47 research outputs found
Ações de alimentação e nutrição na atenção básica: a experiência de organização no Governo Brasileiro
- Author
- Ana Carolina Feldenheimer da Silva
- Ana Maria Cavalcante de Lima
- Baltussen R
- Birch LL
- Brown T
- Buss PM.
- Campos GW
- Campos GWS
- Castro CM
- Coutinho JG
- Cunha GT.
- De-Regil LM
- Dewey KG
- Fall CH
- Ferreira VA
- Garden FL
- Gisele Ane Bortolini
- Gonzalez-Suarez C
- Grantham-McGregor S
- Hallal PC
- Horton S.
- Jaime PC
- Jordão RE
- Katz Dl
- Leal MC
- Macinko J
- Mahecha MS
- Manson JB
- Mendes EV.
- Monteiro CA
- Parra DC
- Patrícia Constante Jaime
- Pérez-Morales ME
- Reis R
- Rolland-Cachera MF
- Santos LMP
- Schmidt MI
- Simoes E
- Sousa MF.
- Szarfarc SC.
- Vieira RCS
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Laparoscopy in management of appendicitis in high-, middle-, and low-income countries: a multicenter, prospective, cohort study.
- Author
- Abantanga F
- Abbas M
- Abbo O
- Abd El Galeel A
- Abd El Hameed OS
- Abd El Hamid N
- Abd El Salam Y
- Abd El Slam M
- Abd El-Salam F
- Abd Elrasoul Y
- Abd-Elrasoul Y
- Abdallah E
- Abdel-Wahab NYE
- AbdelFattah I
- Abdelgelil A
- Abdelghany S
- Abdelkader M
- Abdelkareem A
- Abdelraheim M
- Abdelshafy M
- Abdulgawad M
- Abdullah AAN
- Abdullah NAN
- Abebe NS
- Abebe NS
- Aber A
- Abington E
- Aboarab A
- Aboraya M
- Aboraya M
- Abouelnasr A
- Abouzahra A
- Abozaid M
- Abozeid K
- Abozyed MAF
- Abudeeb H
- Abuseif M
- Acharya P
- Adams R
- Adebanjo A
- Adekoya A
- Adel A
- Adel A
- Ademuyiwa A
- Ademuyiwa AO
- Adeniran J
- Adeniyi A
- Adesanya O
- Adesina A
- Adesuyi A
- Adeyeye A
- Adham W
- Afandy A
- Afifi AM
- Afzal M
- Agalianos C
- Agarwal A
- Agius M
- Aguilar-Jimenez J
- Aguilera M
- Aguilera O
- Ahlqvist S
- Ahmed A
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- Ahmed H
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- Al-Faifi JJ
- Al-Hameedi HII
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- Al-Obaedi O
- Al-shammari A
- Alahmady O
- Alakaloko F
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- Zardab A
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
BACKGROUND: Appendicitis is the most common abdominal surgical emergency worldwide. Differences between high- and low-income settings in the availability of laparoscopic appendectomy, alternative management choices, and outcomes are poorly described. The aim was to identify variation in surgical management and outcomes of appendicitis within low-, middle-, and high-Human Development Index (HDI) countries worldwide. METHODS: This is a multicenter, international prospective cohort study. Consecutive sampling of patients undergoing emergency appendectomy over 6 months was conducted. Follow-up lasted 30 days. RESULTS: 4546 patients from 52 countries underwent appendectomy (2499 high-, 1540 middle-, and 507 low-HDI groups). Surgical site infection (SSI) rates were higher in low-HDI (OR 2.57, 95% CI 1.33-4.99, p = 0.005) but not middle-HDI countries (OR 1.38, 95% CI 0.76-2.52, p = 0.291), compared with high-HDI countries after adjustment. A laparoscopic approach was common in high-HDI countries (1693/2499, 67.7%), but infrequent in low-HDI (41/507, 8.1%) and middle-HDI (132/1540, 8.6%) groups. After accounting for case-mix, laparoscopy was still associated with fewer overall complications (OR 0.55, 95% CI 0.42-0.71, p < 0.001) and SSIs (OR 0.22, 95% CI 0.14-0.33, p < 0.001). In propensity-score matched groups within low-/middle-HDI countries, laparoscopy was still associated with fewer overall complications (OR 0.23 95% CI 0.11-0.44) and SSI (OR 0.21 95% CI 0.09-0.45). CONCLUSION: A laparoscopic approach is associated with better outcomes and availability appears to differ by country HDI. Despite the profound clinical, operational, and financial barriers to its widespread introduction, laparoscopy could significantly improve outcomes for patients in low-resource environments. TRIAL REGISTRATION: NCT02179112
Mortality from gastrointestinal congenital anomalies at 264 hospitals in 74 low-income, middle-income, and high-income countries: a multicentre, international, prospective cohort study
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- Yunus A
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- Zaman ASK
- Zanellato JB
- Zea-Salazar LE
- Zeinelabdeen A
- Zelada JA
- Zhao X
- Zhu J
- Zhu L
- Zidan M
- Zivanovic D
- Zreeg DAS
- Zurikat RO
- Zvizdic N
- Zvizdic Z
- Publication venue
- ELSEVIER SCIENCE INC
- Publication date
- 24/07/2021
- Field of study
Background: Congenital anomalies are the fifth leading cause of mortality in children younger than 5 years globally. Many gastrointestinal congenital anomalies are fatal without timely access to neonatal surgical care, but few studies have been done on these conditions in low-income and middle-income countries (LMICs). We compared outcomes of the seven most common gastrointestinal congenital anomalies in low-income, middle-income, and high-income countries globally, and identified factors associated with mortality. // Methods: We did a multicentre, international prospective cohort study of patients younger than 16 years, presenting to hospital for the first time with oesophageal atresia, congenital diaphragmatic hernia, intestinal atresia, gastroschisis, exomphalos, anorectal malformation, and Hirschsprung's disease. Recruitment was of consecutive patients for a minimum of 1 month between October, 2018, and April, 2019. We collected data on patient demographics, clinical status, interventions, and outcomes using the REDCap platform. Patients were followed up for 30 days after primary intervention, or 30 days after admission if they did not receive an intervention. The primary outcome was all-cause, in-hospital mortality for all conditions combined and each condition individually, stratified by country income status. We did a complete case analysis. // Findings: We included 3849 patients with 3975 study conditions (560 with oesophageal atresia, 448 with congenital diaphragmatic hernia, 681 with intestinal atresia, 453 with gastroschisis, 325 with exomphalos, 991 with anorectal malformation, and 517 with Hirschsprung's disease) from 264 hospitals (89 in high-income countries, 166 in middle-income countries, and nine in low-income countries) in 74 countries. Of the 3849 patients, 2231 (58·0%) were male. Median gestational age at birth was 38 weeks (IQR 36–39) and median bodyweight at presentation was 2·8 kg (2·3–3·3). Mortality among all patients was 37 (39·8%) of 93 in low-income countries, 583 (20·4%) of 2860 in middle-income countries, and 50 (5·6%) of 896 in high-income countries (p<0·0001 between all country income groups). Gastroschisis had the greatest difference in mortality between country income strata (nine [90·0%] of ten in low-income countries, 97 [31·9%] of 304 in middle-income countries, and two [1·4%] of 139 in high-income countries; p≤0·0001 between all country income groups). Factors significantly associated with higher mortality for all patients combined included country income status (low-income vs high-income countries, risk ratio 2·78 [95% CI 1·88–4·11], p<0·0001; middle-income vs high-income countries, 2·11 [1·59–2·79], p<0·0001), sepsis at presentation (1·20 [1·04–1·40], p=0·016), higher American Society of Anesthesiologists (ASA) score at primary intervention (ASA 4–5 vs ASA 1–2, 1·82 [1·40–2·35], p<0·0001; ASA 3 vs ASA 1–2, 1·58, [1·30–1·92], p<0·0001]), surgical safety checklist not used (1·39 [1·02–1·90], p=0·035), and ventilation or parenteral nutrition unavailable when needed (ventilation 1·96, [1·41–2·71], p=0·0001; parenteral nutrition 1·35, [1·05–1·74], p=0·018). Administration of parenteral nutrition (0·61, [0·47–0·79], p=0·0002) and use of a peripherally inserted central catheter (0·65 [0·50–0·86], p=0·0024) or percutaneous central line (0·69 [0·48–1·00], p=0·049) were associated with lower mortality. // Interpretation: Unacceptable differences in mortality exist for gastrointestinal congenital anomalies between low-income, middle-income, and high-income countries. Improving access to quality neonatal surgical care in LMICs will be vital to achieve Sustainable Development Goal 3.2 of ending preventable deaths in neonates and children younger than 5 years by 2030
