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Sequence logic at enhancers governs a dual mechanism of endodermal organ fate induction by FOXA pioneer factors
FOXA pioneer transcription factors (TFs) associate with primed enhancers in endodermal organ precursors. Using a human stem cell model of pancreas differentiation, we here discover that only a subset of pancreatic enhancers is FOXA-primed, whereas the majority is unprimed and engages FOXA upon lineage induction. Primed enhancers are enriched for signal-dependent TF motifs and harbor abundant and strong FOXA motifs. Unprimed enhancers harbor fewer, more degenerate FOXA motifs, and FOXA recruitment to unprimed but not primed enhancers requires pancreatic TFs. Strengthening FOXA motifs at an unprimed enhancer near NKX6.1 renders FOXA recruitment pancreatic TF-independent, induces priming, and broadens the NKX6.1 expression domain. We make analogous observations about FOXA binding during hepatic and lung development. Our findings suggest a dual role for FOXA in endodermal organ development: first, FOXA facilitates signal-dependent lineage initiation via enhancer priming, and second, FOXA enforces organ cell type-specific gene expression via indirect recruitment by lineage-specific TFs
Search for single top quarks in the tau+jets channel using 4.8 fb of collision data
We present the first direct search for single top quark production using tau
leptons. The search is based on 4.8 fb of integrated luminosity
collected in collisions at =1.96 TeV with the D0 detector
at the Fermilab Tevatron Collider. We select events with a final state
including an isolated tau lepton, missing transverse energy, two or three jets,
one or two of them tagged. We use a multivariate technique to discriminate
signal from background. The number of events observed in data in this final
state is consistent with the signal plus background expectation. We set in the
tau+jets channel an upper limit on the single top quark cross section of
\TauLimObs pb at the 95% C.L. This measurement allows a gain of 4% in expected
sensitivity for the observation of single top production when combining it with
electron+jets and muon+jets channels already published by the D0 collaboration
with 2.3 fb of data. We measure a combined cross section of
\SuperCombineXSall pb, which is the most precise measurement to date.Comment: 12 pages, 5 figure
Measurement of Z/gamma*+jet+X angular distributions in ppbar collisions at sqrt{s}=1.96 TeV
We present the first measurements at a hadron collider of differential cross
sections for Z+jet+X production in delta phi(Z, jet), |delta y(Z, jet)| and
|y_boost(Z, jet)|. Vector boson production in association with jets is an
excellent probe of QCD and constitutes the main background to many small cross
section processes, such as associated Higgs production. These measurements are
crucial tests of the predictions of perturbative QCD and current event
generators, which have varied success in describing the data. Using these
measurements as inputs in tuning event generators will increase the
experimental sensitivity to rare signals.Comment: Published in Physics Letters B 682 (2010), pp. 370-380. 15 pages, 6
figure
Search for the standard model Higgs boson in tau final states
We present a search for the standard model Higgs boson using hadronically
decaying tau leptons, in 1 inverse femtobarn of data collected with the D0
detector at the Fermilab Tevatron ppbar collider. We select two final states:
tau plus missing transverse energy and b jets, and tau+ tau- plus jets. These
final states are sensitive to a combination of associated W/Z boson plus Higgs
boson, vector boson fusion and gluon-gluon fusion production processes. The
observed ratio of the combined limit on the Higgs production cross section at
the 95% C.L. to the standard model expectation is 29 for a Higgs boson mass of
115 GeV.Comment: publication versio
Search for W' bosons decaying to an electron and a neutrino with the D0 detector
This Letter describes the search for a new heavy charged gauge boson W'
decaying into an electron and a neutrino. The data were collected with the D0
detector at the Fermilab Tevatron proton-antiproton Collider at a
center-of-mass energy of 1.96 TeV, and correspond to an integrated luminosity
of about 1 inverse femtobarn. Lacking any significant excess in the data in
comparison with known processes, an upper limit is set on the production cross
section times branching fraction, and a W' boson with mass below 1.00 TeV can
be excluded at the 95% C.L., assuming standard-model-like couplings to
fermions. This result significantly improves upon previous limits, and is the
most stringent to date.Comment: submitted to Phys. Rev. Let
Search for a scalar or vector particle decaying into Zgamma in ppbar collisions at sqrt(s) = 1.96 TeV
We present a search for a narrow scalar or vector resonance decaying into
Zgamma with a subsequent Z decay into a pair of electrons or muons. The data
for this search were collected with the D0 detector at the Fermilab Tevatron
ppbar collider at a center of mass energy sqrt(s) = 1.96 TeV. Using 1.1 (1.0)
fb-1 of data, we observe 49 (50) candidate events in the electron (muon)
channel, in good agreement with the standard model prediction. From the
combination of both channels, we derive 95% C.L. upper limits on the cross
section times branching fraction (sigma x B) into Zgamma. These limits range
from 0.19 (0.20) pb for a scalar (vector) resonance mass of 600 GeV/c^2 to 2.5
(3.1) pb for a mass of 140 GeV/c^2.Comment: Published by Phys. Lett.
