30 research outputs found
Genetic mechanisms of critical illness in COVID-19.
- Author
- A A Roger Thompson
- A Abraheem
- A Agasou
- A Ahmed
- A Ali
- A Allan
- A Altabaibeh
- A Alvaro
- A Aspinwall
- A Ayers
- A Bamford
- A Barron
- A Bashyal
- A Bellini
- A Bociek
- A Botello
- A Bowes
- A Brady
- A Brayne
- A Brown
- A Brown
- A Butler
- A Campbell
- A Carter
- A Collins
- A Cowley
- A Cowton
- A Cowton
- A Cox
- A Crew
- A Dance
- A Daniel
- A Daniels
- A Dela Rosa
- A Drummond
- A Durie
- A E Heron
- A Easthope
- A Easthope
- A Evans
- A Fofano
- A Gales
- A Ganesan
- A Gardner
- A Garg
- A Gherman
- A Gordon
- A Gratrix
- A Gulati
- A Gupta
- A Haigh
- A Haldeos
- A Harrison
- A Harvey
- A Hayes
- A Higham
- A Higham
- A Hilldrith
- A Holden
- A Hormis
- A Hutcheon
- A Javaid
- A Joseph
- A Kaliappan
- A Katary
- A Kay
- A Kayani
- A Kent
- A Kirkby
- A Knight
- A Kubisz-Pudelko
- A Kuravi
- A Lewis
- A Loveridge
- A Lyle
- A Mayer
- A McAlpine
- A McCarthy
- A McGregor
- A McGregor
- A Meikle
- A Mitchell
- A Mitra
- A Morris
- A Morrison
- A Naranjo
- A Nicholson
- A Nicholson
- A Nilsson
- A Noakes
- A Patel
- A Pickard
- A Poole
- A Price
- A Puxty
- A Quinn
- A Quinn
- A Raithatha
- A Rattray
- A Reddy
- A Reed
- A Reyes
- A Rose
- A Rose
- A Rostron
- A Roy
- A Roynon-Reed
- A S Raj
- A Salberg
- A Sanderson
- A Serrano-Ruiz
- A Solesbury
- A Sukha
- A Swain
- A Tariq
- A Thomas
- A Thomas
- A Todd
- A Tomas
- A Tridente
- A Tucci
- A Turnbull
- A Uriel
- A Ustianowski
- A Vochin
- A Vuylsteke
- A Waite
- A Walden
- A Whileman
- A Wilkinson
- A Williams
- A Williams
- A Wilson
- A Zak
- A Zaki
- Achille Iolascon
- Adam Auton
- Adam Brown
- Agnese Verzuri
- Agostino Ognibene
- Agostino Riva
- Ailsa Golightly
- Alan Maclean
- Alessandra
- Alessandra Stella
- Alessandra Vergori
- Alessia Giorli
- Alexander J Mentzer
- Alice Donati
- Alison M Meynert
- Alistair Nichol
- Ana da Silva Filipe
- Andrea Antinori
- Andrea Cossarizza
- Andrea Ganna
- Andrea Tommasi
- Andrew Rambaut
- Andrew Stenhouse
- Andy Law
- Anjali J Shastri
- Anna Canaccini
- Anna Maria Pinto
- Annarita Giliberti
- Annemarie B Docherty
- Antonella D'Arminio Monforte
- Antonia Ying Wai Ho
- Antonio Di Biagio
- Antony Symons
- Arianna Emiliozzi
- Arianna Gabrieli
- Audrey Coutts
- B Anwar
- B Attwood
- B Baines
- B Blackledge
- B Borislavova
- B Chandler
- B Charles
- B Creagh-Brown
- B David
- B Deacon
- B Deacon
- B Digby
- B Faulkner
- B Fuller
- B Gumbrill
- B Gurung
- B Hadebe
- B Hairsine
- B Hopkins
- B Johnston
- B Lenagh
- B Masunda
- B Ogg
- B Patel
- B Player
- B Purewal
- B Scholefield
- B Shelley
- B Sloan
- B Thomas
- B Wadams
- B Welsh
- B Wilkinson
- B Winter-Goodwin
- B Yates
- Baillie J Kenneth
- Barbara Rossetti
- Beale Rupert
- Beatrice Alex
- Benjamin Bach
- Bretherick Andrew D
- Bruno Frediani
- C Adams
- C Ahmed
- C Almaden-Boyle
- C Ashbrook-Raby
- C Basikolo
- C Battle
- C Beazley
- C Beith
- C Borra
- C Brandwood
- C Brantwood
- C Burnett
- C Castro Delgado
- C Clark
- C Clulow
- C Collins
- C Cruz
- C Davis
- C Demetriou
- C Dennis
- C Dexter
- C Downes
- C Dunmore
- C Eastgate
- C Eckbad
- C Finch
- C Gibson
- C Gorman
- C Hays
- C Hewitt
- C Holl
- C Howcroft
- C Humphrey
- C Jackson
- C Jardine
- C Jennings
- C Jones
- C Kaye
- C Lynch
- C Lyons
- C McCulloch
- C McParland
- C McParland
- C Murphy
- C Parmar
- C Pawley
- C Phillips
- C Phillips
- C Pothecary
- C Pothecary
- C Prendergast
- C Price
- C Rishton
- C Sell
- C Shovelton
- C Sicat
- C Stuart
- C Summers
- C Swan
- C Thompson
- C Thorpe
- C Tibke
- C Tierney
- C Vigurs
- C Wells
- C Whitton
- C Whyte
- C Wrey Brown
- Cameron J Fairfield
- Carmelo Piscopo
- Carmen Marciano
- Caroline Abernathy
- Carrol Gamble
- Caterina Lo Rizzo
- Catherine A Shaw
- Catherine H Weldon
- Caulfield Mark
- Ceilia Boz
- Cesira Nencioni
- Chelsea Ye
- Chiara Fallerini
- Chiara Gabbi
- Chiara Spertilli
- Chloe Donohue
- Chris Ponting
- Christoper A Green
- Cinthia E Jannes
- Clare Jackson
- Clohisey Sara
- Cristina Mussini
- D Antcliffe
- D Bakthavatsalam
- D Banach
- D Baptista
- D Bell
- D Branney
- D Brealey
- D Brealey
- D Butcher
- D Butcher
- D Childs
- D Clarke
- D Collier
- D Collier
- D Cristiano
- D Dawson
- D Donaldson
- D Duffin
- D Fottrell-Gould
- D Golden
- D Griffin
- D Hamilton
- D Hawcutt
- D Hope
- D Horner
- D Kallon
- D Kaye
- D Kelly
- D Loader
- D Lomas
- D Martin
- D McGlynn
- D McLaughlanv
- D Melia
- D Menzies
- D Mullan
- D Pogson
- D Potla
- D Potoczna
- D Purohit
- D Raynard
- D Salutous
- D Salutous
- D Scaletta
- D Shaw
- D Skinner
- D Smyth
- D Strachan
- D Tetla
- D Thornton
- D Trodd
- D Vedage
- D Walker
- D Warren
- D Williams
- D Wood
- D Wright
- Daniela Francisci
- Daniella Coker
- Danilo Tacconi
- David A van Heel
- David Bennet
- David L Robertson
- David Stuart
- Dawn Law
- Debby Bogaert
- Derek Murphy
- Domenico A Coviello
- E Abaleke
- E Allan
- E Anastasescu
- E Andrews
- E Apetri
- E B Jude
- E Beech
- E Beranova
- E Bevan
- E Black
- E Brinkworth
- E Collins
- E Combes
- E Davies
- E Dobson
- E Dooks
- E Fisher
- E Gendall
- E Goff
- E Goodwin
- E Gordon
- E Heeney