A global experiment on motivating social distancing during the COVID-19 pandemic
- Author
- Abbas Nida
- Aberson Christopher L
- Aczel Balazs
- Adamkovič Matúš
- Adamus Sylwia
- Adetula Adeyemi
- Adetula Gabriel Agboola
- Adiguzel Arca
- Adoric Vera Cubela
- Afhami Reza
- Agadullina Elena
- Ahlgren Lina
- Ahmed Afroja
- Ahn El Rim
- Akkas Handan
- Akter Shahunur
- Albayrak-Aydemir Nihan
- Allred Tara Bulut
- Almeida Inês AT
- Alvarez Daniela Serrato
- Alves Sara G
- Anjum Gulnaz
- Ankushev Vladislav
- Anne Michele
- Antazo Benedict
- Antfolk Jan
- Anton-Boicuk Lisa
- Antoniadi Maria
- Antwerpen Natasha van
- ARABI Kanza AITEL
- Arinze Azuka Ikechukwu
- Arinze Nwadiogo Chisom
- Arriaga Patricia
- Aruta John Jamir Benzon
- Arvanitis Alexios
- Askelund Adrian Dahl
- Atari Mohammad
- Azab Habiba
- Azevedo Flavio
- Azouaghe Soufian
- Babinčák Peter
- Bai Hui
- Baklanova Ekaterina
- Balci Busra Bahar
- Ballantyne Tonia
- Banik Gabriel
- Barkoukis Vassilis
- Barzykowski Krystian
- Baskin Ernest
- Basnight-Brown Dana M
- Batres Carlota
- Bavolar Jozef
- Bayyat Manal M
- Beatrix Labadi
- Beaudry Jennifer L
- Becker Maja
- Behzadnia Behzad
- Beitner Julia
- Belaus Anabel
- Benka Jozef
- Berkessel Jana B
- Bernardo Márcia
- Beshears Julie E
- Betlehem Ruben
- Bialek Michal
- Bialobrzeska Olga
- Biberauer Theresa
- Bijlstra Gijsbert
- Bogatyreva Natalia
- Bokkour Ahmed
- Boller Daniel
- Bosch Jasmijn
- Bosma Minke Jasmijn
- Boucher Leanne
- Boudesseul Jordane
- Bozdoc Andreea Ioana
- Bradford Maria
- Bradshaw Emma L
- Bran Alexandre
- Bravo Olalla Niño
- Brohmer Hilmar
- Brownlow Charlotte
- Buchanan Erin M
- Bundt Carsten
- Butt Muhammad Mussaffa
- Bylinina Lisa
- Calin-Jageman Robert J
- Campos Olatz
- Capizzi Mariagrazia
- Carpentier Joelle
- Ceary Chris D
- Cellini Nicola
- Chakarova Desislava
- Chanal Julien
- Chartier Christopher R
- Charyate Abdelilah Ca
- Chen Sau-Chin
- Chen Zhang
- Chiu Faith
- Chopik William J
- Chou Wei-Lun
- Chuan-Peng Hu
- Cocco Beatrice
- Cohen Noga
- Coles Nicholas A
- Collins W Matthew
- Colloff Melissa F
- Corral-Frías Nadia S
- Correa Pablo Sebastián
- Correia Rita C
- Costa Sebastiano
- Cruz Vásquez Julio E
- Cyrus-Lai Wilson
- Czamanski-Cohen Johanna
- Czarnek Gabriela
- Cárcamo Rodrigo A
- Daches Shimrit
- Dalgar Ilker
- Damnjanović Kaja
- Davis William E
- De la Rosa-Gomez Anabel
- Delgado Lady Grey Javela
- DePaola Chloe
- Desai Kermeka
- Dimova Daliborka
- Dixson Barnaby James Wyld
- Djamai Ikhlas
- Djordjevic Jasna Milosevic
- Domurat Artur
- Doren Natalia Van
- Drexler Shira Meir
- Du Hongfei
- Du Xinkai
- Dubrov Dmitrii
- Dujols Olivier
- Dunleavy Daniel
- Dunn Megan R
- Dursun Pinar
- Ebersole Charles R
- Emmanuel Agesin Bamikole B
- Espinoza Barría Mauricio F
- Esteban-Serna Celia
- Etebari Zahra
- Eudave Luis
- Evans Kortnee
- FatahModares Saeideh
- Fedotov Maksim
- Feldman Gilad
- Ferguson Lisa J
- Ferreira Ana
- Ferreyra Cecilia
- Filip Katarzyna
- Findor Andrej
- Flowe Heather
- Forbes Paul AG
- Forest Jacques
- Foroni Francesco
- Forscher Patrick S
- Frias-Armenta Martha
- Friedemann Maja
- Frizzo Thomas
- Fu Cynthia HY
- Galindo-Caballero Oscar J
- Garcia Elkin Oswaldo Luis
- Gargurevich Rafael
- Geiger Sandra J
- Geniole Shawn N
- Gialitaki Zoi
- Gill Tripat
- Gjoneska Biljana
- Godbersen Hendrik
- Gourdon-Kanhukamwe Amélie
- Grano Caterina
- Greenburgh Anna
- Grigoryev Dmitry
- Grinberg Maurice
- Groyecka-Bernard Agata
- Grzech Karolina
- Gugliandolo Maria C
- Gunton Lesley-Ann
- Habib Sumaiya
- Habte Redeate
- Hajdu Nandor
- Hanel Paul HP
- Hartanto Andree
- Harutyunyan Mikayel
- Hassan Widad
- Hedgebeth Mattie V
- Hernandez Alejandrina
- Herrera Dora
- Hofer Gabriela
- Holford Dawn Liu
- Hostler Thomas J
- House Thea
- Houston Ralph
- Hoyer Karlijn
- Hricova Monika
- Hristova Evgeniya
- Hruška Matej
- Hubena Barbora
- Ihaya Keiko
- IJzerman Hans
- Isager Peder Mortvedt
- Ishii Tatsunori
- Ishkhanyan Byurakn
- Ivanov Aleksandr
- Iyer Aishwarya
- Izquierdo Sara Morales
- Jackson Emily A
- Jaeger Bastian
- Jai-ai Rachadaporn
- Janak Allison
- Jang Yuna
- Janjić Kristina
- Jansen Martine
- Janssen Steve MJ
- Jaremka Lisa M
- Jernsäther Teodor
- Jiang Xiaoming
- Jimenez-Leal William
- Johannes Niklas
- Jones Marc V
- Joy-Gaba Jennifer A
- Jurković Anita Penić
- Kabir Muhib
- Kadreva Veselina Hristova
- Kaliska Lada
- Kamburidis Julia
- Kaminski Gwenael
- Kappes Heather Barry
- Karaarslan Cemre
- Karababa Alper
- Karashiali Christiana
- Karekla Maria
- Kassianos Angelos P
- Kačmár Pavol
- Khaobunmasiri Sirikon
- Khaoudi Ahmed
- Khosla Meetu
- Khumkom Sakda
- Kielińska Julita
- Kirgizova Komila
- Kiselnikova Natalia
- Klevjer Kristoffer
- Kocalar Halil Emre
- Koehn Monica A
- Kohlová Markéta Braun
- Koptjevskaja-Tamm Maria
- Korbmacher Max
- Korobova Tatiana
- Kossowska Małgorzata
- Kovic Vanja
- Kowal Marta
- Kozma Luca
- Krafnick Anthony J
- Križanić Valerija
- Krupić Dajana
- Krupić Dino
- Kung Franki YH
- Kunisato Yoshihiko
- Kunst Jonas R
- Kurfali Merve A
- Kurfalı Murathan
- Kushnir Elizaveta
- Kuzminska Anna O
- Kácha Ondřej
- Lamm Claus
- Landry Anais Thibault
- Law Wilbert
- Lazarevic Ljiljana B
- Lee Jeong Min
- Legate Nicole
- Legault Lisa
- Lerche Veronika
- Levine Shelby L
- Levitan Carmel A
- Levy Neil
- Lewis David MG
- Lewis Savannah
- Li Manyu
- Li Ranran
- Liga Francesca
- Lima Tiago JS
- Lin Yijun
- Lins de Holanda Coelho Gabriel
- Lins Samuel
- Lu Jackson G
- Lucas Marc Y
- Lund Maria Louise
- Luxon Alexandria M
- Macapagal Paulo Manuel
- Machin Michael A
- Machin Tanya
- Magrin Maria Elena
- Majeed Nadyanna M
- Maldonado Mónica Alarcón
- Mallik Peter R
- Manavalan Mathi
- Maniaci Michael R
- Manley Harry
- Manunta Efisio
- Marcu Gabriela Mariana
- Marinova Evelina
- Marko Dafne
- Marszalek Magdalena
- Martela Frank
- Martin Neil I
- Martončik Marcel
- Massoni Sébastien
- Matos Lennia
- Maturan Princess Lovella G
- McCarthy Randy
- Mensink Michael C
- Messerschmidt Johanna
- Metin-Orta Irem
- Metz Molly A
- Micheli Leticia
- Miller Jeremy K
- Mioni Giovanna
- Miranda Jacob F
- Misiak Michal
- Modena Arianna
- Mokady Aviv
- Mola Débora
- Moller Arlen
- Monajem Arash
- Monteiro Renan P
- Moon Karis
- Morbée Sofie
- Moreau David
- Morris Katherine
- Mosannenzadeh Farnaz
- Moshontz Hannah
- Moss Jennifer D
- Muchembled Fany
- Muda Rafał
- Muminov Abdumalik
- Musser Erica
- Nadif Khaoula
- Ndukaihe Izuchukwu LG
- Nedelcheva-Datsova Mina
- Neubauer Andreas B
- Ngyuen Thuy-vy
- Nicolotti Matilde
- Niemiec Christopher P
- Nilsonne Gustav
- Nock Nora L
- Noone Chris
- Norton James O
- Ntoumanis Nikos
- Ogbonnaya Chisom Esther
- Oliveira Raquel
- Olofsson Jonas K
- Onie Sandersan
- Oosterlinck Marlies
- Ordoñez-Riaño Santiago
- Ortiz Manuel S
