A Preliminary Investigation of Child, Parent and Programme Leader Reflections on Participation in and Delivery of a Family- Based Weight Intervention Programme.

Childhood obesity is considered to be the greatest public health risk to children today, placing young people at considerable risk for adult obesity and consequent CVD, diabetes, liver dysfunction, and other morbidities (Doro-Altan et al., 2008; Singh et al., 2008). As a result numerous interventions with the potential to reduce obesity levels or associated risk of chronic diseases have been devised (Steinberger et al., 2003; Flynn et al., 2006). Not withstanding the need for further quantitative evaluation of the effect of such interventions, key publications have now called for qualitative evaluations to be undertaken in order to create an evidence base from the views of participants that may highlight why certain interventions may be more, or less successful (National Institute for Health and Clinical Excellence, 2006; Luttikhuis et al., 2009). In response to these very recent calls, this abstract intends to present, from qualitative methods of enquiry, preliminary findings of parent, child and programme leader experiences of, reflections on and future intentions following participation in and delivery of a nationally implemented family-based weight intervention programme in the UK. Data from semi-structured interviews with 6 families who completed the programme in December 2008 and 1 programme leader will be presented. Informal thematic analysis will be utilised to identify emergent themes with data presentation accentuating the qualitative, ‘lived’ experience of the programme and the impact of the various aspects of the intervention on intentions for future behaviours. It is anticipated that the outcomes of this study will help to inform the organisation, content, implementation and nature of future intervention programmes in order to enhance their effectiveness

Age and Grip Strength Predict Hand Dexterity in Adults.

In the scientific literature, there is much evidence of a relationship between age and dexterity, where increased age is related to slower, less nimble and less smooth, less coordinated and less controlled performances. While some suggest that the relationship is a direct consequence of reduced muscle strength associated to increased age, there is a lack of research that has systematically investigated the relationships between age, strength and hand dexterity. Therefore, the aim of this study was to examine the associations between age, grip strength and dexterity. 107 adults (range 18-93 years) completed a series of hand dexterity tasks (i.e. steadiness, line tracking, aiming, and tapping) and a test of maximal grip strength. We performed three phases of analyses. Firstly, we evaluated the simple relationships between pairs of variables; replicating the existing literature; and found significant relationships of increased age and reduced strength; increased age and reduced dexterity, and; reduced strength and reduced dexterity. Secondly, we used standard Multiple Regression (MR) models to determine which of the age and strength factors accounted for the greater variance in dexterity. The results showed that both age and strength made significant contributions to the data variance, but that age explained more of the variance in steadiness and line tracking dexterity, whereas strength explained more of the variance in aiming and tapping dexterity. In a third phase of analysis, we used MR analyses to show an interaction between age and strength on steadiness hand dexterity. Simple Slopes posthoc analyses showed that the interaction was explained by the middle to older aged adults showing a relationship between reduced strength and reduced hand steadiness, whereas younger aged adults showed no relationship between strength and steadiness hand dexterity. The results are discussed in terms of how age and grip strength predict different types of hand dexterity in adults

Renal tubular function in children and adolescents with Gitelnian's syndrome, the hypocalciuric variant of Bartter's syndrome

Renal tubular function was studied in 14 patients with Gitelman's syndrome and 14 control subjects. Apart from the biochemical hallmarks of Gitelman's syndrome, namely alkalaemia, hyperbi carbonataemia, hypokalaemia, hypomagnesaemia (with increased magnesium over creatinine ratio), increased urinary chloride over creatinine ratio, and low urinary calcium over creatinine, the patients were found to have hyperproteinaemia, hypochloraemia, high total plasma calcium concentration, reduced plasma ionized calcium concentration, and high urinary sodium excretion. A statistically significant negative linear relationship between plasma magnesium concentration and magnesium excretion corrected for glomerular filtration was observed in patients. The fractional calcium clearance and the urinary excretion of calcium corrected for glomerular filtration was significantly decreased in patients. In patients the urin ary osmolality after overnight water deprivation ranged from 526 to 1067 mmol/kg. Glucosuria and aminoacid uria were similar in patients and controls. The results of the study demonstrate the renal origin of hypomag nesaemia and hypocalciuria in Gitelman's syndrome. The failure to demonstrate hyperaminoaciduria, hyperglucosuria, hyperphosphaturia, hyperuricosuria, and severely impaired urinary concentrating ability provide evidence for a defect residing in the distal convoluted tubul

