On Halo Formation Times and Assembly Bias

In this paper we use the ``Millennium Simulation'' to re-examine the mass assembly history of dark matter halos and the age dependence of halo clustering. We use eight different definitions of halo formation times to characterize the different aspects of the assembly history of a dark matter halo. We find that these formation times have different dependence on halo mass. While some formation times characterize well the hierarchical nature of halo formation, in the sense that more massive halos have later formation, the trend is reversed for other definitions of the formation time. In particular, the formation times that are likely to be related to the formation of galaxies in dark halos show strong trends of ``down-sizing'', in that lower-mass halos form later. We also investigate how the correlation amplitude of dark matter halos depends on the different formation times. We find that this dependence is quite strong for some definitions of formation time but weak or absent for other definitions. In particular, the correlation amplitude of halos of a given mass is almost independent of their last major merger time. For the definitions that are expected to be more related to the formation of galaxies in dark halos, a significant assembly bias is found only for halos less massive than M_*. We discuss our results in connection to the hierarchical assembly of dark matter halos, the ``archaeological down-sizing'' observed in the galaxy population, and the observed color-dependence of the clustering strength of galaxy groups and clusters.Comment: 9 pages, 4 figures, submitted to MNRA

Height and timing of growth spurt during puberty in young people living with vertically acquired HIV in Europe and Thailand.

OBJECTIVE: The aim of this study was to describe growth during puberty in young people with vertically acquired HIV. DESIGN: Pooled data from 12 paediatric HIV cohorts in Europe and Thailand. METHODS: One thousand and ninety-four children initiating a nonnucleoside reverse transcriptase inhibitor or boosted protease inhibitor based regimen aged 1-10 years were included. Super Imposition by Translation And Rotation (SITAR) models described growth from age 8 years using three parameters (average height, timing and shape of the growth spurt), dependent on age and height-for-age z-score (HAZ) (WHO references) at antiretroviral therapy (ART) initiation. Multivariate regression explored characteristics associated with these three parameters. RESULTS: At ART initiation, median age and HAZ was 6.4 [interquartile range (IQR): 2.8, 9.0] years and -1.2 (IQR: -2.3 to -0.2), respectively. Median follow-up was 9.1 (IQR: 6.9, 11.4) years. In girls, older age and lower HAZ at ART initiation were independently associated with a growth spurt which occurred 0.41 (95% confidence interval 0.20-0.62) years later in children starting ART age 6 to 10 years compared with 1 to 2 years and 1.50 (1.21-1.78) years later in those starting with HAZ less than -3 compared with HAZ at least -1. Later growth spurts in girls resulted in continued height growth into later adolescence. In boys starting ART with HAZ less than -1, growth spurts were later in children starting ART in the oldest age group, but for HAZ at least -1, there was no association with age. Girls and boys who initiated ART with HAZ at least -1 maintained a similar height to the WHO reference mean. CONCLUSION: Stunting at ART initiation was associated with later growth spurts in girls. Children with HAZ at least -1 at ART initiation grew in height at the level expected in HIV negative children of a comparable age

Prognostic factors of a lower CD4/CD8 ratio in long term viral suppression HIV infected children

Background Combination antiretroviral therapy (cART) is associated with marked immune reconstitution. Although a long term viral suppression is achievable, not all children however, attain complete immunological recovery due to persistent immune activation. We use CD4/CD8 ratio like a marker of immune reconstitution. Methods Perinatal HIV-infected children who underwent a first-line cART, achieved viral suppression in the first year and maintained it for more than 5 years, with no viral rebound were included. Logistic models were applied to estimate the prognostic factors, clinical characteristics at cART start, of a lower CD4/CD8 ratio at the last visit. Results 146 HIV-infected children were included: 77% Caucasian, 45% male and 28% CDC C. Median age at cART initiation was 2.3 years (IQR: 0.5-6.2). 42 (30%) children received mono-dual therapy previously to cART. Time of undetectable viral load was 9.5 years (IQR: 7.8, 12.5). 33% of the children not achieved CD4/CD8 ratio >1. Univariate analysis showed an association between CD4/CD8 <1 with lower CD4 nadir and baseline CD4; older age at diagnosis and at cART initiation; and a previous exposure to mono-dual therapy. Multivariate analysis also revealed relationship between CD4/CD8 <1 and lower CD4 nadir (OR: 1.002, CI 95% 1.000-1.004) as well as previous exposure to mono-dual therapy (OR: 0.16, CI 95% 0.003-0.720). Conclusions CD4/CD8 > 1 was not achieved in 33% of the children. Lower CD4 nadir and previous exposure to suboptimal therapy, before initiating cART, are factors showing independently association with a worse immune recovery (CD4/CD8 < 1)