- Ostermann Thomas
- Ouherrou Nihal
- Overkott Clara
- Ozery Daphna Hausman
- Očovaj Sanja Batić
- Paltrow Tamar
- Pantazi Myrto
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- Singh Anisha
- Sinkolova Sladjana
- Sirota Miroslav
- Skowronek Anna
- Smit Eline Suzanne
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- Solorzano Claudio Singh
- Song Xin
- Sorokowska Agnieszka
- Sorokowski Piotr
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- Standage Martyn
- Staniaszek Karolina
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- Stojanovska Marija
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- Sunami Naoyuki
- Suter Lilian
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- Terskova Maria
- Theodoropoulou Andriana
- Thogersen-Ntoumani Cecilie
- Thomas Andrew G
- Thommesen Katrine Krabbe
- Todsen Anna Louise
- Topor Marta
- Toro Mónica
- Torres Adriana Olaya
- Torunsky Nathan
- Tran Ulrich S
- Travaglino Giovanni A
- Tshonda Sarah Suzette
- Tullett Alexa M
- Tümer Murat
- Unanue Wenceslao
- Urban Jan
- Urooj Anum
- Urriago-Rayo Joan
- Urry Heather L
- Uttley Jim
- Vaidis David C
- Valentova Jaroslava Varella
- Vally Zahir
- van Hooff Madelon LM
- van Schie Kevin
- van Steenkiste IMM
- Vansteenkiste Maarten
- Varella Marco AC
- Vargas-Nieto Juan Camilo
- Vasilev Martin R
- Vaughn Leigh Ann
- Vdovic Milica
- Vega Diego
- Verbruggen Frederick
- Verharen Jeroen PH
- Vermote Branko J
- Vezirian Kevin
- Victoria Ortiz María
- Vieira Luc
- Vilar Roosevelt
- Vilares Iris
- Vilsmeier Johannes K
- Vintr Jáchym
- Volz Leonhard
- von Bastian Claudia C
- von Bormann Suparpit M
- Voracek Martin
- Vranka Marek
- Vračar Selena
- Wachowicz Jakub
- Wajanatinapart Piyaorn
- Walczak Radoslaw B
- Wang Chunhui
- Warmelink Lara
- Waterschoot Joachim
- Weinstein Netta
- Westerlund Minja
- Westgate Erin C
- Whitt Cassie M
- Wichman Aaron L
- Wielgus Magdalena
- Willis Megan
- Wilson John Paul
- Wolfe Kelly
- Wylie Keith
- Xiao Qinyu
- Yamada Yuki
- Yao Elvin
- Yeung Siu Kit
- Yu Karen
- Zakharov Ilya
- Zdybek Przemysław
- Ziano Ignazio
- Zickfeld Janis
- Zorjan Saša
- Zrimsek Miha
- Zsido Andras N
- Çoksan Sami
- Özdoğru Asil Ali
- Čadek Martin
- Šakan Dušana
- Štrukelj Eva
- Žuro Barbara
- Publication venue
- 'Proceedings of the National Academy of Sciences'
- Publication date
- 27/05/2022
- Field of study
Finding communication strategies that effectively motivate social distancing continues to be a global public health priority during the COVID-19 pandemic. This cross-country, preregistered experiment (n = 25,718 from 89 countries) tested hypotheses concerning generalizable positive and negative outcomes of social distancing messages that promoted personal agency and reflective choices (i.e., an autonomy-supportive message) or were restrictive and shaming (i.e., a controlling message) compared with no message at all. Results partially supported experimental hypotheses in that the controlling message increased controlled motivation (a poorly internalized form of motivation relying on shame, guilt, and fear of social consequences) relative to no message. On the other hand, the autonomy-supportive message lowered feelings of defiance compared with the controlling message, but the controlling message did not differ from receiving no message at all. Unexpectedly, messages did not influence autonomous motivation (a highly internalized form of motivation relying on one’s core values) or behavioral intentions. Results supported hypothesized associations between people’s existing autonomous and controlled motivations and self-reported behavioral intentions to engage in social distancing. Controlled motivation was associated with more defiance and less long-term behavioral intention to engage in social distancing, whereas autonomous motivation was associated with less defiance and more short- and long-term intentions to social distance. Overall, this work highlights the potential harm of using shaming and pressuring language in public health communication, with implications for the current and future global health challenges
Global burden of 369 diseases and injuries in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019
- Author
- Abbafati C
- Abbas KM
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- Malta DC
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- Umeokonkwo CD
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- Wondmieneh AB
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- Wu A-M
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- Wunrow HY
- Xie Y
- Xu G
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- Yamagishi K
- Yaminfirooz M
- Yano Y
- Yaya S
- Yazdi-Feyzabadi V
- Yearwood JA
- Yeheyis TY
- Yeshitila YG
- Yilgwan CS
- Yilma MT
- Yip P
- Yonemoto N
- Yoon S-J
- York HW
- Younis MZ
- Younker TP
- Yousefi B
- Yousefi Z
- Yousefifard M
- Yousefinezhadi T
- Yousuf AY
- Yu C
- Yu Y
- Yuan C-W
- Yuce D
- Yusefzadeh H
- Zadey S
- Zahabi SS
- Zaidi SS
- Zaki L
- Zaki MES
- Zakzuk J
- Zamani M
- Zamanian M
- Zandian H
- Zangeneh A
- Zarafshan H
- Zastrozhin MS
- Zewdie KA
- Zhang J
- Zhang Y
- Zhang Z-J
- Zhao JT
- Zhao X-JG
- Zhao Y
- Zheleva B
- Zheng P
- Zhou M
- Zhu C
- Ziapour A
- Zimsen SRM
- Zlavog BS
- Zodpey S
- Publication venue
- 'Elsevier BV'
- Publication date
- 17/10/2020
- Field of study
Five insights from the Global Burden of Disease Study 2019
- Author
- Abbafati C
- Abbas KM
- Abbasi M
- Abbasi-Kangevari M
- Abbasifard M
- Abbastabar H
- Abd El Razek HM
- Abd El Razek MM
- Abd-Allah F
- Abdelalim A
- Abdollahi M
- Abdollahpour I
- Abdulkader RS
- Abdullah KH
- Abedi A
- Abedi P
- Abegaz KH
- Abolhassani H
- Abosetugn AE
- Aboyans V
- Abrams EM
- Abreu LG
- Abrigo MRM
- Abu Haimed AK
- Abu-Gharbieh E
- Abu-Raddad LJ
- Abualhasan A
- Abushouk AI
- Acebedo A
- Ackerman IN
- Adabi M
- Adair T
- Adamu AA
- Adebayo OM
- Adedeji IA
- Adekanmbi V
- Adelson JD
- Adeoye AM
- Adetokunboh OO
- Adham D
- Advani SM
- Afarideh M
- Afshari M
- Afshin A
- Agardh EE
- Agarwal G
- Agasthi P
- Agesa KM
- Aghaali M
- Aghamir SMK
- Agrawal A
- Ahmad T
- Ahmadi A
- Ahmadi K
- Ahmadi M
- Ahmadieh H
- Ahmadpour E
- Ahmed MB
- Aji B
- Akalu TY
- Akinyemi RO
- Akinyemiju T
- Akombi B
- Akunna CJ
- Al-Aly Z
- Al-Mekhlafi HM
- Al-Raddadi RM
- Alahdab F
- Alam K
- Alam N
- Alam S
- Alam T
- Alanezi FM
- Alanzi TM
- Albertson SB
- Alcalde-Rabanal JE
- Alema NM
- Alemu BW
- Alemu YM
- Alhabib KF
- Alhassan RK
- Ali M
- Ali S
- Alicandro G
- Alijanzadeh M
- Alinia C
- Alipour V
- Alizade H
- Aljunid SM
- Alla F
- Allebeck P
- Almadi MAH
- Almasi A
- Almasi-Hashiani A
- Almasri NA
- Almulhim AM
- Alonso J
- Altirkawi KA
- Alumran AK
- Alvis-Guzman N
- Alvis-Zakzuk NJ
- Amare AT
- Amare B
- Amini S
- Amini-Rarani M
- Aminorroaya A
- Amiri F
- Amit AML
- Amugsi DA
- Amul GGH
- Anbesu EW
- Ancuceanu R
- Anderlini D
- Anderson JA
- Andrei CL
- Andrei T
- Androudi S
- Angus C
- Anjomshoa M
- Ansari F
- Ansari I
- Ansari-Moghaddam A
- Antonazzo IC
- Antonio CAT
- Antony CM
- Antriyandarti E
- Anvari D
- Anwer R
- Appiah SCY
- Arab-Zozani M
- Arabloo J
- Aravkin AY
- Arba AAK
- Aremu O
- Ariani F
- Aripov T
- Armoon B
- Arnlov J
- Arowosegbe OO
- Aryal KK
- Arzani A
- Asaad M
- Asadi-Aliabadi M
- Asadi-Pooya AA
- Asgari S
- Asghari B
- Ashbaugh C
- Assmus M
- Atafar Z
- Athari SS
- Atnafu DD
- Atout MMW
- Atre SR
- Atteraya MS
- Ausloos F
- Ausloos M
- Avila-Burgos L
- Avokpaho EFGA
- Ayano G
- Ayanore MA
- Aynalem GL
- Aynalem YA
- Ayza MA
- Azari S
