The Development of Lexical-Semantic Skills in Early Sequential Cantonese-English Bilingual Children

The purpose of this study is to explore lexical-semantic development in early sequential bilingual children who speak Cantonese (L1) as a home language from birth and started to learn English (L2) as a second language in a preschool setting. Linguistically- and culturally- appropriate picture naming and picture identification tasks were developed to assess participants’ expressive and receptive vocabulary knowledge. In Study 1, seventy children participated in picture naming and picture identification tasks comparing their performance as a function of language (L1 or L2), modality (expressive or receptive), age, length of time at the preschool, and performance on standardized vocabulary assessment tools. In Study 2, the results on these tasks of five children on an Individualized Education Plan (IEP) were compared with typically developing, age-matched peers. Results from Study 1 indicate that there is a correlation between a child’s scores with their age, time in school and their scores on standardized tools in both tasks in English and picture identification tasks in Cantonese, but not with picture naming in Cantonese. Results from Study 2 show that only one of five children on IEPs had noticeably lower scores in tasks in both languages when compared to typically-developing peers. This underscores the importance of a culturally and linguistically appropriate assessment tool in distinguishing bilingual children who have a language difference from those with a language disorder

The Effect of Strength and Plyometric Training on Functional Dance Performance in Elite Ballet and Modern Dancers

Background: Ballet and modern dance are both art forms that require technique, artistry, grace and precision. Both dance forms require a degree of strength and muscular endurance for optimal performance. It is not known what value strength or plyometric training may have on functional dance performance. Objective: To systematically review the effects of strength and/or plyometric training on functional dance performance in elite ballet and modern dancers. Methods: A systematic review of literature indexed in the following databases: Medline, CINAHL, SportsDiscus, Physiotherapy Evidence Database (PEDro) and PubMed was conducted. The quality of the studies was graded using the PEDro Scale. Results: Eight studies satisfied the eligibility criteria and were included in this review. The studies\u27 population age range was 19?27?years. Methodological scores based on the PEDro scale were 4 to 6 out of 10. All of the included studies (100%) scored 4 out of 10 or higher on the PEDro scale. Strength training resulted in significant improvements in jump height (P? Conclusion: Moderate evidence indicates that supplementary strength training interventions via traditional resistance training or whole-body vibration methods and plyometric training interventions may increase certain dance-performance measures such as jump height and general aesthetic facility without changing certain anthropometric measures in elite ballet and modern dancers

Valproic acid and fatalities in children: a review of individual case safety reports in VigiBase

Introduction Valproic acid is an effective first line drug for the treatment of epilepsy. Hepatotoxicity is a rare and potentially fatal adverse reaction for this medicine. Objective Firstly to characterise valproic acid reports on children with fatal outcome and secondly to determine reporting over time of hepatotoxicity with fatal outcome. Methods Individual case safety reports (ICSRs) for children ≤17 years with valproic acid and fatal outcome were retrieved from the WHO Global ICSR database, VigiBase, in June 2013. Reports were classified into hepatotoxic reactions or other reactions. Shrinkage observed-to-expected ratios were used to explore the relative reporting trend over time and for patient age. The frequency of polytherapy, i.e. reports with more than one antiepileptic medicine, was investigated. Results There have been 268 ICSRs with valproic acid and fatal outcome in children, reported from 25 countries since 1977. A total of 156 fatalities were reported with hepatotoxicity, which has been continuously and disproportionally reported over time. There were 31 fatalities with pancreatitis. Other frequently reported events were coma/encephalopathy, seizures, respiratory disorders and coagulopathy. Hepatotoxicity was disproportionally and most commonly reported in children aged 6 years and under (104/156 reports) but affected children of all ages. Polytherapy was significantly more frequently reported for valproic acid with fatal outcome (58%) compared with non-fatal outcome (34%). Conclusion Hepatotoxicity remains a considerable problem. The risk appears to be greatest in young children (6 years and below) but can occur at any age. Polytherapy is commonly reported and seems to be a risk factor for hepatotoxicity, pancreatitis and other serious adverse drug reactions with valproic acid

Migräne im Kindes- und Jugendalter — Ausblick auf innovative Behandlungsansätze im Rahmen multimodaler Therapiekonzepte