- E Horsley
- E Hughes
- E Johnson
- E Knights
- E Lee
- E London
- E Maccacari
- E Massey
- E McKenna
- E Meadows
- E Moncur
- E Morino
- E Mwaura
- E Peasgood
- E Perkins
- E Radford
- E Raith
- E Raith
- E Salciute
- E Smith
- E Smithson
- E Stoddard
- E Stones
- E Thomas
- E Tilney
- E Timlick
- E Treus Gude
- E Virgilio
- E Watson
- E Wilby
- Edoardo Conticini
- Egle Saviciute
- Elena Bargagli
- Elena Desanctis
- Elisa Benetti
- Elisa Frullanti
- Elisabetta Menatti
- Elisabetta Schiaroli
- Ellie Mcmaster
- Emma C Thomson
- Emmanuelle Marques
- Enrico Martinelli
- Esther Duncan
- Esther Merlini
- Ewen M Harrison
- F Anderson
- F Auld
- F Bibi
- F Davies
- F Farquhar
- F Fisher
- F Hurford
- F Kibutu
- F McNeela
- F Moore
- F Nasir
- F Trim
- F Wakinshaw
- F Williams
- Fabio Lena
- Fawkes Angie
- Federico Anedda
- Federico Franchi
- Ferdinando Giannattasio
- Filip Taneski
- Filippo Aucella
- Filippo Biscarini
- Floriana Valentino
- Fourman Max Head
- Francesca Andretta
- Francesca Fava
- Francesca Gatti
- Francesca Mari
- Francesca Montagnani
- Francesco Castelli
- Francesco Raimondi
- Furniss James
- G Andrew
- G Arbane
- G Bell
- G Bercades
- G Croston
- G Debreceni
- G Durrant
- G Hambrook
- G Hobden
- G Houston
- G Hughes
- G Jones
- G Lubimbi
- G Maloney
- G Martir
- G Millen
- G Mills
- G O'Connor
- G Padden
- G Randell
- G Sadera
- G Seddon
- G Sera Howe
- G Sloane
- G Subramanian
- G Tsinaslanidis
- G Turner
- G Watson
- G Wray
- Gabriella Coiro
- Gabriella Doddato
- Gail Carson
- Gardar Sveinbjornsson
- Gary Leeming
- Genni Spargi
- Georgios Pollakis
- Giacomo Zanelli
- Gian Piero Caldarelli
- Giancarlo Bosio
- Giuseppe Fiorentino
- Giuseppe Merla
- Gountouna Elvina
- Graham S Cooke
- Griffiths Fiona
- Grimes Graeme
- H Bancroft
- H Bates
- H Belfield
- H Blackman
- H Blakemore
- H Brooke
- H Button
- H Coles
- H Curgenven
- H Filipe
- H Fox
- H Golding
- H Hill
- H Holcombe
- H Houlden
- H Jeffrey
- H Kent
- H Langton
- H McGuinness
- H Meghari
- H Millward
- H Moore
- H Parker
- H Pearson
- H Prady
- H Quinn
- H Rangarajan
- H Rehman
- H Reschreiter
- H Riley
- H Sainsbury
- H Savill
- H Sturgeon
- H T-Michael
- H Tench
- H Tiveran
- H Turner
- H Whittle
- H Willis
- H Wood
- Haley Chris
- Hanning Mal
- Harrison David
- Hayley Hardwick
- Hayward Caroline
- Helen Szoor-McElhinney
- Hinds Charles
- Ho Antonia
- Horby Peter
- I Ali Mohamed Ali
- I Balagosa
- I Birkinshaw
- I Burn
- I Chadbourn
- I D Clement
- I Edmond
- I Frost
- I Hass
- I Hussain
- I Lancoma-Malcolm
- I Leadbitter
- I Nagra
- I Otahal
- I Otahal
- I Turner-Bone
- I Welters
- I White
- I Wynter
- Ilaria Meloni
- Immacolata Andolfo
- Isabella Zanella
- J Allan
- J Barker
- J Bewley
- J Biddle
- J Birch
- J Birch
- J Bradley-Potts
- J Brown
- J Bryant
- J Butler
- J Camsooksai
- J Carter
- J Caterson
- J Cebrian Suarez
- J Cockerill-Taylor
- J Cole
- J Colley
- J Cooper
- J Cupitt
- J Cuttler
- J Daglish
- J Dasgin
- J Dawson
- J Dearden
- J Deery
- J Donnachie
- J Dykes
- J Easton
- J Egan
- J Fernandez Roman
- J Finn
- J Fletcher
- J Frankham
- J Gaylard
- J Gill
- J Godden
- J Goodsell
- J Gregory
- J Greig
- J Gurasashvili
- J Hardy
- J Harris
- J Hatton
- J Hawes
- J Highgate
- J Hornsby
- J Hulme
- J Hunt
- J Hutter
- J Ingham
- J Jones
- J Jones
- J K Baillie
- J Kassam
- J Kenneth Baillie
- J Kenneth Baillie
- J Keshet-Price
- J Liew
- J Little
- J Mallinson
- J Martin
- J Matthews
- J McCormick
- J Medhora
- J Melville
- J Moreno Cuesta
- J Morgan
- J Naisbitt
- J Norris
- J North
- J Parkin
- J Pendlebury
- J Perez
- J Perry
- J Pheby
- J Philbin
- J Pinnell
- J Queiroz
- J Radhakrishnan
- J Reid
- J Rhodes
- J Riches
- J Ritzema
- J Ruddy
- J Ryan-Smith
- J Scriven
- J Scriven
- J Scriven
- J Shiel
- J Singh
- J Singleton
- J Smith
- J Sowter
- J Strickley
- J Summers
- J Taylor
- J Tebbutt
- J Texeira
- J Thomas
- J Thrush
- J Tomlinson
- J Valentine
- J Whiteside
- J Wilkins
- J Willson
- J Zamikula
- Jake Dunning
- Jane Weaver
- Janet Harrison
- Janet T Scott
- Janie F Shelton
- Jen Meikle
- Jo Dalton
- Johnny Millar
- Jorge Esparza-Gordillo
- Jose E Krieger
- Julian A Hiscox
- K Archer
- K Austin
- K Baines
- K Bauchmuller
- K Beaumont
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- K Criste
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- K Dent
- K Douglas
- K Duffy
- K Elliott
- K Elston
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- K Fernandes
- K Fletcher
- K Gilbert
- K Golder
- K Hammerton
- K Hanson
- K Hanson
- K Hard
- K Harrington
- K Hayes
- K Holding
- K Holdroyd
- K Howard
- K Hugill
- K Inweregbu
- K Jackson-Lawrence
- K Karthik
- K King
- K Knowles
- K Lang
- K Liyanage
- K Manso
- K Netherton
- K Postlethwaite
- K Potts
- K Prager
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- K Pritchard
- K Puxty
- K Reid
- K Riches
- K Rooney
- K Sellick
- K Shuker
- K Simpson
- K Simpson
- K Slevin
- K Smith
- K Sollesta
- K Stammers
- K Stroud
- K Sweet
- K Tatham
- K Turner
- K Webster
- K White
- K Williams
- K Xavier
- Katarzyna Hafezi
- Keating Sean
- Kenneth A Mclean
- Kirstie Morrice
- Klaric Lucija
- Klenerman Paul
- Knight Julian