- Azarian G
- Azene ZN
- Azhar G
- Azzopardi PS
- Babaee E
- Badawi A
- Badiye AD
- Bagherzadeh M
- Bagli E
- Bahrami MA
- Baig AA
- Bairwa M
- Bakhshaei MH
- Bakhtiari A
- Bakkannavar SM
- Balachandran A
- Balakrishnan S
- Balalla S
- Balassyano S
- Baldasseroni A
- Bali AO
- Ball K
- Ballew SH
- Balzi D
- Banach M
- Bandpei MAM
- Banerjee SK
- Banik PC
- Bannick MS
- Bante AB
- Bante SA
- Baraki AG
- Barboza MA
- Barker-Collo SL
- Barnighausen TW
- Barrero LH
- Barthelemy CM
- Barua L
- Barzegar A
- Basaleem H
- Bassat Q
- Basu S
- Baune BT
- Bayati M
- Baye BA
- Bazmandegan G
- Becker JS
- Bedi N
- Beghi E
- Behzadifar M
- Bejot Y
- Bekuma TTT
- Bell ML
- Bello AK
- Ben L
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- Bennett DA
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- Bensenor IM
- Benziger CP
- Berhe K
- Berman AE
- Bernabe E
- Bernstein RS
- Bertolacci GJ
- Bhagavathula AS
- Bhageerathy R
- Bhala N
- Bhandari D
- Bhardwaj P
- Bhat AG
- Bhattacharyya K
- Bhattarai S
- Bhutta ZA
- Bibi S
- Bicer BK
- Biehl MH
- Bijani A
- Bikbov B
- Bilano V
- Bin Sayeed MS
- Bin Zaman S
- Biondi A
- Birihane BM
- Bisanzio D
- Bisignano C
- Biswas RK
- Bitew H
- Bjorge T
- Bockarie MJ
- Bohlouli S
- Bohluli M
- Bojia HA
- Bolla SR
- Boloor A
- Boon-Dooley AS
- Borges G
- Borzi AM
- Borzouei S
- Bose D
- Bosetti C
- Boston S
- Boufous S
- Bourne R
- Brady OJ
- Braithwaite D
- Brauer M
- Brayne C
- Breitborde NJK
- Breitner S
- Brenner H
- Breusov AV
- Briant PS
- Briggs AM
- Briko AN
- Briko NI
- Britton GB
- Brugha T
- Bryazka D
- Buchbinder R
- Bumgarner BR
- Burkart K
- Burnett RT
- Busse R
- Butt ZA
- Caetano dos Santos FL
- Cahill LE
- Cahuana-Hurtado L
- Cai T
- Callender CSKH
- Camera LA
- Campos-Nonato IR
- Cao J
- Car J
- Car LT
- Cardenas R
- Carreras G
- Carrero JJ
- Carvalho F
- Castaldelli-Maia JM
- Castaneda-Orjuela CA
- Castelpietra G
- Castle CD
- Castro E
- Castro F
- Catala-Lopez F
- Causey K
- Cederroth CR
- Cercy KM
- Cerin E
- Chalek J
- Chandan JS
- Chang AR
- Chang AY
- Chang J-C
- Chang K-L
- Charan J
- Charlson FJ
- Chattu VK
- Chaturvedi S
- Cherbuin N
- Chimed-Ochir O
- Chin KL
- Chirinos-Caceres JL
- Cho DY
- Choi J-YJ
- Christensen H
- Chu D-T
- Chung MT
- Chung S-C
- Cicuttini FM
- Ciobanu LG
- Cirillo M
- Cislaghi B
- Classen TKD
- Cohen AJ
- Collins EL
- Comfort H
- Compton K
- Conti S
- Cooper OR
- Corso B
- Cortesi PA
- Costa VM
- Cousin E
- Cowden RG
- Cowie BC
- Cromwell EA
- Croneberger AJ
- Cross DH
- Cross M
- Crowe CS
- Cruz JA
- Cummins S
- Cunningham M
- D'Amico E
- da Silva DD
- Dahlawi SMA
- Dai H
- Dai H
- Damasceno AAM
- Damiani G
- Dandona L
- Dandona R
- Daneshpajouhnejad P
- Dangel WJ
- Danielsson A-K
- Dargan PI
- Darshan BB
- Darwesh AM
- Daryani A
- Das Gupta R
- Das Neves J
- Das JK
- Dash AP
- Davey G
- Davila-Cervantes CA
- Davis AC
- Davitoiu DV
- Davletov K
- De Leo D
- De Neve J-W
- Dean FE
- DeCleene NK
- Deen A
- Defo BK
- Degenhardt L
- DeLang M
- Dellavalle RP
- Demeke FM
- Demoz GT
- Demsie DG
- Denova-Gutierrez E
- Dereje ND
- Deribe K
- Dervenis N
- Desai R
- Desalew A
- Dessie GA
- Deuba K
- Dharmaratne SD
- Dhungana GP
- Dianatinasab M
- Diaz D
- Dichgans M
- Didarloo A
- Dingels ZV
- Dippenaar IN
- Dirac MA
- Djalalinia S
- Do HT
- Dokova K
- Doku DT
- Dolecek C
- Dolgert AJ
- Dorostkar F
- Doshi CP
- Doshi PP
- Doshmangir L
- Douiri A
- Doxey MC
- Doyle KE
- Driscoll TR
- Dubljanin E
- Dunachie SJ
- Duncan BB
- Duraes AR
- Eagan AW
- Ebrahimi H
- Edvardsson D
- Effiong A
- Ehrlich JR
- El Nahas N
- El Sayed I
- El Tantawi M
- El-Jaafary SI
- Elbarazi I
- Elgendy IY
- Elhabashy HR
- Elsharkawy A
- Elyazar IRF
- Emamian MH
- Emmons-Bell S
- Erskine HE
- Eshrati B
- Eskandari K
- Eskandarieh S
- Esmaeilnejad S
- Esmaeilzadeh F
- Esteghamati A
- Esteghamati S
- Estep K
- Etemadi A
- Etisso AE
- Ezekannagha O
- Fanzo J
- Farag T
- Farahmand M
- Faraj A
- Faraon EJA
- Fareed M
- Faridnia R
- Farinha CSES
- Farioli A
- Faris PS
- Faro A
- Faruque M
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- Publication venue
- Publication date
- 01/01/2020
- Field of study
The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 provides a rules-based synthesis of the available evidence on levels and trends in health outcomes, a diverse set of risk factors, and health system responses. GBD 2019 covered 204 countries and territories, as well as first administrative level disaggregations for 22 countries, from 1990 to 2019. Because GBD is highly standardised and comprehensive, spanning both fatal and non-fatal outcomes, and uses a mutually exclusive and collectively exhaustive list of hierarchical disease and injury causes, the study provides a powerful basis for detailed and broad insights on global health trends and emerging challenges. GBD 2019 incorporates data from 281 586 sources and provides more than 3.5 billion estimates of health outcome and health system measures of interest for global, national, and subnational policy dialogue. All GBD estimates are publicly available and adhere to the Guidelines on Accurate and Transparent Health Estimate Reporting. From this vast amount of information, five key insights that are important for health, social, and economic development strategies have been distilled. These insights are subject to the many limitations outlined in each of the component GBD capstone papers.Peer reviewe
Pooled analysis of WHO Surgical Safety Checklist use and mortality after emergency laparotomy
- Author
- Aahlin EK
- Aamer A
- Aaniana K
- Ababneh A
- Abaliksta T
- Abantanga F
- Abantanga F
- Abbas A
- Abbas M
- Abbasy J
- Abbo O
- Abbo O
- Abbott T
- Abbouch M
- Abd El Galeel A
- Abd El Hameed OS
- Abd El Hamid N
- Abd El Salam Y
- Abd El Slam M
- Abd El-Salam F
- Abd Elrasoul Y
- Abd-Elmawla M
- Abd-Elrasoul Y
- Abdallah E
- Abdallah E
- Abdel-Aty A
- Abdel-Hameed N
- Abdel-Kader SM
- Abdel-Wahab NYE
- Abdelaal A
- Abdelaty M
- Abdelazeam AR
- Abdelazim G
- Abdelaziz MA
- Abdelbadeai K
- Abdelfatah A
- AbdelFattah I
- Abdelgelil A
- Abdelghany S
- Abdelhady S
- Abdelhamed R
- Abdelhamid A
- Abdelhaq A
- Abdelkader M
- Abdelkader M
- Abdelkader O
- Abdelkareem A
- Abdelkhalek M
- Abdelmageed E
- Abdelmotaleb I
- Abdelraheim M
- Abdelraouf AM
- Abdelrouf DM
- Abdelshafy M
- Abdelshakour M
- Abdrabou AK
- Abdul-Latif S
- Abdulaziz H
- Abdulaziz M
- Abdulbagi O
- Abdulgawad M
- Abdulhakeem EM
- Abdullah AAN
- Abdullah MA
- Abdullah N
- Abdullah NAN
- Abdullah NAN
- Abdullahi L
- Abdurrazzaaq A
- Abebe NS
- Abebe NS
- Abem OE
- Aber A
- Abington E
- Abiola O
- Aboarab A
- Aboelella M
- Aboelmagd O
- Aboelsoud MR
- Aboraya M
- Aboraya M
- Abouelnasr A
- Aboul-Naga MS
- Abouzahra A
- Abouzaid A
- Abozaid M
- Abozeid K
- Abozyed MAF
- Abu Qumbos A
- Abu-toyour M
- Abubakr M
- Abudeeb H
- Abuowda Y
- Abuqwaider E
- Abusalem L
- Abuseif M
- Abushamleh S
- Acharya P
- Ackom E
- Acquah E
- Adam A
- Adam N
- Adams R
- Adamu A
- Adawi I
- Adawi M
- Adebanjo A
- Adebanjo A
- Adebola O
- Adedeji A
- Adekoya A
- Adel A
- Adel A
- Adel BE
- Adel I
- Adella FJ
- Adelshone A
- Ademuyiwa A
- Ademuyiwa A
- Ademuyiwa AO
- Ademuyiwa AO
- Ademuyiwa AO
- Ademuyiwa AO
- Adenekan B
- Adeniran J
- Adeniran J
- Adeniyi A
- Adeniyi A
- Adesanya O
- Adesanya O
- Adesina A
- Adesina A
- Adesuyi A
- Adeyeye A
- Adeyeye A
- Adeyeye A
- Adham W
- Adhitama N
- Adil M
- Adisa AO
- Adisa AO
- Adu-Aryee N
- Afana S
- Afandy A
- Afifi AM
- Afzal M
- Agalianos C
- Agalianos C
- Agarwal A
- Agarwal A
- Agarwal A
- Agbedinu K
