4,751 research outputs found
A phase-field model of Hele-Shaw flows in the high viscosity contrast regime
A one-sided phase-field model is proposed to study the dynamics of unstable
interfaces of Hele-Shaw flows in the high viscosity contrast regime. The
corresponding macroscopic equations are obtained by means of an asymptotic
expansion from the phase-field model. Numerical integrations of the phase-field
model in a rectangular Hele-Shaw cell reproduce finger competition with the
final evolution to a steady state finger the width of which goes to one half of
the channel width as the velocity increases
Vibration and buckling of thin-walled composite I-beams with arbitrary lay-ups under axial loads and end moments
A finite element model with seven degrees of freedom per node is developed to study vibration and buckling of thin-walled composite I-beams with arbitrary lay-ups under constant axial loads and equal end moments. This model is based on the classical lamination theory, and accounts for all the structural coupling coming from material anisotropy. The governing differential equations are derived from the Hamilton’s principle. Numerical results are obtained for thin-walled composite I-beams to investigate the effects of axial force, bending moment and fiber orientation on the buckling moments, natural frequencies, and corresponding vibration mode shapes as well as axial-moment-frequency interaction curves
PCV23 REDUCTIONS IN CORONARY HEART DISEASE MORTALITY ASSOCIATED WITH CHANGES IN RISK FACTORS AND TREATMENT UPTAKES IN ONTARIO BETWEEN 1994 AND 2005
The pulsating hot subdwarf Balloon 090100001: results of the 2005 multisite campaign
We present the results of a multisite photometric campaign on the pulsating
sdB star Balloon 090100001. The star is one of the two known hybrid hot
subdwarfs with both long- and short-period oscillations. The campaign involved
eight telescopes with three obtaining UBVR data, four B-band data, and one
Stromgren uvby photometry. The campaign covered 48 nights, providing a temporal
resolution of 0.36microHz with a detection threshold of about 0.2mmag in
B-filter data.
Balloon 090100001 has the richest pulsation spectrum of any known pulsating
subdwarf B star and our analysis detected 114 frequencies including 97
independent and 17 combination ones. The strongest mode (f_1) in the 2.8mHz
region is most likely radial while the remaining ones in this region form two
nearly symmetric multiplets: a triplet and quintuplet, attributed to
rotationally split \ell=1 and 2 modes, respectively. We find clear increases of
splitting in both multiplets between the 2004 and 2005 observing campaigns,
amounting to 15% on average. The observed splittings imply that the rotational
rate in Bal09 depends on stellar latitude and is the fastest on the equator. We
use a small grid of models to constrain the main mode (f_1), which most likely
represents the radial fundamental pulsation. The groups of p-mode frequencies
appear to lie in the vicinity of consecutive radial overtones, up to the third
one. Despite the large number of g-mode frequencies observed, we failed to
identify them, most likely because of the disruption of asymptotic behaviour by
mode trapping. The observed frequencies were not, however, fully exploited in
terms of seismic analysis which should be done in the future with a larger grid
of reliable evolutionary models of hot subdwarfs.Comment: accepted for publication in MNRA
Invariant higher-order variational problems II
Motivated by applications in computational anatomy, we consider a
second-order problem in the calculus of variations on object manifolds that are
acted upon by Lie groups of smooth invertible transformations. This problem
leads to solution curves known as Riemannian cubics on object manifolds that
are endowed with normal metrics. The prime examples of such object manifolds
are the symmetric spaces. We characterize the class of cubics on object
manifolds that can be lifted horizontally to cubics on the group of
transformations. Conversely, we show that certain types of non-horizontal
geodesics on the group of transformations project to cubics. Finally, we apply
second-order Lagrange--Poincar\'e reduction to the problem of Riemannian cubics
on the group of transformations. This leads to a reduced form of the equations
that reveals the obstruction for the projection of a cubic on a transformation
group to again be a cubic on its object manifold.Comment: 40 pages, 1 figure. First version -- comments welcome
Transient Magnetic and Doppler Features Related to the White-light Flares in NOAA 10486
Rapidly moving transient features have been detected in magnetic and Doppler
images of super-active region NOAA 10486 during the X17/4B flare of 28 October
2003 and the X10/2B flare of 29 October 2003. Both these flares were extremely
energetic white-light events. The transient features appeared during impulsive
phases of the flares and moved with speeds ranging from 30 to 50 km s.
