700 research outputs found
Instability of the symmetric Couette-flow in a granular gas: hydrodynamic field profiles and transport
We investigate the inelastic hard disk gas sheared by two parallel bumpy
walls (Couette-flow). In our molecular dynamic simulations we found a
sensitivity to the asymmetries of the initial condition of the particle places
and velocities and an asymmetric stationary state, where the deviation from
(anti)symmetric hydrodynamic fields is stronger as the normal restitution
coefficient decreases. For the better understanding of this sensitivity we
carried out a linear stability analysis of the former kinetic theoretical
solution [Jenkins and Richman: J. Fluid. Mech. {\bf 171} (1986)] and found it
to be unstable. The effect of this asymmetry on the self-diffusion coefficient
is also discussed.Comment: 9 pages RevTeX, 14 postscript figures, sent to Phys. Rev.
Imaging Alzheimer's genetic risk using Diffusion MRI: a systematic review
Diffusion magnetic resonance imaging (dMRI) is an imaging technique which probes the random motion of water molecules in tissues and has been widely applied to investigate changes in white matter microstructure in Alzheimerâs Disease. This paper aims to systematically review studies that examined the effect of Alzheimerâs risk genes on white matter microstructure. We assimilated findings from 37 studies and reviewed their diffusion pre-processing and analysis methods. Most studies estimate the diffusion tensor (DT) and compare derived quantitative measures such as fractional anisotropy and mean diffusivity between groups. Those with increased AD genetic risk are associated with reduced anisotropy and increased diffusivity across the brain, most notably the temporal and frontal lobes, cingulum and corpus callosum. Structural abnormalities are most evident amongst those with established Alzheimerâs Disease. Recent studies employ signal representations and analysis frameworks beyond DT MRI but show that dMRI overall lacks specificity to disease pathology. However, as the field advances, these techniques may prove useful in pre-symptomatic diagnosis or staging of Alzheimerâs disease
Sequences of Bubbles and Holes: New Phases of Kaluza-Klein Black Holes
We construct and analyze a large class of exact five- and six-dimensional
regular and static solutions of the vacuum Einstein equations. These solutions
describe sequences of Kaluza-Klein bubbles and black holes, placed alternately
so that the black holes are held apart by the bubbles. Asymptotically the
solutions are Minkowski-space times a circle, i.e. Kaluza-Klein space, so they
are part of the (\mu,n) phase diagram introduced in hep-th/0309116. In
particular, they occupy a hitherto unexplored region of the phase diagram,
since their relative tension exceeds that of the uniform black string. The
solutions contain bubbles and black holes of various topologies, including
six-dimensional black holes with ring topology S^3 x S^1 and tuboid topology
S^2 x S^1 x S^1. The bubbles support the S^1's of the horizons against
gravitational collapse. We find two maps between solutions, one that relates
five- and six-dimensional solutions, and another that relates solutions in the
same dimension by interchanging bubbles and black holes. To illustrate the
richness of the phase structure and the non-uniqueness in the (\mu,n) phase
diagram, we consider in detail particular examples of the general class of
solutions.Comment: 71 pages, 22 figures, v2: Typos fixed, comment added in sec. 5.
Thin-Film Metamaterials called Sculptured Thin Films
Morphology and performance are conjointed attributes of metamaterials, of
which sculptured thin films (STFs) are examples. STFs are assemblies of
nanowires that can be fabricated from many different materials, typically via
physical vapor deposition onto rotating substrates. The curvilinear--nanowire
morphology of STFs is determined by the substrate motions during fabrication.
The optical properties, especially, can be tailored by varying the morphology
of STFs. In many cases prototype devices have been fabricated for various
optical, thermal, chemical, and biological applications.Comment: to be published in Proc. ICTP School on Metamaterials (Augsut 2009,
Sibiu, Romania
Age and anatomy of the Gongga Shan batholith, eastern Tibetan Plateau, and its relationship to the active Xianshui-he fault
The Gongga Shan batholith of eastern Tibet, previously documented as a ca. 32â12.8 Ma granite pluton, shows some of the youngest U-Pb granite crystallization ages recorded from the Tibetan Plateau, with major implications for the tectonothermal history of the region. Field observations indicate that the batholith is composite; some localities show at least seven crosscutting phases of granitoids that range in composition from diorite to leucocratic monzogranite. In this study we present U-Pb ages of zircon and allanite dated by laser ablationâinductively coupled plasmaâmass spectrometry on seven samples, to further investigate the chronology of the batholith. The age data constrain two striking tectonic-plutonic events: a complex TriassicâJurassic (ca. 215â159 Ma) record of biotite-hornblende granodiorite, K-feldspar megacrystic granite and leucogranitic plutonism, and a Miocene (ca. 14â5 Ma) record of monzonite-leucogranite emplacement. The former age range is attributed to widespread Indosinian tectonism, related to Paleo-Tethyan subduction zone magmatism along the western Yangtze block of south China. The younger component may be related to localized partial melting (muscovite dehydration) of thickened Triassic flysch-type sediments in the Songpan-Ganze terrane, and are among the youngest crustal melt granites exposed on the Tibetan Plateau. Zircon and allanite ages reflect multiple crustal remelting events; the youngest, ca. 5 Ma, resulted in dissolution and crystallization of zircons and growth and/or resetting of allanites. The young garnet, muscovite, and biotite leucogranites occur mainly in the central part of the batholith and adjacent to the eastern margin of the batholith at Kangding, where they are cut by the left-lateral Xianshui-he fault. The Xianshui-he fault is the most seismically active strike-slip fault in Tibet and is thought to record the eastward extrusion of the central part of the Tibetan Plateau. The fault obliquely cuts all granites of the Gongga Shan massif and has a major transpressional component in the Kangding-Moxi region. The course of the Xianshui Jiang river is offset by âź62 km along the Xianshui-he fault and in the Kangding area granites as young as ca. 5 Ma are cut by the fault. Our new geochronological data show that only a part of the Gongga Shan granite batholith is composed of young (Miocene) melt, and we surmise that as most of eastern Tibet is composed of PrecambrianâTriassic Indosinian rocks, there is no geological evidence to support regional Cenozoic internal thickening or metamorphism and no evidence for eastward-directed lower crustal flow away from Tibet. We suggest that underthrusting of Indian lower crust north as far as the Xianshui-he fault resulted in Cenozoic uplift of the eastern plateau