- Agius M
- Aglan A
- Aguado Suarez N
- Aguilar-Jimenez J
- Aguilera M
- Aguilera ML
- Aguilera ML
- Aguilera ML
- Aguilera O
- Aguilera-Arevalo M-L
- Ahlonsou G
- Ahlqvist S
- Ahlqvist S
- Ahlqvist S
- Ahmed A
- Ahmed A
- Ahmed A
- Ahmed EA
- Ahmed H
- Ahmed H
- Ahmed H
- Ahmed LAM
- Ahmed S
- Ahmed S
- Ahmed SM
- Ahounou EYS
- Aigrain Y
- Aiyaman C
- Ajah J
- Ajai O
- Ajao A
- Ajao AE
- Ajiboye A
- Akatibo E
- Akeel N
- Akhtar M
- Akoto E
- Akpenyi O
- Al Amin S
- Al Attar SM
- Al Awwad S
- Al Barrawi FE
- Al Bastawis F
- Al Meligy A
- Al Rafati AAR
- Al Raouf EA
- Al Saied G
- Al Subaie N
- Al-Aarag AA-R
- Al-Azraqi IAA
- Al-Bahrani A
- Al-Buhaisi A
- Al-Dakka E
- Al-Faifi JJ
- Al-faqawi M
- Al-farram H
- Al-Hameedi HII
- Al-Hasani RKMJ
- Al-khatib A
- Al-Mallah A
- Al-Marakby D
- Al-Mousa M
- Al-Nahrawi S
- Al-Obaedi O
- Al-saqqa S
- Al-Saqqa SW
- Al-Saqqa SW
- Al-shammari A
- Al-Slaibi I
- Al-taher T
- Alaael-Dein S
- Alada M
- Alahmady O
- Alakaloko F
- Alakaloko F
- Alaloul E
- Alamin S
- Alamoudi M
- Alamoudi U
- Albeladi B
- Albiety A
- Alcca Ticona W
- Aldalaq A
- Aldhafeeri S
- Aledrisy M
- Alejos Bermudez YE
- Alexander P
- Alexander P
- Alexander P
- Alexandre C
- Alfarsi MA
- Alghamdi A
- Alghamdi B
- Alghamdi M
- Alghamdi MSA
- Algohary O
- Alhabli I
- Alhady K
- Alhammali T
- Alhassan B
- Alhazmi W
- Alhendy M
- Alherz M
- Ali A
- Ali A
- Ali A
- Ali CDM
- Ali E
- Ali FM
- Ali H
- Ali S
- Ali SAWEW
- Ali SS
- Ali THA
- Ali W
- Alihonou T
- Alimi Q
- Alis H
- Aliyu H
- Aliyu M
- Aliyu S
- Aljboor K
- Aljiffry M
- Aljiffry M
- Aljohani E
- Aljohani E
- Aljohani S
- Alkaaki A
- Alkammash A
- Alkelani M
- Alkhabbaz D
- Alkhouri M
- Allam M
- Allam M
- Allam Y
- Allegri A
- Allegri A
- Allen JLY
- Allott R
- Almallah A
- Almoflihi A
- Almuallem S
- Almy J
- Alnaby MH
- Alnawam E
- Alnuqaydan SA
- Alnusairat A
- Alomar IN
- Alqahtani E
- Alqahtani S
- Alrahawy M
- Alrajraji M
- Alrifaie A
- AlRowais M
- Alsaggaf M
- Alsaggaf MU
- Alsaggaf MU
- Alser OH
- Alshareef R
- Altaf A
- Altaf A
- Altamimi A
- Altamimi A
- Altamimi A
- Altamimi A
- Altamini A
- Altarayra M
- Althwainy A
- Altibi A
- Altinel Y
- Altinel Y
- Altoe F
- Altwigry AM
- Altwijri A
- Alvarado Jaramillo R
- Alvarez Barreda LM
- Alvi AR
- Alwafai MG
- Aly AK
- Aly MYM
- Alyacoubi S
- Alyahya R
- Alyami R
- Alyami R
- AlYoussef I
- Alzahrani A
- Alzahrani M
- Alzahrani M
- Alzayat T
- Aman NF
- Amandito R
- Amandito R
- Amandito R
- Amandito R
- Ambrona-Zafra D
- Ambrozeviciute V
- Ameen M
- Amer MA
- Amin HAA
- Amin J
- Amin J
- Amjad M
- Ammar M
- Ammar MS
- Amoah M
- Amoako J
- Amoako PT
- Amoako-Boateng M
- Amole I
- Amreia M
- Amreia M
- Anandkumar D
- Anderson D
- Anderson F
- Anderson R
- Anderson-Knight H
- Andersson L
- Andika FFA
- Andreotti D
- Andres Garcia-Marin J
- Andress C
- Andriola V
- Ang YL
- Angelieri D
- Anis E
- Ansaloni L
- Ansaloni L
- Ansaloni L
- Ansaloni L
- Ansaloni L
- Antar S
- Antezana D
- Anthoulakis C
- Anthoulakis C
- Antoniozzi A
- Anwar AW
- Anwar N
- Anwer W
- Anyanwu L-J
- Anyanwu L-J
- Aonzo P
- Appeadu-Mensah W
- Appiah EK
- Aql S
- Aquilino F
- Arachchi PP
- Arachchige LAJJ
- Arafa O
- Arafa S
- Arango MCM
- Arango MCM
- Aranzabal Durand SY
- Araujo R
- Arcudi C
- Ardley R
- Arenas A
- Arevalo Azmitia JR
- Arias Pacheco RD
- Arman S
- Arman S
- Armando ChunguiBravo J
- Armellini A
- Arnaud A
- Arnaud AP
- Arnaud AP
- Arnaud AP
- Arroyo Basto CA
- Arshad MM
- Arslan E
- Arsyad HM
- Arthur T
- Arulampalam T
- Aruldas N
- Asal M
- Asar YH
- Asare-Bediako K
- Asele FA
- Ashour A
- Ashour A
- Ashour K
- Ashraf SF
- Ashtari M
- Ashton A
- Asi F
- Asilah SMD
- Assal A
- Assouto PA
- Asturia S
- Asumah H
- Ata A
- Ata AAA
- Ata AY
- Atiyeh A
- Atkins ET
- Atkinson K
- Atobatele K
- Attallah NA
- Attard M
- Attia A
- Attia AM
- Augestad KM
- Aung KP
- Austraite A
- Aviles S
- Avoka A
- Awad I
- Awad SA
- Awadallah S
- Awuku-Asabre J
- Ayad S
- Ayandipo O
- Ayandipo OO
- Aydin MC
- Ayyar S
- Aziz DNA
- Aziz MRA
- Aziz NA
- Azizeldine MG
- Azmitia Mendizabal CA
- Azodo IA
- Azzie G
- Azzie G
- Azzis O
- Baba S
- Bachri H
- Badawy M
- Badenjki MA
- Badicel M
- Badr A
- Badr MFM
- Badwi NM
- Badwi NM
- Badwy A
- Bahar S
- Baheeg M
- Bailey K
- Baillie K
- Baillie K
- Baird A
- Bakhaidar M
- Baki BE
- Bakr A
- Bakry HM
- Bala M
- Balalis D
- Baldacchino M
- Balducci G
- Balila RMH
- Balkan AZA
- Ballouhey Q
- Balmaceda R
- Balmaceda R
- Balmaceda R
- Balogun F
- Baltrunas R
- Baluch F
- Bamford R
- Bamicha A
- Bamicha A
- Banaitis VJ
- Bandi A
- Bandoh D
- Bani-Sadar A
- Banipal GS
- Baraka H
- Barakat SAE
- Barendegere V
- Barker T
- Barkolias C
- Barmayehvar B
- Barnabas GN
- Barnacle J
- Barneo L
- Barrionuevo Ojeda RR
- Barrios E
- Barrios E
- Barros De Castro Segundo LC
- Barroso de Lima CV
- Barry J
- Basilico S
- Basir ERM
- Bassem M
- Bassit KA
- Basso SMM
- Basson S
- Batt J
- Bayram S
- Beamon M
- Beasley W
- Beaton C
- Bedada AG
- Bediako-Bowan A
- Behar N
- Beisa V
- Beisa V
- Bekhet AH
- Bekhet NM
- Beleno AEM
- Belkouchi A
- Belli A
- Bello B
- Benammi S
- Benevento A
- Benevento A
- Benger M
- Bennai RM
- Benons N
- Bentounsi Z
- Benyaiche C
- Berti S
- Bertuello I
- Beuran M
- Beuran M
- Beyene R
- Bezerra Morais PA
- Bezzina M
- Bhang A
- Bhangu A
- Bhangu A
- Bhargava A
- Bharj IS
- Bhat S
- Bhatnagar A
- Bhattacharya S
- Bhopal KF
- Bhopal KF
- Bianco F
- Bigaran A
- Billy M
- Bin Adnan A
- Bin Hasnan M
- Bin Ismail MJ
- Bin Mahamood A
- Birindelli A
- Birring A
- Bisset C
- Bjorklund I
- Bjorklund I
- Blacker S
- Blackwell J
- Blanco R
- Blanco-Colino R
- Blencowe N
- Blencowe N
- Bliksoen M
- Blower E
- Bluelle R
- Blundell R
- Boakye-Yiadom K
- Boal M
- Bocchetti T
- Boddy A
- Bode C
- Bode C
- Bodur S
- Boereboom C
- Boggon A
- Boijsen M
- Bokhari S
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- Bonavina L
- Bonavina L
- Bond-Smith G
- Bondin J
- Bondurri A
- Bondurri A
- Boni S
- Bonnard A
- Bonney W
- Borda Luque G
- Borda-Luque G
- Borda-Luque G
- Borg E
- Borg E
- Borg E
- Borin E
- Bortolasi L
- Bortolasi L
- Boshnaq M
- Botes S
- Bottini C
- Botto N
- Bouali O
- Bougard H
- Boukhal K
- Bowabsak A
- Bowe R
- Bowley D
- Bowling K
- Bowman C
- Boyce T
- Bradulskis S
- Bradulskis S
- Bratu M
- Bratu MR
- Bratu R-M
- Braungart S
- Bray LD
- Breaud J
- Breistrand M
- Breitenstein S
- Breslin R
- Brincat SD
- Broch A
- Brogden T
- Brown D
- Brown E
- Brown J
- Brown J
- Browning DRL
- Brunoni B
- Bsisu I
- Bucci L
- Bugaev N
- Bugeja R
- Buisson P
- Bukari M
- Bunting D
- Burger S
- Burmistrovas A
- Burns H
- Bustangi N
- Butt MT
- Cabala Chiong JA
- Cabala Chiong JA
- Cacurri A
- Cadogan DD
- Cahill R
- Cakaloglu HC
- Caliman C
- Callan R
- Camacho R
- Cameron B
- Camilleri GM
- Camilleri-Brennan J
- Camilleri-Brennan J
- Camilleri-Brennan JF
- Camilo Correa J
- Campagnaro T
- Canta Calua A
- Capito C
- Capleton P
- Carabott K
- Careta MC
- Carlucci M
- Carmela Lapitan M
- Carmona JM
- Carpio J
- Carrasco N
- Carreira J-A
- Carreiro De Freitas AV
- Cassar K
- Castro Mollo M
- Catani M
- Cautiero R
- Caydiid H
- Cecilia T
- Celik S
- Cengiz TB
- Cengiz Y
- Cengiz Y
- Cengiz Y
- Cengiz Y
- Ceriani C
- Cevik M
- Chabok A
- Chachulski W
- Chai C-A
- Chai FY
- Chambers A
- Chambers A
- Chan E
- Chan L
- Chan T-YK
- Chan XW
- Chan Z
- Chandrakumar C
- Chang K
- Chang KY-C
- Chapman A
- Chapman SJ
- Charles A
- Cheah AEZ
- Chen CY
- Chen KY
- Chen T-L
- Chenn R
- Cheong YJ
- Chetta N
- Cheung YHE
- Chew LS
- Chhabra S
- Chibuye C