These features were located near the previously reported compact acoustic
\cite{Donea05} and seismic sources \cite{Zharkova07}. We examine the origin of
these features and their relationship with various aspects of the flares, {\it
viz.}, hard X-ray emission sources and flare kernels observed at different
layers - (i) photosphere (white-light continuum), (ii) chromosphere (H
6563\AA), (iii) temperature minimum region (UV 1600\AA), and (iv) transition
region (UV 284\AA).Comment: 26 pages, 13 figures, 2 tables, accepted for publication in Solar
Physic
Trypanosoma brucei BRCA2 acts in a life cycle-specific genome stability process and dictates BRC repeat number-dependent RAD51 subnuclear dynamics
Trypanosoma brucei survives in mammals through antigenic variation, which is driven by RAD51-directed homologous recombination of Variant Surface Glycoproteins (VSG) genes, most of which reside in a subtelomeric repository of >1000 silent genes. A key regulator of RAD51 is BRCA2, which in T. brucei contains a dramatic expansion of a motif that mediates interaction with RAD51, termed the BRC repeats. BRCA2 mutants were made in both tsetse fly-derived and mammal-derived T. brucei, and we show that BRCA2 loss has less impact on the health of the former. In addition, we find that genome instability, a hallmark of BRCA2 loss in other organisms, is only seen in mammal-derived T. brucei. By generating cells expressing BRCA2 variants with altered BRC repeat numbers, we show that the BRC repeat expansion is crucial for RAD51 subnuclear dynamics after DNA damage. Finally, we document surprisingly limited co-localization of BRCA2 and RAD51 in the T. brucei nucleus, and we show that BRCA2 mutants display aberrant cell division, revealing a function distinct from BRC-mediated RAD51 interaction. We propose that BRCA2 acts to maintain the huge VSG repository of T. brucei, and this function has necessitated the evolution of extensive RAD51 interaction via the BRC repeats, allowing re-localization of the recombinase to general genome damage when needed
Search for electromagnetic properties of the neutrinos at the LHC
Exclusive production of neutrinos via photon-photon fusion provides an
excellent opportunity to probe electromagnetic properties of the neutrinos at
the LHC. We explore the potential of processes pp-> p gamma gamma p -> p nu
anti-nu p and pp -> p gamma gamma p -> p nu anti-nu Z p to probe
neutrino-photon and neutrino-two photon couplings. We show that these reactions
provide more than seven orders of magnitude improvement in neutrino-two photon
couplings compared to LEP limits.Comment: 11 pages, 4 tables, New backgrounds have been adde
Functionally heterogeneous human satellite cells identified by single cell RNA sequencing.
Although heterogeneity is recognized within the murine satellite cell pool, a comprehensive understanding of distinct subpopulations and their functional relevance in human satellite cells is lacking. We used a combination of single cell RNA sequencing and flow cytometry to identify, distinguish, and physically separate novel subpopulations of human PAX7+ satellite cells (Hu-MuSCs) from normal muscles. We found that, although relatively homogeneous compared to activated satellite cells and committed progenitors, the Hu-MuSC pool contains clusters of transcriptionally distinct cells with consistency across human individuals. New surface marker combinations were enriched in transcriptional subclusters, including a subpopulation of Hu-MuSCs marked by CXCR4/CD29/CD56/CAV1 (CAV1+). In vitro, CAV1+ Hu-MuSCs are morphologically distinct, and characterized by resistance to activation compared to CAV1- Hu-MuSCs. In vivo, CAV1+ Hu-MuSCs demonstrated increased engraftment after transplantation. Our findings provide a comprehensive transcriptional view of normal Hu-MuSCs and describe new heterogeneity, enabling separation of functionally distinct human satellite cell subpopulations
Vacuum Instabilities with a Wrong-Sign Higgs-Gluon-Gluon Amplitude
The recently discovered 125 GeV boson appears very similar to a Standard
Model Higgs, but with data favoring an enhanced h to gamma gamma rate. A number
of groups have found that fits would allow (or, less so after the latest
updates, prefer) that the h-t-tbar coupling have the opposite sign. This can be
given meaning in the context of an electroweak chiral Lagrangian, but it might
also be interpreted to mean that a new colored and charged particle runs in
loops and produces the opposite-sign hGG amplitude to that generated by
integrating out the top, as well as a contribution reinforcing the W-loop
contribution to hFF. In order to not suppress the rate of h to WW and h to ZZ,
which appear to be approximately Standard Model-like, one would need the loop
to "overshoot," not only canceling the top contribution but producing an
opposite-sign hGG vertex of about the same magnitude as that in the SM. We
argue that most such explanations have severe problems with fine-tuning and,
more importantly, vacuum stability. In particular, the case of stop loops
producing an opposite-sign hGG vertex of the same size as the Standard Model
one is ruled out by a combination of vacuum decay bounds and LEP constraints.
We also show that scenarios with a sign flip from loops of color octet charged
scalars or new fermionic states are highly constrained.Comment: 20 pages, 8 figures; v2: references adde
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