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Biocompatible functionalisation of nanoclays for improved environmental remediation
Among the wide range of materials used for remediating environmental contaminants, modified and functionalised nanoclays show particular promise as advanced sorbents, improved dispersants, or biodegradation enhancers. However, many chemically modified nanoclay materials are incompatible with living organisms when they are used in natural systems with detrimental implications for ecosystem recovery. Here we critically review the pros and cons of functionalised nanoclays and provide new perspectives on the synthesis of environmentally friendly varieties. Particular focus is given to finding alternatives to conventional surfactants used in modified nanoclay products, and to exploring strategies in synthesising nanoclay-supported metal and metal oxide nanoparticles. A large number of promising nanoclay-based sorbents are yet to satisfy environmental biocompatibility in situ but opportunities are there to tailor them to produce "biocompatible" or regenerative/reusable materials
Superconductivity at the Border of Electron Localization and Itinerancy
The superconducting state of iron pnictides and chalcogenides exists at the
border of antiferromagnetic order. Consequently, these materials could provide
clues about the relationship between magnetism and unconventional
superconductivity. One explanation, motivated by the so-called bad-metal
behaviour of these materials, proposes that magnetism and superconductivity
develop out of quasi-localized magnetic moments which are generated by strong
electron-electron correlations. Another suggests that these phenomena are the
result of weakly interacting electron states that lie on nested Fermi surfaces.
Here we address the issue by comparing the newly discovered alkaline iron
selenide superconductors, which exhibit no Fermi-surface nesting, to their iron
pnictide counterparts. We show that the strong-coupling approach leads to
similar pairing amplitudes in these materials, despite their different Fermi
surfaces. We also find that the pairing amplitudes are largest at the boundary
between electronic localization and itinerancy, suggesting that new
superconductors might be found in materials with similar characteristics.Comment: Version of the published manuscript prior to final journal-editting.
Main text (23 pages, 4 figures) + Supplementary Information (14 pages, 7
figures, 3 tables). Calculation on the single-layer FeSe is added.
Enhancement of the pairing amplitude in the vicinity of the Mott transition
is highlighted. Published version is at
http://www.nature.com/ncomms/2013/131115/ncomms3783/full/ncomms3783.htm
Protective effect of stromal Dickkopf-3 in prostate cancer: opposing roles for TGFBI and ECM-1
Aberrant transforming growth factor–β (TGF-β) signaling is a hallmark of the stromal microenvironment in cancer. Dickkopf-3 (Dkk-3), shown to inhibit TGF-β signaling, is downregulated in prostate cancer and upregulated in the stroma in benign prostatic hyperplasia, but the function of stromal Dkk-3 is unclear. Here we show that DKK3 silencing in WPMY-1 prostate stromal cells increases TGF-β signaling activity and that stromal cellconditioned media inhibit prostate cancer cell invasion in a Dkk-3-dependent manner. DKK3 silencing increased the level of the cell-adhesion regulator TGF-β–induced protein (TGFBI) in stromal and epithelial cell-conditioned media, and recombinant TGFBI increased prostate cancer cell invasion. Reduced expression of Dkk-3 in patient tumors was associated with increased expression of TGFBI. DKK3 silencing reduced the level of extracellular matrix protein-1 (ECM-1) in prostate stromal cell-conditioned media but increased it in epithelial cell-conditioned media, and recombinant ECM-1 inhibited TGFBI-induced prostate cancer cell invasion. Increased ECM1 and DKK3 mRNA expression in prostate tumors was associated with increased relapse-free survival. These observations are consistent with a model in which the loss of Dkk-3 in prostate cancer leads to increased secretion of TGFBI and ECM-1, which have tumor-promoting and tumor-protective roles, respectively. Determining how the balance between the opposing roles of extracellular factors influences prostate carcinogenesis will be key to developing therapies that target the tumor microenvironment
Optimizing the colour and fabric of targets for the control of the tsetse fly Glossina fuscipes fuscipes
Background:
Most cases of human African trypanosomiasis (HAT) start with a bite from one of the subspecies of Glossina fuscipes. Tsetse use a range of olfactory and visual stimuli to locate their hosts and this response can be exploited to lure tsetse to insecticide-treated targets thereby reducing transmission. To provide a rational basis for cost-effective designs of target, we undertook studies to identify the optimal target colour.
