393 research outputs found
Weak pairwise correlations imply strongly correlated network states in a neural population
- Author
- A Arieli
- A Riehle
- A-L Barabási
- AP Georgopoulos
- D Eytan
- DH Perkel
- DH Perkel
- DJ Amit
- E Schneidman
- E Zohary
- Elad Schneidman
- ES Frechette
- ET Jaynes
- F Rieke
- G Bi
- H Barlow
- J Lin
- JJ Hopfield
- JJ Hopfield
- JL Puchalla
- JN Darroch
- L Brillouin
- L Martignon
- LD Landau
- LF Abbott
- LH Hartwell
- M Meister
- M Meister
- M Mezard
- M Shamir
- MB Eisen
- Michael J. Berry
- MJ Schnitzer
- N Hatsopoulos
- NS Holter
- O Alter
- R Segev
- Ronen Segev
- S Grun
- S Smirnakis
- SP Strong
- T Hosoya
- TM Cover
- W Bair
- William Bialek
- Y Dan
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 06/12/2005
- Field of study
Biological networks have so many possible states that exhaustive sampling is
impossible. Successful analysis thus depends on simplifying hypotheses, but
experiments on many systems hint that complicated, higher order interactions
among large groups of elements play an important role. In the vertebrate
retina, we show that weak correlations between pairs of neurons coexist with
strongly collective behavior in the responses of ten or more neurons.
Surprisingly, we find that this collective behavior is described quantitatively
by models that capture the observed pairwise correlations but assume no higher
order interactions. These maximum entropy models are equivalent to Ising
models, and predict that larger networks are completely dominated by
correlation effects. This suggests that the neural code has associative or
error-correcting properties, and we provide preliminary evidence for such
behavior. As a first test for the generality of these ideas, we show that
similar results are obtained from networks of cultured cortical neurons.Comment: Full account of work presented at the conference on Computational and
Systems Neuroscience (COSYNE), 17-20 March 2005, in Salt Lake City, Utah
(http://cosyne.org
A systematic review and meta-synthesis of the impact of low back pain on people's lives
- Author
- A Allegretti
- A Schutz
- A Tong
- AE Young
- AL Morris
- AM Skelton
- BL Wade
- BN Ong
- BN Ong
- BN Ong
- C Bombardier
- C Campbell
- C Coole
- C Coole
- C Marston
- CA Chew
- Christian Fossum
- CJ Murray
- Clive Seale
- CMDF Bombardier
- CR May
- D Carnes
- Dévan Rajendran
- E Scarry
- EE Georgy
- FM Cook
- G Noblit
- G Rose
- G Waddell
- H Busch
- H Hooper
- I Holloway
- J Borkan
- J Hush
- J Strong
- J Strong
- J Walker
- J Walker
- JA Smith
- JE Jeffrey
- JM Bowman
- JM Bowman
- JM Bowman
- JM Hush
- KM Dunn
- L De Souza
- L Donaldson
- LH De Souza
- M Corbett
- M Crowe
- M Layzell
- M Osborn
- M Osborn
- M Reid
- M Sloots
- Martin Underwood
- MW Heymans
- N Britten
- N Maniadakis
- NE Foster
- NE Foster
- O Airaksinen
- O Benjaminsson
- O Sokunbi
- P Croft
- PJ Martin
- PR Croft
- R Buchbinder
- R Froud
- R Mullis
- RA Deyo
- RH Dworkin
- RL Morton
- Robert Froud
- S Keen
- S Parsons
- S Snelgrove
- Sandra Eldridge
- SC Slade
- SC Slade
- SC Slade
- SD Liddle
- SG Dean
- SS Tavafian
- Sue Patterson
- T Greenhalgh
- T Sanders
- T Tarasuk
- T Vos
- Tamar Pincus
- TH Tveito
- U Muller
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2014
- Field of study
Copyright @ 2014 Froud et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative
Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and
reproduction in any medium, provided the original work is properly credited.Background - Low back pain (LBP) is a common and costly problem that many interpret within a biopsychosocial model. There is renewed concern that core-sets of outcome measures do not capture what is important. To inform debate about the coverage of back pain outcome measure core-sets, and to suggest areas worthy of exploration within healthcare consultations, we have synthesised the qualitative literature on the impact of low back pain on people’s lives.
Methods - Two reviewers searched CINAHL, Embase, PsycINFO, PEDro, and Medline, identifying qualitative studies of people’s experiences of non-specific LBP. Abstracted data were thematic coded and synthesised using a meta-ethnographic, and a meta-narrative approach.
Results - We included 49 papers describing 42 studies. Patients are concerned with engagement in meaningful activities; but they also want to be believed and have their experiences and identity, as someone ‘doing battle’ with pain, validated. Patients seek diagnosis, treatment, and cure, but also reassurance of the absence of pathology. Some struggle to meet social expectations and obligations. When these are achieved, the credibility of their pain/disability claims can be jeopardised. Others withdraw, fearful of disapproval, or unable or unwilling to accommodate social demands. Patients generally seek to regain their pre-pain levels of health, and physical and emotional stability. After time, this can be perceived to become unrealistic and some adjust their expectations accordingly.