- Kousathanas Athanasios
- L Abel
- L Akeroyd
- L Allen
- L Armstrong
- L Barclay
- L Benham
- L Botfield
- L Bough
- L Brimfield
- L Bunni
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- L Folkes
- L Foster
- L Garner
- L Gemmell
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- L Glass
- L Glass
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- L Grimmer
- L Gurr
- L Harrison
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- L Hudig
- L Keating
- L Kittridge
- L Lankester
- L Lennon
- L Lim
- L Ma
- L Marshall
- L Matupe
- L McMorrow
- L McQuillan
- L Mew
- L Mostoles
- L Mwaura
- L Newey
- L O'Brien
- L O'Malley
- L O'Neill
- L Ortiz-Ruiz de Gordoa
- L Ortiz-Ruiz de Gordoa
- L Park
- L Pippard
- L Prentice
- L Rad
- L Ramos
- L Riddles
- L Roche
- L Roche
- L Rooney
- L Rosaroso
- L Shaw
- L Smith
- L Stevenson
- L Symon
- L Thomis
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- L Thrasyvoulou
- L Ting
- L Tonks
- L Turner
- L van Koutrik
- L Wilcox
- L Wild
- L Wilding
- L Woods
- L Wren
- L Zitter
- Lance C W Turtle
- Laura Bergantini
- Laura Di Sarno
- Laura Marsh
- Laura Merson
- Law Andrew
- Leonardo Croci
- Lia Crotti
- Ling Lowell
- Lisa Norman
- Lorenzo Salerni
- Lorna Donnelly
- Louise Cullum
- Louise Macgillivray
- Louise Sigfrid
- Luca Cantarini
- Luca Guidelli
- Luca Masucci
- Luisa Tavecchia
- M Abdelrazik
- M Al-Moasseb
- M Balasubramaniam
- M Bates
- M Bellamy
- M Birt
- M Blunt
- M Bokhari
- M Bolton
- M Brady
- M Breekes
- M Brett
- M Bromley
- M Bruce
- M Brunton
- M Burton
- M Callaghan
- M Carmody
- M Carnahan
- M Casey
- M Caswell
- M Chablani
- M Clapham
- M Clark
- M Clark
- M Coulding
- M Croft
- M Cunningham
- M Davey
- M Davies
- M Davies
- M Edward
- M Elhassan
- M Elsaadany
- M Faulkner
- M Forsey
- M Frise
- M Gellamucho
- M Gill
- M Gummadi
- M Halkes
- M Harkins
- M Hill
- M Hobrok
- M Holland
- M Home
- M Hussain
- M Jackson
- M K Phull
- M Kent
- M Khan
- M Latif
- M Leigh
- M Lopez Martinez
- M Lyons
- M MacMahon
- M Male
- M Marani
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- M Marotti
- M Matharu
- M McLaughlin
- M McPhail
- M Meredith
- M Mpelembue
- M Msiska
- M Mulcahy
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- M Nauman Akhtar
- M Newton
- M Oblak
- M Odam
- M Ostermann
- M Patel
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- M Penacerrada
- M Peters
- M Popescu
- M Poulaka
- M Purewal
- M Raj
- M Robinson
- M Sangombe
- M Shankar-Hari
- M Sim
- M Slaughter
- M Smith
- M Smith
- M Spivey
- M T Hijazi
- M Taylor
- M Taylor
- M Taylor
- M Taylor
- M Taylor
- M Templeton
- M Thankachen
- M Thirumaran
- M Thomas
- M Tolson
- M Usher
- M Varghese
- M Verlander
- M Vertue
- M Watters
- M White
- M Wiles
- M Williams
- M Wills
- M Woodruff
- M Young
- Maaike Swets
- Mahdad Noursadeghi
- Manu Shankar-Hari
- Marco Castori
- Marco Feri
- Marco Gori
- Marco Mandalà
- Marco Sita
- Margherita Baldassarri
- Mari E K Niemi
- Mari Ward
- Maria Antonietta Mazzei
- Maria Antonietta Mencarelli
- Maria Bandini
- Maria Eugenia Quiros-Roldan
- Maria Palmieri
- Maria Zambon
- Marie Connor
- Mario Capasso
- Mario U Mondelli
- Marta Corridi
- Maslove David
- Massimiliano Fabbiani
- Massimo Carella
- Massimo Girardis
- Massimo Palmarini
- Massimo Vaghi
- Matteo Bassetti
- Matteo Della Monica
- Matteo Siano
- Mattia Cordioli
- Maurizio Sanarico
- Maurizio Sanguinetti
- Maurizio Spagnesi
- McAuley Danny
- Meera Chand
- Meynert Alison
- Michelle Girvan
- Millar Jonathan
- Mirella Bruttini
- Miriana D'Alessandro
- Montgomery Hugh
- Moore Shona C
- Moutsianas Loukas
- Murphy Lee
- Murray Wham
- N Ahmad
- N Bandla
- N Baxter
- N Boyle
- N Capps
- N Clarke
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- Nichol Alistair
- Nicholas Parkinson
- Nicholas Price
- Nicky Day
- Nicola Picchiotti
- O Adanini
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- O Mercer
- O Mitchelmore
- O Olufuwa
- O Prysyazhna
- O Zongo
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- Openshaw Peter J M
- P Alexander
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- P Barry
- P Boyle
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- P Coghlan
- P Doble
- P Donnison
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- P Harding
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- P Mercer
- P O'Brien
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- P Saunderson
- P Shanmugasundaram
- P Springle
- P Szedlak
- P Turner
- P Williams
- Pairo-Castineira Erola
- Pamela Raggi
- Paola Magro
- Paolo Cameli
- Paolo Piacentini
- Parkinson Nick
- Pasko Dorota
- Patrick Sulem
- Patrizia Zucchi
- Paul Finernan
- Paul Klenerman
- Pereira Alexandre C
- Peter W Horby
- Pier Giorgio Scotton
- Pierpaolo Parravicini
- Pietro Pinoli
- Ponting Chris P
- Porteous David J
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- R Barber
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- R Bi
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- R Clark
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- R Crowe
- R Cusack
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- R Doonan