Methodology/Principal Findings:
On the Chamaunga islands of Lake Victoria , Kenya, studies were made of the numbers of G. fuscipes fuscipes attracted to targets consisting of a panel (25 cm square) of various coloured fabrics flanked by a panel (also 25 cm square) of fine black netting. Both panels were covered with an electrocuting grid to catch tsetse as they contacted the target. The reflectances of the 37 different-coloured cloth panels utilised in the study were measured spectrophotometrically. Catch was positively correlated with percentage reflectance at the blue (460 nm) wavelength and negatively correlated with reflectance at UV (360 nm) and green (520 nm) wavelengths. The best target was subjectively blue, with percentage reflectances of 3%, 29%, and 20% at 360 nm, 460 nm and 520 nm respectively. The worst target was also, subjectively, blue, but with high reflectances at UV (35% reflectance at 360 nm) wavelengths as well as blue (36% reflectance at 460 nm); the best low UV-reflecting blue caught 3× more tsetse than the high UV-reflecting blue.
Conclusions/Significance:
Insecticide-treated targets to control G. f. fuscipes should be blue with low reflectance in both the UV and green bands of the spectrum. Targets that are subjectively blue will perform poorly if they also reflect UV strongly. The selection of fabrics for targets should be guided by spectral analysis of the cloth across both the spectrum visible to humans and the UV region
Non-standard interactions versus non-unitary lepton flavor mixing at a neutrino factory
The impact of heavy mediators on neutrino oscillations is typically described
by non-standard four-fermion interactions (NSIs) or non-unitarity (NU). We
focus on leptonic dimension-six effective operators which do not produce
charged lepton flavor violation. These operators lead to particular
correlations among neutrino production, propagation, and detection non-standard
effects. We point out that these NSIs and NU phenomenologically lead, in fact,
to very similar effects for a neutrino factory, for completely different
fundamental reasons. We discuss how the parameters and probabilities are
related in this case, and compare the sensitivities. We demonstrate that the
NSIs and NU can, in principle, be distinguished for large enough effects at the
example of non-standard effects in the --sector, which basically
corresponds to differentiating between scalars and fermions as heavy mediators
as leading order effect. However, we find that a near detector at superbeams
could provide very synergistic information, since the correlation between
source and matter NSIs is broken for hadronic neutrino production, while NU is
a fundamental effect present at any experiment.Comment: 32 pages, 5 figures. Final version published in JHEP. v3: Typo in Eq.
(27) correcte
Potential climatic transitions with profound impact on Europe
We discuss potential transitions of six climatic subsystems with large-scale impact on Europe, sometimes denoted as tipping elements. These are the ice sheets on Greenland and West Antarctica, the Atlantic thermohaline circulation, Arctic sea ice, Alpine glaciers and northern hemisphere stratospheric ozone. Each system is represented by co-authors actively publishing in the corresponding field. For each subsystem we summarize the mechanism of a potential transition in a warmer climate along with its impact on Europe and assess the likelihood for such a transition based on published scientific literature. As a summary, the ‘tipping’ potential for each system is provided as a function of global mean temperature increase which required some subjective interpretation of scientific facts by the authors and should be considered as a snapshot of our current understanding. <br/
Effective Rheology of Bubbles Moving in a Capillary Tube
We calculate the average volumetric flux versus pressure drop of bubbles
moving in a single capillary tube with varying diameter, finding a square-root
relation from mapping the flow equations onto that of a driven overdamped
pendulum. The calculation is based on a derivation of the equation of motion of
a bubble train from considering the capillary forces and the entropy production
associated with the viscous flow. We also calculate the configurational
probability of the positions of the bubbles.Comment: 4 pages, 1 figur
Akt phosphorylation on Thr308 but not on Ser473 correlates with Akt protein kinase activity in human non-small cell lung cancer
Oral medications including clomiphene citrate or aromatase inhibitors with gonadotropins for controlled ovarian stimulation in women undergoing in vitro fertilisation
We thank:• Richard Kirubakaran, Cochrane South Asia, Prof. BV Moses Centre for Evidence-Informed Health Care and Health Policy, Christian Medical College, Vellore, India;• Marian Showell, Information Specialist for the Cochrane Gynaecology and Fertility Group;• Editorial team of the Cochrane Gynaecology and Fertility Group for their support and assistancePeer reviewedPublisher PD
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