228 research outputs found
Negative time delay for wave reflection from a one-dimensional semi-harmonic well
It is reported that the phase time of particles which are reflected by a
one-dimensional semi-harmonic well includes a time delay term which is negative
for definite intervals of the incoming energy. In this interval, the absolute
value of the negative time delay becomes larger as the incident energy becomes
smaller. The model is a rectangular well with zero potential energy at its
right and a harmonic-like interaction at its left.Comment: 6 pages, 5 eps figures. Talk presented at the XXX Workshop on
Geometric Methods in Physics, Bialowieza, Poland, 201
Relative Oscillation Theory, Weighted Zeros of the Wronskian, and the Spectral Shift Function
We develop an analog of classical oscillation theory for Sturm-Liouville
operators which, rather than measuring the spectrum of one single operator,
measures the difference between the spectra of two different operators.
This is done by replacing zeros of solutions of one operator by weighted
zeros of Wronskians of solutions of two different operators. In particular, we
show that a Sturm-type comparison theorem still holds in this situation and
demonstrate how this can be used to investigate the finiteness of eigenvalues
in essential spectral gaps. Furthermore, the connection with Krein's spectral
shift function is established.Comment: 26 page
X-Ray and Radio Observations of Bright GeV Sources
We present X-ray and radio studies of sources which are brightabove 1 GeV
(F_{>1GeV} > 4e-8 ph/cm^2/s. Only 11 out of ~30 of these gamma-ray sources have
been identified with lower energy counterparts: 5 blazars and 6 pulsars. Three
of these pulsars are surrounded by radio pulsar wind nebulae (PWN), two of
which are also seen as bright, extended X-ray synchrotron nebulae. The ASCA
X-ray telescope has observed 28 of the bright GeV sources, revealing an excess
of F_{2-10keV} > 10e-12 ergs/cm^2/s sources within the {\it EGRET} error
contours of the unidentified sources. Although several supernova remnants are
positionally coincident with these sources, we find no X-ray evidence of high
energy particle production in SNR shell shocks consistent with the GeV
positions. We also present initial results from follow on radio imaging studies
of several fields containing unidentified sources. We have discovered new
X-ray/radio nebulae in three of these fields which are strong candidates for
PWN. These sources, along with a similar nebula in CTA 1 and the PWN around PSR
B1853+01 in W44, are all positionally coincident with variable EGRET sources.
This suggests a class of variable gamma-ray sources associated with synchrotron
emitting regions powered by the winds of young pulsars.Comment: 18 pages, 26 figures, To appear in the proceedings of the workshop:
"The Nature of the Unidentified Galactic Gamma-Ray Sources" held at INAOE,
Mexico, October 2000, (A.Carraminana, O. Reiner and D. Thompson,
New hadrons as ultra-high energy cosmic rays
Ultra-high energy cosmic ray (UHECR) protons produced by uniformly
distributed astrophysical sources contradict the energy spectrum measured by
both the AGASA and HiRes experiments, assuming the small scale clustering of
UHECR observed by AGASA is caused by point-like sources. In that case, the
small number of sources leads to a sharp exponential cutoff at the energy
E<10^{20} eV in the UHECR spectrum. New hadrons with mass 1.5-3 GeV can solve
this cutoff problem. For the first time we discuss the production of such
hadrons in proton collisions with infrared/optical photons in astrophysical
sources. This production mechanism, in contrast to proton-proton collisions,
requires the acceleration of protons only to energies E<10^{21} eV. The diffuse
gamma-ray and neutrino fluxes in this model obey all existing experimental
limits. We predict large UHE neutrino fluxes well above the sensitivity of the
next generation of high-energy neutrino experiments. As an example we study
hadrons containing a light bottom squark. These models can be tested by
accelerator experiments, UHECR observatories and neutrino telescopes.Comment: 17 pages, revtex style; v2: shortened, as to appear in PR
On the selection of AGN neutrino source candidates for a source stacking analysis with neutrino telescopes
The sensitivity of a search for sources of TeV neutrinos can be improved by
grouping potential sources together into generic classes in a procedure that is
known as source stacking. In this paper, we define catalogs of Active Galactic
Nuclei (AGN) and use them to perform a source stacking analysis. The grouping
of AGN into classes is done in two steps: first, AGN classes are defined, then,
sources to be stacked are selected assuming that a potential neutrino flux is
linearly correlated with the photon luminosity in a certain energy band (radio,
IR, optical, keV, GeV, TeV). Lacking any secure detailed knowledge on neutrino
production in AGN, this correlation is motivated by hadronic AGN models, as
briefly reviewed in this paper.