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- Raffaele Scala
- Rawlik Konrad
- Renieri
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- Richard Clark
- Richard S Tedder
- Richmond Anne
- Riinu Pius
- Rita Perna
- Roberta Russo
- Ross Hendry
- Rossella Tita
- Rowan Kathy
- Russell Clark D
- Ruth Armstrong
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- S Yussuf
- Sabino Scolletta
- Samreen Ijaz
- Sandro Mancarella
- Sandro Panese
- Sara Amitrano
- Sara McDonald
- Sarah Law
- Sarah McCafferty
- Saverio Giuseppe Parisi
- Saye Khoo
- Scott Richard
- Semple Malcolm G
- Serafina Valente
- Serena Ludovisi
- Sergio Daga
- Seán Keating
- Shankar-Hari Manu
- Shen Xia
- Shih Barbara
- Shiranee Sriskandan
- Shona C Moore
- Silvia Cappelli
- Simona Marcantonio
- Simone Furini
- Sophie Halpin
- Sophie Venturelli
- Stefania Mantovani
- Stefano Baratti
- Stefano Ceri
- Stefano Rusconi
- Stella Aslibekyan
- Stephanie Roberts
- Stephen R Knight
- Summers Charlotte
- Susanna Croci
- Susanna Guerrini
- T Anderson
- T Arden
- T Baird
- T Behan
- T Bemand
- T Cosier
- T Coventry
- T Duncan
- T Felton
- T Geary
- T Hazleton
- T Joefield
- T Kannan
- T Lawton
- T Marsden
- T Martin
- T McHugh
- T Newman
- T Nortcliffe
- T O Jones
- T Pogreban
- T Rees
- T Samakomva
- T Smith
- T Smith
- T Szakmany
- T Varghes
- T Williams
- T Wood
- Tammy Gilchrist
- Tenesa Albert
- Teresa Filshtein-Sonmez
- Thomas M Drake
- Thushan de Silva
- Tim Walsh
- Tom Fletcher
- Tom Solomon
- Tony Wackett
- Trevor Paterson
- Tullio Trotta
- Turtle Lance
- U Poultney
- V Amin
- V Anumakonda
- V Bastion
- V Cannons
- V Crickmore
- V Gopal
- V Irvine
- V Kasipandian
- V Krishnamurthy
- V Lake
- V Linnett
- V Martinson
- V Nagarajan
- V Page
- V Parris
- V Parris
- V Pristopan
- V Ratnam
- V Rivers
- V Sarathy
- V Thomas
- V Thwaites
- V Tuckey
- V Turner
- V Wagstaff
- V Waugh
- Valentina Anemoli
- Vanessa Sancho-Shimizu
- Victoria Shaw
- Vitart Veronique
- W Harrison
- W Khaliq
- W Khaliq
- W McCormick
- W Woodyatt
- Walker Susan
- Walsh Timothy
- Wang Bo
- Wei Shen Lim
- Wendy S Barclay
- William A Paxton
- William Greenhalf
- Wilson James F
- Wrobel Nicola
- Wu Yang
- X Qiu
- Y Baird
- Y Choudhury
- Y Hussain
- Y Jackson
- Y Thirlwall
- Yang Jian
- Yang Zhijian
- Z Alldis
- Z Belagodu
- Z Bradshaw
- Z Coton
- Z Daly
- Z Farzad
- Z Fernandez
- Z Garland
- Z Maqsood
- Z Omar
- Z Prime
- Z Scott
- Zechner Marie
- Zhai Ranran
- Zheng Chenqing
- Publication venue
- Nature
- Publication date
- 01/01/2020
- Field of study
Host-mediated lung inflammation is present1, and drives mortality2, in the critical illness caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with critical illness may identify mechanistic targets for therapeutic development3. Here we report the results of the GenOMICC (Genetics Of Mortality In Critical Care) genome-wide association study in 2,244 critically ill patients with COVID-19 from 208 UK intensive care units. We have identified and replicated the following new genome-wide significant associations: on chromosome 12q24.13 (rs10735079, P = 1.65 × 10-8) in a gene cluster that encodes antiviral restriction enzyme activators (OAS1, OAS2 and OAS3); on chromosome 19p13.2 (rs74956615, P = 2.3 × 10-8) near the gene that encodes tyrosine kinase 2 (TYK2); on chromosome 19p13.3 (rs2109069, P = 3.98 × 10-12) within the gene that encodes dipeptidyl peptidase 9 (DPP9); and on chromosome 21q22.1 (rs2236757, P = 4.99 × 10-8) in the interferon receptor gene IFNAR2. We identified potential targets for repurposing of licensed medications: using Mendelian randomization, we found evidence that low expression of IFNAR2, or high expression of TYK2, are associated with life-threatening disease; and transcriptome-wide association in lung tissue revealed that high expression of the monocyte-macrophage chemotactic receptor CCR2 is associated with severe COVID-19. Our results identify robust genetic signals relating to key host antiviral defence mechanisms and mediators of inflammatory organ damage in COVID-19. Both mechanisms may be amenable to targeted treatment with existing drugs. However, large-scale randomized clinical trials will be essential before any change to clinical practice
Whole-genome sequencing reveals host factors underlying critical COVID-19
- Author
- Abd Elghafar M. S.
- Abdel-Aziz M.
- Abdelrazik M.
- Abdollahi H.
- Abdullah T.
- Abecasis G. R.
- Abedalthagafi M.
- Abel L.
- Abernathy C.
- Abraheem A.
- Abul-Husn N. S.
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2–4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease
Relationship between the Clinical Frailty Scale and short-term mortality in patients ≥ 80 years old acutely admitted to the ICU: a prospective cohort study.
- Author
- Abraham P.
- Adamik B.
- Adorni A.
- Aguilar G.
- Aguilar G.
- Agvald-Öhman Christina
- Ahmed H.
- Aidoni Z.
- Aidoni Z.
- Aikaterini K.
- Aissaoui N.
- Al-Subaie N.
- Allgäuer S.
- Aloizos S.
- Alvarez J. Trenado
- Andersen F. H.
- Andersen F. H.
- Andersen Finn H.
- Antoniou A.
- Artigas Antonio
- Babini M.
- Baird Y.
- Balasubramaniam M.
- Balasubramaniam M.
- Ball J.
- Barattini M.
