The SNR Kes 17-ISM interaction: a fresh view from radio and γ\gamma rays

This paper presents a comprehensive analysis of the Galactic SNR Kes 17 (G304.6+0.1) with focus on its radio synchrotron emission, environs, and the factors contributing to the observed gamma rays. The firstly-obtained integrated radio continuum spectrum from 88 to 8800 MHz yields an index alpha = -0.488 +/- 0.023 (S_nu $\propto$ nu^alpha), indicative of a linear particle acceleration process at the shock front. Accounting for the SNR radio shell size, the distribution of atomic hydrogen (n_H ~ 10 cm^-3), and assuming the SNR is in the Sedov-Taylor stage of its evolution, we estimate Kes 17 to be roughly 11 kyr. From 12CO and 13CO (J=1-0) emission-line data as a proxy for molecular hydrogen we provided the first evidence that the eastern shell of Kes 17 is engulfing a molecular enhancement, with 4.2 x 10^4 M_sun and n ~ 300 cm^-3. Towards the western boundary of Kes 17 there are not CO signatures above 3 sigma, despite previously reported infrared observations have revealed shocked molecular gas at that location. This suggests the existence of a CO-dark interacting molecular gas, a phenomenon also recorded in other Galactic SNRs (e.g. CTB 37A and RX J1713.7-3946). Additionally, by analysing ~14.5 yr of data from Fermi-LAT, we determined a power-law photon index in the 0.3-300 GeV range of Gamma = 2.39 +/- 0.04^+0.063_-0.114 (+/-stat +/-syst) in agreement with prior studies. The energy flux turns out to be (2.98 +/- 0.14) x 10^-11 erg cm-2 s-1 implying a luminosity (2.22 +/- 0.45) x 10^35 erg s-1 at ~8 kpc. Finally, we successfully modelled the multiwavelength SED by incorporating the improved radio synchrotron spectrum and the new gamma-ray measurements. Our analysis indicates that the observed GeV flux most likely originates from the interaction of Kes 17 with western ''dark'' CO zone with a proton density n_p ~ 400 cm-3.Comment: 9 pages, 6 figures, 2 tables. Accepted for publication in the Astronomy & Astrophysics Journal. The quality of the figures has been degrade

Extrinsic and intrinsic factors drive the timing of gestation and reproductive success of Scandinavian brown bears

Introduction: Climate change is altering the reproductive phenology of many organisms, but the factors that influence the timing of gestation in ursids are still poorly understood. Higher temperatures in spring are already causing an earlier den exit in some brown bear populations, and a temporal mismatch between hibernation and reproduction could have dramatic consequences for reproductive success. Therefore, understanding the factors that control the timing of these events is important to forecast the consequences of climate change on population growth rates.Methods: In this study, we used abdominal temperature loggers and GPS collars with acceleration sensors on 23 free-ranging pregnant female brown bears living in two areas in Sweden (61°N and 67°N latitude) to pinpoint hibernation and reproductive events. We investigated how intrinsic and extrinsic factors influence the termination of embryonic diapause and parturition, as well as their impact on reproductive success.Results: The termination of embryonic diapause was later in the northern area compared to the southern area and occurred earlier when ambient temperature at den entry was higher in both areas. In the southern area, young adults (i.e., females = 7 years old) had a delayed parturition when bilberry abundance was low the year of mating. Additionally, young adults had a lower reproductive success than adults and their probability to reproduce successfully was dependent on bilberry abundance, whereas adult females were not affected by this parameter.Discussion: As den exit occurs later in the northern study area, we suggest that a later parturition might ensure that females lactate their cubs in the den for a reasonable amount of time while fasting. Similarly, a later parturition combined with an earlier emergence could allow young adults to spend less time in the den lactating if they could not reach an optimal body condition prior to hibernation. But as a result, their cubs are younger and more vulnerable when they leave the den leading to lower survival rates. Our results suggest that a decreased berry abundance in the fall could impact the reproductive and hibernation phenology of Scandinavian brown bear females and lead to a lower cub survival with potential consequences on the population dynamics

Extrinsic and intrinsic factors drive the timing of gestation and reproductive success of Scandinavian brown bears