Conclusions - The social component of the biopsychosocial model is not well represented in current core-sets of outcome measures. Clinicians should appreciate that the broader impact of low back pain includes social factors; this may be crucial to improving patients’ experiences of health care. Researchers should consider social factors to help develop a portfolio of more relevant outcome measures.Arthritis Research U
Pilot evaluation of a walking school bus program in a low-income, urban community
- Author
- Publication venue
- BioMed Central
- Publication date
- 01/01/2009
- Field of study
<p>Abstract</p> <p>Background</p> <p>To evaluate the impact of a walking school bus (WSB) program on student transport in a low-income, urban neighborhood.</p> <p>Methods</p> <p>The design was a controlled, quasi-experimental trial with consecutive cross-sectional assessments. The setting was three urban, socioeconomically disadvantaged, public elementary schools (1 intervention vs. 2 controls) in Seattle, Washington, USA. Participants were ethnically diverse students in kindergarten-5<sup>th </sup>grade (aged 5–11 years). The intervention was a WSB program consisting of a part-time WSB coordinator and parent volunteers. Students' method of transportation to school was assessed by a classroom survey at baseline and one-year follow-up. The Pearson Chi-squared test compared students transported to school at the intervention versus control schools at each time point. Due to multiple testing, we calculated adjusted p-values using the Ryan-Holm stepdown Bonferroni procedure. McNemar's test was used to examine the change from baseline to 12-month follow-up for walking versus all other forms of school transport at the intervention or control schools.</p> <p>Results</p> <p>At baseline, the proportions of students (n = 653) walking to the intervention (20% +/- 2%) or control schools (15% +/- 2%) did not differ (<it>p </it>= 0.39). At 12-month follow up, higher proportions of students (n = 643, <it>p </it>= 0.001)) walked to the intervention (25% +/- 2%) versus the control schools (7% +/- 1%). No significant changes were noted in the proportion of students riding in a car or taking the school bus at baseline or 12-month follow up (all <it>p </it>> 0.05). Comparing baseline to 12-month follow up, the numbers of students who walked to the intervention school increased while the numbers of students who used the other forms of transport did not change (<it>p </it>< 0.0001). In contrast, the numbers of students who walked to the control schools decreased while the numbers of students who used the other forms of transport did not change (<it>p </it>< 0.0001).</p> <p>Conclusion</p> <p>A WSB program is a promising intervention among urban, low-income elementary school students that may promote favorable changes toward active transport to school.</p> <p>Trial Registration</p> <p>ClinicalTrials.gov NCT00402701</p
Jet energy measurement with the ATLAS detector in proton-proton collisions at root s=7 TeV
- Author
- Aad G
- Abbott B
- Abdallah J
- Abdelalim AA
- Abdesselam A
- Abdinov O
- Abi B
- Abolins M
- Abramowicz H
- Abreu H
- Acerbi E
- Acharya BS
- Adams DL
- Addy TN
- Adelman J
- Aderholz M
- Adomeit S
- Adragna P
- Adye T
- Aefsky S
- Aguilar-Saavedra JA
- Aharrouche M
- Ahlen SP
- Ahles F
- Ahmad A
- Ahsan M
- Aielli G
- Akdogana T
- Akesson TPA
- Akimoto G
- Akimov AV
- Akiyama A
- Aktas A
- Alam MA
- Alam MS
- Albert J
- Albrand S
- Aleksa M
- Aleksandrov IN
- Alessandria F
- Alexa C
- Alexander G
- Alexandre G
- Alexopoulos T
- Alhroob M
- Aliev M
- Alimonti G
- Alison J
- Aliyev M
- Allport PP
- Allwood-Spiers SE
- Almenar CC
- Almond J
- Aloisio A
- Alon R
- Alonso A
- Alviggi MG
- Amako K
- Amaral P
- Amelung C
- Ammosov VV
- Amorim A
- Amoros G
- Amram N
- Anastopoulos C
- Ancu LS
- Andari N
- Andeen T
- Anders CF
- Anders G
- Anderson KJ
- Andreazza A
- Andrei V
- Andrieux M-L
- Anduaga XS
- Angerami A
- Anghinolfi F
- Anh TV
- Anjos N
- Annovi A
- Antonaki A
- Antonelli M
- Antonov A
- Antos J
- Anulli F
- Aoun S
- Apolle R
- Arabidze G
- Aracena I
- Arai Y
- Aranda CP
- Arce ATH
- Archambault JP
- Arfaoui S
- Arguin J-F
- Arik E
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- Armbruster AJ
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- Yilmaz M
- Yoosootiniya R
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- Zarzhitsky P
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- Zhemchugov A
- Zheng S
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- Zhuravlov V
- Zieminska D
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- Zimmermann S
- Zinonos Z
- Ziolkowski M
- Zitoun R
- Zivkovic L
- Zmouchko VV
- Zobernig G
- Zoccoli A
- Zolnierowski Y
- Zsenei A
- Zutshi V