- Barbagallo M.
- Bark B.
- Barnes K.
- Barnes V.
- Barros I.
- Barros I.
- Barros N.
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- Barth E.
- Bassford C.
- Bastiansen A.
- Beil Michael
- Belkhair W. Ali
- Bell L.
- Belskiy V.
- Belskiy V.
- Bergström A.
- Berkius J.
- Berkius J.
- Bernas S.
- Berruto F.
- Besch G.
- Besch G.
- Biernacka A.
- Biernawska J.
- Biskup E.
- Bjorsvik G.
- Blanco J. B.
- Bloos F.
- Bocchi A.
- Bocci M. G.
- Bodi M. A.
- Bohatyrewicz R.
- Bolger C.
- Bolger C.
- Bollen Pinto B.
- Bollen Pinto Bernardo
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- Boroli F.
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- Boskholov B.
- Bottazzi A.
- Boulanger C.
- Boulanger C.
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- Brenner T.
- Brizio E.
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- Brresen O. M.
- Bruno R. Romano
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- Calamai I.
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- Castaneray J.
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- Cecconi Maurizio
- Chagnon J. L.
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- Charron C.
- Chilton P.
- Christensen S.
- Christensen Steffen
- Chukkambotla S.
- Cilloniz C.
- Clark R.
- Clark T.
- Clementi S.
- Codazzi D.
- Coetzee S.
- Collins A.
- Constantin B.
- Cornet A. D.
- Cortegiani A.
- Cowton A.
- Cowton A.
- Cracchiolo A. Neville
- Craig J.
- Cramer C.
- Crayford A.
- Cubattoli L.
- Cubero P. Jimeno
- Cupitt J.
- Cupitt J.
- Cwyl K.
- Cwyl K.
- Cyrankiewicz W.
- Cyrankiewicz W.
- Czuczwar M.
- Czuczwar M.
- Dahle B. E. S.
- De Buysscher P.
- De Buysscher P.
- De Geer L.
- De Geer L.
- De Gordoa L. Ortiz-Ruiz
- de Jager P.
- de Lange D.
- de Lange D.
- de Lange Dylan W.
- De Neve N.
- de Neve N.
- de Smet A. G. E.
- de Waard M. C.
- Dempsey G.
- Dey N.
- Di Lascio G.
- Dias C.
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- Dieck T.
- Dieperink W.
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- Forceville X.
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- Fronczek Jakub
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- Moreno Rui
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- Spyropoulou A.
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- Sviri Sigal
- Swinnen W.
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- Valentin Andreas
- Valette X.
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- Velasco G. Navarro
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- Villamayor M. Ibarz
- Vinsonneau C.
- VIP2 study group [missing]
- Vizcaychipi M.
- Vulcano G. A.
- Wakefield P.
- Walther S.
- Walther S.
- Walther Sten
- Watson Ximena
- Wawrzyniak K.
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- Ørsnes D.
- Żukowski M.
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2021
- Field of study
BACKGROUND: The Clinical Frailty Scale (CFS) is frequently used to measure frailty in critically ill adults. There is wide variation in the approach to analysing the relationship between the CFS score and mortality after admission to the ICU. This study aimed to evaluate the influence of modelling approach on the association between the CFS score and short-term mortality and quantify the prognostic value of frailty in this context. METHODS: We analysed data from two multicentre prospective cohort studies which enrolled intensive care unit patients ≥ 80 years old in 26 countries. The primary outcome was mortality within 30-days from admission to the ICU. Logistic regression models for both ICU and 30-day mortality included the CFS score as either a categorical, continuous or dichotomous variable and were adjusted for patient's age, sex, reason for admission to the ICU, and admission Sequential Organ Failure Assessment score. RESULTS: The median age in the sample of 7487 consecutive patients was 84 years (IQR 81-87). The highest fraction of new prognostic information from frailty in the context of 30-day mortality was observed when the CFS score was treated as either a categorical variable using all original levels of frailty or a nonlinear continuous variable and was equal to 9% using these modelling approaches (p < 0.001). The relationship between the CFS score and mortality was nonlinear (p < 0.01). CONCLUSION: Knowledge about a patient's frailty status adds a substantial amount of new prognostic information at the moment of admission to the ICU. Arbitrary simplification of the CFS score into fewer groups than originally intended leads to a loss of information and should be avoided. Trial registration NCT03134807 (VIP1), NCT03370692 (VIP2)
Whole-genome sequencing reveals host factors underlying critical COVID-19
- Author
- Abd Elghafar M.S.
- Abdel-Aziz M.
- Abdelrazik M.
- Abdollahi H.
- Abdullah T.
- Abecasis G.R.
- Abecasis G.R.
- Abedalthagafi M.
- Abel L.
- Abernathy C.
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- Abul-Husn N.S.
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- Publication venue
- Springer Science and Business Media LLC
- Publication date
- 07/07/2022
- Field of study
Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2,3,4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease
Observation of gravitational waves from the coalescence of a 2.5−4.5 M⊙ compact object and a neutron star
- Author
- Abac Adrian
- Abbott R.
- Abouelfettouh I.
- Acernese F.
- Ackley Kendall
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Afif Ismail M.
- Agarwal Deepali
- Agathos Michalis
- Aghaei Abchouyeh Maryam
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akcay Sarp
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Al-Shammari S.
- Albanesi Simone
- Alex iandolo Guido
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Altin Paul
- Alvarez-Lopez Sofia
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Amra C.
- Ananyeva A.
- Anderson Stuart
- Anderson Warren G.
- Andia Manuel
- Ando M.
- Andrade T.
- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés Vallejo Peña Sergio
- Andrés-Carcasona Marc
- Anglin J.
- Anne Bizouard Marie
- Ansoldi Stefano
- Antelis Javier M.
- Antier Sarah
- Antoni Ramis Vidal Felip
- Antonietta Palaia Maria
- Antonio Font Roda Jose
- Aoumi M.
- Appavuravther E. Z.
- Appert S.
- Apple S. K.
- Arai Koji
- Araya Akito
- Araya Melody
- Areeda Joseph
- Argianas L.
- Arif Shaikh Md
- Aritomi N.
- Armato Federico
- Arnaud Nicolas
- Arogeti Megan
- Aronson Scott
- Arun K. G.
- Ashton Gregory
- Aso Yoichi
- Assiduo M.
- Aston S. M.
- Astone Pia
- Attadio Francesca
- Aubin Florian
- AVALLONE Guerino
- Azrad D.
- Babak Stanislav
- Badaracco Francesca
- Badger C.
- Bae Sangwook
- Bagnasco Stefano
- Bagui E.
- Baier Jeremy
- Baiotti Luca
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- Bejger Michał
- Belardinelli Daniele
- Bell Angus
- Benedetto V.
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- Bentley Joe
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- Berbel Marina
- Bergamin Fabio
- Berger Beverly
- Bernuzzi Sebastiano
- Beroiz Martin
- Berry Christopher P. L.