© 2022 Lemière, Thiel, Fuchs, Gilot-Fromont, Hertel, Friebe, Kindberg, Støen, Arnemo and Evans. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.Climate change is altering the reproductive phenology of many organisms, but the factors that influence the timing of gestation in ursids are still poorly understood. Higher temperatures in spring are already causing an earlier den exit in some brown bear populations, and a temporal mismatch between hibernation and reproduction could have dramatic consequences for reproductive success. Therefore, understanding the factors that control the timing of these events is important to forecast the consequences of climate change on population growth rates. In this study, we used abdominal temperature loggers and GPS collars with acceleration sensors on 23 free-ranging pregnant female brown bears living in two areas in Sweden (61◦N and 67◦N latitude) to pinpoint hibernation and reproductive events. We investigated how intrinsic and extrinsic factors influence the termination of embryonic diapause and parturition, as well as their impact on reproductive success. The termination of embryonic diapause was later in the northern area compared to the southern area and occurred earlier when ambient temperature at den entry was higher in both areas. In the southern area, young adults (i.e., females = 7 years old) had a delayed parturition when bilberry abundance was low the year of mating. Additionally, young adults had a lower reproductive success than adults and their probability to reproduce successfully was dependent on bilberry abundance, whereas adult females were not affected by this parameter. As den exit occurs later in the northern study area, we suggest that a later parturition might ensure that females lactate their cubs in the den for a reasonable amount of time while fasting. Similarly, a later parturition combined with an earlier emergence could allow young adults to spend less time in the den lactating if they could not reach an optimal body condition prior to hibernation. But as a result, their cubs are younger and more vulnerable when they leave the den leading to lower survival rates. Our results suggest that a decreased berry abundance in the fall could impact the reproductive and hibernation phenology of Scandinavian brown bear females and lead to a lower cub survival with potential consequences on the population dynamics.publishedVersio

Meta-analysis of SHANK Mutations in Autism Spectrum Disorders: A Gradient of Severity in Cognitive Impairments.

International audienceSHANK genes code for scaffold proteins located at the post-synaptic density of glutamatergic synapses. In neurons, SHANK2 and SHANK3 have a positive effect on the induction and maturation of dendritic spines, whereas SHANK1 induces the enlargement of spine heads. Mutations in SHANK genes have been associated with autism spectrum disorders (ASD), but their prevalence and clinical relevance remain to be determined. Here, we performed a new screen and a meta-analysis of SHANK copy-number and coding-sequence variants in ASD. Copy-number variants were analyzed in 5,657 patients and 19,163 controls, coding-sequence variants were ascertained in 760 to 2,147 patients and 492 to 1,090 controls (depending on the gene), and, individuals carrying de novo or truncating SHANK mutations underwent an extensive clinical investigation. Copy-number variants and truncating mutations in SHANK genes were present in ∼1% of patients with ASD: mutations in SHANK1 were rare (0.04%) and present in males with normal IQ and autism; mutations in SHANK2 were present in 0.17% of patients with ASD and mild intellectual disability; mutations in SHANK3 were present in 0.69% of patients with ASD and up to 2.12% of the cases with moderate to profound intellectual disability. In summary, mutations of the SHANK genes were detected in the whole spectrum of autism with a gradient of severity in cognitive impairment. Given the rare frequency of SHANK1 and SHANK2 deleterious mutations, the clinical relevance of these genes remains to be ascertained. In contrast, the frequency and the penetrance of SHANK3 mutations in individuals with ASD and intellectual disability-more than 1 in 50-warrant its consideration for mutation screening in clinical practice

Broadband Multi-wavelength Properties of M87 during the 2017 Event Horizon Telescope Campaign