- Chidambaram S
- Chiesa D
- Chilton G
- Chin PX
- Chin YR
- Chiu S
- Chiu S
- Chiu SMY
- Choi J
- Choi P
- Chong BFHK
- Chong CL
- Chong CL
- Chong CL
- Chong CS
- Chong H-Y
- Chong HY
- Choudhry A
- Chow CYN
- Chowdhury A
- Chowdhury D
- Chu K
- Chun A
- Chun T
- Chung KJ
- Chung S
- Ciccioli E
- Cirocchi R
- Ciubotaru C
- Claire R
- Clarissa A
- Clark DJ
- Clark T
- Clegg-Lampety J-N
- Clegg-Lamptey J-N
- Clement KD
- Clements JM
- Clerico G
- Clifford C
- Cloro LM
- Coasaca Huaraya R
- Coccolini F
- Coccolini F
- Coccolini F
- Coccolini F
- Cocker DM
- Cocorullo G
- Cohen DM
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- Cole S
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- Coletti M
- Colombani J-F
- Cona C
- Conci S
- Confalonieri G
- Conlon KC
- Connor K
- Connor K
- Contreras Merida SM
- Contreras Urquizu M
- Contreras Vergara AL
- Contreras E
- Coomber R
- Coompson CL
- Corbellini C
- Corbellino M
- Cornick J
- Coronel J
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- Corro-Diaz S
- Costa C
- Costa-Maia J
- Costa-Maia J
- Costas-Chavarri A
- Costas-Chavarri A
- Courboin E
- Court E
- Cox D
- Cox M
- Coyoy-Gaitan O
- Cragg J
- Craus-Miguel A
- Cross K
- Cruz DH
- Cruz H
- Cucumazzo S
- Cullen F
- Curletti G
- Currow C
- Currow C
- D'aguzan N
- D'Amours S
- D'amours SK
- D'cruz R
- D'Souza MS
- D'Souza R
- Da Silva LA
- Dabboor M
- Dabbour K
- Dabessa D
- Dablouk M
- Dablouk MO
- Dagoe E
- Dahy A
- Dainius E
- Dakubo J
- Dal Canto M
- Dalli J
- Dally C
- Dambrauskas Z
- Dambrauskas Z
- Dan I
- Danelli P
- Daniels I
- Daniyan M
- Danys D
- Dao W
- Daqeeq A
- Dar M
- Dar W
- Dardenne S
- Darweesh M
- Darwish AKZ
- Das A
- Das K
- Das S
- Dasari M
- Dashnyam E
- Dassah V
- Datta U
- Davenport R
- Davies J
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- Dawnay G
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- Dawoud H
- Dayie M
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- De Bono P
- De Franciscis S
- De Luca E
- De Marco P
- De Sousa AV
- Deal R
- Dean R
- Deane C
- Debrah S
- Deckelbaum DL
- Decker E
- Dedekind B
- Dedey F
- Deichsel F
- Del Basso C
- del Pilar Paucar A
- Delforge X
- Dell A
- Dempster E
- Denakpo M
- Denewar A
- Depalma N
- Deputy M
- Der Y
- Dervenis C
- Despotidis V
- Desta S
- Deutschmann P
- Devadasar GH
- Dharamshi HA
- Dhillon D
- Di Franco F
- Di Martino N
- Di Saverio S
- Di Saverio S
- Diab A
- Diaconescu B
- Diaconescu I-B
- Dias S
- Diaz Vico T
- Diaz-Jover P
- Diaz-Zorrilla C
- Dick L
- Dickfos M
- Dickson L
- Dijan E
- Dimech T
- Din F
- Dindyal S
- Dindyal S
- Dione Parreno-Sacdalan M
- Dissanayake T
- Djivoh F
- Domini E
- Domini E
- Donnelly P
- Donoghue D
- Dorani RMNR
- Dorisme A
- dos Santos DV
- Dossou F
- Doughan S
- Doughty J
- Dousset B
- Dragatas D
- Drake TM
- Drake TM
- Drake TM
- Driscoll A
- Drungilas M
- Du Plessis D
- du Plooy F
- Du Toit F
- Duane T
- Dubois A
- Duffy L
- Duhoranenayo D
- Duinhouwer L
- Dulskas A
- Dwydar A
- Ebdewi H
- Ebidy M
- Ebidy MM
- Ebrahim OS
- Eduard P
- Edwards J
- Edye M
- Eid MM
- Eisner L
- Ekow M
- El Ashal G
- El Dahab AA
- El Deen KN
- El Gendy A
- El Gendy NH
- El Halawany M
- El Jamassi A
- El Kashash A
- El Kholy A
- El Magd AA
- El Mesery S
- El Sayed GS
- El Sayed IM
- El Shoura Y
- El-badawy HA
- El-Dien KS
- El-Dien KS
- El-Din RA
- El-Din SA
- El-Gizawy E
- El-Hamouly AS
- El-Kashef H
- El-Latif NK
- El-Ma'doul AS
- El-Rabaa S
- El-Sagheer N
- El-Sawy A
- El-Sehily A
- El-Shahat NS
- El-Sheemy H
- El-Taher E
- Elabdin HZ
- Elashmawy M
- Elashry R
- Elazab A
- Elazayem AA
- Elazoul M
- Elbanby E
- Elbanby ES
- Elbatahgy A
- Elbe P
- Elbermawy M
- Elbisomy KH
- Eldafrawy M
- Eldamaty L
- Eldeeb AZ
- Eldeen EA
- Eldin MAB
- EldosoukyMohammed A
- Elebute O
- Elebute O
- Elena G
- Elfarargy A
- Elfeki H
- Elfeki H
- Elfiky M
- Elfil M
- Elfouly N
- Elfouly N
- Elfouly Y
- Elfouly Y
- Elgebaly A
- Elgendy AH
- Elgendy FI
- Elgheriany M
- Elhadad A
- Elhadary NM
- Elhadry S
- Elhalawany E
- Elhamouly S
- Elhelbawy MS
- Elhendawy A
- Elhendawy AOA
- Elhoseny G
- Elhusseiny AAE
- Elizabeth Lopez C
- Elkadsh I
- Elkady F
- Elkelany A
- Elkelany A
- Elkelany A
- Elkelany A
- Elkhadrawi M
- Elkhalek EA
- Elkholy A
- Elkholy SS
- Elkolaly SS
- Elkorashy AM
- Ellison Q
- Elmashala A
- Elmasry M
- Elmelegy R
- Elmihy S
- Elnagar A
- Elnajjar MA
- Elnemr AE
- Elrazek AA
- Elsabbagh N
- Elsameea AA
- Elsawahly DME
- Elsawy A
- Elsayed M
- Elsayed M
- Elsayed N
- Elsayed NAR
- Elsayed ZM
- Elsebaaye AO
- Elsehimy M
- Elsemelawy R
- Elshaar M
- Elshaer K
- Elshaer M
- Elshaer M
- Elshafay AE
- Elshami M
- Elshanwany S
- Elsharkawy AA
- Elsheikh S
- Elsherbiney S
- Elsherbiny AS
- Elsherif FA
- Elshobary M
- Elsiddig M
- Elsobky S
- Elsorogy DEAA
- Elwaey A
- Elwakil H
- Elwan A
- Elwan A
- Elwy E
- Elzahed N
- Elzayat I
- Elzayat M
- Elzayyat I
- Elzowawi F
- Emadeldin D
- Emadeldin H
- Emara E
- Emile S
- Eng C
- English W
- Esam A
- Escalante Salas MDC
- Espin-Basany E
- Espinoza F
- Essam A
- Essam AA
- Essam M
- Essoun S
- Esteban E
- Estee MM
- Estupinian S
- Etchill E
- Etchill E
- Etienne S
- Etman M
- Etwire V
- Evajelista CV
- Evans D
- Evans E
- Eysa A
- Eyssartier E
- Ezzat E
- Ezzat T
- Faboya O
- Faccincani R
- Fadel A
- Fahiem A
- Fahim M
- Fahmy MAB
- Fahy C
- Fairfield C
- Fairfield C
- Fairfield C
- Fairfield C
- Fakher R
- Falaschi F
- Falco N
- Falzon M
- Farag A
- Farag S
- Farah A
- Farahat MM
- Faraz A
- Fares M
- Farhad M
- Farhan-Alanie MMH
- Farhangmehr N
- Farinella E
- Farmakis K
- Farooq T
- Farouk SAM
- Farquharson A
- Farrugia A
- Farrugia A
- Faruq A
- Fathy AM
- Fattah AA
- Fatuga A
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- Wold TB
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- Wong CY
- Wong F
- Wong HY
- Wood G
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- Worku M
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- Wredberg C
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- Wright NJ
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- Yahaya MT
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- Yeung ENW
- Yeung MHA
- Yifieyeh A
- Yildirim R
- Yip C
- Ymeri S
- Yoganathan P
- Yolcu S
- Yong CO
- Yong GL
- Younis A
- Youssef D
- Youssef H
- Youssef M
- Youssif JH
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- Zaa'treh R
- Zachariades D-C
- Zadoroznas A
- Zahran D
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- Zakaria M
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- Zamarin K
- Zammit S
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- Zani A
- Zani A
- Zani A
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- Zanini N
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- Zapata Ponze De Leon M
- Zapata F
- Zarb C
- Zardab A
- Zegarra S
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- Zelada Alvarez II
- Zerihun AB
- Zeta Solis LA
- Zhang Z
- Zheng F
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- Zidan H
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- Zilinskas J
- Zilinskas J
- Zilinskas J
- Zilinskiene R
- Zilinskiene R
- Zimmermann EF
- Ziubryte G
- Zohair A
- Zorrilla CD
- Zuber M
- Zuber M
- Zuk G
- Zulkifli A
- Zumbuhl L
- Publication venue
- Publication date
- 15/10/2018
- Field of study