- Bersanetti Diego
- Bertolini A.
- Betzwieser Joseph
- Beveridge Damon
- Bevins Nathaniel
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- Concetta Tringali Maria
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- Corsi Alessandra
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- Cullen Torrey
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- D'Angelo Beatrice
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- d'Emilio V.
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- Dal Canton Tito
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- Divyajyoti
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- Eassa C.
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- Eckhardt Tobias
- Eddolls Graeme
- Edelman Bruce
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- Eisenmann M.
- Eisenstein R. A.
- Ejlli Aldo
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- Elizabeth Ramirez Guevara Karla
- Emma Mattia
- Endo K.
- enea romano antonio
- Engl A. J.
- Enloe E.
- Erasmo Peña Arellano Fabián
- Errico Luciano
- error error
- error error
- Estellés Estrella Héctor
- Estevez Dimitri
- Etzel T.
- Evans Matthew J.
- Evstafyeva T.
- Ewing B. E.
- Fabrizi Federica
- Faedi F.
- Fafone Viviana
- Fairhurst Stephen
- Farah Amanda M.
- Farr Ben
- Farr Will M.
- Favaro Giulio
- Favata Marc
- Fays Maxime
- Fazio M.
- Feicht J.
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- felicetti riccardo
- Fenyvesi Edit
- Ferguson Deborah
- ferraiuolo sarah
- Ferrante Isidoro
- Ferreira T. A.
- Fidecaro Francesco
- Figura Przemysław
- Fiori Alessio
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- Fishbach Maya
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- FIUMARA VINCENZO.
- Flaminio R.
- Fleischer Svenja
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- Fornal Bartosz
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- Yang Fengwei
- Yang Kate Z.
- Yang Yi
- Yarbrough Zach
- Yasui H.
- Yeh S. -W.
- Yelikar A. B.
- Yin X.
- Yokoyama Jun'ichi
- Yokozawa T.
- Yoo Jooheon
- Yu Hang
- Yuan S.
- Yuzurihara Hirotaka
- Zadrożny A.
- Zanolin M.
- Zeeshan M.
- Zelenova T.
- Zendri J. -P.
- Zeoli M.
- Zerrad M.
- Zevin Michael
- Zhang A. C.
- Zhang L.
- Zhang Rui
- Zhang T.
- Zhang Ya
- Zhao C.
- Zhao Yue
- Zhao Yuhang
- Zheng Yanyan
- Zhong Haowen
- Zhou R.
- Zhu Xingjiang
- Zhu Zong-Hong
- Zimmerman Aaron
- Zucker M. E.
- Zweizig John
- Árpád Gergely László
- 劉 國欽
- 都丸 隆行
- Publication venue
- Publication date
- 23/04/2024
- Field of study
Changes to the Fossil Record of Insects through Fifteen Years of Discovery
- Author
- A Arillo
- A Arillo
- A Arillo
- A Baz
- A Baz
- A Borkent
- A Borkent
- A Handlirsch
- A Handlirsch
- A Handlirsch
- A Handlirsch
- A Handlirsch
- A Handlirsch
- A Herczek
- A Huguet
- A Nagatomi
- A Nagatomi
- A Nagatomi
- A Nel
- A Nel
- A Nel
- A Nel
- A Nel
- A Nel
- A Nel
- A Nel
- A Nel
- A Nel
- A Nel
- A Nel
- A Nel
- A Nel
- A Nel
- A Nel
- A Nel
- A Nel
- A Nel
- A Nel
- A Nel
- A Nel
- A Nel
- A Nel
- A Nel
- A Nel
- A Nel
- A Nel
- A Nel
- A Nel
- A Nel
- A Nel
- A Nel
- A Nel
- A Nel
- A Nel
- A Nel
- A Nel
- A Nel
- A Nel
- A Nel
- A Nel
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- A Pütz
- AA Legalov
- AA Legalov
- AB Smith
- AC Harris
- AC Rehn
- AG Kirejtshuk
- AG Kirejtshuk
- AG Kirejtshuk
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- AG Kirejtshuk
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- AG Kirejtshuk
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- AG Ponomarenko
- AG Ponomarenko
- AG Ponomarenko
- AG Ponomarenko
- AG Ponomarenko
- AG Ponomarenko
- AG Ponomarenko
- AG Ponomarenko
- AG Ponomarenko
- AG Ponomarenko
- AG Ponomarenko
- AG Ponomarenko
- AG Ponomarenko
- AG Ponomarenko
- AG Ponomarenko
- AG Sharov
- AH Haliday
- AH Kirk-Spriggs
- AH Staniczek
- AH Staniczek
- AJ Ross
- AJ Ross
- AJ Ross
- AJ Ross
- AJ Ross
- AJ Ross
- AK Brodsky
- Andrew J. Ross
- AO Koçak
- AP Rasnitsyn
- AP Rasnitsyn
- AP Rasnitsyn
- AP Rasnitsyn
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- AP Rasnitsyn
- AP Rasnitsyn
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- AP Rasnitsyn
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- AP Rasnitsyn
- AP Rasnitsyn
- AP Rasnitsyn
- AP Rasnitsyn
- AP Rasnitsyn
- AP Rasnitsyn
- AP Rasnitsyn
- AP Rasnitsyn
- AP Rasnitsyn
- AP Rasnitsyn
- AP Rasnitsyn
- AP Rasnitsyn
- AP Rasnitsyn
- AP Rasnitsyn
- AP Rasnitsyn
- AP Rasnitsyn
- AS Packard
- AS Shmakov
- AS Shmakov
- AS Yang
- AV Gorokhov
- AV Gorokhov
- AV Gorokhov
- AV Gorokhov
- AV Gorokhov
- AV Gorokhov
- AV Gorokhov
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- AV Gorokhov
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- AV Gorokhov
- AV Gorokhov
- AV Gorokhov
- AV Gorokhov
- AV Gorokhov
- AV Gumovsky
- AV Gumovsky
- AV Martynov
- AV Martynov
- AW Skalski
- B Cairncross
- B Efron
- B Hannisdal
- B Wang
- B Wang
- B Wang
- B Wang
- BB Britt
- BB Rohdendorf
- Ben J Mans
- C Brauckmann
- C Brauckmann
- C Brauckmann
- C Brauckmann
- C Brauckmann
- C Brauckmann
- C Brauckmann
- C Brauckmann
- C Brauckmann
- C Brauckmann
- C Brongniart
- C Börner
- C Costa
- C Lienhard
- C Lopez-Vaamonde
- C Lopez-Vaamonde
- C Soriano
- C Soriano
- C Soriano
- C Soriano
- CC Labandeira
- CC Labandeira
- CC Labandeira
- CC Labandeira
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- CC Labandeira
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- CK Shih
- CL Bellamy
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- D Azar
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- DA Grimaldi
- DA Grimaldi
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- DA Grimaldi
- DA Grimaldi
- David B. Nicholson
- DB Nicholson
- DC Peng
- DE Pérez
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- DSAE Rindal
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- DY Huang
- DY Huang
- DY Huang
- DY Huang
- DY Huang
- DY Huang
- DY Huang
- DY Huang
- DY Huang
- DY Huang
- E Clifford
- E Krzeminska
- E Krzeminska
- E Mey
- E Peñalver
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- E Peñalver
- E Simon
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- EE Perkovsky
- EF Riek
- EH Tilgner