Abstract: In 2017, the Event Horizon Telescope (EHT) Collaboration succeeded in capturing the first direct image of the center of the M87 galaxy. The asymmetric ring morphology and size are consistent with theoretical expectations for a weakly accreting supermassive black hole of mass ∼6.5 × 109 M ⊙. The EHTC also partnered with several international facilities in space and on the ground, to arrange an extensive, quasi-simultaneous multi-wavelength campaign. This Letter presents the results and analysis of this campaign, as well as the multi-wavelength data as a legacy data repository. We captured M87 in a historically low state, and the core flux dominates over HST-1 at high energies, making it possible to combine core flux constraints with the more spatially precise very long baseline interferometry data. We present the most complete simultaneous multi-wavelength spectrum of the active nucleus to date, and discuss the complexity and caveats of combining data from different spatial scales into one broadband spectrum. We apply two heuristic, isotropic leptonic single-zone models to provide insight into the basic source properties, but conclude that a structured jet is necessary to explain M87’s spectrum. We can exclude that the simultaneous γ-ray emission is produced via inverse Compton emission in the same region producing the EHT mm-band emission, and further conclude that the γ-rays can only be produced in the inner jets (inward of HST-1) if there are strongly particle-dominated regions. Direct synchrotron emission from accelerated protons and secondaries cannot yet be excluded

The SNR Kes 17-ISM interaction: a fresh view from radio and γ\gamma rays

International audienceThis paper presents a comprehensive analysis of the Galactic SNR Kes 17 (G304.6+0.1) with focus on its radio synchrotron emission, environs, and the factors contributing to the observed gamma rays. The firstly-obtained integrated radio continuum spectrum from 88 to 8800 MHz yields an index alpha = -0.488 +/- 0.023 (S_nu $\propto$ nu^alpha), indicative of a linear particle acceleration process at the shock front. Accounting for the SNR radio shell size, the distribution of atomic hydrogen (n_H ~ 10 cm^-3), and assuming the SNR is in the Sedov-Taylor stage of its evolution, we estimate Kes 17 to be roughly 11 kyr. From 12CO and 13CO (J=1-0) emission-line data as a proxy for molecular hydrogen we provided the first evidence that the eastern shell of Kes 17 is engulfing a molecular enhancement, with 4.2 x 10^4 M_sun and n ~ 300 cm^-3. Towards the western boundary of Kes 17 there are not CO signatures above 3 sigma, despite previously reported infrared observations have revealed shocked molecular gas at that location. This suggests the existence of a CO-dark interacting molecular gas, a phenomenon also recorded in other Galactic SNRs (e.g. CTB 37A and RX J1713.7-3946). Additionally, by analysing ~14.5 yr of data from Fermi-LAT, we determined a power-law photon index in the 0.3-300 GeV range of Gamma = 2.39 +/- 0.04^+0.063_-0.114 (+/-stat +/-syst) in agreement with prior studies. The energy flux turns out to be (2.98 +/- 0.14) x 10^-11 erg cm-2 s-1 implying a luminosity (2.22 +/- 0.45) x 10^35 erg s-1 at ~8 kpc. Finally, we successfully modelled the multiwavelength SED by incorporating the improved radio synchrotron spectrum and the new gamma-ray measurements. Our analysis indicates that the observed GeV flux most likely originates from the interaction of Kes 17 with western ''dark'' CO zone with a proton density n_p ~ 400 cm-3

The SNR Kes 17-ISM interaction: a fresh view from radio and γ\gamma rays

International audienceThis paper presents a comprehensive analysis of the Galactic SNR Kes 17 (G304.6+0.1) with focus on its radio synchrotron emission, environs, and the factors contributing to the observed gamma rays. The firstly-obtained integrated radio continuum spectrum from 88 to 8800 MHz yields an index alpha = -0.488 +/- 0.023 (S_nu $\propto$ nu^alpha), indicative of a linear particle acceleration process at the shock front. Accounting for the SNR radio shell size, the distribution of atomic hydrogen (n_H ~ 10 cm^-3), and assuming the SNR is in the Sedov-Taylor stage of its evolution, we estimate Kes 17 to be roughly 11 kyr. From 12CO and 13CO (J=1-0) emission-line data as a proxy for molecular hydrogen we provided the first evidence that the eastern shell of Kes 17 is engulfing a molecular enhancement, with 4.2 x 10^4 M_sun and n ~ 300 cm^-3. Towards the western boundary of Kes 17 there are not CO signatures above 3 sigma, despite previously reported infrared observations have revealed shocked molecular gas at that location. This suggests the existence of a CO-dark interacting molecular gas, a phenomenon also recorded in other Galactic SNRs (e.g. CTB 37A and RX J1713.7-3946). Additionally, by analysing ~14.5 yr of data from Fermi-LAT, we determined a power-law photon index in the 0.3-300 GeV range of Gamma = 2.39 +/- 0.04^+0.063_-0.114 (+/-stat +/-syst) in agreement with prior studies. The energy flux turns out to be (2.98 +/- 0.14) x 10^-11 erg cm-2 s-1 implying a luminosity (2.22 +/- 0.45) x 10^35 erg s-1 at ~8 kpc. Finally, we successfully modelled the multiwavelength SED by incorporating the improved radio synchrotron spectrum and the new gamma-ray measurements. Our analysis indicates that the observed GeV flux most likely originates from the interaction of Kes 17 with western ''dark'' CO zone with a proton density n_p ~ 400 cm-3