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/03/2013
- Field of study
The jet energy scale and its systematic uncertainty are determined for jets measured with the ATLAS detector at the LHC in proton-proton collision data at a centre-of-mass energy of √s = 7TeV corresponding to an integrated luminosity of 38 pb-1. Jets are reconstructed with the anti-kt algorithm with distance parameters R=0. 4 or R=0. 6. Jet energy and angle corrections are determined from Monte Carlo simulations to calibrate jets with transverse momenta pT≥20 GeV and pseudorapidities {pipe}η{pipe}<4. 5. The jet energy systematic uncertainty is estimated using the single isolated hadron response measured in situ and in test-beams, exploiting the transverse momentum balance between central and forward jets in events with dijet topologies and studying systematic variations in Monte Carlo simulations. The jet energy uncertainty is less than 2. 5 % in the central calorimeter region ({pipe}η{pipe}<0. 8) for jets with 60≤pT<800 GeV, and is maximally 14 % for pT<30 GeV in the most forward region 3. 2≤{pipe}η{pipe}<4. 5. The jet energy is validated for jet transverse momenta up to 1 TeV to the level of a few percent using several in situ techniques by comparing a well-known reference such as the recoiling photon pT, the sum of the transverse momenta of tracks associated to the jet, or a system of low-pT jets recoiling against a high-pT jet. More sophisticated jet calibration schemes are presented based on calorimeter cell energy density weighting or hadronic properties of jets, aiming for an improved jet energy resolution and a reduced flavour dependence of the jet response. The systematic uncertainty of the jet energy determined from a combination of in situ techniques is consistent with the one derived from single hadron response measurements over a wide kinematic range. The nominal corrections and uncertainties are derived for isolated jets in an inclusive sample of high-pT jets. Special cases such as event topologies with close-by jets, or selections of samples with an enhanced content of jets originating from light quarks, heavy quarks or gluons are also discussed and the corresponding uncertainties are determined. © 2013 CERN for the benefit of the ATLAS collaboration
Search for the neutral Higgs bosons of the minimal supersymmetric standard model in pp collisions at root s=7 TeV with the ATLAS detector
- Author
- Aad G
- Abajyan T
- Abbott B
- Abdallah J
- Abdelalim AA
- Abdinov O
- Abi B
- Abolins M
- AbouZeid OS
- Abramowicz H
- Abreu H
- Acharya BS
- Adam ER
- Adamczyk L
- Adams DL
- Addy TN
- Adelman J
- Adomeit S
- Adragna P
- Adye T
- Aesky S
- Agar-Savedra JA
- Agustoni M
- Ahlen SP
- Ahles F
- Ahmad A
- Ahsan M
- Aielli G
- Akesson TPA
- Akimoto G
- Akimov AV
- Alam MA
- Albert J
- Albrand S
- Aleksa M
- Aleksandrov IN
- Alessandria F
- Alexa C
- Alexander G
- Alexandre G
- Alexopoulos T
- Alhroob M
- Aliev M
- Alimonti G
- Alison J
- Allbrooke BMM
- Allison LJ
- Allport PP
- Allwood-Spiers SE
- Almenar CC
- Almond J
- Aloisio A
- Alon R
- Alonso A
- Alonso F
- Altheimer A
- Alviggi MG
- Amako K
- Amelung C
- Ammosov VV
- Amor Dos Santos SP
- Amorim A
- Amoroso S
- Amram N
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- Anders CF
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- Anderson KJ
- Andreazza A
- Andrei V
- Andrieux M-L
- Anduaga XS
- Angelidakis S
- Anger P
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- Anghinolfi F
- Anh TV
- Anisenkov A
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- Annovi A
- Antonaki A
- Antonelli M
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- Antos J
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- Aoki M
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- Apolle R
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- van Huysduynen LH
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- Viehhauser GHA
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- Vlachos S
- Vladoiu D
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- von Radziewski H
- von Toerne E
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- Vorwerk V
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- Voss R
- Vossebeld JH
- Vranjes N
- Vrba V
- Vreeswijk M
- Vuillermet R
- Vukotic I
- Wagner P
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- Wickens FJ
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- Yamamoto S
- Yamamura T
- Yamanaka T
- Yamauchi K
- Yamazaki T
- Yamazaki Y
- Yan Z
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- Yang H
- Yang UK
- Yang Y
- Yang Z
- Yanush S
- Yao L
- Yasu Y
- Yatsenko E
- Ye J
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- Yen AL
- Yilmaz M
- Yoosoofmiya R
- Yorita K
- Yoshida R
- Yoshihara K
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- Young CJ