- EHPA Haeckel
- EL Bernard
- EL Mockford
- EM Bordy
- ES Ross
- F Fernández-Rubio
- F Fernández-Rubio
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- F Menon
- F Menon
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- F Papier
- F Silvestri
- FL Carle
- FM Carpenter
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- FW Preston
- G Bechly
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- G Fleck
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- G Gentilini
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- G Poinar
- G Schliephake
- G Shi
- G Zalessky
- GAP Gibson
- GAP Gibson
- GJ Svenson
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- GO Poinar
- GO Poinar
- GO Poinar
- GO Poinar
- GO Poinar
- GO Poinar
- GO Poinar
- GO Poinar
- GO Poinar
- González JA Casasola
- GX Zhang
- H Berger
- H Bolton
- H Bolton
- H Geertsema
- H Pohl
- H Pohl
- H Schmied
- H Sturm
- H Özdikmen
- H Özdikmen
- HC Zhang
- HC Zhang
- HC Zhang
- HF Kaddumi
- HH Basibuyuk
- HL Chang
- HM Wilson
- HW Meyer
- I Foldi
- I Fujiyama
- I Kania
- ID Naumann
- ID Pinto
- ID Pinto
- ID Pinto
- ID Pinto
- ID Sukatsheva
- ID Sukatsheva
- ID Sukatsheva
- ID Sukatsheva
- ID Sukatsheva
- ID Sukatsheva
- J Alonso
- J Alroy
- J Alroy
- J Alroy
- J Alroy
- J Alroy
- J Alroy
- J Alroy
- J Alroy
- J Ansorge
- J Ansorge
- J Ansorge
- J Ansorge
- J Ansorge
- J Ansorge
- J Ansorge
- J Ansorge
- J Ansorge
- J Ansorge
- J Bitsch
- J Böcher
- J Damgaard
- J Damgaard
- J Damgaard
- J Grazia
- J Hava
- J Koteja
- J Koteja
- J Koteja
- J Koteja
- J Koteja
- J Koteja
- J Koteja
- J Kukalová
- J Kukalová
- J Kukalová
- J Kukalová-Peck
- J Kukalová-Peck
- J Kukalová-Peck
- J Kukalová-Peck
- J Kukalová-Peck
- J Kupryjanowicz
- J Ortega-Blanco
- J Prokop
- J Prokop
- J Prokop
- J Prokop
- J Prokop
- J Prokop
- J Prokop
- J Prokop
- J Rust
- J Rust
- J Rust
- J Schneider
- J Schneider
- J Szwedo
- J Szwedo
- J Szwedo
- J Szwedo
- J Szwedo
- J Szwedo
- J Szwedo
- J Szwedo
- J Szwedo
- J Szwedo
- J Willkommen
- J Zajíc
- JC Fabricius
- JC Gall
- JC Zamboni
- JCM Carvalho
- JD Huang
- JE Jepson
- JE Jepson
- JE Jepson
- JF Lawrence
- JF Petrulevicius
- JF Petrulevicius
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- JF Petrulevicius
- JF Petrulevicius
- JF Petrulevicius
- JF Petrulevicius
- JF Petrulevicius
- JF Petrulevicius
- JF Petrulevicius
- JF Zhang
- JF Zhang
- JF Zhang
- JF Zhang
- JF Zhang
- JF Zhang
- JF Zhang
- JF Zhang
- JF Zhang
- JF Zhang
- JF Zhang
- JF Zhang
- JF Zhang
- JF Zhang
- JG Ogg
- JH Liang
- JH Liang
- JH Stuke
- JH Sun
- JH Sun
- JJ Sepkoski Jr
- JJ Tan
- JJ Tan
- JJ Tan
- JL Rainford
- JL Ware
- JM Adrain
- JM Heraty
- JP Haenni
- JP Hall
- JR Winkler
- JT Huber
- JT Jennings
- JW Evans
- JW Lubbock
- K Brunner von Wattenwyl
- K Christiansen
- K Christiansen
- K Krishna
- K Rognes
- K Wolf-Schwenninger
- KD Klass
- KGA Hamilton
- Kraemer MM Solórzano
- KY Zhang
- KY Zhang
- KY Zhang
- L Navás
- L Vilhelmsen
- LA Mazzarolo
- LA Mound
- LF Gáll
- LF Mendes
- LM Jacobus
- LM Jacobus
- LN Pritykina
- LN Pritykina
- M Foote
- M Hauser
- M Jaschhof
- M Jaschhof
- M Kotrba
- M Liu
- M López Ruf
- M Ohl
- M von Tschirnhaus
- MA Wills
- MB Mostovski
- MB Mostovski
- MB Mostovski
- MB Mostovski
- MB Mostovski
- MB Mostovski
- MD Hubbard
- MF Braby
- MF Whiting
- MJ Benton
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- MJ Benton
- MJ Benton
- ML Pescador
- MS Engel
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- MS Engel
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- MS Engel
- MS Engel
- MS Engel
- MS Engel
- MS Engel
- MS Engel
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- MS Engel
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- MS Engel
- MS Engel
- MS Engel
- MS Engel
- MS Engel
- MS Engel
- MS Engel
- MS Engel
- MS Engel
- MS Engel
- MS Engel
- MS Engel
- MS Engel
- MS Engel
- MS Engel
- MS Engel
- MS Engel
- MS Engel
- MS Engel
- MV Kozlov
- MV Kozlov
- MX Wang
- N Bonde
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- NS Kalugina
- O Béthoux
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- O Béthoux
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- O Béthoux
- O Béthoux
- O Béthoux
- O Béthoux
- O Béthoux
- O Béthoux
- O Béthoux
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- O Béthoux
- O Béthoux
- O Béthoux
- O Béthoux
- O Béthoux
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- O Béthoux
- O Béthoux
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- O Zompro
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- OE Heie
- OE Heie
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- P Bouchard
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- P Nel
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- P Vršanskyý
- P Vršanskyý
- P Vršanskyý
- P Wegierek
- P Wegierek
- P Wegierek
- P Wegrzynowicz
- PA Jell
- PA Selden
- PC Fitzgerald
- PES Whalley
- PES Whalley
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- Peter J. Mayhew
- PJ Mayhew
- PJ Mayhew
- PJ Mayhew
- PJ Mayhew
- PR Gutiérrez
- PW Signor
- QB Lin
- QB Lin
- QB Lin
- QB Lin
- QB Lin
- QB Lin
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- R Beattie
- R de Jong
- R Garrouste
- R Kinzelbach
- R Wagner
- R Wagner
- R Willmann
- R Willmann
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- RA Coram
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- RB Davis
- RBJ Benson
- RC Dalgleish
- RC McKellar
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- RE Harbach
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- RJ Beckemeyer
- RJ Beckemeyer
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- RJ Godunko
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- T Bourgoin
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- T Nyman
- T Osten
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- T Wappler
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- TH Ogden
- THG Ezard
- TP Gao
- TT Li
- U Aspöck
- U Spahr
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- V Blagoderov
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- V Michelsen
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- V Perrichot