Background The World Health Organization (WHO) Surgical Safety Checklist has fostered safe practice for 10 years, yet its place in emergency surgery has not been assessed on a global scale. The aim of this study was to evaluate reported checklist use in emergency settings and examine the relationship with perioperative mortality in patients who had emergency laparotomy. Methods In two multinational cohort studies, adults undergoing emergency laparotomy were compared with those having elective gastrointestinal surgery. Relationships between reported checklist use and mortality were determined using multivariable logistic regression and bootstrapped simulation. Results Of 12 296 patients included from 76 countries, 4843 underwent emergency laparotomy. After adjusting for patient and disease factors, checklist use before emergency laparotomy was more common in countries with a high Human Development Index (HDI) (2455 of 2741, 89.6 per cent) compared with that in countries with a middle (753 of 1242, 60.6 per cent; odds ratio (OR) 0.17, 95 per cent c.i. 0.14 to 0.21, P <0001) or low (363 of 860, 422 per cent; OR 008, 007 to 010, P <0.001) HDI. Checklist use was less common in elective surgery than for emergency laparotomy in high-HDI countries (risk difference -94 (95 per cent c.i. -11.9 to -6.9) per cent; P <0001), but the relationship was reversed in low-HDI countries (+121 (+7.0 to +173) per cent; P <0001). In multivariable models, checklist use was associated with a lower 30-day perioperative mortality (OR 0.60, 0.50 to 073; P <0.001). The greatest absolute benefit was seen for emergency surgery in low- and middle-HDI countries. Conclusion Checklist use in emergency laparotomy was associated with a significantly lower perioperative mortality rate. Checklist use in low-HDI countries was half that in high-HDI countries.Peer reviewe
GSTT1 and GSTM1 null variants in Mestizo and Amerindian populations from northwestern Mexico and a literature review
- Author
- Abbas A
- Acevedo CA
- Agusa T
- Al-Achkar W
- Al-Dayel F
- Angel Licón-Trillo
- Angélica Martínez-Hernández
- Arand M
- Aydin-Sayitoglu M
- Baclig MO
- Binková B
- Board PG
- Bu H
- Buchard A
- Chan JY
- Chiurillo MA
- Cornelis MC
- Csejtei A
- Dandara C
- Danileviciute A
- Dialyna IA
- Dunna NR
- Emilio J. Córdova
- Eslami S
- Everardo González-Rodríguez
- Fujihara J
- Fundia AF
- Galal AM
- García-González I
- Garte S
- Gaspar PA
- Gates MA
- Gra O
- Gutiérrez-Amavizca BE
- Hamdy SI
- Hatagima A
- He HR
- Hishida A
- Irene Leal-Berumen
- Jaramillo-Rangel G
- Juronen E
- Kabesch M
- Kassogue Y
- Kim JH
- Klaus A
- Klinchid J
- Krajinovic M
- Liang S
- Lisker R
- Liu D
- Liu L
- Lorena Orozco
- Luo W
- Luz Elena Palma-Cano
- Masimirembwa CM
- Masood N
- Mauricio González-Ponce
- Miguel Cid
- Ouerhani S
- Pajaud J
- Palli D
- Pemble S
- Petrovic D
- Piacentini S
- Pérez-Morales R
- Pérez-Morales R
- Rafiee L
- Rao DK
- Reszka E
- Ruano-Ravina A
- Ruth Lechuga-Valles
- Sandoval-Carrillo A
- Santovito A
- Song K
- Spurdle AB
- Stosic I
- Sui C
- Sánchez-Guerra M
- Tew KD
- Toncheva DI
- Verónica Moreno-Brito
- Wild CP
- Xu S
- Zhang H
- Zhang J
- Zhang Y
- Zuntar I
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
The outcome of acute schistosomiasis infection in adult mice with postnatal exposure to maternal malnutrition
- Author
- Abath FG
- Adriana Cardoso Gomes
- Ahima RS
- Akpom CA
- Akpom CA
- Alencar ACMB
- Andrade ZA
- Assis AM
- Atinmo T
- Brindley PJ
- Buettner R
- Carmiel-Haggai M
- Casapía M
- Christiane Leal Corrêa
- Costa MFFL
- Costa MFFL
- Costa-Silva M
- Coutinho EM
- Coutinho EM
- Coutinho EM
- Coutinho EM
- Crompton DW
- de Moura EG
- de Moura EG
- Desai M
- Doenhoff MJ
- Doenhoff MJ
- Egberto Gaspar de Moura
- El Ridi R
- Elaine de Oliveira
- Erhuma A
- Fagundes AT
- Fagundes ATS
- Ferreira HS
- Freire N
- Godfrey KM
- Hughes S
- Jardim-Botelho A
- José Roberto Machado-Silva
- Kanuft RF
- Katz N
- Kristan DM
- Lennert K
- Lenzi HL
- Lenzi HL
- Lenzi HL
- Li Hsü HF
- Lisboa PC
- Lisboa PC
- Machado e Silva JR
- Machado e Silva JR
- Magalhães LA
- Marques CM
- Marques RG
- Martinez EM
- Morales-Montor J
- Mota E
- Moura EG
- Moura EG
- Muniz PT
- Neves RH
- Neves RH
- Neves RH
- Normanton H
- Oliveira G
- Oliveira SA
- Ozanne SE
- Parraga IM
- Passos MCF
- Passos MCF
- Patrícia Cristina Lisboa
- Pearce EJ
- Petry CJ
- Picard C
- Plagemann A
- Potter JJ
- Rao MS
- Reeves PG
- Regina Maria Figueiredo de Oliveira
- Rocha H
- Simões C
- Sleigh AC
- Souza-Mello V
- Stephenson LS
- Szücs N
- Tallima H
- Vicente LL
- Vickers MH
- Zhang BH
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Immunoglobulin, glucocorticoid, or combination therapy for multisystem inflammatory syndrome in children: a propensity-weighted cohort study
- Author
- Abdelmeguid Y
- Adams C
- Agrafiotou A
- Agrimbau Vázquez J
- Ahmed YHHZ
- Akomolafe T
- Akyüz Özkan E
- Al-Abadi E
- Alacheva ZA
- Alders N
- Alexeeva E
- Alifieraki S
- Almeida Farias CG
- Almeida FJ
- Altman M
- Alves Leal I
- Amer MA
- Ampuero C
- Ananin PV
- Anaya-Enriquez N
- Andreozzi L
- Angoulvant F
- Ansumanu H
- Antachopoulos C
- Antsupova M
- Araujo da Silva AR
- Araujo e Silva AE
- Aravena J
- Aslam N
- Aston E
- Avila-Aguero ML
- Avram P
- Badheka A
- Badib A
- Badran S
- Badreldin K
- Bailey DM
- Bakradze MD
- Bamford A
- Banegas Pineda LY
- Banks M
- Barreiro STA
- Basu Roy R
- Beattie T
- Belot A
- Berbenyuk A
- Beske F
- Bianco F
- Biggs CM
- Blyuss O
- Bobkova P
- Boleti O
- Bomfim Prado da Silva DG
- Borisova G
- Borjas Aguilar KL
- Borzakova S
- Boyarchuk O
- Boychenko L
- Boyko Y
- Bracken A
- Brenes-Chacón H
- Britton PN
- Broad J
- Broderick C
- Brodin P
- Brotschi B
- Bucciarelli V
- Buonsenso D
- Burch AK
- Burgner DP
- Burns JC
- Bustos B R
- Cai J
- Camacho-Badilla K
- Camacho-Moreno G
- Cantillano Quintero EM
- Carey E
- Carmona R
- Carreon-Guerrero JM
- Carrera JM
- Carrol ED
- Carter M
- Carter MJ
- Casanova D
- Castaño E
- Cervi MC
- Cetin BS
- Chacon-Cruz E
- Chandran A
- Channon-Wells S
- Charisi K
- Charlesworth J
- Chashchina IL
- Chawla J
- Cheung López M
- Chouli M
- Cichon C
- Cimaz R
- Cirks B
- Collia AG
- Cooper H
- Cooray S
- Crawford NW
- Cruces P
- Cunnington AJ
- D'Souza G
- Dallman MD
- David M
- Davies P
- Davis F
- Daza Timana CA
- De Leon T
- De Luca M
- De T
- Dehoorne J
- Delany DR
- Dellepiane RM
- Diaz F
- Dimitrova A
- Diudenko N
- Dos Santos Naja Cardoso MV
- Drysdale SB
- Dunk J
- Dyvonyak O
- Dzora E
- El-Taravi Y
- Eleftheriou I
- Elkhashab Y
- Ellis A
- Emonts M
- Epalza C
- Erdeniz EH
- Estripeaut D
- Evans C
- Fabi M
- Fairchok M
- Farkas D
- Farmaki E
- Faugier Fuentes E
- Fidler K
- Filice E
- Fisenko AP
- Fonseca Flores M
- Foster C
- Fotis L
- Friedman S
- Gadzinska J
- Ganeva M
- García-Domínguez M
- García-Salum T
- Gautier MS
- Geracht J
- Giron Vargas AL
- Giuliano H
- Glazyrina A
- Godoy L
- Gong C
- Gongrun B
- Gonzalez C
- Gorgun B
- Gorlenko C
- Grandjean L
- Grant K
- Grasa CD
- Grosheva M
- Guo J
- Hacohen Y
- Haerynck F
- Hall J
- Hamadouche N
- Hamdan A
- Hamid HKS
- Hassell J
- Heep A
- Heinonen S
- Henriques Teixeira C
- Herberg JA
- Hernandez R
- Heshmat H
- Hesketh C
- Hewlett J
- Hnieno A
- Hoggart C
- Holt-Davis H
- Holter W
- Horne A
- Hossain A
- Hoste L
- Hu S
- Huamán G
- Hudson LD
- Hussein A
- Iakovleva E
- Ibrahim S
- Inchley C
- Ip P
- Iramain R
- Ivankovich-Escoto G
- Jarovsky D
- Jheeta S
- Johnson M
- Johnson S
- Jyothish D
- Kafetzis D
- Kaforou M
- Kalcakosz S
- Kampmann B
- Kandawasvika G
- Kasiyan O
- Katerynych K
- Kavirayani A
- Kelly D
- Keren I
- Ketharanathan N
- Kirubakaran A
- Kiselev H
- Klevberg S
- Knudsen PK
- Koletsi P
- Kondrikova E
- Korobyants E
- Korsunskiy AA
- Kostyuchenko L
