156 research outputs found
SYNTHESIS AND SAR STUDIES OF NEW 3-METHYL-5-(5-PROPYL-1H-1-R'-3-PYRAZOLYL)-1H-1-R-4-NITROSOPYRAZOLES AS ANTIMICOTIC AGENTS.
Evolución del suelo y vegetación en zonas restauradas de las Marismas de Doñana, en presencia y ausencia de ganadería
We have studied the effect of restoration practices on soil and plant cover in banks of wetland areas surrounding the Doñana National Park, which had formerly been partially drained for agricultural purposes (for further details, see another related communication in these same proceedings). We used 6 100m2 fenced and 6 100m2 unfenced plots to evaluate the effect of cattle on the regeneration process, since previous studies (Garcia et al. 2003) suggested that a high cattle pressure might be responsible for the observed low regeneration rates of plant communities in the restored areas. We measured 13 soil variables, bare soil, plant cover (woody species), and aerial biomass (for herbaceous species) along the two years following the restoration.Se evalúan los efectos de las obras de restauración en los suelos y en la cubierta vegetal en las áreas más elevadas de la Marisma Gallega (parcialmente drenada hace 30 años), a partir de datos obtenidos dentro y fuera de cercados dispuestos en zonas afectadas y no afectadas por las obras de restauración, así como determinar la evolución de algunos parámetros del suelo y de la cubierta vegetal transcurridos uno y dos años desde la finalización de las últimas obras de restauración efectuadas en la zona, en el marco del Plan Doñana 2005
TGFβ Governs the Pleiotropic Activity of NDRG1 in Triple-Negative Breast Cancer Progression
In triple-negative breast cancer (TNBC), the pleiotropic NDRG1 (N-Myc downstream regulated gene 1)
promotes progression and worse survival, yet contradictory results were documented, and the mechanisms
remain unknown. Phosphorylation and localization could drive NDRG1 pleiotropy, nonetheless, their role in
TNBC progression and clinical outcome was not investigated. We found enhanced p-NDRG1 (Thr346) by
TGFβ1 and explored whether it drives NDRG1 pleiotropy and TNBC progression. In tissue microarrays of 81
TNBC patients, we identified that staining and localization of NDRG1 and p-NDRG1 (Thr346) are biomarkers
and risk factors associated with shorter overall survival. We found that TGFβ1 leads NDRG1, downstream of
GSK3β, and upstream of NF-κB, to differentially regulate migration, invasion, epithelial-mesenchymal transition,
tumor initiation, and maintenance of different populations of cancer stem cells (CSCs), depending on the
progression stage of tumor cells, and the combination of TGFβ and GSK3β inhibitors impaired CSCs. The
present study revealed the striking importance to assess both total NDRG1 and p-NDRG1 (Thr346)
positiveness and subcellular localization to evaluate patient prognosis and their stratification. NDRG1
pleiotropy is driven by TGFβ to differentially promote metastasis and/or maintenance of CSCs at different
stages of tumor progression, which could be abrogated by the inhibition of TGFβ and GSK3β.Instituto de Salud Carlos III
European Commission PI15/00336
PI19/01533
CP14/00197
CP19/00029
PIE16/00045Ministry of Science and Innovation, Spain (MICINN)Instituto de Salud Carlos IIISpanish Government RTI2018.101309B-C22Chair "Doctors Galera-Requena in cancer stem cell research" CMC-CTS963European Regional Development Fund (European Union)Ministerio de Universidades FPU19/04450Junta de Andalucia RH-0139-2020Sistema Nacional de Garantia Juvenil (Fondo Social Europeo) 8064Junta de Andalucia, Consejeria de Transformacion Economica, Industria, Conocimiento y Universidades DOC_01686Fundacion Cientifica Asociacion Espanola Contra el Cancer, Junta Provincial de Jaen (AECC) PRDJA19001BLA
Boundary stabilization of numerical approximations of the 1-D variable coefficients wave equation: A numerical viscosity approach
In this paper, we consider the boundary stabilization problem associated to the 1- d wave equation with both variable density and diffusion coefficients and to its finite difference semi-discretizations. It is well-known that, for the finite difference semi-discretization of the constant coefficients wave equation on uniform meshes (Tébou and Zuazua, Adv. Comput. Math. 26:337–365, 2007) or on somenon-uniform meshes (Marica and Zuazua, BCAM, 2013, preprint), the discrete decay rate fails to be uniform with respect to the mesh-size parameter. We prove that, under suitable regularity assumptions on the coefficients and after adding an appropriate artificial viscosity to the numerical scheme, the decay rate is uniform as the mesh-size tends to zero. This extends previous results in Tébou and Zuazua (Adv. Comput.Math. 26:337–365, 2007) on the constant coefficient wave equation. The methodology of proof consists in applying the classical multiplier technique at the discrete level, with a multiplier adapted to the variable coefficients
Desarrollo de un entorno integrado para un computador didáctico elemental, para la asignatura de Fundamentos de Informática del nuevo grado en Ingeniería de Tecnologías de Telecomunicación
El objetivo principal de este trabajo es la potenciación y mejora de la
metodología docente en la asignatura de Fundamentos de Informática,
asignatura obligatoria correspondiente al nuevo Grado en Ingeniería de
Tecnologías de Telecomunicación de la Universidad de Granada. Para ello, se
ha desarrollado un entorno integrado didáctico que engloba, en una sola
aplicación, tanto el simulador como el ensamblador de un Computador
Didáctico Elemental desarrollado en nuestro departamento, CODE-2, y que,
además, incorpora un programa editor y un ensamblador en línea con el que el
alumno puede visualizar directamente el código máquina generado por el
código ensamblador que está escribiendo en tiempo real. De esta forma,
