335 research outputs found
Clinicopathological and Genomic Characterization of a Simmental Calf with Generalized Bovine Juvenile Angiomatosis
Bovine juvenile angiomatosis (BJA) comprises a group of single or multiple proliferative vascular anomalies in the skin and viscera of affected calves. The purpose of this study was to characterize the clinicopathological phenotype of a 1.5-month-old Simmental calf with multiple cutaneous, subcutaneous, and visceral vascular hamartomas, which were compatible with a generalized form of BJA, and to identify genetic cause for this phenotype by whole-genome sequencing (WGS). The calf was referred to the clinics as a result of its failure to thrive and the presence of multiple cutaneous and subcutaneous nodules, some of which bled abundantly following spontaneous rupture. Gross pathology revealed similar lesions at the inner thoracic wall, diaphragm, mediastinum, pericardium, inner abdominal wall, and mesentery. Histologically, variably sized cavities lined by a single layer of plump cells and supported by a loose stroma with occasional acute hemorrhage were observed. Determined by immunochemistry, the plump cells lining the cavities displayed a strong cytoplasmic signal for PECAM-1, von Willebrand factor, and vimentin. WGS revealed six private protein-changing variants affecting different genes present in the calf and absent in more than 4500 control genomes. Assuming a spontaneous de novo mutation event, one of the identified variants found in the PREX1, UBE3B, PCDHGA2, and ZSWIM6 genes may represent a possible candidate pathogenic variant for this rare form of vascular malformation
Literature Reviews in HCI: A Review of Reviews
This paper analyses Human-Computer Interaction (HCI) literature reviews to provide a clear conceptual basis for authors, reviewers, and readers. HCI is multidisciplinary and various types of literature reviews exist, from systematic to critical reviews in the style of essays. Yet, there is insufficient consensus of what to expect of literature reviews in HCI. Thus, a shared understanding of literature reviews and clear terminology is needed to plan, evaluate, and use literature reviews, and to further improve review methodology. We analysed 189 literature reviews published at all SIGCHI conferences and ACM Transactions on Computer-Human Interaction (TOCHI) up until August 2022. We report on the main dimensions of variation: (i) contribution types and topics; and (ii) structure and methodologies applied. We identify gaps and trends to inform future meta work in HCI and provide a starting point on how to move towards a more comprehensive terminology system of literature reviews in HCI
Shape modeling technique KOALA validated by ESA Rosetta at (21) Lutetia
We present a comparison of our results from ground-based observations of
asteroid (21) Lutetia with imaging data acquired during the flyby of the
asteroid by the ESA Rosetta mission. This flyby provided a unique opportunity
to evaluate and calibrate our method of determination of size, 3-D shape, and
spin of an asteroid from ground-based observations. We present our 3-D
shape-modeling technique KOALA which is based on multi-dataset inversion. We
compare the results we obtained with KOALA, prior to the flyby, on asteroid
(21) Lutetia with the high-spatial resolution images of the asteroid taken with
the OSIRIS camera on-board the ESA Rosetta spacecraft, during its encounter
with Lutetia. The spin axis determined with KOALA was found to be accurate to
within two degrees, while the KOALA diameter determinations were within 2% of
the Rosetta-derived values. The 3-D shape of the KOALA model is also confirmed
by the spectacular visual agreement between both 3-D shape models (KOALA pre-
and OSIRIS post-flyby). We found a typical deviation of only 2 km at local
scales between the profiles from KOALA predictions and OSIRIS images, resulting
in a volume uncertainty provided by KOALA better than 10%. Radiometric
techniques for the interpretation of thermal infrared data also benefit greatly
from the KOALA shape model: the absolute size and geometric albedo can be
derived with high accuracy, and thermal properties, for example the thermal
inertia, can be determined unambiguously. We consider this to be a validation
of the KOALA method. Because space exploration will remain limited to only a
few objects, KOALA stands as a powerful technique to study a much larger set of
small bodies using Earth-based observations.Comment: 15 pages, 8 figures, 2 tables, accepted for publication in P&S
Origins of the open-circuit voltage in ternary organic solar cells and design rules for minimized voltage losses
The power conversion efficiency of ternary organic solar cells (TOSCs), consisting of one host binary blend and one guest component, remains limited by large voltage losses. The fundamental understanding of the open-circuit voltage (V OC) in TOSCs is controversial, limiting rational design of the guest component. In this study, we systematically investigate how the guest component affects the radiative and non-radiative related parts of V OC of a series of TOSCs using the detailed balanced principle. We highlight that the thermal population of charge-transfer and local exciton states provided by the guest binary blend (that is, the guest-component-based binary blend) has a significant influence on the non-radiative voltage losses. Ultimately, we provide two design rules for enhancing the V OC in TOSCs: high emission yield for the guest binary blend and similar charge-transfer-state energies for host/guest binary blends; high miscibility of the guest component with the low gap component in the host binary blend