- Youssef S
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- Zaytsev A
- Zeitnitz C
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- Zemla A
- Zenin O
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- Zerwas D
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- Zhang X
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- Zhao Z
- Zhemchugov A
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- Zhu CG
- Zhu H
- Zhu J
- Zhu Y
- Zhuang X
- Zhuravlov V
- Zibell A
- Zieminska D
- Zimin NI
- Zimmermann R
- Zimmermann S
- Zimmermann S
- Zinonos Z
- Ziolkowski M
- Zitoun R
- Zivkovic L
- Zmouchko VV
- Zobernig G
- Zoccoli A
- zur Nedden M
- Zutshi V
- Zwalinski L
- Publication venue
- Publication date
- 01/02/2013
- Field of study
A search for neutral Higgs bosons of the Minimal Supersymmetric Standard Model (MSSM) is reported. The analysis is based on a sample of proton-proton collisions at a centre-of-mass energy of 7TeV recorded with the ATLAS detector at the Large Hadron Collider. The data were recorded in 2011 and correspond to an integrated luminosity of 4.7 fb-1 to 4.8 fb-1. Higgs boson decays into oppositely-charged muon or τ lepton pairs are considered for final states requiring either the presence or absence of b-jets. No statistically significant excess over the expected background is observed and exclusion limits at the 95% confidence level are derived. The exclusion limits are for the production cross-section of a generic neutral Higgs boson, φ, as a function of the Higgs boson mass and for h/A/H production in the MSSM as a function of the parameters mA and tan β in the mhmax scenario for mA in the range of 90GeV to 500 GeV. Copyright CERN
Development and Notch Signaling Requirements of the Zebrafish Choroid Plexus
- Author
- A Geling
- A Nasevicius
- AE Davidson
- AS Barreto
- Ashley M. Spahn
- B Trevarrow
- Brent R. Bill
- D Balciunas
- D Traver
- Darius Balciunas
- DK Irvin
- E Candal
- Eric D. Young
- GJ Wright
- Hernan Lopez-Schier
- JH Millonig
- Joshua A. McCarra
- K Lorent
- KF Liem Jr
- KJ Lee
- KJ Lee
- LH Strong
- Lisa A. Schimmenti
- LK Barthel
- M Amoyel
- M Garcia-Lecea
- M Jacobsen
- M Tanaka
- M Westerfield
- Marta Garcia-Lecea
- ME Robu
- MG Netsky
- N Strazielle
- ND Lawson
- NL Hunter
- RC Marcus
- RR Sturrock
- S Hermanson
- S Isogai
- SA Holley
- Stephen C. Ekker
- SY Yeo
- Toua Xiong
- Vladimir Korzh
- VM Tennyson
- Y Liu
- Publication venue
- Public Library of Science
- Publication date
- 01/09/2008
- Field of study
The choroid plexus (CP) is an epithelial and vascular structure in the ventricular system of the brain that is a critical part of the blood-brain barrier. The CP has two primary functions, 1) to produce and regulate components of the cerebral spinal fluid, and 2) to inhibit entry into the brain of exogenous substances. Despite its importance in neurobiology, little is known about how this structure forms.Here we show that the transposon-mediated enhancer trap zebrafish line Et(Mn16) expresses green fluorescent protein within a population of cells that migrate toward the midline and coalesce to form the definitive CP. We further demonstrate the development of the integral vascular network of the definitive CP. Utilizing pharmacologic pan-notch inhibition and specific morpholino-mediated knockdown, we demonstrate a requirement for Notch signaling in choroid plexus development. We identify three Notch signaling pathway members as mediating this effect, notch1b, deltaA, and deltaD.This work is the first to identify the zebrafish choroid plexus and to characterize its epithelial and vasculature integration. This study, in the context of other comparative anatomical studies, strongly indicates a conserved mechanism for development of the CP. Finally, we characterize a requirement for Notch signaling in the developing CP. This establishes the zebrafish CP as an important new system for the determination of key signaling pathways in the formation of this essential component of the vertebrate brain
Search for R-parity-violating supersymmetry in events with four or more leptons in sqrt(s) =7 TeV pp collisions with the ATLAS detector
- Author
- Aad G
- Abajyan T
- Abbott B
- Abdallah J
- Khalek SA
- Abdelalim AA
- Abdinov O
- Aben R
- Abi B
- Abolins M
- AbouZeid OS
- Abramowicz H
- Abreu H
- Acharya BS
- Adamczyk L
- Adams DL
- Addy TN
- Adelman J
- Adomeit S
- Adragna P
- Adye T
- Aefsky S
- Aguilar-Saavedra JA
- Agustoni M
- Aharrouche M
- Ahlen SP
- Ahles F
- Ahmad A
- Ahsan M
- Aielli G
- Akesson TPA
- Akimoto G
- Akimov AV
- Alam MS
- Alam MA
- Albert J
- Albrand S
- Aleksa M
- Aleksandrov IN
- Alessandria F
- Alexa C
- Alexander G
- Alexandre G
- Alexopoulos T
- Alhroob M
- Aliev M
- Alimonti G
- Alison J
- Allbrooke BMM