The radial distribution of galaxies in groups and clusters

We present a new catalogue of 55,121 groups and clusters centred on Luminous Red Galaxies from SDSS DR7 in the redshift range 0.15<z<0.4. We provide halo mass estimates for each of these groups derived from a calibration between the optical richness of bright galaxies (M_r<-20.5) within 1 Mpc, and X-ray-derived mass for a small subset of 129 groups and clusters with X-ray measurements. We derive the mean (stacked) surface number density profiles of galaxies as a function of total halo mass in different mass bins. We find that derived profiles can be well-described by a projected NFW profile with a concentration parameter (~2.6) that is approximately a factor of two lower than that of the dark matter (as predicted by N-body cosmological simulations) and nearly independent of halo mass. Interestingly, in spite of the difference in shape between the galaxy and dark matter radial distributions, both exhibit a high degree of self-similarity. A self-consistent comparison to several recent semi-analytic models of galaxy formation indicates that: (1) beyond ~0.3 r_500 current models are able to reproduce both the shape and normalisation of the satellite profiles; and (2) within ~0.3 r_500 the predicted profiles are sensitive to the details of the satellite-BCG merger timescale calculation. The former is a direct result of the models being tuned to match the global galaxy luminosity function combined with the assumption that the satellite galaxies do not suffer significant tidal stripping, even though their surrounding dark matter haloes can be removed through this process. Combining our results with measurements of the intracluster light should provide a way to inform theoretical models on the efficacy of the tidal stripping and merging processes.Comment: Resubmitted to MNRAS with minor revision

The cytotoxic T cell proteome and its shaping by the kinase mTOR

High-resolution mass spectrometry maps the cytotoxic T lymphocyte (CTL) proteome and the impact of mammalian target of rapamycin complex 1 (mTORC1) on CTLs. The CTL proteome was dominated by metabolic regulators and granzymes and mTORC1 selectively repressed and promoted expression of subset of CTL proteins (~10%). These included key CTL effector molecules, signaling proteins and a subset of metabolic enzymes. Proteomic data highlighted the potential for mTORC1 negative control of phosphatidylinositol (3,4,5)-trisphosphate (PtdIns(3,4,5)P(3)) production in CTL. mTORC1 was shown to repress PtdIns(3,4,5)P(3) production and to determine the mTORC2 requirement for activation of the kinase Akt. Unbiased proteomic analysis thus provides a comprehensive understanding of CTL identity and mTORC1 control of CTL function

Planck Intermediate Results. XI: The gas content of dark matter halos: the Sunyaev-Zeldovich-stellar mass relation for locally brightest galaxies

Contains fulltext : 119332.pdf (preprint version ) (Open Access

Euclid: Modelling massive neutrinos in cosmology -- a code comparison

The measurement of the absolute neutrino mass scale from cosmological large-scale clustering data is one of the key science goals of the Euclid mission. Such a measurement relies on precise modelling of the impact of neutrinos on structure formation, which can be studied with $N$-body simulations. Here we present the results from a major code comparison effort to establish the maturity and reliability of numerical methods for treating massive neutrinos. The comparison includes eleven full $N$-body implementations (not all of them independent), two $N$-body schemes with approximate time integration, and four additional codes that directly predict or emulate the matter power spectrum. Using a common set of initial data we quantify the relative agreement on the nonlinear power spectrum of cold dark matter and baryons and, for the $N$-body codes, also the relative agreement on the bispectrum, halo mass function, and halo bias. We find that the different numerical implementations produce fully consistent results. We can therefore be confident that we can model the impact of massive neutrinos at the sub-percent level in the most common summary statistics. We also provide a code validation pipeline for future reference.Comment: 43 pages, 17 figures, 2 tables; published on behalf of the Euclid Consortium; data available at https://doi.org/10.5281/zenodo.729797