1,744 research outputs found
Plane-symmetric inhomogeneous Brans-Dicke cosmology with an equation of state
We present a new exact solution in Brans-Dicke theory. The solution describes
inhomogeneous plane-symmetric perfect fluid cosmological model with an equation
of state . Some main properties of the solution are discussed.Comment: 6 pages, Late
UV-Green Iridescence Predicts Male Quality during Jumping Spider Contests
10.1371/journal.pone.0059774PLoS ONE84
Nonperturbative QCD corrections to the effective coefficients of the four-Fermi operators
We calculate the leading nonperturbative contributions to the effective
Wilson coefficient of the four-fermion operators arising from the QCD penguin,
and we demonstrate how the usual perturbative one loop contribution is
augmented by nonperturbative condensates. These corrections, which are obtained
by quark and gluon condensate insertions into the quark loops, enter at the
next-to-leading logarithm precision.
Our results indicate for the charmed quark loop that the gluon condensate
contribution is quite sensitive to the momentum transfer to the quark-antiquark
pair.Comment: 12 pages, Revtex, 3 postscript figures (included
Nanoscale stiffness topography reveals structure and mechanics of the transport barrier in intact nuclear pore complexes
The nuclear pore complex (NPC) is the gate for transport between the cell nucleus and the cytoplasm. Small molecules cross the NPC by passive diffusion, but molecules larger than âź5â
nm must bind to nuclear transport receptors to overcome a selective barrier within the NPC1. Although the structure and shape of the cytoplasmic ring of the NPC are relatively well characterized2, 3, 4, 5, the selective barrier is situated deep within the central channel of the NPC and depends critically on unstructured nuclear pore proteins5, 6, and is therefore not well understood. Here, we show that stiffness topography7 with sharp atomic force microscopy tips can generate nanoscale cross-sections of the NPC. The cross-sections reveal two distinct structures, a cytoplasmic ring and a central plug structure, which are consistent with the three-dimensional NPC structure derived from electron microscopy2, 3, 4, 5. The central plug persists after reactivation of the transport cycle and resultant cargo release, indicating that the plug is an intrinsic part of the NPC barrier. Added nuclear transport receptors accumulate on the intact transport barrier and lead to a homogenization of the barrier stiffness. The observed nanomechanical properties in the NPC indicate the presence of a cohesive barrier to transport and are quantitatively consistent with the presence of a central condensate of nuclear pore proteins in the NPC channel
Long-Term Safety and Efficacy of Adalimumab in Patients with Noninfectious Intermediate Uveitis, Posterior Uveitis, or Panuveitis
Purpose: To evaluate long-term efficacy and safety of extended treatment with adalimumab in patients with noninfectious intermediate, posterior, or panuveitis. Design: Open-label, multicenter, phase 3 extension study (VISUAL III). Participants: Adults who had completed a randomized, placebo-controlled phase 3 parent trial (VISUAL I or II) without treatment failure (inactive uveitis) or who discontinued the study after meeting treatment failure criteria (active uveitis). Methods: Patients received subcutaneous adalimumab 40 mg every other week. Data were collected for ⤠362 weeks. Adverse events (AEs) were recorded until 70 days after the last dose. Main Outcome Measures: Long-term safety and quiescence; other efficacy variables included inflammatory lesions, anterior chamber cell and vitreous haze grade, macular edema, visual acuity, and dose of uveitis-related systemic corticosteroids. Results: At study entry, 67% of patients (283/424) showed active uveitis and 33% (141/424) showed inactive uveitis; 60 patients subsequently met exclusion criteria, and 364 were included in the intention-to-treat analysis. Efficacy variables were analyzed through week 150, when approximately 50% of patients (214/424) remained in the study. Patients showing quiescence increased from 34% (122/364) at week 0 to 85% (153/180) at week 150. Corticosteroid-free quiescence was achieved by 54% (66/123) and 89% (51/57) of patients with active or inactive uveitis at study entry. Mean daily dose of systemic corticosteroids was reduced from 9.4 ¹ 17.1 mg/day at week 0 (n = 359) to 1.5 ¹ 3.9 mg/day at week 150 (n = 181). The percentage of patients who achieved other efficacy variables increased over time for those with active uveitis at study entry and was maintained for those with inactive uveitis. The most frequently reported treatment-emergent AEs of special interest were infections (n = 275; 79 events/100 patient-years [PY]); AEs and serious AEs occurred at a rate of 396 events/100 PY and 15 events/100 PY, respectively. Conclusions: Long-term treatment with adalimumab led to quiescence and reduced corticosteroid use for patients who entered VISUAL III with active uveitis and led to maintenance of quiescence for those with inactive uveitis. AEs were comparable with those reported in the parent trials and consistent with the known safety profile of adalimumab
Inhomogeneous cosmologies, the Copernican principle and the cosmic microwave background: More on the EGS theorem
We discuss inhomogeneous cosmological models which satisfy the Copernican
principle. We construct some inhomogeneous cosmological models starting from
the ansatz that the all the observers in the models view an isotropic cosmic
microwave background. We discuss multi-fluid models, and illustrate how more
general inhomogeneous models may be derived, both in General Relativity and in
scalar-tensor theories of gravity. Thus we illustrate that the cosmological
principle, the assumption that the Universe we live in is spatially
homogeneous, does not necessarily follow from the Copernican principle and the
high isotropy of the cosmic microwave background.Comment: 17 pages; to appear in GR
Cardiovascular magnetic resonance of pulmonary artery growth and ventricular function after Norwood procedure with Sano modification
For hypoplastic left heart syndrome (HLHS), there have been concerns regarding pulmonary artery growth and ventricular dysfunction after first stage surgery consisting of the Norwood procedure modified with a right ventricle-to-pulmonary artery conduit. We report our experience using cardiovascular magnetic resonance (CMR) to determine and follow pulmonary arterial growth and ventricular function in this cohort
Search for scalar bottom quarks and third-generation leptoquarks in ppbar collisions at sqrt(s) = 1.96 TeV
We report the results of a search for pair production of scalar bottom quarks
(sbottom) and scalar third-generation leptoquarks in 5.2 fb-1 of ppbar
collisions at the D0 experiment of the Fermilab Tevatron Collider. Scalar
bottom quarks are assumed to decay to a neutralino and a quark, and we set
95% C.L. lower limits on their production in the (m_sbottom, m_neutralino) mass
plane such as m_sbottom>247 GeV for m_neutralino=0 and m_neutralino>110 GeV for
160<m_sbottom<200 GeV. The leptoquarks are assumed to decay to a tau neutrino
and a quark, and we set a 95% C.L. lower limit of 247 GeV on the mass of a
charge-1/3 third-generation scalar leptoquark.Comment: Published by Phys. Lett.
Sarcopenic obesity and risk of new onset depressive symptoms in older adults: English Longitudinal Study of Ageing
We examined the role of sarcopenic obesity as a risk factor for new-onset depressive symptoms over 6-year follow-up in a large sample of older adults
Standalone vertex ďŹnding in the ATLAS muon spectrometer
A dedicated reconstruction algorithm to find decay vertices in the ATLAS muon spectrometer is presented. The algorithm searches the region just upstream of or inside the muon spectrometer volume for multi-particle vertices that originate from the decay of particles with long decay paths. The performance of the algorithm is evaluated using both a sample of simulated Higgs boson events, in which the Higgs boson decays to long-lived neutral particles that in turn decay to bbar b final states, and pp collision data at âs = 7 TeV collected with the ATLAS detector at the LHC during 2011
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