- Allport PP
- Allwood-Spiers SE
- Almond J
- Aloisio A
- Alon R
- Alonso A
- Alonso F
- Altheimer A
- Gonzalez BA
- Alviggi MG
- Amako K
- Amelung C
- Ammosov VV
- Amor Dos Santos SP
- Amorim A
- Amram N
- Anastopoulos C
- Ancu LS
- Andari N
- Andeen T
- Anders CF
- Anders G
- Anderson KJ
- Andreazza A
- Andrei V
- Andrieux M-L
- Anduaga XS
- Angelidakis S
- Anger P
- Angerami A
- Anghinolfi F
- Anisenkov A
- Anjos N
- Annovi A
- Antonaki A
- Antonelli M
- Antonov A
- Antos J
- Anulli F
- Aoki M
- Aoun S
- Bella LA
- Apolle R
- Arabidze G
- Aracena I
- Arai Y
- Arce ATH
- Arfaoui S
- Arguin J-F
- Argyropoulos S
- Arik E
- Arik M
- Armbruster AJ
- Arnaez O
- Arnal V
- Arnault C
- Artamonov A
- Artoni G
- Arutinov D
- Asai S
- Ask S
- Asman B
- Asquith L
- Assamagan K
- Astbury A
- Atkinson M
- Aubert B
- Auge E
- Augsten K
- Aurousseau M
- Avolio G
- Avramidou R
- Axen D
- Azuelos G
- Azuma Y
- Baak MA
- Baccaglioni G
- Bacci C
- Bach AM
- Bachacou H
- Bachas K
- Backes M
- Backhaus M
- Mayes JB
- Badescu E
- Bagnaia P
- Bahinipati S
- Bai Y
- Bailey DC
- Bain T
- Baines JT
- Baker OK
- Baker MD
- Baker S
- Balek P
- Banas E
- Banerjee P
- Banerjee S
- Banfi D
- Bangert A
- Bansal V
- Bansil HS
- Barak L
- Baranov SP
- Galtieri AB
- Barber T
- Barberio EL
- Barberis D
- Barbero M
- Bardin DY
- Barillari T
- Barisonzi M
- Barklow T
- Barlow N
- Barnett BM
- Barnett RM
- Baroncelli A
- Barone G
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- Barreiro F
- da Costa JBG
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- Bartoldus R
- Barton AE
- Bartsch V
- Basye A
- Bates RL
- Batkova L
- Batley JR
- Battaglia A
- Battistin M
- Bauer F
- Bawa HS
- Beale S
- Beau T
- Beauchemin PH
- Beccherle R
- Bechtle P
- Beck HP
- Becker K
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- Beckingham M
- Becks KH
- Beddall AJ
- Beddall A
- Bedikian S
- Bednyakov VA
- Bee CP
- Beemster LJ
- Begel M
- Harpaz SB
- Behera PK
- Beimforde M
- Belanger-Champagne C
- Bell PJ
- Bell WH
- Bella G
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- Beltramello O
- Benary O
- Benchekroun D
- Bendtz K
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- Benhammou Y
- Noccioli EB
- Garcia JAB
- Benjamin DP
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- Bensinger JR
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- Bernhard R
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- Besana MI
- Besjes GJ
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- Bobrovnikov VS
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- Bocci A
- Boddy CR
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- Bogdanchikov A
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- Bohm C
- Bohm J
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- Bomben M
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- Bordoni S
- Borer C
- Borisov A
- Borissov G
- Borjanovic I
- Borri M
- Borroni S
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- Bortolotto V
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- Boumediene D
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- Boyko IR
- Bozovic-Jelisavcic I
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- Branchini P
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- Brelier B
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- de Renstrom PAB
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- Buchholz P
- Buckingham RM
- Buckley AG
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- Budagov IA
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- Buescher V
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- Bulekov O
- Bundock AC
- Bunse M
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- Burdin S
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- Busato E
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- Buszello CP
- Butler B
- Butler JM
- Buttar CM
- Butterworth JM
- Buttinger W
- Byszewski M
- Cabrera Urban S
- Caforio D
- Cakir O
- Calafiura P
- Calderini G
- Calfayan P
- Calkins R
- Caloba LP
- Caloi R
- Calvet D
- Calvet S
- Toro RC
- Camarri P
- Cameron D
- Caminada LM
- Caminal Armadans R
- Campana S
- Campanelli M
- Canale V
- Canelli F
- Canepa A
- Cantero J
- Cantrill R
- Capasso L
- Garrido MDMC
- Caprini I
- Caprini M
- Capriotti D
- Capua M
- Caputo R
- Cardarelli R
- Carli T
- Carlino G
- Carminati L
- Caron B
- Caron S
- Carquin E
- Carrillo-Montoya GD
- Carter AA
- Carter JR
- Carvalho J
- Casadei D
- Casado MP
- Cascella M
- Caso C
- Castaneda Hernandez AM
- Castaneda-Miranda E
- Castillo Gimenez V
- Castro NF
- Cataldi G
- Catastini P
- Catinaccio A
- Catmore JR
- Cattai A
- Cattani G
- Caughron S
- Cavaliere V
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- Cavalli D
- Cavalli-Sforza M
- Cavasinni V
