The ANTENATAL multicentre study to predict postnatal renal outcome in fetuses with posterior urethral valves: objectives and design

Abstract Background Posterior urethral valves (PUV) account for 17% of paediatric end-stage renal disease. A major issue in the management of PUV is prenatal prediction of postnatal renal function. Fetal ultrasound and fetal urine biochemistry are currently employed for this prediction, but clearly lack precision. We previously developed a fetal urine peptide signature that predicted in utero with high precision postnatal renal function in fetuses with PUV. We describe here the objectives and design of the prospective international multicentre ANTENATAL (multicentre validation of a fetal urine peptidome-based classifier to predict postnatal renal function in posterior urethral valves) study, set up to validate this fetal urine peptide signature. Methods Participants will be PUV pregnancies enrolled from 2017 to 2021 and followed up until 2023 in >30 European centres endorsed and supported by European reference networks for rare urological disorders (ERN eUROGEN) and rare kidney diseases (ERN ERKNet). The endpoint will be renal/patient survival at 2 years postnatally. Assuming α = 0.05, 1–β = 0.8 and a mean prevalence of severe renal outcome in PUV individuals of 0.35, 400 patients need to be enrolled to validate the previously reported sensitivity and specificity of the peptide signature. Results In this largest multicentre study of antenatally detected PUV, we anticipate bringing a novel tool to the clinic. Based on urinary peptides and potentially amended in the future with additional omics traits, this tool will be able to precisely quantify postnatal renal survival in PUV pregnancies. The main limitation of the employed approach is the need for specialized equipment. Conclusions Accurate risk assessment in the prenatal period should strongly improve the management of fetuses with PUV

Cracks, microcracks and fracture in polymer structures: Formation, detection, autonomic repair

The first author would like to acknowledge the financial support from the European Union under the FP7 COFUND Marie Curie Action. N.M.P. is supported by the European Research Council (ERC StG Ideas 2011 n. 279985 BIHSNAM, ERC PoC 2015 n. 693670 SILKENE), and by the EU under the FET Graphene Flagship (WP 14 “Polymer nano-composites” n. 696656)

Langues indigènes de l'Amérique hispanique

Launey Michel. Langues indigènes de l'Amérique hispanique. In: École pratique des hautes études. 4e section, sciences historiques et philologiques. Livret 10. 1994-1995. 1996. pp. 191-192

Que faire d’intelligent avec les langues maternelles ?

Des contraintes acceptées Les réflexions qui suivent s’inscrivent dans deux données incontournables. D’une part, la langue française se trouve en position exclusive dans la sphère publique et, d’autre part, il existe, comme parties constitutives de l’ensemble national, des départements et collectivités d’outre-mer, habités par des citoyens français qui présentent par rapport au prototype hexagonal un certain nombre de spécificités linguistico-culturelles. Prenant acte de la première c..

Langues indigènes de l'Amérique hispanique

Launey Michel. Langues indigènes de l'Amérique hispanique. In: École pratique des hautes études. 4e section, sciences historiques et philologiques. Livret 10. 1994-1995. 1996. pp. 191-192

Olmos, Fray A. de. — Arte de la lengua mexicana

Launey Michel. Olmos, Fray A. de. — Arte de la lengua mexicana. In: Journal de la Société des Américanistes. Tome 81, 1995. pp. 348-352