On the Nature of Fossil Galaxy Groups: Are they really fossils ?

We use SDSS-DR4 photometric and spectroscopic data out to redshift z~0.1 combined with ROSAT All Sky Survey X-ray data to produce a sample of twenty-five fossil groups (FGs), defined as bound systems dominated by a single, luminous elliptical galaxy with extended X-ray emission. We examine possible biases introduced by varying the parameters used to define the sample and the main pitfalls are discussed. The spatial density of FGs, estimated via the V/V_ MAX} test, is 2.83 x 10^{-6} h_{75}^3 Mpc^{-3} for L_x > 0.89 x 10^42 h_{75}^-2 erg/s consistent with Vikhlinin et al. (1999), who examined an X-ray overluminous elliptical galaxy sample (OLEG). We compare the general properties of FGs identified here with a sample of bright field ellipticals generated from the same dataset. These two samples show no differences in the distribution of neighboring faint galaxy density excess, distance from the red sequence in the color-magnitude diagram, and structural parameters such as a$_{4}$ and internal color gradients. Furthermore, examination of stellar populations shows that our twenty-five FGs have similar ages, metallicities, and $\alpha$-enhancement as the bright field ellipticals, undermining the idea that these systems represent fossils of a physical mechanism that occurred at high redshift. Our study reveals no difference between FGs and field ellipticals, suggesting that FGs might not be a distinct family of true fossils, but rather the final stage of mass assembly in the Universe.Comment: 18 pages, Accepted to A

Fresh Activity in Old Systems: Radio AGN in Fossil Groups of Galaxies

We present the first systematic 1.4 GHz Very Large Array radio continuum survey of fossil galaxy group candidates. These are virialized systems believed to have assembled over a gigayear in the past through the merging of galaxy group members into a single, isolated, massive elliptical galaxy and featuring an extended hot X-ray halo. We use new photometric and spectroscopic data from SDSS Data Release 7 to determine that three of the candidates are clearly not fossil groups. Of the remaining 30 candidates, 67% contain a radio-loud (L_1.4GHz > 10^23 W Hz^-1) active galactic nucleus (AGN) at the center of their dominant elliptical galaxy. We find a weak correlation between the radio luminosity of the AGN and the X-ray luminosity of the halo suggesting that the AGN contributes to energy deposition into the intragroup medium. We only find a correlation between the radio and optical luminosity of the central elliptical galaxy when we include X-ray selected, elliptically dominated non-fossil groups, indicating a weak relationship between AGN strength and the mass assembly history of the groups. The dominant elliptical galaxy of fossil groups is on average roughly an order of magnitude more luminous than normal group elliptical galaxies in optical, X-ray, and radio luminosities and our findings are consistent with previous results that the radio-loud fraction in elliptical galaxies is linked to the stellar mass of a population. The current level of activity in fossil groups suggests that AGN fueling continues long after the last major merger. We discuss several possibilities for fueling the AGN at the present epoch.Comment: Accepted for publication in A

Dosimetric evaluation of Acuros XB Advanced Dose Calculation algorithm in heterogeneous media

<p>Abstract</p> <p>Background</p> <p>A study was realised to evaluate and determine relative figures of merit of a new algorithm for photon dose calculation when applied to inhomogeneous media.</p> <p>Methods</p> <p>The new Acuros XB algorithm implemented in the Varian Eclipse treatment planning system was compared against a Monte Carlo method (VMC++), and the Analytical Anisotropic Algorithm (AAA). The study was carried out in virtual phantoms characterized by simple geometrical structures. An insert of different material and density was included in a phantom built of skeletal-muscle and HU = 0 (setting "A"): Normal Lung (lung, 0.198 g/cm³); Light Lung (lung, 0.035 g/cm³); Bone (bone, 1.798 g/cm³); another phantom (setting "B") was built of adipose material and including thin layers of bone (1.85 g/cm³), adipose (0.92 g/cm³), cartilage (1.4745 g/cm³), air (0.0012 g/cm³). Investigations were performed for 6 and 15 MV photon beams, and for a large (13 × 13 cm²) and a small (2.8 × 13 cm²) field.</p> <p>Results</p> <p>Results are provided in terms of depth dose curves, transverse profiles and Gamma analysis (3 mm/3% and 2 mm/2% distance to agreement/dose difference criteria) in planes parallel to the beam central axis; Monte Carlo simulations were assumed as reference. Acuros XB gave an average gamma agreement, with a 3 mm/3% criteria, of 100%, 86% and 100% for Normal Lung, Light Lung and Bone settings, respectively, and dose to medium calculations. The same figures were 86%, 11% and 100% for AAA, where only dose rescaled to water calculations are possible.</p> <p>Conclusions</p> <p>In conclusion, Acuros XB algorithm provides a valid and accurate alternative to Monte Carlo calculations for heterogeneity management.</p