The source stacking search for neutrinos from generic AGN classes is
illustrated using the data collected by the AMANDA-II high energy neutrino
detector during the year 2000. No significant excess for any of the suggested
groups was found.Comment: 43 pages, 12 figures, accepted by Astroparticle Physic
Efeito da severidade de oídio e crestamento foliar de cercospora na produtividade da cultura da soja
Meta-analysis of genome-wide association studies of anxiety disorders.
Anxiety disorders (ADs), namely generalized AD, panic disorder and phobias, are common, etiologically complex conditions with a partially genetic basis. Despite differing on diagnostic definitions based on clinical presentation, ADs likely represent various expressions of an underlying common diathesis of abnormal regulation of basic threat-response systems. We conducted genome-wide association analyses in nine samples of European ancestry from seven large, independent studies. To identify genetic variants contributing to genetic susceptibility shared across interview-generated DSM-based ADs, we applied two phenotypic approaches: (1) comparisons between categorical AD cases and supernormal controls, and (2) quantitative phenotypic factor scores (FS) derived from a multivariate analysis combining information across the clinical phenotypes. We used logistic and linear regression, respectively, to analyze the association between these phenotypes and genome-wide single nucleotide polymorphisms. Meta-analysis for each phenotype combined results across the nine samples for over 18 000 unrelated individuals. Each meta-analysis identified a different genome-wide significant region, with the following markers showing the strongest association: for case-control contrasts, rs1709393 located in an uncharacterized non-coding RNA locus on chromosomal band 3q12.3 (P=1.65 × 10(-8)); for FS, rs1067327 within CAMKMT encoding the calmodulin-lysine N-methyltransferase on chromosomal band 2p21 (P=2.86 × 10(-9)). Independent replication and further exploration of these findings are needed to more fully understand the role of these variants in risk and expression of ADs.Molecular Psychiatry advance online publication, 12 January 2016; doi:10.1038/mp.2015.197
A First Search for coincident Gravitational Waves and High Energy Neutrinos using LIGO, Virgo and ANTARES data from 2007
We present the results of the first search for gravitational wave bursts
associated with high energy neutrinos. Together, these messengers could reveal
new, hidden sources that are not observed by conventional photon astronomy,
particularly at high energy. Our search uses neutrinos detected by the
underwater neutrino telescope ANTARES in its 5 line configuration during the
period January - September 2007, which coincided with the fifth and first
science runs of LIGO and Virgo, respectively. The LIGO-Virgo data were analysed
for candidate gravitational-wave signals coincident in time and direction with
the neutrino events. No significant coincident events were observed. We place
limits on the density of joint high energy neutrino - gravitational wave
emission events in the local universe, and compare them with densities of
merger and core-collapse events.Comment: 19 pages, 8 figures, science summary page at
http://www.ligo.org/science/Publication-S5LV_ANTARES/index.php. Public access
area to figures, tables at
https://dcc.ligo.org/cgi-bin/DocDB/ShowDocument?docid=p120000
Animal models for COVID-19
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the aetiological agent of coronavirus disease 2019 (COVID-19), an emerging respiratory infection caused by the introduction of a novel coronavirus into humans late in 2019 (first detected in Hubei province, China). As of 18 September 2020, SARS-CoV-2 has spread to 215 countries, has infected more than 30 million people and has caused more than 950,000 deaths. As humans do not have pre-existing immunity to SARS-CoV-2, there is an urgent need to develop therapeutic agents and vaccines to mitigate the current pandemic and to prevent the re-emergence of COVID-19. In February 2020, the World Health Organization (WHO) assembled an international panel to develop animal models for COVID-19 to accelerate the testing of vaccines and therapeutic agents. Here we summarize the findings to date and provides relevant information for preclinical testing of vaccine candidates and therapeutic agents for COVID-19
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