Mime: The Musical

This is a script, including scores and lyrics, for a new musical. Premise Listening is the key to harmony. Those who do not listen to others provoke disorder, chaos, and war; but a listening ear brings peace, love, and happiness. Cast of Characters Siga -A rebellious mime prince, who believes in talking and especially singing; Rayrna -The beautiful princess of Speak City; King- The old fashioned king of Speak City; Queen- The King\u27s nagging wife; Advisor- The King\u27s evil advisor, who wants to marry Rayma; Guard 1- One of the King\u27s guards; Guard 2- Another Guard; Guard 3 - One of the King\u27 s goofy spies; Guard 4- An equally goofy spy. Time and Place Setting - The play is set in Speak City. In a fairytale time period of the past, when Mimes inhabited a portion of the earth

Georgia College & State University Nursing Program

In order to evaluate the effectiveness of the Georgia College & State University (GC&SU) Nursing Program, a non-experimental, survey research study was conducted by senior nursing students in the Nursing Research class. The survey evaluated the teaching and learning strategies used in the program, the students\u27 perceptions of preparedness for nursing after graduation, and the students\u27 perceptions of the strengths and weaknesses of the GC&SU nursing curriculum. Each participant signed an informed consent form. Forty-five out of a possible 142 nursing students responded to the survey. A statistical analysis of the responses was conducted and comparisons of answers were analyzed across the different nursing cohorts. Implications and recommendations for changes for the GC&SU Nursing Program were stated. As demand for registered nurses continues to increase, nursing programs in the United States are rising to meet this need by educating clinically proficient nurses. GC&SU nursing program graduates approximately 80 nursing students per year. In May 2003, 94% of the nursing graduates passed the licensure exam, helping fill the need in healthcare settings. Nursing faculty realize that they must prepare nurses who are adept at performing essential nursing skills including assessment, safe medication administration, nursing care for ill clients and health teaching

Genome-wide Analyses Identify KIF5A as a Novel ALS Gene

To identify novel genes associated with ALS, we undertook two lines of investigation. We carried out a genome-wide association study comparing 20,806 ALS cases and 59,804 controls. Independently, we performed a rare variant burden analysis comparing 1,138 index familial ALS cases and 19,494 controls. Through both approaches, we identified kinesin family member 5A (KIF5A) as a novel gene associated with ALS. Interestingly, mutations predominantly in the N-terminal motor domain of KIF5A are causative for two neurodegenerative diseases: hereditary spastic paraplegia (SPG10) and Charcot-Marie-Tooth type 2 (CMT2). In contrast, ALS-associated mutations are primarily located at the C-terminal cargo-binding tail domain and patients harboring loss-of-function mutations displayed an extended survival relative to typical ALS cases. Taken together, these results broaden the phenotype spectrum resulting from mutations in KIF5A and strengthen the role of cytoskeletal defects in the pathogenesis of ALS.Peer reviewe

Genetic correlation between amyotrophic lateral sclerosis and schizophrenia

A. Palotie on työryhmän Schizophrenia Working Grp Psychiat jäsen.We have previously shown higher-than-expected rates of schizophrenia in relatives of patients with amyotrophic lateral sclerosis (ALS), suggesting an aetiological relationship between the diseases. Here, we investigate the genetic relationship between ALS and schizophrenia using genome-wide association study data from over 100,000 unique individuals. Using linkage disequilibrium score regression, we estimate the genetic correlation between ALS and schizophrenia to be 14.3% (7.05-21.6; P = 1 x 10(-4)) with schizophrenia polygenic risk scores explaining up to 0.12% of the variance in ALS (P = 8.4 x 10(-7)). A modest increase in comorbidity of ALS and schizophrenia is expected given these findings (odds ratio 1.08-1.26) but this would require very large studies to observe epidemiologically. We identify five potential novel ALS-associated loci using conditional false discovery rate analysis. It is likely that shared neurobiological mechanisms between these two disorders will engender novel hypotheses in future preclinical and clinical studies.Peer reviewe

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

The Neutralization Theory of Hatred

We argue herein that, while often conceptualized as an extreme form of anger, hatred is a human emotion distinct from anger, with unique triggers, conceptual orientations, and terminating conditions. An examination of the social conditions of our species’ evolutionary history reveals that hatred evolved to address its own distinct adaptive problem: individuals whose existence was -- on balance -- costly to the hater. Because a well-designed system for solving this problem would have been tailored toward neutralizing those costs, we call this hypothesis ‘the neutralization theory of hatred.’ This theory places the features of hatred within a functional framework. Specifically, we argue that hatred is triggered by cues that an individual’s existence causes fitness decrements for the hater. Cognitively, hatred orients the mind so as to view costs heaped onto the hated person as benefits to the hater -- thus motivating spiteful behavior -- and can be characterized as maintaining a negative intrinsic welfare tradeoff parameter toward the hated person. Behaviorally, hatred can motivate either avoidance or a predatory style cost infliction strategy that is designed to weaken, incapacitate, or terminate the target. Hatred can be a dangerous emotion, and we believe a more thorough understanding of its evolved function is crucial for developing strategies that help mitigate its costs to society at large

Freeze-Form Extrusion Fabrication of Functionally Graded Material Composites Using Zirconium Carbide and Tungsten

Ultra-high-temperature ceramics are being investigated for future use in aerospace applications due to their superior thermo-mechanical properties, as well as their oxidation resistance, at temperatures above 2000°C. However, their brittleness makes them susceptible to thermal shock failure. As graded composites, components fabricated as functionally-graded materials (FGMs) can combine the superior properties of ceramics with the toughness of an underlying refractory metal. This paper discusses the grading of two materials through the use of a Freeze-form Extrusion Fabrication (FEF) system to build FGM parts consisting of zirconium carbide (ZrC) and tungsten (W). Aqueous-based colloidal suspensions of ZrC and W were developed and utilized in the FEF process to fabricate test bars graded from 100%ZrC to 50%-W50%ZrC (volume percent). After FEF processing, the test bars were co-sintered at 2300°C and characterized to determine their resulting density and microstructure. Four-point bending tests were performed to assess the flexural strength of the test bars made using the FEF process, compared to that prepared using conventional powder processing and isostatic pressing techniques, for five distinct ZrC-W compositions. Scanning electron microscopy (SEM) was used to examine the inner structure of composite parts built using the FEF process.Mechanical Engineerin