Le Petit Roi d’Amour : entre dévotion privée et politique

À la veille du second conflit mondial, une Augustine hospitalière du Morbihan, Yvonne-Aimée de Malestroit (1901-1951), promeut le culte du Petit Roi d’Amour. Depuis la fin du Moyen Âge, et surtout à partir du XVIIe siècle, la dévotion à l’Enfant Jésus a une dimension politique très nette. À travers les notions de « spiritualité victimale » et de « logique sacrificielle », l’Enfant Jésus véhicule – comme le culte du Sacré-Cœur auquel il est partiellement lié – l’idée d’un retour à une France catholique et monarchique. Quant à Mère Yvonne-Aimée, elle est désignée par Dieu pendant la guerre pour « expier » les fautes des hommes pécheurs. Elle interprète le deuxième conflit mondial comme un « châtiment de Dieu » et rêve d’une France « régénérée » et « réconciliée avec Dieu ». Tout portait donc la religieuse à adhérer à la Révolution nationale du maréchal Pétain qui dénonçait une « France pécheresse » et parlait de « réparations nécessaires ». Pourtant, dès les premiers jours du conflit, Yvonne-Aimée soutient activement les réseaux de résistance bretons, au point de recevoir le 22 juillet 1945 la légion d’honneur des mains du général de Gaulle. La mystique devient une « héroïne nationale ». En revanche, l’Église, en 1960 – à la veille de Vatican II – suspend son procès de béatification et désavoue sans appel l’héroïne.Just before the second world war, an hospitaller Augustinian of Morbihan, Yvonne-Aimée de Malestroit (1901-1951), promotes the devotion to the Little King of Love. Since the end of the Middle Age, and especially from the XVIIth century, the devotion to the Christ Child has a political dimension. Through notions of “victimale spirituality” and “sacrificial logic”, the Christ Child brings – like the cult of Bled-Heart to which it is particularly linked – the idea of a return to a catholic and monarchic France. As for Yvonne-Aimée, God calls her during the war to “expiate” offences of a sinner humanity. Indeed she interprets the war like “God’s punishment”. Therefore, Yvonne-Aimée and her devotion are really in agreement with the marshal Pétain National Revolution which denounced a “sinner France” and talk about “necessary reparations”. However, as soon as the war begins, Yvonne-Aimée supports resistance networks in Brittany, and then receives in 1945 the Legion of Honour from the general De Gaulle himself. The mystic becomes a “national heroine”. In return, in 1960 the Church – at Vatican II eve – suspends her beatification proceedings and denies the heroine.En vísperas del segundo conflicto mundial, una Augustiniana hospitalaria del Morbihan, Yvonne-Aimée de Malestroit (1901-1951) promeve el culto del Pequeño Rei de Amor. Desde el fin de la Edad Media, y sobre todo a partir del siglo XVII la devoción al Niño Jesús tiene una dimensión política muy clara. A través de las nociones de “spiritualidad victímala” y de “lógica sacrifíciala”, el Niño Jesús transmite -como el culto del Sagrado Corazón al cual está particularmente atado- la idea de un regreso a una Francia católica y monárquica. En cuanto a la Madre Yvonne-Aimée, está designada por Dios durante la guerra para “expiar” las faltas de los hombres pecadores e interpreta el segundo conflicto mundial como un “castigo de Dios”. Así Madre Yvonne-Aimée parece adherirse a la Revolución Nacional del mariscal Pétain que denunciaba une “Francia pecadora” y hablaba de “reparaciones necesarias”. Sin embargo, desde los primeros días del conflicto, Yvonne-Aimée sostiene activamente las redes de Resistancia en Bretaña, hasta recibir, el 22 de julio del 1945, la Legión de Honor de los manos del General de Gaulle. La mística llega a una “heroína nacional”. En cambio, en 1960, la Iglesia -en vísperas de Vatican II- suspende su proceso de beatificación y renega la heroína

Novel concept to guide systolic heart failure medication by repeated biomarker testing-results from TIME-CHF in context of predictive, preventive, and personalized medicine

Background It is uncertain whether repeated measurements of a multi-target biomarker panel may help to personalize medical heart failure (HF) therapy to improve outcome in chronic HF. Methods This analysis included 499 patients from the Trial of Intensified versus standard Medical therapy in Elderly patients with Congestive Heart Failure (TIME-CHF), aged >= 60 years, LVEF = II, who had repeated clinical visits within 19 months follow-up. The interaction between repeated measurements of biomarkers and treatment effects of loop diuretics, spironolactone, beta-blockers, and renin-angiotensin system (RAS) inhibitors on risk of HF hospitalization or death was investigated in a hypothesis-generating analysis. Generalized estimating equation (GEE) models were used to account for the correlation between recurrences of events in a patient. Results One hundred patients (20%) had just one event (HF hospitalization or death) and 87 (17.4%) had at least two events. Loop diuretic up-titration had a beneficial effect for patients with high interleukin-6 (IL6) or high high-sensitivity C-reactive protein (hsCRP) (interaction, P = 0.013 and P = 0.001), whereas the opposite was the case with low hsCRP (interaction, P = 0.013). Higher dosage of loop diuretics was associated with poor outcome in patients with high blood urea nitrogen (BUN) or prealbumin (interaction, P = 0.006 and P = 0.001), but not in those with low levels of these biomarkers. Spironolactone up-titration was associated with lower risk of HF hospitalization or death in patients with high cystatin C (CysC) (interaction, P = 0.021). beta-Blockers up-titration might have a beneficial effect in patients with low soluble fms-like tyrosine kinase-1 (sFlt) (interaction, P = 0.021). No treatment biomarker interactions were found for RAS inhibition. Conclusion The data of this post hoc analysis suggest that decision-making using repeated biomarker measurements may be very promising in bringing treatment of heart failure to a new level in the context of predictive, preventive, and personalized medicine. Clearly, prospective testing is needed before this novel concept can be adopted