Search for the associated production of a b quark and a neutral supersymmetric Higgs boson which decays to tau pairs
We report results from a search for production of a neutral Higgs boson in
association with a quark. We search for Higgs decays to pairs with
one subsequently decaying to a muon and the other to hadrons. The data
correspond to 2.7fb of \ppbar collisions recorded by the D0 detector
at TeV. The data are found to be consistent with background
predictions. The result allows us to exclude a significant region of parameter
space of the minimal supersymmetric model.Comment: Submitted to Phys. Rev. Letter
Search for charged Higgs bosons in top quark decays
We present a search for charged Higgs bosons in top quark decays. We analyze
the \eplus, \muplus, , , , \etau and \mutau final states from
top quark pair production events, using data from about 1 of
integrated luminosity recorded by the \dzero experiment at the Fermilab
Tevatron Collider. We consider different scenarios of possible charged Higgs
boson decays, one where the charged Higgs boson decays purely hadronically into
a charm and a strange quark, another where it decays into a lepton and a
neutrino and a third one where both decays appear. We extract limits on
the branching ratio for all these models. We use two methods,
one where the production cross section is fixed, and one where the
cross section is fitted simultaneously with . Based on the
extracted limits, we exclude regions in the charged Higgs boson mass and parameter space for different scenarios of the minimal supersymmetric
standard model.Comment: 10 pages, 8 figures, submitted to PL
VERTIGO (VERtical Transport In the Global Ocean) : a study of particle sources and flux attenuation in the North Pacific
Author Posting. © Elsevier B.V., 2008. This is the author's version of the work. It is posted here by permission of Elsevier B.V. for personal use, not for redistribution. The definitive version was published in Deep Sea Research Part II: Topical Studies in Oceanography 55 (2008): 1522-1539, doi:10.1016/j.dsr2.2008.04.024.The VERtical Transport In the Global Ocean (VERTIGO) study examined particle sources and
fluxes through the ocean’s “twilight zone” (defined here as depths below the euphotic zone to
1000 m). Interdisciplinary process studies were conducted at contrasting sites off Hawaii
(ALOHA) and in the NW Pacific (K2) during 3 week occupations in 2004 and 2005, respectively.
We examine in this overview paper the contrasting physical, chemical and biological settings and
how these conditions impact the source characteristics of the sinking material and the transport
efficiency through the twilight zone. A major finding in VERTIGO is the considerably lower
transfer efficiency (Teff) of particulate organic carbon (POC), POC flux 500 / 150 m, at ALOHA
(20%) vs. K2 (50%). This efficiency is higher in the diatom-dominated setting at K2 where
silica-rich particles dominate the flux at the end of a diatom bloom, and where zooplankton and
their pellets are larger. At K2, the drawdown of macronutrients is used to assess export and
suggests that shallow remineralization above our 150 m trap is significant, especially for N
relative to Si. We explore here also surface export ratios (POC flux/primary production) and
possible reasons why this ratio is higher at K2, especially during the first trap deployment. When
we compare the 500 m fluxes to deep moored traps, both sites lose about half of the sinking POC
by >4000 m, but this comparison is limited in that fluxes at depth may have both a local and
distant component. Certainly, the greatest difference in particle flux attenuation is in the
mesopelagic, and we highlight other VERTIGO papers that provide a more detailed examination
of the particle sources, flux and processes that attenuate the flux of sinking particles. Ultimately,
we contend that at least three types of processes need to be considered: heterotrophic degradation
of sinking particles, zooplankton migration and surface feeding, and lateral sources of suspended
and sinking materials. We have evidence that all of these processes impacted the net attenuation
of particle flux vs. depth measured in VERTIGO and would therefore need to be considered and
quantified in order to understand the magnitude and efficiency of the ocean’s biological pump.Funding for VERTIGO was provided primarily by research grants
from the US National Science Foundation Programs in Chemical and Biological Oceanography
(KOB, CHL, MWS, DKS, DAS). Additional US and non-US grants included: US Department
of Energy, Office of Science, Biological and Environmental Research Program (JKBB); the
Gordon and Betty Moore Foundation (DMK); the Australian Cooperative Research Centre
program and Australian Antarctic Division (TWT); Chinese NSFC and MOST programs (NZJ);
Research Foundation Flanders and Vrije Universiteit Brussel (FD, ME); JAMSTEC (MCH); New
Zealand Public Good Science Foundation (PWB); and internal WHOI sources and a contribution
from the John Aure and Cathryn Ann Hansen Buesseler Foundation (KOB)
Measurement of the differential cross section for the production of an isolated photon with associated jet in ppbar collisions at sqrt(s)=1.96 TeV
The process ppbar -> photon + jet + X is studied using 1.0 fb^-1 of data
collected by the D0 detector at the Fermilab Tevatron ppbar collider at a
center-of-mass energy sqrt(s)=1.96 TeV. Photons are reconstructed in the
central rapidity region |y_gamma|<1.0 with transverse momenta in the range
30<Pt_gamma<400 GeV while jets are reconstructed in either the central
|y_jet|15 GeV.
The differential cross section d^3sigma/dPt_gamma dy_gamma dy_jet is measured
as a function of Pt_gamma in four regions, differing by the relative
orientations of the photon and the jet in rapidity. Ratios between the
differential cross sections in each region are also presented. Next-to-leading
order QCD predictions using different parameterizations of parton distribution
functions and theoretical scale choices are compared to the data. The
predictions do not simultaneously describe the measured normalization and
Pt_gamma dependence of the cross section in any of the four measured regions.Comment: 13 pages, 10 figure
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