 15th (2006) and 20th (2012) years of progress and more recently, in 2018, in Ponta Delgada, Portugal, 25 Years of Progress in Radar Altimetry. On this latter occasion it was decided to collect contributions of scientists, engineers and managers involved in the worldwide altimetry community to depict the state of altimetry and propose recommendations for the altimetry of the future. This paper summarizes contributions and recommendations that were collected and provides guidance for future mission design, research activities, and sustainable operational radar altimetry data exploitation. Recommendations provided are fundamental for optimizing further scientific and operational advances of oceanographic observations by altimetry, including requirements for spatial and temporal resolution of altimetric measurements, their accuracy and continuity. There are also new challenges and new openings mentioned in the paper that are particularly crucial for observations at higher latitudes, for coastal oceanography, for cryospheric studies and for hydrology. The paper starts with a general introduction followed by a section on Earth System Science including Ocean Dynamics, Sea Level, the Coastal Ocean, Hydrology, the Cryosphere and Polar Oceans and the ‘‘Green” Ocean, extending the frontier from biogeochemistry to marine ecology. Applications are described in a subsequent section, which covers Operational Oceanography, Weather, Hurricane Wave and Wind Forecasting, Climate projection. Instruments’ development and satellite missions’ evolutions are described in a fourth section. A fifth section covers the key observations that altimeters provide and their potential complements, from other Earth observation measurements to in situ data. Section 6 identifies the data and methods and provides some accuracy and resolution requirements for the wet tropospheric correction, the orbit and other geodetic requirements, the Mean Sea Surface, Geoid and Mean Dynamic Topography, Calibration and Validation, data accuracy, data access and handling (including the DUACS system). Section 7 brings a transversal view on scales, integration, artificial intelligence, and capacity building (education and training). Section 8 reviews the programmatic issues followed by a conclusion

Altimetry for the future: building on 25 years of progress

In 2018 we celebrated 25 years of development of radar altimetry, and the progress achieved by this methodology in the fields of global and coastal oceanography, hydrology, geodesy and cryospheric sciences. Many symbolic major events have celebrated these developments, e.g., in Venice, Italy, the 15th (2006) and 20th (2012) years of progress and more recently, in 2018, in Ponta Delgada, Portugal, 25 Years of Progress in Radar Altimetry. On this latter occasion it was decided to collect contributions of scientists, engineers and managers involved in the worldwide altimetry community to depict the state of altimetry and propose recommendations for the altimetry of the future. This paper summarizes contributions and recommendations that were collected and provides guidance for future mission design, research activities, and sustainable operational radar altimetry data exploitation. Recommendations provided are fundamental for optimizing further scientific and operational advances of oceanographic observations by altimetry, including requirements for spatial and temporal resolution of altimetric measurements, their accuracy and continuity. There are also new challenges and new openings mentioned in the paper that are particularly crucial for observations at higher latitudes, for coastal oceanography, for cryospheric studies and for hydrology. The paper starts with a general introduction followed by a section on Earth System Science including Ocean Dynamics, Sea Level, the Coastal Ocean, Hydrology, the Cryosphere and Polar Oceans and the “Green” Ocean, extending the frontier from biogeochemistry to marine ecology. Applications are described in a subsequent section, which covers Operational Oceanography, Weather, Hurricane Wave and Wind Forecasting, Climate projection. Instruments’ development and satellite missions’ evolutions are described in a fourth section. A fifth section covers the key observations that altimeters provide and their potential complements, from other Earth observation measurements to in situ data. Section 6 identifies the data and methods and provides some accuracy and resolution requirements for the wet tropospheric correction, the orbit and other geodetic requirements, the Mean Sea Surface, Geoid and Mean Dynamic Topography, Calibration and Validation, data accuracy, data access and handling (including the DUACS system). Section 7 brings a transversal view on scales, integration, artificial intelligence, and capacity building (education and training). Section 8 reviews the programmatic issues followed by a conclusion

Silicon+-post processing CMOS wafers to create integrated sensors, MEMS and electro-optic systems