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- W Etter
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- W Wichard
- W Wichard
- W Wichard
- W Wichard
- W Wichard
- W Zessin
- W Zessin
- W Zessin
- W Zessin
- W Zessin
- WD Maxwell
- WJ Pulawski
- WP McCafferty
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- WP McCafferty
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- WP McCafferty
- X Delclòs
- X Delclòs
- X Delclòs
- XH Li
- XW Zhang
- Y Wang
- YA Popov
- YA Popov
- YA Popov
- YA Popov
- YA Popov
- YA Popov
- YA Popov
- YA Popov
- YC Hong
- YC Hong
- YC Hong
- YC Hong
- YC Hong
- YC Hong
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- YC Hong
- YC Hong
- YC Hong
- YC Hong
- YC Hong
- YC Hong
- YC Hong
- YC Hong
- YC Hong
- YC Hong
- YC Hong
- YC Hong
- YC Hong
- YL Li
- YS Liu
- YS Liu
- YS Liu
- YS Liu
- YS Liu
- YS Liu
- YZ Yao
- YZ Yao
- YZ Yao
- YZ Yao
- YZ Yao
- Z Kvacek
- Z Li
- ZJ Zhang
- ZL Zhang
- ZQ Zhang
- ZW Liu
- Ø Hammer
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 15/07/2015
- Field of study
The first and last occurrences of hexapod families in the fossil record are compiled from publications up to end-2009. The major features of these data are compared with those of previous datasets (1993 and 1994). About a third of families (>400) are new to the fossil record since 1994, over half of the earlier, existing families have experienced changes in their known stratigraphic range and only about ten percent have unchanged ranges. Despite these significant additions to knowledge, the broad pattern of described richness through time remains similar, with described richness increasing steadily through geological history and a shift in dominant taxa, from Palaeoptera and Polyneoptera to Paraneoptera and Holometabola, after the Palaeozoic. However, after detrending, described richness is not well correlated with the earlier datasets, indicating significant changes in shorter-term patterns. There is reduced Palaeozoic richness, peaking at a different time, and a less pronounced Permian decline. A pronounced Triassic peak and decline is shown, and the plateau from the mid Early Cretaceous to the end of the period remains, albeit at substantially higher richness compared to earlier datasets. Origination and extinction rates are broadly similar to before, with a broad decline in both through time but episodic peaks, including end-Permian turnover. Origination more consistently exceeds extinction compared to previous datasets and exceptions are mainly in the Palaeozoic. These changes suggest that some inferences about causal mechanisms in insect macroevolution are likely to differ as well
Congenital hypofibrinogenemia associated with a novel heterozygous nonsense mutation in the globular C-terminal domain of the γ-chain (p.Glu275Stop)
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2019
- Field of study
The Importance and Complications of Sequencing of Von Willebrand Gene in Von Willebrand Disease
- Author
- Publication venue
- 'Walter de Gruyter GmbH'
- Publication date
- 01/04/2019
- Field of study
Genetic testing in patients with von Willebrand disease completes phenotypic testing with an aim to confirm the von Willebrand factor defect at a molecular level. Structure of the VWF gene was described 30 years ago; since then a large number of mutations leading to VWD have been described in this gene. Thanks to describing these mechanisms it is possible to understand the pathogenesis of the most common congenital bleeding disorder
Genetic variants in the fgb and fgg genes mapping in the beta and gamma nodules of the fibrinogen molecule in congenital quantitative fibrinogen disorders associated with a thrombotic phenotype
- Author
- Publication venue
- 'MDPI AG'
- Publication date
- 29/06/2020
- Field of study
Fibrinogen is a hexameric plasmatic glycoprotein composed of pairs of three chains (A\u3b1, B\u3b2, and \u3b3), which play an essential role in hemostasis. Conversion of fibrinogen to insoluble polymer fibrin gives structural stability, strength, and adhesive surfaces for growing blood clots. Equally important, the exposure of its non-substrate thrombin-binding sites after fibrin clot formation promotes antithrombotic properties. Fibrinogen and fibrin have a major role in multiple biological processes in addition to hemostasis and thrombosis, i.e., fibrinolysis (during which the fibrin clot is broken down), matrix physiology (by interacting with factor XIII, plasminogen, vitronectin, and fibronectin), wound healing, inflammation, infection, cell interaction, angiogenesis, tumour growth, and metastasis. Congenital fibrinogen deficiencies are rare bleeding disorders, characterized by extensive genetic heterogeneity in all the three genes: FGA, FGB, and FGG (enconding the A\u3b1, B\u3b2, and \u3b3 chain, respectively). Depending on the type and site of mutations, congenital defects of fibrinogen can result in variable clinical manifestations, which range from asymptomatic conditions to the life-threatening bleeds or even thromboembolic events. In this manuscript, we will briefly review the main pathogenic mechanisms and risk factors leading to thrombosis, and we will specifically focus on molecular mechanisms associated with mutations in the C-terminal end of the beta and gamma chains, which are often responsible for cases of congenital afibrinogenemia and hypofibrinogenemia associated with thrombotic manifestations
An Aquatic Water Scavenger Beetle in Early Miocene Amber from the Dominican Republic (Coleoptera: Hydrophilidae)
- Author
- d'Orchymont A.
- Damgaard J.
- Dunlop J.A.
- Engel M. S.
- Fikáček M.
- Fikáček M.
- Fikáček M.
- Gentili E.
- Gistl J.
- Hiura I.
- Iturralde-Vinent M. A.
- Iturralde-Vinent M.A.
- Jelínek J.
- Katinas V.
- Kirsch T. F. W.
- Klebs R.
- Komarek A.
- Komarek A.
- Komarek A.
- Komarek A.
- Kubisz D.
- LeConte J. L.
- Leonhard K. C.
- MacLeay W. S.
- Martin Fikáček
- Michael S. Engel
- Motschulsky V.
- Ritzkowski S.
- Short A. E. Z.
- Solorzáno-Kraemer M. M.
- Spahr A.
- Williamson G. C.
- Publication venue
- 'Museum and Institute of Zoology at the Polish Academy of Sciences'
- Publication date
- Field of study