HIV patients treated with low-dose prednisolone exhibit lower immune activation than untreated patients

HIV-associated general immune activation is a strong predictor for HIV disease progression, suggesting that chronic immune activation may drive HIV pathogenesis. Consequently, immunomodulating agents may decelerate HIV disease progression. In an observational study, we determined immune activation in HIV patients receiving low-dose (5 mg/day) prednisolone with or without highly-active antiretroviral therapy (HAART) compared to patients without prednisolone treatment. Lymphocyte activation was determined by flow cytometry detecting expression of CD38 on CD8(+) T cells. The monocyte activation markers sCD14 and LPS binding protein (LBP) as well as inflammation markers soluble urokinase plasminogen activated receptor (suPAR) and sCD40L were determined from plasma by ELISA. CD38-expression on CD8+ T lymphocytes was significantly lower in prednisolone-treated patients compared to untreated patients (median 55.40% [percentile range 48.76-67.70] versus 73.34% [65.21-78.92], p = 0.0011, Mann-Whitney test). Similarly, we detected lower levels of sCD14 (3.6 μg/ml [2.78-5.12] vs. 6.11 μg/ml [4.58-7.70]; p = 0.0048), LBP (2.18 ng/ml [1.59-2.87] vs. 3.45 ng/ml [1.84-5.03]; p = 0.0386), suPAR antigen (2.17 μg/ml [1.65-2.81] vs. 2.56 μg/ml [2.24-4.26]; p = 0.0351) and a trend towards lower levels of sCD40L (2.70 pg/ml [1.90-4.00] vs. 3.60 pg/ml [2.95-5.30]; p = 0.0782). Viral load in both groups was similar (0.8 × 105 ng/ml [0.2-42.4 × 105] vs. 1.1 × 105 [0.5-12.2 × 105]; p = 0.3806). No effects attributable to prednisolone were observed when patients receiving HAART in combination with prednisolone were compared to patients who received HAART alone.\ud Patients treated with low-dose prednisolone display significantly lower general immune activation than untreated patients. Further longitudinal studies are required to assess whether treatment with low-dose prednisolone translates into differences in HIV disease progression

Display of probability densities for data from a continuous distribution

Based on cumulative distribution functions, Fourier series expansion and Kolmogorov tests, we present a simple method to display probability densities for data drawn from a continuous distribution. It is often more efficient than using histograms.Comment: 5 pages, 4 figures, presented at Computer Simulation Studies XXIV, Athens, GA, 201

Blood Glucose and Risk of Incident and Fatal Cancer in the Metabolic Syndrome and Cancer Project (Me-Can): Analysis of Six Prospective Cohorts

Tanja Stocks and colleagues carry out an analysis of six European cohorts and confirm that abnormal glucose metabolism is linked with increased risk of cancer overall and at specific sites

Measurement of Branching Fraction and Dalitz Distribution for B0->D(*)+/- K0 pi-/+ Decays

We present measurements of the branching fractions for the three-body decays B0 -> D(*)-/+ K0 pi^+/-$and their resonant submodes$B0 -> D(*)-/+ K*+/- using a sample of approximately 88 million BBbar pairs collected by the BABAR detector at the PEP-II asymmetric energy storage ring. We measure: B(B0->D-/+ K0 pi+/-)=(4.9 +/- 0.7(stat) +/- 0.5 (syst)) 10^{-4} B(B0->D*-/+ K0 pi+/-)=(3.0 +/- 0.7(stat) +/- 0.3 (syst)) 10^{-4} B(B0->D-/+ K*+/-)=(4.6 +/- 0.6(stat) +/- 0.5 (syst)) 10^{-4} B(B0->D*-/+ K*+/-)=(3.2 +/- 0.6(stat) +/- 0.3 (syst)) 10^{-4} From these measurements we determine the fractions of resonant events to be : f(B0-> D-/+ K*+/-) = 0.63 +/- 0.08(stat) +/- 0.04(syst) f(B0-> D*-/+ K*+/-) = 0.72 +/- 0.14(stat) +/- 0.05(syst)Comment: 7 pages, 3 figures submitted to Phys. Rev. Let