Guideline implementation, drug sequencing, and quality of care in heart failure:design and rationale of TITRATE-HF

Aims: Current heart failure (HF) guidelines recommend to prescribe four drug classes in patients with HF with reduced ejection fraction (HFrEF). A clear challenge exists to adequately implement guideline-directed medical therapy (GDMT) regarding the sequencing of drugs and timely reaching target dose. It is largely unknown how the paradigm shift from a serial and sequential approach for drug therapy to early parallel application of the four drug classes will be executed in daily clinical practice, as well as the reason clinicians may not adhere to new guidelines. We present the design and rationale for the real-world TITRATE-HF study, which aims to assess sequencing strategies for GDMT initiation, dose titration patterns (order and speed), intolerance for GDMT, barriers for implementation, and long-term outcomes in patients with de novo, chronic, and worsening HF. Methods and results: A total of 4000 patients with HFrEF, HF with mildly reduced ejection fraction, and HF with improved ejection fraction will be enrolled in &gt;40 Dutch centres with a follow-up of at least 3 years. Data collection will include demographics, physical examination and vital parameters, electrocardiogram, laboratory measurements, echocardiogram, medication, and quality of life. Detailed information on titration steps will be collected for the four GDMT drug classes. Information will include date, primary reason for change, and potential intolerances. The primary clinical endpoints are HF-related hospitalizations, HF-related urgent visits with a need for intravenous diuretics, all-cause mortality, and cardiovascular mortality. Conclusions: TITRATE-HF is a real-world multicentre longitudinal registry that will provide unique information on contemporary GDMT implementation, sequencing strategies (order and speed), and prognosis in de novo, worsening, and chronic HF patients.</p

Azimuthal anisotropy of charged jet production in root s(NN)=2.76 TeV Pb-Pb collisions

We present measurements of the azimuthal dependence of charged jet production in central and semi-central root s(NN) = 2.76 TeV Pb-Pb collisions with respect to the second harmonic event plane, quantified as nu(ch)(2) (jet). Jet finding is performed employing the anti-k(T) algorithm with a resolution parameter R = 0.2 using charged tracks from the ALICE tracking system. The contribution of the azimuthal anisotropy of the underlying event is taken into account event-by-event. The remaining (statistical) region-to-region fluctuations are removed on an ensemble basis by unfolding the jet spectra for different event plane orientations independently. Significant non-zero nu(ch)(2) (jet) is observed in semi-central collisions (30-50% centrality) for 20 <p(T)(ch) (jet) <90 GeV/c. The azimuthal dependence of the charged jet production is similar to the dependence observed for jets comprising both charged and neutral fragments, and compatible with measurements of the nu(2) of single charged particles at high p(T). Good agreement between the data and predictions from JEWEL, an event generator simulating parton shower evolution in the presence of a dense QCD medium, is found in semi-central collisions. (C) 2015 CERN for the benefit of the ALICE Collaboration. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).Peer reviewe

Production of He-4 and (4) in Pb-Pb collisions at root(NN)-N-S=2.76 TeV at the LHC

Results on the production of He-4 and (4) nuclei in Pb-Pb collisions at root(NN)-N-S = 2.76 TeV in the rapidity range vertical bar y vertical bar <1, using the ALICE detector, are presented in this paper. The rapidity densities corresponding to 0-10% central events are found to be dN/dy4(He) = (0.8 +/- 0.4 (stat) +/- 0.3 (syst)) x 10(-6) and dN/dy4 = (1.1 +/- 0.4 (stat) +/- 0.2 (syst)) x 10(-6), respectively. This is in agreement with the statistical thermal model expectation assuming the same chemical freeze-out temperature (T-chem = 156 MeV) as for light hadrons. The measured ratio of (4)/He-4 is 1.4 +/- 0.8 (stat) +/- 0.5 (syst). (C) 2018 Published by Elsevier B.V.Peer reviewe

Forward-central two-particle correlations in p-Pb collisions at root s(NN)=5.02 TeV

Two-particle angular correlations between trigger particles in the forward pseudorapidity range (2.5 2GeV/c. (C) 2015 CERN for the benefit of the ALICE Collaboration. Published by Elsevier B. V.Peer reviewe

90-річчя члена-кореспондента НАН України Г.К. Степанковської

The p(T)-differential production cross section of electrons from semileptonic decays of heavy-flavor hadrons has been measured at midrapidity in proton-proton collisions at root s = 2.76 TeV in the transverse momentum range 0.5 < p(T) < 12 GeV/c with the ALICE detector at the LHC. The analysis was performed using minimum bias events and events triggered by the electromagnetic calorimeter. Predictions from perturbative QCD calculations agree with the data within the theoretical and experimental uncertainties