- Kourtesi K
- Kovygina K
- Krainz M
- Krasnaya E
- Kucera F
- Kurbanova S
- Kurdup MK
- Kwan MYW
- Kwok J
- Ladj MS
- Lampidi S
- Lanari M
- Langer D
- Langs-Barlow A
- Lau YL
- Lawson G
- Lees EA
- Lenihan R
- Levin M
- Levy J
- Liakopoulou T
- Lillie J
- Lo Vecchio A
- Longbottom K
- Lopez Hernández L
- Lopez Segura N
- Lopez A
- Lopez-Delgado I
- Luder A
- Ludwikowska K
- Lyall H
- Macharia A-M
- Mackdermott N
- Maltby S
- Mamenko M
- Mamutova AV
- Mandziuk J
- Mann K
- Maritsi D
- Martinon-Torres F
- Martins Araujo J
- Masjosthusmann K
- Mastrolia MV
- Mauro A
- Mazankova L
- Mazza A
- McArdle AJ
- Mclelland T
- McMahon A-M
- McMinn A
- Medina RA
- Melendo S
- Melhem I
- Melnyk K
- Menchaca Aguayo HF
- Mendez-Echevarria A
- Mesa Guzmán JM
- Meyer Sauteur P
- Miagka N
- Michailidou E
- Milioudi M
- Miller D
- Miranda M
- Mirza L
- Mitushin IL
- Mohamed Hussein AH
- Montaño-Duron JG
- Morrison Z
- Moshal K
- Moussa A
- Mparmpounaki I
- Mujuru HA
- Muller J
- Munaico M
- Munblit D
- Munblit D
- Musiime G
- Musuka P
- Myttaraki E
- Måseide PH
- Naaman Berezin E
- Nadel S
- Nair S
- Naranjo-Zuniga G
- Nargizyan A
- Natta D
- Nazarenko L
- Nezgoda I
- Nijman RG
- Norero X
- Nuttall L
- Okarska-Napierała M
- Oremakinde O
- Orlova YO
- Osaghae D
- Osman F
- Osmanov IM
- Ostrzewska A
- Ouldali N
- Paccagnella D
- Pace D
- Pachlopnik Schmid J
- Padhye A
- Palacios Argueta JR
- Palazzi Sáfadi MA
- Palmblad K
- Panthula M
- Papa MV
- Papachatzi E
- Papadimitriou E
- Papadopoulou C
- Papaevangelou V
- Patel F
- Patel H
- Patel H
- Paternina-de la Ossa RA
- Payne H
- Pazukhina E
- Penner J
- Peralta C
- Polandi S
- Polyakova AS
- Prader S
- Prendergast AJ
- Pushkareva A
- Pérez L
- Pérez-Gaxiola G
- Quade A
- Ramirez KA
- Ramnarayan P
- Ramnarayan P
- Ramos Tiñini P
- Ranasinghe L
- Ravichandran M
- Record J
- Reel B
- Reiter K
- Relly C
- Rhys-Evans S
- Riordan A
- Rivero-Calle I
- Rivière J
- Rockett J
- Rodrigues CMC
- Rodríguez-González M
- Roe L
- Roilides E
- Rojas-Bonilla M
- Rojo P
- Romaine S
- Romani L
- Romanova O
- Rubiños M
- Rykova S
- Samitova E
- Sanchez Manubens J
- Santos RP
- Sayed IA
- Scarano SM
- Schelstraete P
- Schlapbach LJ
- Schobi N
- Scuccimarri R
- Seaby EG
- Seddon J
- Seiler M
- Seminario D
- Shah P
- Shahin AA
- Shingadia D
- Shoman W
- Shvedova A
- Sikdar O
- Simonini G
- Soler-Palacin P
- Sologub A
- Soriano-Arandes A
- Soriano-Fallas A
- Souza Vieira C
- Srivastava A
- Stefanov S
- Strasser S
- Struik S
- Sun T
- Svyst O
- Szekeres K
- Tagarro A
- Tan R
- Tan RW
- Taylor A
- Taylor A
- Taylor A
- Telcharova-Mihaylovska A
- Tepaev RF
- Teslenko M
- Tipo V
- Tkacheva AA
- To K
- Torpiano P
- Tostado-Morales E
- Tran S
- Tremoulet A
- Tremoulet A
- Trykosh M
- Trück J
- Tsagkaris S
- Tsiatsiou O
- Tsolas G
- Tsolia M
- Tudor-Williams G
- Ulloa-Gutierrez R
- Ulloa-Gutierrez R
- Ulreich R
- Umaru S
- Valadez J
- Valenzuela Galaz G
- Van den Berg S
- Van den Heuvel I
- Van der Velden F
- Vandekerckhove K
- Vantsi P
- Vasilenko N
- Veliz N
- Ventilacion L
- Verdoni L
- Vermont C
- Villaverde S
- Vito O
- Volokha A
- Von Both U
- Wangai F
- Wasserman S
- Weber K
- Wellman PA
- Whittaker E
- Widener R
- Willems J
- Wilson C
- Withers Green J
- Withington D
- Wong JSC
- Wong M
- Wong S
- Wood N
- Wütz D
- Yakout RM
- Yanney MP
- Yegiyan M
- Yeung S
- Yock-Corrales A
- Yori S
- Yusupova V
- Zapata Yarlequé EH
- Zholobova E
- Zsigmond B
- Zurl C
- Şahin IO
- Publication venue
- 'Elsevier BV'
- Publication date
- 13/01/2023
- Field of study
Background Multisystem inflammatory syndrome in children (MIS-C), a hyperinflammatory condition associated with SARS-CoV-2 infection, has emerged as a serious illness in children worldwide. Immunoglobulin or glucocorticoids, or both, are currently recommended treatments. Methods The Best Available Treatment Study evaluated immunomodulatory treatments for MIS-C in an international observational cohort. Analysis of the first 614 patients was previously reported. In this propensity-weighted cohort study, clinical and outcome data from children with suspected or proven MIS-C were collected onto a web-based Research Electronic Data Capture database. After excluding neonates and incomplete or duplicate records, inverse probability weighting was used to compare primary treatments with intravenous immunoglobulin, intravenous immunoglobulin plus glucocorticoids, or glucocorticoids alone, using intravenous immunoglobulin as the reference treatment. Primary outcomes were a composite of inotropic or ventilator support from the second day after treatment initiation, or death, and time to improvement on an ordinal clinical severity scale. Secondary outcomes included treatment escalation, clinical deterioration, fever, and coronary artery aneurysm occurrence and resolution. This study is registered with the ISRCTN registry, ISRCTN69546370. Findings We enrolled 2101 children (aged 0 months to 19 years) with clinically diagnosed MIS-C from 39 countries between June 14, 2020, and April 25, 2022, and, following exclusions, 2009 patients were included for analysis (median age 8·0 years [IQR 4·2–11·4], 1191 [59·3%] male and 818 [40·7%] female, and 825 [41·1%] White). 680 (33·8%) patients received primary treatment with intravenous immunoglobulin, 698 (34·7%) with intravenous immunoglobulin plus glucocorticoids, 487 (24·2%) with glucocorticoids alone; 59 (2·9%) patients received other combinations, including biologicals, and 85 (4·2%) patients received no immunomodulators. There were no significant differences between treatments for primary outcomes for the 1586 patients with complete baseline and outcome data that were considered for primary analysis. Adjusted odds ratios for ventilation, inotropic support, or death were 1·09 (95% CI 0·75–1·58; corrected p value=1·00) for intravenous immunoglobulin plus glucocorticoids and 0·93 (0·58–1·47; corrected p value=1·00) for glucocorticoids alone, versus intravenous immunoglobulin alone. Adjusted average hazard ratios for time to improvement were 1·04 (95% CI 0·91–1·20; corrected p value=1·00) for intravenous immunoglobulin plus glucocorticoids, and 0·84 (0·70–1·00; corrected p value=0·22) for glucocorticoids alone, versus intravenous immunoglobulin alone. Treatment escalation was less frequent for intravenous immunoglobulin plus glucocorticoids (OR 0·15 [95% CI 0·11–0·20]; p<0·0001) and glucocorticoids alone (0·68 [0·50–0·93]; p=0·014) versus intravenous immunoglobulin alone. Persistent fever (from day 2 onward) was less common with intravenous immunoglobulin plus glucocorticoids compared with either intravenous immunoglobulin alone (OR 0·50 [95% CI 0·38–0·67]; p<0·0001) or glucocorticoids alone (0·63 [0·45–0·88]; p=0·0058). Coronary artery aneurysm occurrence and resolution did not differ significantly between treatment groups. Interpretation Recovery rates, including occurrence and resolution of coronary artery aneurysms, were similar for primary treatment with intravenous immunoglobulin when compared to glucocorticoids or intravenous immunoglobulin plus glucocorticoids. Initial treatment with glucocorticoids appears to be a safe alternative to immunoglobulin or combined therapy, and might be advantageous in view of the cost and limited availability of intravenous immunoglobulin in many countries. Funding Imperial College London, the European Union's Horizon 2020, Wellcome Trust, the Medical Research Foundation, UK National Institute for Health and Care Research, and National Institutes of Health