Silicon based integrated circuit technology has shown astonishing progress scaling to smaller geometries as the industry follows Moore's predictions. However, in recent years the cost associated with staying at the leading edge of silicon IC technology has resulted in many companies being either unable, or unwilling, to afford the investment required. As a consequence some have decided to use foundry technology and/or diversify into new device types and associated novel application areas. All of these diverse Silicon+ technologies have one particular feature in common, namely they all use silicon as a platform for system integration with the added value being the innovation associated with post-processing and/or technology integration, which in many cases is realised on standard foundry technology. This paper examines many of the issues associated with integrating foundry and custom IC wafers with both new materials and technologies such as MEMS based sensors and actuators. In particular it examines the various options available for companies considering Silicon+ technology applications and presents examples of successful applications of this approach. Some of these are illustrated below

Integration of IC technology with MEMS: silicon+ technology for the future

As silicon microelectronics continues its remarkable evolution, the technology is simultaneously scaling to smaller geometries and diversifying into new device types and associated novel application areas. Recent examples of this diversification include smart power (integration of power devices with microelectronics), RF systems (integration of other semiconductor technologies such as SiGe, GaAs and passives with CMOS), microsystems (integration of a wide range of MEMS devices and sensors with CMOS), microdisplays (liquid crystal, light emitting polymers on silicon), bioelectronics (lab on a chip) and silicon photonics (integration of optical components on a silicon platform). All of these diverse Silicon+ technologies have one particular feature in common, namely the use of silicon as a platform for system integration with the added value being the innovation associated with post-processing and/or integration, which in many cases will be on standard foundry technology. The attraction of silicon as a platform technology arises from its dominance as a high performance and cost effective microelectronics technology. It is highly probable that Silicon+ will become the mainstream silicon research direction when scaling has run its course and hits a combination of technological and economic barriers. One vision of Silicon+ is that it effectively treats the platform silicon integrated circuit (IC) technology as a commodity element of the system, and with much of mainstream CMOS being foundry based, the value added part becomes the bespoke processing and the associated IP. One of the attractions of this approach is that state-of-the-art CMOS technology is readily available without the need for any capital investment and so the potential exists for SMEs and startup companies to readily exploit any IC/device technology that is developed. Another appeal is that as foundry-processes are updated the technology is immediately accessible making this element of any technology/product development future proofed without the requirement for any capital investment. This paper will examine the options associated with integrating both foundry and custom IC technology with both new materials and other technologies such as MEMS (sensors and actuators) and present examples of the various options

CD -27°11535 : evidence for a triple system in the β Pictoris moving group

Funding: This work was supported in part by NASA grants NNX14AJ80G, 80NSSC21K0958 (E.L.N. and A.E.P.), and 21-ADAP21-0130 (E.L.N. and A.S.) and authored by employees of Caltech/IPAC under contract No. 80GSFC21R0032 with the National Aeronautics and Space Administration.We present new spatially resolved astrometry and photometry of the CD –27°11535 system, a member of the β Pictoris moving group consisting of two resolved K-type stars on a ∼20 yr orbit. We fit an orbit to relative astrometry measured from NIRC2, GPI, and archival NaCo images, in addition to literature measurements. However, the total mass inferred from this orbit is significantly discrepant from that inferred from stellar evolutionary models using the luminosity of the two stars. We explore two hypotheses that could explain this discrepant mass sum: a discrepant parallax measurement from Gaia due to variability, and the presence of an additional unresolved companion to one of the two components. We find that the ∼20 yr orbit could not bias the parallax measurement, but that variability of the components could produce a large-amplitude astrometric motion, an effect that cannot be quantified exactly without the individual Gaia measurements. The discrepancy could also be explained by an additional star in the system. We jointly fit the astrometric and photometric measurements of the system to test different binary and triple architectures for the system. Depending on the set of evolutionary models used, we find an improved goodness of fit for a triple system architecture that includes a low-mass (M = 0.177 ± 0.055 M⊙) companion to the primary star. Further studies of this system will be required in order to resolve this discrepancy, either by refining the parallax measurement with a more complex treatment of variability-induced astrometric motion or by detecting a third companion.Publisher PDFPeer reviewe