Power saturation in standard and double-AR unfolded laser diode cavities

We report modeling and experimental results that demonstrate mechanisms limiting the output power of broad area semiconductor lasers. The modeling comprises numerical simulations of the laser cavity with evolution of non-uniform carrier density, photon density, temperature and index. We measure unfolded laser cavities to validate simulation methods and input parameters. © 2016 IEICE-ES

Finite Temperature Meson Correlation Functions in HTL Approximation

We calculate temporal correlators and their spectral functions with meson quantum numbers in the deconfined phase of QCD using the hard thermal loop (HTL) approximation for the quark propagator. Although this approach does not result in a complete next-to-leading order perturbative calculation it takes into account important medium effects such as thermal quark masses and Landau damping in the quark-gluon plasma. We show that both effects lead to competing modifications of the free mesonic correlation functions. We find that correlators in scalar channels are only moderately influenced by the HTL medium effects, while the HTL-vertex corrections lead to divergent vector correlators.Comment: 14 pages, LaTeX2e File, 8 EPS-files, minor changes in abstract and text, to appear in Phys. Lett.

Equity in science: advocating for a triple-blind review system

We propose 'triple-blind review' for peer-reviewed journals – a process that keeps author identities and affiliations blind to manuscript editors until after first appraisal. Blinded appraisalwill help to reduce the biases that negatively affect under-represented and minority scientists, ultimately better supporting equity in scientific publishing.En prens

Relativistic D-brane Scattering is Extremely Inelastic

We study the effects of quantum production of open strings on the relativistic scattering of D-branes. We find strong corrections to the brane trajectory from copious production of highly-excited open strings, whose typical oscillator level is proportional to the square of the rapidity. In the corrected trajectory, the branes rapidly coincide and remain trapped in a configuration with enhanced symmetry. This is a purely stringy effect which makes relativistic brane collisions exceptionally inelastic. We trace this effect to velocity-dependent corrections to the open-string mass, which render open strings between relativistic D-branes surprisingly light. We observe that pair-creation of open strings could play an important role in cosmological scenarios in which branes approach each other at very high speeds.Comment: 30 pages; added references and a comment about velocity-dependent masse

Incorporating non-stomatal limitation improves the performance of leaf and canopy models at high vapour pressure deficit