- Ceradini F
- Cerqueira AS
- Cerri A
- Cerrito L
- Cerutti F
- Cetin SA
- Chafaq A
- Chakraborty D
- Chalupkova I
- Chan K
- Chang P
- Chapleau B
- Chapman JD
- Chapman JW
- Chareyre E
- Charlton DG
- Chavda V
- Barajas CAC
- Cheatham S
- Chekanov S
- Chekulaev SV
- Chelkov GA
- Chelstowska MA
- Chen C
- Chen H
- Chen S
- Chen X
- Chen Y
- Cheng Y
- Cheplakov A
- El Moursli RC
- Chernyatin V
- Cheu E
- Cheung SL
- Chevalier L
- Chiefari G
- Chikovani L
- Childers JT
- Chilingarov A
- Chiodini G
- Chisholm AS
- Chislett RT
- Chitan A
- Chizhov MV
- Choudalakis G
- Chouridou S
- Christidi IA
- Christov A
- Chromek-Burckhart D
- Chu ML
- Chudoba J
- Ciapetti G
- Ciftci AK
- Ciftci R
- Cinca D
- Cindro V
- Ciocca C
- Ciocio A
- Cirilli M
- Cirkovic P
- Citron ZH
- Citterio M
- Ciubancan M
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- Clark PJ
- Clarke RN
- Cleland W
- Clemens JC
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- Cogan JG
- Coggeshall J
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- Colas J
- Cole S
- Colijn AP
- Collins NJ
- Collins-Tooth C
- Collot J
- Colombo T
- Colon G
- Compostella G
- Conde Muino P
- Coniavitis E
- Conidi MC
- Consonni SM
- Consorti V
- Constantinescu S
- Conta C
- Conti G
- Conventi F
- Cooke M
- Cooper BD
- Cooper-Sarkar AM
- Copic K
- Cornelissen T
- Corradi M
- Corriveau F
- Cortes-Gonzalez A
- Cortiana G
- Costa G
- Costa MJ
- Costanzo D
- Cote D
- Courneyea L
- Cowan G
- Cowden C
- Cox BE
- Cranmer K
- Crescioli F
- Cristinziani M
- Crosetti G
- Crepe-Renaudin S
- Cuciuc C-M
- Almenar CC
- Donszelmann TC
- Cummings J
- Curatolo M
- Curtis CJ
- Cuthbert C
- Cwetanski P
- Czirr H
- Czodrowski P
- Czyczula Z
- D'Auria S
- D'Onofrio M
- D'Orazio A
- Da Cunha Sargedas De Sousa MJ
- Da Via C
- Dabrowski W
- Dafinca A
- Dai T
- Dallapiccola C
- Dam M
- Dameri M
- Damiani DS
- Danielsson HO
- Dao V
- Darbo G
- Darlea GL
- Dassoulas JA
- Davey W
- Davidek T
- Davidson N
- Davidson R
- Davies E
- Davies M
- Davignon O
- Davison AR
- Davygora Y
- Dawe E
- Dawson I
- Daya-Ishmukhametova RK
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- de Asmundis R
- De Castro S
- De Cecco S
- de Graat J
- De Groot N
- de Jong P
- De la Taille C
- De la Torre H
- De Lorenzi F
- de Mora L
- De Nooij L
- De Pedis D
- De Salvo A
- De Sanctis U
- De Santo A
- De Regie JBDV
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- Dearnaley WJ
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- Dedovich DV
- Degenhardt J
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- Delemontex T
- Deliyergiyev M
- Dell'Acqua A
- Dell'Asta L
- Della Pietra M
- della Volpe D
- Delmastro M
- Delsart PA
- Deluca C
- Demers S
- Demichev M
- Demirkoz B
- Denisov SP
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- Devetak E
- Deviveiros PO
- Dewhurst A
- DeWilde B
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- Dhullipudi R
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- Di Donato C
- Di Girolamo A
- Di Girolamo B
- Di Luise S
- Di Mattia A
- Di Micco B
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- Di Simone A
- Di Sipio R
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- Diehl EB
- Dietrich J
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- Ereditato A
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- Yanush S
- Yao L
- Yao Y
- Yasu Y
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- Ye J
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- Yilmaz M
- Yoosoofmiya R
- Yorita K
- Yoshida R
- Yoshihara K
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- Youssef S
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- Yurkewicz A
- Zabinski B
- Zaidan R
- Zaitsev AM
- Zajacova Z
- Zanello L
- Zanzi D
- Zaytsev A
- Zeitnitz C
- Zeman M
- Zemla A
- Zendler C
- Zenin O
- Zenis T
- Zinonos Z
- Zerwas D
- della Porta GZ
- Zhang D
- Zhang H
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- Zhao Z
- Zhemchugov A
- Zhong J
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- Zhuravlov V
- Zibell A
- Zieminska D
- Zimin NI
- Zimmermann R
- Zimmermann S
- Zimmermann S
- Ziolkowski M
- Zitoun R
- Zivkovic L
- Zmouchko VV
- Zobernig G
- Zoccoli A
- zur Nedden M
- Zutshi V
- Zwalinski L
- Collaboration ATLAS
- Publication venue
- Springer Verlag
- Publication date
- 01/01/2008
- Field of study
A search for new phenomena in final states with four or more leptons (electrons or muons) is presented. The analysis is based on 4.7 fb−1 of s=7TeV proton-proton collisions delivered by the Large Hadron Collider and recorded with the ATLAS detector. Observations are consistent with Standard Model expectations in two signal regions: one that requires moderate values of missing transverse momentum and another that requires large effective mass. The results are interpreted in a simplified model of R-parity-violating supersymmetry in which a 95% CL exclusion region is set for charged wino masses up to 540 GeV. In an R-parity-violating MSUGRA/CMSSM model, values of m 1/2 up to 820 GeV are excluded for 10 < tan β < 40
