Long-term central nervous system (CNS) consequences of COVID-19 in children

Introduction: neurological/neuropsychiatric symptoms are commonly reported by children/young people with long COVID, especially headache, fatigue, cognitive deficits, anosmia and ageusia, dizziness, mood symptoms, and sleep problems. However, reported prevalence estimates are highly variable due to study heterogeneity and often small sample size; most studies only considered short-term follow-ups; and, apart from mood and sleep problems, neuropsychiatric conditions have received less attention. Considering the potential debilitating effects of neurological/neuropsychiatric conditions, a comprehensive review of the topic is timely, and needed to support clinical recognition as well as to set the direction for future research.Areas covered: the authors discuss neurological/neuropsychiatric manifestations of long COVID in pediatric populations, with a focus on prevalence, associated demographic characteristics, and potential pathogenetic mechanisms.Expert opinion: children/young people may develop persistent neurological/neuropsychiatric symptoms following acute SARS-CoV-2 infection, which may affect daily functioning and well-being. Studies in larger samples with longer follow-ups are needed to clarify prevalence and symptom duration; as well as less investigated risk factors, including genetic predisposition, ethnicity, and comorbidities. Controlled studies may help separate infection-related direct effects from pandemic-related psychosocial stressors. Clarifying pathogenetic mechanisms is paramount to develop more targeted and effective treatments; whilst screening programs and psychoeducation may enhance early recognition.</p

Duality and Restoration of Manifest Supersymmetry

World-sheet and spacetime supersymmetries that are manifest in some string backgrounds may not be so in their T-duals. Nevertheless, they always remain symmetries of the underlying conformal field theory. In previous work the mechanism by which T-duality destroys manifest supersymmetry and gives rise to non-local realizations was found. We give the general conditions for a 2-dim N=1 supersymmetric sigma-model to have non-local and hence non-manifest extended supersymmetry. We then examine T-duality as a mechanism of restoring manifest supersymmetry. This happens whenever appropriate combinations of non-local parafermions of the underlying conformal field theory become local due to non-trivial world-sheet effects. We present, in detail, an example arising from the model SU(2)/U(1) X SL(2,R)/U(1) and obtain a new exact 4-dim axionic instanton, that generalizes the SU(2) X U(1) semi-wormhole, and has manifest spacetime as well as N=4 world-sheet supersymmetry. In addition, general necessary conditions for abelian T-duality to preserve manifest N=4 world-sheet supersymmetry are derived and applied to WZW models based on quaternionic groups. We also prove some theorems for sigma-models with non-local N=4 world-sheet supersymmetry.Comment: 29 pages, harvmac, no figures. Very minor changes. Version to appear in Nucl. Phys.

On quantum equivalence of dual sigma models: SL(3)SL(3) examples

The equivalence of several $SL(3)$ sigma models and their special Abelian duals is investigated in the two loop order of perturbation theory. The investigation is based on extracting and comparing various $\beta$ functions of the original and dual models. The role of the discrete global symmetries is emphasized.Comment: Plain TEX, 24 page

Annual accountability report fiscal year 2008-2009

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Annual report of the John de la Howe School to the General Assembly of South Carolina 1981-82

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Annual accountability report fiscal year 2003-2004

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