The SNR Kes 17-ISM interaction: a fresh view from radio and γ\gamma rays

International audienceThis paper presents a comprehensive analysis of the Galactic SNR Kes 17 (G304.6+0.1) with focus on its radio synchrotron emission, environs, and the factors contributing to the observed gamma rays. The firstly-obtained integrated radio continuum spectrum from 88 to 8800 MHz yields an index alpha = -0.488 +/- 0.023 (S_nu $\propto$ nu^alpha), indicative of a linear particle acceleration process at the shock front. Accounting for the SNR radio shell size, the distribution of atomic hydrogen (n_H ~ 10 cm^-3), and assuming the SNR is in the Sedov-Taylor stage of its evolution, we estimate Kes 17 to be roughly 11 kyr. From 12CO and 13CO (J=1-0) emission-line data as a proxy for molecular hydrogen we provided the first evidence that the eastern shell of Kes 17 is engulfing a molecular enhancement, with 4.2 x 10^4 M_sun and n ~ 300 cm^-3. Towards the western boundary of Kes 17 there are not CO signatures above 3 sigma, despite previously reported infrared observations have revealed shocked molecular gas at that location. This suggests the existence of a CO-dark interacting molecular gas, a phenomenon also recorded in other Galactic SNRs (e.g. CTB 37A and RX J1713.7-3946). Additionally, by analysing ~14.5 yr of data from Fermi-LAT, we determined a power-law photon index in the 0.3-300 GeV range of Gamma = 2.39 +/- 0.04^+0.063_-0.114 (+/-stat +/-syst) in agreement with prior studies. The energy flux turns out to be (2.98 +/- 0.14) x 10^-11 erg cm-2 s-1 implying a luminosity (2.22 +/- 0.45) x 10^35 erg s-1 at ~8 kpc. Finally, we successfully modelled the multiwavelength SED by incorporating the improved radio synchrotron spectrum and the new gamma-ray measurements. Our analysis indicates that the observed GeV flux most likely originates from the interaction of Kes 17 with western ''dark'' CO zone with a proton density n_p ~ 400 cm-3

Asthma Control Score Based on Filled Medication Prescriptions: A Validation Study

BACKGROUND: Periodic measurement of disease control is recommended to characterize asthma and monitor treatment

Impact of cadmium on forage kale (Brassica oleracea var. viridis cv \textquotedblleftProver\textquotedblright) after 3-,10- and 56-day exposure to a Cd-spiked field soil

ACLCadmium (Cd) is a highly toxic element for living organisms and is widespread in metal-contaminated soils. As organisms which can grow up on these polluted areas, plants have some protection mechanisms against Cd issues. Among the plant kingdom, the Brassicaceae family includes species which are known to be able to tolerate and accumulate Cd in their tissues. In this study, Brassica oleracea var. viridis cv “Prover” was exposed to a range of artificially Cd-contaminated soils (from 2.5 up to 20 mg kg−1) during 3, 10, and 56 days and the effects on life traits, photosynthesis activity, antioxidant enzymatic activities were studied. Metal accumulation was quantified, as well as DNA damage, by means of the comet assay and immunodetection of 8-OHdG levels. Globally, B. oleracea was relatively tolerant to those Cd exposures. However, comet assay and detection of 8-OHdG revealed some DNA damage but which are not significant. According to metal accumulation analysis, B. oleracea var. viridis cv Prover could be a good candidate for alternative growing in contaminated areas