Search for high-mass resonances decaying to dilepton final states in pp collisions at s√=7 TeV with the ATLAS detector
- Author
- Aad G
- Abajyan T
- Abbott B
- Abdallah J
- Abdelalim AA
- Abdinov O
- Aben R
- Abi B
- Abolins M
- AbouZeid OS
- Abramowicz H
- Abreu H
- Acharya BS
- Adamczyk L
- Adams DL
- Addy TN
- Adelman J
- Adomeit S
- Adragna P
- Adye T
- Aefsky S
- Aguilar-Saavedra JA
- Agustoni M
- Aharrouche M
- Ahlen SP
- Ahles R
- Ahmad A
- Ahsan M
- Aielli G
- Akesson TPA
- Akimoto G
- Akimov AV
- Alam MA
- Alam MS
- Albert J
- Albrand S
- Aleksa M
- Aleksandrov IN
- Alessandria F
- Alexa C
- Alexander G
- Alexandre G
- Alexopoulos T
- Alhroob M
- Aliev M
- Alimonti G
- Alison J
- Allbrooke BMM
- Allport PP
- Allwood-Spiers SE
- Almenar CC
- Almond J
- Aloisio A
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- Alonso A
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- Altheimer A
- Alviggi MG
- Amako K
- Amelung C
- Ammosov VV
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- Anders CF
- Anders G
- Anderson KJ
- Andreazza A
- Andrei V
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- Anduaga XS
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- Anghinolfi F
- Anh TV
- Anisenkov A
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- Annovi A
- Antonaki A
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- Watson MF
- Watts G
- Watts S
- Waugh AT
- Waugh BM
- Weber MS
- Webster JS
- Weidberg AR
- Weigell P
- Weingarten J
- Weiser C
- Wells PS
- Wemans ADV
- Wenaus T
- Wendland D
- Wengler T
- Wengu Z
- Wenig S
- Wermes N
- Werner M
- Werner P
- Werth M
- Wessels M
- Wetter J
- Weydert C
- Whalen K
- White A
- White MJ
- White S
- Whitehead SR
- Whiteson D
- Whittington D
- Wicek F
- Wicke D
- Wickens FJ
- Wiedenmann W
- Wielers M
- Wienemann P
- Wiglesworth C
- Wiik-Fuchs LAM
- Wijeratne PA
- Wildauer A
- Wildt MA
- Wilhelm I
- Wilkens HG
- Will JZ
- Williams E
- Williams HH
- Willis W
- Willocoq S
- Wilson A
- Wilson JA
- Wilson MG
- Wingerter-Seez I
- Winkelmann S
- Winklmeier F
- Wittgen M
- Wollstadt SJ
- Wolter MW
- Wolters H
- Wong WC
- Wooden G
- Wosiek BK
- Wotschack J
- Woudstra MJ
- Wozniak KW
- Wraight K
- Wright M
- Wrona B
- Wu SL
- Wu X
- Wu Y
- Wulf E
- Wynne BM
- Xella S
- Xiao M
- Xie S
- Xu C
- Xu D
- Xu L
- Yabsley B
- Yacoob S
- Yagci KD
- Yamada M
- Yamaguchi H
- Yamamoto A
- Yamamoto K
- Yamamoto S
- Yamamura T
- Yamanaka T
- Yamazaki T
- Yamazaki Y
- Yan Z
- Yang H
- Yang UK
- Yang Y
- Yang Z
- Yanush S
- Yao L
- Yao Y
- Yasu Y
- Ye J
- Ye S
- Yildiz HD
- Yilmaz M
- Yoosoofmiya R
- Yorita K
- Yoshida R
- Yoshihara K
- Young C
- Young CJ
- Youssef S
- Yu D
- Yu DR
- Yu J
- Yu J
- Yuan L
- Yurkewicz A
- Zabinski B
- Zaidan R
- Zaitsev AM
- Zajacova Z
- Zanello L
- Zanzi D
- Zaytsev A
- Zeitnitz C
- Zeman M
- Zemla A
- Zendler C
- Zenin O
- Zenis T
- Zerwas D
- Zhang D
- Zhang H
- Zhang J
- Zhang X
- Zhang Z
- Zhao L
- Zhao Z
- Zhemchugov A
- Zhong J
- Zhou B
- Zhou N
- Zhou Y
- Zhu CG
- Zhu H
- Zhu J
- Zhu Y
- Zhuang X
- Zhuravlov V
- Zibell A
- Zieminska D
- Zimin NI
- Zimmermann R
- Zimmermann S
- Zimmermann S
- Zinonos Z
- Ziolkowski M
- Zitoun R
- Zivkovic L
- Zmouchko VV
- Zobernig G
- Zoccoli A
- zur Nedden M
- Zutshi V
- Zwalinski L
- Publication venue
- Springer
- Publication date
- 23/11/2012
- Field of study
The ATLAS detector at the Large Hadron Collider is used to search for high-mass resonances decaying to an electron-positron pair or a muon-antimuon pair. The search is sensitive to heavy neutral Z′ gauge bosons, Randall-Sundrum gravitons, Z * bosons, techni-mesons, Kaluza-Klein Z/γ bosons, and bosons predicted by Torsion models. Results are presented based on an analysis of pp collisions at a center-of-mass energy of 7 TeV corresponding to an integrated luminosity of 4.9 fb−1 in the e + e − channel and 5.0 fb−1 in the μ + μ −channel. A Z ′ boson with Standard Model-like couplings is excluded at 95 % confidence level for masses below 2.22 TeV. A Randall-Sundrum graviton with coupling k/MPl=0.1 is excluded at 95 % confidence level for masses below 2.16 TeV. Limits on the other models are also presented, including Technicolor and Minimal Z′ Models
Synapse loss in the prefrontal cortex is associated with cognitive decline in amyotrophic lateral sclerosis
- Author
- A Canosa
- AJ Hudson
- Albert C. Ludolph
- BSF Poletti
- C Schuster
- Chris-Anne McKenzie
- Christine A. F. von Arnim
- Christopher M. Henstridge
- CM Henstridge
- CM Henstridge
- Colin Smith
- D Lulé
- Danielle Leighton