Transport spectroscopy in a time-modulated open quantum dot
We have investigated the time-modulated coherent quantum transport phenomena
in a ballistic open quantum dot. The conductance and the electron dwell
time in the dots are calculated by a time-dependent mode-matching method. Under
high-frequency modulation, the traversing electrons are found to exhibit three
types of resonant scatterings. They are intersideband scatterings: into
quasibound states in the dots, into true bound states in the dots, and into
quasibound states just beneath the subband threshold in the leads. Dip
structures or fano structures in are their signatures. Our results show
structures due to 2 intersideband processes. At the above
scattering resonances, we have estimated, according to our dwell time
calculation, the number of round-trip scatterings that the traversing electrons
undertake between the two dot openings.Comment: 8 pages, 5 figure
Promoter Sequences Prediction Using Relational Association Rule Mining
In this paper we are approaching, from a computational perspective, the problem of promoter sequences prediction, an important problem within the field of bioinformatics. As the conditions for a DNA sequence to function as a promoter are not known, machine learning based classification models are still developed to approach the problem of promoter identification in the DNA. We are proposing a classification model based on relational association rules mining. Relational association rules are a particular type of association rules and describe numerical orderings between attributes that commonly occur over a data set. Our classifier is based on the discovery of relational association rules for predicting if a DNA sequence contains or not a promoter region. An experimental evaluation of the proposed model and comparison with similar existing approaches is provided. The obtained results show that our classifier overperforms the existing techniques for identifying promoter sequences, confirming the potential of our proposal
Tomato: a crop species amenable to improvement by cellular and molecular methods
Tomato is a crop plant with a relatively small DNA content per haploid genome and a well developed genetics. Plant regeneration from explants and protoplasts is feasable which led to the development of efficient transformation procedures.
In view of the current data, the isolation of useful mutants at the cellular level probably will be of limited value in the genetic improvement of tomato. Protoplast fusion may lead to novel combinations of organelle and nuclear DNA (cybrids), whereas this technique also provides a means of introducing genetic information from alien species into tomato. Important developments have come from molecular approaches. Following the construction of an RFLP map, these RFLP markers can be used in tomato to tag quantitative traits bred in from related species. Both RFLP's and transposons are in the process of being used to clone desired genes for which no gene products are known. Cloned genes can be introduced and potentially improve specific properties of tomato especially those controlled by single genes. Recent results suggest that, in principle, phenotypic mutants can be created for cloned and characterized genes and will prove their value in further improving the cultivated tomato.
VHL substrate transcription factor ZHX2 as an oncogenic driver in clear cell renal cell carcinoma
Inactivation of the von Hippel-Lindau (VHL) E3 ubiquitin ligase protein is a hallmark of clear cell renal cell carcinoma (ccRCC). Identifying how pathways affected by VHL loss contribute to ccRCC remains challenging. We used a genome-wide in vitro expression strategy to identify proteins that bind VHL when hydroxylated. Zinc fingers and homeoboxes 2 (ZHX2) was found as a VHL target, and its hydroxylation allowed VHL to regulate its protein stability. Tumor cells from ccRCC patients with VHL loss-of-function mutations usually had increased abundance and nuclear localization of ZHX2. Functionally, depletion of ZHX2 inhibited VHL-deficient ccRCC cell growth in vitro and in vivo. Mechanistically, integrated chromatin immunoprecipitation sequencing and microarray analysis showed that ZHX2 promoted nuclear factor ÎşB activation. These studies reveal ZHX2 as a potential therapeutic target for ccRCC
Search for a W' boson decaying to a bottom quark and a top quark in pp collisions at sqrt(s) = 7 TeV
Results are presented from a search for a W' boson using a dataset
corresponding to 5.0 inverse femtobarns of integrated luminosity collected
during 2011 by the CMS experiment at the LHC in pp collisions at sqrt(s)=7 TeV.
The W' boson is modeled as a heavy W boson, but different scenarios for the
couplings to fermions are considered, involving both left-handed and
right-handed chiral projections of the fermions, as well as an arbitrary
mixture of the two. The search is performed in the decay channel W' to t b,
leading to a final state signature with a single lepton (e, mu), missing
transverse energy, and jets, at least one of which is tagged as a b-jet. A W'
boson that couples to fermions with the same coupling constant as the W, but to
the right-handed rather than left-handed chiral projections, is excluded for
masses below 1.85 TeV at the 95% confidence level. For the first time using LHC
data, constraints on the W' gauge coupling for a set of left- and right-handed
coupling combinations have been placed. These results represent a significant
improvement over previously published limits.Comment: Submitted to Physics Letters B. Replaced with version publishe
- âŚ