Bulk-Processed Pd Nanocube-Poly(methyl methacrylate) Nanocomposites as Plasmonic Plastics for Hydrogen Sensing
Nanoplasmonic hydrogen sensors are predicted to play a key role in safety systems of the emerging hydrogen economy. Pd nanoparticles are the active material of choice for sensor prototype development due to their ability to form a hydride at ambient conditions, which creates the optical contrast. Here, we introduce plasmonic hydrogen sensors made from a thermoplastic nanocomposite material, that is, a bulk material that can be molded with standard plastic processing techniques, such as extrusion and three-dimensional (3D) printing, while at the same time being functionalized at the nanoscale. Specifically, our plasmonic plastic is composed of hydrogensensitive and plasmonically active Pd nanocubes mixed with a poly(methyl methacrylate) matrix, and we optimize it by characterization from the atomic to the macroscopic level. We demonstrate meltprocessed deactivation-resistant plasmonic hydrogen sensors, which retain full functionality even after SO weeks. From a wider perspective, we advertise plasmonic plastic nanocomposite materials for application in a multitude of active plasmonic technologies since they provide efficient scalable processing and almost endless functional material design opportunities via tailored polymer- colloidal nanocrystal combinations
Model-independent evidence for contributions to decays
The data sample of decays acquired with the
LHCb detector from 7 and 8~TeV collisions, corresponding to an integrated
luminosity of 3 fb, is inspected for the presence of or
contributions with minimal assumptions about
contributions. It is demonstrated at more than 9 standard deviations that
decays cannot be described with
contributions alone, and that contributions play a dominant role in
this incompatibility. These model-independent results support the previously
obtained model-dependent evidence for charmonium-pentaquark
states in the same data sample.Comment: 21 pages, 12 figures (including the supplemental section added at the
end
Quantum numbers of the state and orbital angular momentum in its decay
Angular correlations in decays, with , and , are used to measure
orbital angular momentum contributions and to determine the value of
the meson. The data correspond to an integrated luminosity of 3.0
fb of proton-proton collisions collected with the LHCb detector. This
determination, for the first time performed without assuming a value for the
orbital angular momentum, confirms the quantum numbers to be .
The is found to decay predominantly through S wave and an upper limit
of at C.L. is set on the fraction of D wave.Comment: 16 pages, 4 figure
Multiplicities of charged pions and unidentified charged hadrons from deep-inelastic scattering of muons off an isoscalar target
Multiplicities of charged pions and unidentified hadrons produced in
deep-inelastic scattering were measured in bins of the Bjorken scaling variable
, the relative virtual-photon energy and the relative hadron energy .
Data were obtained by the COMPASS Collaboration using a 160 GeV muon beam and
an isoscalar target (LiD). They cover the kinematic domain in the photon
virtuality > 1(GeV/c, , and . In addition, a leading-order pQCD analysis was performed using the
pion multiplicity results to extract quark fragmentation functions
Expected Performance of the ATLAS Experiment - Detector, Trigger and Physics
A detailed study is presented of the expected performance of the ATLAS
detector. The reconstruction of tracks, leptons, photons, missing energy and
jets is investigated, together with the performance of b-tagging and the
trigger. The physics potential for a variety of interesting physics processes,
within the Standard Model and beyond, is examined. The study comprises a series
of notes based on simulations of the detector and physics processes, with
particular emphasis given to the data expected from the first years of
operation of the LHC at CERN
Limit on the Radiative Neutrinoless Double Electron Capture of Ar from GERDA Phase I
Neutrinoless double electron capture is a process that, if detected, would
give evidence of lepton number violation and the Majorana nature of neutrinos.
A search for neutrinoless double electron capture of Ar has been
performed with germanium detectors installed in liquid argon using data from
Phase I of the GERmanium Detector Array (GERDA) experiment at the Gran Sasso
Laboratory of INFN, Italy. No signal was observed and an experimental lower
limit on the half-life of the radiative neutrinoless double electron capture of
Ar was established: 3.6 10 yr at 90 % C.I.Comment: 7 pages, 3 figure
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