- Dimitrios I. Sideris
- Dorothée Lulé
- DX Medina
- E Niven
- EH Bigio
- Elaine Cleary
- EM Cleary
- Emily Carroll
- H Braak
- H Qiu
- HA Black
- HC Tai
- HC Tai
- IR Mackenzie
- J Brettschneider
- J Brettschneider
- J Brettschneider
- J Prudlo
- JD Rothstein
- JH Morrison
- Jon Warner
- Judith Newton
- KD Micheva
- KJ Kopeikina
- KJ Kopeikina
- KJ Kopeikina
- KR Kay
- LH Goldstein
- M Elamin
- Makis Tzioras
- MC Wilde de
- MD Cykowski
- ME Murray
- MJ Fogarty
- MJ Fogarty
- MJ Strong
- MJ Strong
- MR Turner
- MR Turner
- MS Feiler
- N Samarasekera
- P Thevenaz
- PG Ince
- R Takeuchi
- RAL Menke
- RC Paolicelli
- RD Terry
- Robert Swingler
- S Abrahams
- S Abrahams
- S Abrahams
- S Hong
- Sally Salomonsson
- Sanziana Rotariu
- SC Ling
- Sharon Abrahams
- Siddharthan Chandran
- T Philips
- Tara L. Spires-Jones
- TH Gillingwater
- Thomas H. Gillingwater
- TL Spires-Jones
- W Yang
- W Yang
- Y Riku
- Z Xu
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/02/2018
- Field of study
Stepped care targeting psychological distress in head and neck and lung cancer patients: a randomized clinical trial
- Author
- A Bredart
- A de Graeff
- A van Straten
- A van Straten
- A Vodermaier
- Aartjan TF Beekman
- Anne-Marie H Krebber
- Annemarie Becker
- Annemieke van Straten
- BA van Hout
- C René Leemans
- CBO NVALT
- CBO NWHHT
- CBO NWHHT
- CBO NWHHT
- CD Fulcher
- CF Snyder
- E Hammerlid
- Egbert F Smit
- EuroQol Group
- Filip Smit
- G Rodin
- G Velikova
- Guus M Eeckhout
- GW Torrance
- HB Rolke
- HU Wittchen
- IM Verdonck-de Leeuw
- IM Verdonck-de Leeuw
- Irma M Verdonck-de Leeuw
- J Catalan
- J Oostenbrink
- J Spijker
- J Walker
- JB Oostenbrink
- JB Oostenbrink
- JF Piccirillo
- JL van den Brink
- JM Hutton
- JM Valderas
- K Bjordal
- K Bjordal
- K Coleman
- L Fillion
- L Mynors-Wallis
- LE Carlson
- LE Carlson
- LH Karnell
- LH van Roijen
- LM Mynors-Wallis
- LM Mynors-Wallis
- MA Tuinman
- MM Ouwens
- MR Katz
- MT Hegel
- MT Hegel
- P Bower
- P Cuijpers
- P Hopwood
- P Spinhoven
- PB Jacobsen
- PC Langley
- Pim Cuijpers
- R Brooks
- R de Bree
- Remco de Bree
- RL Osborn
- SA McLachlan
- SB Detmar
- SJ Lepore
- T Luckett
- V Spek
- V Strong
- WB Brouwer
- World Health Organisation
- Publication venue
- Publication date
- 01/01/2012
- Field of study
<p>Abstract</p> <p>Background</p> <p>Psychological distress is common in cancer survivors. Although there is some evidence on effectiveness of psychosocial care in distressed cancer patients, referral rate is low. Lack of adequate screening instruments in oncology settings and insufficient availability of traditional models of psychosocial care are the main barriers. A stepped care approach has the potential to improve the efficiency of psychosocial care. The aim of the study described herein is to evaluate efficacy of a stepped care strategy targeting psychological distress in cancer survivors.</p> <p>Methods/design</p> <p>The study is designed as a randomized clinical trial with 2 treatment arms: a stepped care intervention programme versus care as usual. Patients treated for head and neck cancer (HNC) or lung cancer (LC) are screened for distress using OncoQuest, a computerized touchscreen system. After stratification for tumour (HNC vs. LC) and stage (stage I/II vs. III/IV), 176 distressed patients are randomly assigned to the intervention or control group. Patients in the intervention group will follow a stepped care model with 4 evidence based steps: 1. Watchful waiting, 2. Guided self-help via Internet or a booklet, 3. Problem Solving Treatment administered by a specialized nurse, and 4. Specialized psychological intervention or antidepressant medication. In the control group, patients receive care as usual which most often is a single interview or referral to specialized intervention. Primary outcome is the Hospital Anxiety and Depression Scale (HADS). Secondary outcome measures are a clinical level of depression or anxiety (CIDI), quality of life (EQ-5D, EORTC QLQ-C30, QLQ-HN35, QLQ-LC13), patient satisfaction with care (EORTC QLQ-PATSAT), and costs (health care utilization and work loss (TIC-P and PRODISQ modules)). Outcomes are evaluated before and after intervention and at 3, 6, 9 and 12 months after intervention.</p> <p>Discussion</p> <p>Stepped care is a system of delivering and monitoring treatments, such that effective, yet least resource-intensive, treatment is delivered to patients first. The main aim of a stepped care approach is to simplify the patient pathway, provide access to more patients and to improve patient well-being and cost reduction by directing, where appropriate, patients to low cost (self-)management before high cost specialist services.</p> <p>Trial registration</p> <p>NTR1868</p
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