Vapour pressure deficit (D) is projected to increase in the future as temperature rises. In response to increased D, stomatal conductance (gs) and photosynthesis (A) are reduced, which may result in significant reductions in terrestrial carbon, water and energy fluxes. It is thus important for gas exchange models to capture the observed responses of gs and A with increasing D. We tested a series of coupled A-gs models against leaf gas exchange measurements from the Cumberland Plain Woodland (Australia), where D regularly exceeds 2 kPa and can reach 8 kPa in summer. Two commonly used A-gs models were not able to capture the observed decrease in A and gs with increasing D at the leaf scale. To explain this decrease in A and gs, two alternative hypotheses were tested: hydraulic limitation (i.e., plants reduce gs and/or A due to insufficient water supply) and non-stomatal limitation (i.e., downregulation of photosynthetic capacity). We found that the model that incorporated a non-stomatal limitation captured the observations with high fidelity and required the fewest number of parameters. Whilst the model incorporating hydraulic limitation captured the observed A and gs, it did so via a physical mechanism that is incorrect. We then incorporated a non-stomatal limitation into the stand model, MAESPA, to examine its impact on canopy transpiration and gross primary production. Accounting for a non-stomatal limitation reduced the predicted transpiration by ~19%, improving the correspondence with sap flow measurements, and gross primary production by ~14%. Given the projected global increases in D associated with future warming, these findings suggest that models may need to incorporate non-stomatal limitation to accurately simulate A and gs in the future with high D. Further data on non-stomatal limitation at high D should be a priority, in order to determine the generality of our results and develop a widely applicable model. © The Author(s) 2019. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: [email protected]. was supported by a PhD scholarship from Hawkesbury Institute for the Environment, Western Sydney University. M.G.D.K. acknowledges funding from the Australian Research Council (ARC) Centre of Excellence for Climate Extremes (CE170100023), the ARC Discovery Grant (DP190101823) and support from the NSW Research Attraction and Acceleration Program. EucFACE was built as an initiative of the Australian Government as part of the Nation-building Economic Stimulus Package and is supported by the Australian Commonwealth in collaboration with Western Sydney University. It is also part of a Terrestrial Ecosystem Research Network Super-site facility

The N-methyl-d-aspartate receptor antagonist CPP alters synapse and spine structure and impairs long-term potentiation and long-term depression induced morphological plasticity in dentate gyrus of the awake rat

Long-term morphological synaptic changes associated with homosynaptic long-term potentiation (LTP) and heterosynaptic long-term depression (LTD) in vivo, in awake adult rats were analyzed using three-dimensional (3-D) reconstructions of electron microscope images of ultrathin serial sections from the molecular layer of the dentate gyrus. For the first time in morphological studies, the specificity of the effects of LTP and LTD on both spine and synapse ultrastructure was determined using an N-methyl-d-aspartate (NMDA) receptor antagonist CPP (3-[(R)-2-carboxypiperazin-4-yl]-propyl-1-phosphonic acid). There were no differences in synaptic density 24 h after LTP or LTD induction, and CPP alone had no effect on synaptic density. LTP increased significantly the proportion of mushroom spines, whereas LTD increased the proportion of thin spines, and both LTP and LTD decreased stubby spine number. Both LTP and LTD increased significantly spine head evaginations (spinules) into synaptic boutons and CPP blocked these changes. Synaptic boutons were smaller after LTD, indicating a pre-synaptic effect. Interestingly, CPP alone decreased bouton and mushroom spine volumes, as well as post-synaptic density (PSD) volume of mushroom spines.These data show similarities, but also some clear differences, between the effects of LTP and LTD on spine and synaptic morphology. Although CPP blocks both LTP and LTD, and impairs most morphological changes in spines and synapses, CPP alone was shown to exert effects on aspects of spine and synaptic structure

Pulsar Timing and its Application for Navigation and Gravitational Wave Detection

Pulsars are natural cosmic clocks. On long timescales they rival the precision of terrestrial atomic clocks. Using a technique called pulsar timing, the exact measurement of pulse arrival times allows a number of applications, ranging from testing theories of gravity to detecting gravitational waves. Also an external reference system suitable for autonomous space navigation can be defined by pulsars, using them as natural navigation beacons, not unlike the use of GPS satellites for navigation on Earth. By comparing pulse arrival times measured on-board a spacecraft with predicted pulse arrivals at a reference location (e.g. the solar system barycenter), the spacecraft position can be determined autonomously and with high accuracy everywhere in the solar system and beyond. We describe the unique properties of pulsars that suggest that such a navigation system will certainly have its application in future astronautics. We also describe the on-going experiments to use the clock-like nature of pulsars to "construct" a galactic-sized gravitational wave detector for low-frequency (f_GW ~1E-9 - 1E-7 Hz) gravitational waves. We present the current status and provide an outlook for the future.Comment: 30 pages, 9 figures. To appear in Vol 63: High Performance Clocks, Springer Space Science Review