conseguimos facilitar que los alumnos puedan adquirir los conocimientos
necesarios para comprender el funcionamiento interno de un computador.Subvencionado parcialmente por el proyecto
de Innovación Docente 10-22 de la Universidad de Granad
Charge separation relative to the reaction plane in Pb-Pb collisions at TeV
Measurements of charge dependent azimuthal correlations with the ALICE
detector at the LHC are reported for Pb-Pb collisions at TeV. Two- and three-particle charge-dependent azimuthal correlations in
the pseudo-rapidity range are presented as a function of the
collision centrality, particle separation in pseudo-rapidity, and transverse
momentum. A clear signal compatible with a charge-dependent separation relative
to the reaction plane is observed, which shows little or no collision energy
dependence when compared to measurements at RHIC energies. This provides a new
insight for understanding the nature of the charge dependent azimuthal
correlations observed at RHIC and LHC energies.Comment: 12 pages, 3 captioned figures, authors from page 2 to 6, published
version, figures at http://aliceinfo.cern.ch/ArtSubmission/node/286
A note on comonotonicity and positivity of the control components of decoupled quadratic FBSDE
In this small note we are concerned with the solution of Forward-Backward
Stochastic Differential Equations (FBSDE) with drivers that grow quadratically
in the control component (quadratic growth FBSDE or qgFBSDE). The main theorem
is a comparison result that allows comparing componentwise the signs of the
control processes of two different qgFBSDE. As a byproduct one obtains
conditions that allow establishing the positivity of the control process.Comment: accepted for publicatio
Transverse sphericity of primary charged particles in minimum bias proton-proton collisions at , 2.76 and 7 TeV
Measurements of the sphericity of primary charged particles in minimum bias
proton--proton collisions at , 2.76 and 7 TeV with the ALICE
detector at the LHC are presented. The observable is linearized to be collinear
safe and is measured in the plane perpendicular to the beam direction using
primary charged tracks with GeV/c in . The
mean sphericity as a function of the charged particle multiplicity at
mid-rapidity () is reported for events with different
scales ("soft" and "hard") defined by the transverse momentum of the leading
particle. In addition, the mean charged particle transverse momentum versus
multiplicity is presented for the different event classes, and the sphericity
distributions in bins of multiplicity are presented. The data are compared with
calculations of standard Monte Carlo event generators. The transverse
sphericity is found to grow with multiplicity at all collision energies, with a
steeper rise at low , whereas the event generators show the
opposite tendency. The combined study of the sphericity and the mean with multiplicity indicates that most of the tested event generators
produce events with higher multiplicity by generating more back-to-back jets
resulting in decreased sphericity (and isotropy). The PYTHIA6 generator with
tune PERUGIA-2011 exhibits a noticeable improvement in describing the data,
compared to the other tested generators.Comment: 21 pages, 9 captioned figures, 3 tables, authors from page 16,
published version, figures from
http://aliceinfo.cern.ch/ArtSubmission/node/308
Centrality dependence of charged particle production at large transverse momentum in Pb-Pb collisions at TeV
The inclusive transverse momentum () distributions of primary
charged particles are measured in the pseudo-rapidity range as a
function of event centrality in Pb-Pb collisions at
TeV with ALICE at the LHC. The data are presented in the range
GeV/ for nine centrality intervals from 70-80% to 0-5%.
The Pb-Pb spectra are presented in terms of the nuclear modification factor
using a pp reference spectrum measured at the same collision
energy. We observe that the suppression of high- particles strongly
depends on event centrality. In central collisions (0-5%) the yield is most
suppressed with at -7 GeV/. Above
GeV/, there is a significant rise in the nuclear modification
factor, which reaches for GeV/. In
peripheral collisions (70-80%), the suppression is weaker with almost independently of . The measured nuclear
modification factors are compared to other measurements and model calculations.Comment: 17 pages, 4 captioned figures, 2 tables, authors from page 12,
published version, figures at
http://aliceinfo.cern.ch/ArtSubmission/node/284
Anisotropic flow of charged hadrons, pions and (anti-)protons measured at high transverse momentum in Pb-Pb collisions at TeV
The elliptic, , triangular, , and quadrangular, , azimuthal
anisotropic flow coefficients are measured for unidentified charged particles,
pions and (anti-)protons in Pb-Pb collisions at TeV
with the ALICE detector at the Large Hadron Collider. Results obtained with the
event plane and four-particle cumulant methods are reported for the
pseudo-rapidity range at different collision centralities and as a
function of transverse momentum, , out to GeV/.
The observed non-zero elliptic and triangular flow depends only weakly on
transverse momentum for GeV/. The small dependence
of the difference between elliptic flow results obtained from the event plane
and four-particle cumulant methods suggests a common origin of flow
fluctuations up to GeV/. The magnitude of the (anti-)proton
elliptic and triangular flow is larger than that of pions out to at least
GeV/ indicating that the particle type dependence persists out
to high .Comment: 16 pages, 5 captioned figures, authors from page 11, published
version, figures at http://aliceinfo.cern.ch/ArtSubmission/node/186
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