Although migraine is a~relevant health issue in children and adolescents, clinical care and research are still underrepresented and underfunded in this field. Quality of life can be significantly reduced when living with frequent episodes of pain. Due to the high level of vulnerability of the developing brain during adolescence, the risk of chronification and persistence into adulthood is high. In this narrative review, we describe the corner stones of a~patient-centered, multimodular treatment regimen. Further, an update on the pathophysiology of migraine is given considering the concept of a~periodically oscillating functional state of the brain in migraine patients (\textquotedblmigraine is a~brain state\textquotedbl). Besides central mechanisms, muscular structures with the symptoms of muscular pain, tenderness, or myofascial trigger points play an important role. Against this background, the currently available nonpharmacological and innovative neuromodulating approaches are presented focusing on the method of repetitive peripheral magnetic stimulation.Die Migräne ist auch im Kindes- und Jugendalter ein häufiges, aber in klinischer Versorgung und Wissenschaft oft unterrepräsentiertes Krankheitsbild. Gerade im Kindes- und Jugendalter bestehen relevante Einschränkungen der Lebensqualität durch das (häufige) Schmerzerfahren. Bedingt durch die entwicklungsspezifisch hohe Vulnerabilität des adoleszenten Gehirns besteht ein hohes Chronifizierungs- und Persistenzrisiko bis ins Erwachsenenalter hinein. In diesem Beitrag werden die Bestandteile eines patientenzentrierten, multimodalen Therapiekonzepts dargestellt. Darüber hinaus werden die aktuellsten Erkenntnisse zu den pathophysiologischen Grundlagen der Migräneerkrankung beleuchtet, nach denen Migräne durch einen sich phasenweise verändernden Funktionszustand des Gehirns entsteht (Stichwort: „migraine is a brain state“). Auch periphere Komponenten wie Muskelschmerzen, -verspannungen und -triggerpunkte spielen eine wichtige Rolle. Vor diesem Hintergrund werden nichtpharmakologische innovative Therapieansätze vorgestellt, die auf dem Prinzip der Neuromodulation beruhen, mit Fokus auf der repetitiven peripheren Magnetstimulation

The Changing Landscape for Stroke\ua0Prevention in AF: Findings From the GLORIA-AF Registry Phase 2

Background GLORIA-AF (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation) is a prospective, global registry program describing antithrombotic treatment patterns in patients with newly diagnosed nonvalvular atrial fibrillation at risk of stroke. Phase 2 began when dabigatran, the first non\u2013vitamin K antagonist oral anticoagulant (NOAC), became available. Objectives This study sought to describe phase 2 baseline data and compare these with the pre-NOAC era collected during phase 1. Methods During phase 2, 15,641 consenting patients were enrolled (November 2011 to December 2014); 15,092 were eligible. This pre-specified cross-sectional analysis describes eligible patients\u2019 baseline characteristics. Atrial fibrillation disease characteristics, medical outcomes, and concomitant diseases and medications were collected. Data were analyzed using descriptive statistics. Results Of the total patients, 45.5% were female; median age was 71 (interquartile range: 64, 78) years. Patients were from Europe (47.1%), North America (22.5%), Asia (20.3%), Latin America (6.0%), and the Middle East/Africa (4.0%). Most had high stroke risk (CHA2DS2-VASc [Congestive heart failure, Hypertension, Age  6575 years, Diabetes mellitus, previous Stroke, Vascular disease, Age 65 to 74 years, Sex category] score  652; 86.1%); 13.9% had moderate risk (CHA2DS2-VASc = 1). Overall, 79.9% received oral anticoagulants, of whom 47.6% received NOAC and 32.3% vitamin K antagonists (VKA); 12.1% received antiplatelet agents; 7.8% received no antithrombotic treatment. For comparison, the proportion of phase 1 patients (of N = 1,063 all eligible) prescribed VKA was 32.8%, acetylsalicylic acid 41.7%, and no therapy 20.2%. In Europe in phase 2, treatment with NOAC was more common than VKA (52.3% and 37.8%, respectively); 6.0% of patients received antiplatelet treatment; and 3.8% received no antithrombotic treatment. In North America, 52.1%, 26.2%, and 14.0% of patients received NOAC, VKA, and antiplatelet drugs, respectively; 7.5% received no antithrombotic treatment. NOAC use was less common in Asia (27.7%), where 27.5% of patients received VKA, 25.0% antiplatelet drugs, and 19.8% no antithrombotic treatment. Conclusions The baseline data from GLORIA-AF phase 2 demonstrate that in newly diagnosed nonvalvular atrial fibrillation patients, NOAC have been highly adopted into practice, becoming more frequently prescribed than VKA in Europe and North America. Worldwide, however, a large proportion of patients remain undertreated, particularly in Asia and North America. (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients With Atrial Fibrillation [GLORIA-AF]; NCT01468701

Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits

Peer reviewe

Full-Waveform Airborne Laser Scanning in Vegetation Studies—A Review of Point Cloud and Waveform Features for Tree Species Classification

In recent years, small-footprint full-waveform airborne laser scanning has become readily available and established for vegetation studies in the fields of forestry, agriculture and urban studies. Independent of the field of application and the derived final product, each study uses features to classify a target object and to assess its characteristics (e.g., tree species). These laser scanning features describe an observable characteristic of the returned laser signal (e.g., signal amplitude) or a quantity of an object (e.g., height-width ratio of the tree crown). In particular, studies dealing with tree species classification apply a variety of such features as input. However, an extensive overview, categorization and comparison of features from full-waveform airborne laser scanning and how they relate to specific tree species are still missing. This review identifies frequently used full-waveform airborne laser scanning-based point cloud and waveform features for tree species classification and compares the applied features and their characteristics for specific tree species detection. Furthermore, limiting and influencing factors on feature characteristics and tree classification are discussed with respect to vegetation structure, data acquisition and processing

Full-Waveform Airborne Laser Scanning in Vegetation Studies—A Review of Point Cloud and Waveform Features for Tree Species Classification

In recent years, small-footprint full-waveform airborne laser scanning has become readily available and established for vegetation studies in the fields of forestry, agriculture and urban studies. Independent of the field of application and the derived final product, each study uses features to classify a target object and to assess its characteristics (e.g., tree species). These laser scanning features describe an observable characteristic of the returned laser signal (e.g., signal amplitude) or a quantity of an object (e.g., height-width ratio of the tree crown). In particular, studies dealing with tree species classification apply a variety of such features as input. However, an extensive overview, categorization and comparison of features from full-waveform airborne laser scanning and how they relate to specific tree species are still missing. This review identifies frequently used full-waveform airborne laser scanning-based point cloud and waveform features for tree species classification and compares the applied features and their characteristics for specific tree species detection. Furthermore, limiting and influencing factors on feature characteristics and tree classification are discussed with respect to vegetation structure, data acquisition and processing

Hood River Valley Parks & Recreation District: Parks & Recreation Master Plan 2012-2022

87 pagesThe Hood River Valley Parks and Recreation District (the Park District) has prepared this 2012 Master Plan to provide a ten-year action plan for development, management, and continued improvement of its parks and recreation facilities. This 2012 Master Plan is an update to the Park District’s 2005 Capital Facilities Master Plan. This Master Plan includes the following: 1) A summary of Park District planning area demographics, 2) An inventory of existing park and recreational facilities in the Park District’s planning area, including those owned by partner agencies, 3) A parks and recreation needs analysis based on community surveys and outreach activities, and 4) Goals and objectives to guide the Park District in developing new projects over the next 10-years.2011 Hood River Valley Parks and Recreation Distric

Oregon Biogas Facility Permitting Guide

36 pagesBiogas, derived from anaerobic decomposition of organic matter, is a small but growing source of energy in Oregon. Given Oregon’s strong agricultural sector, there is the potential to close the loop on the nutrient cycle while increasing energy production through development of biogas projects within the state. However, there are a number of challenges, such as permitting, financing, and neighbor opposition that can hinder development of biogas facilities. The purpose of the Biogas Facility Permitting and Siting Guide (the Guide) is to provide agricultural developers, farmers, third party energy developers, or anyone interested in developing a biogas facility with the information they need to do so in Oregon