Renal function during rofecoxib therapy in patients with metastatic cancer: retrospective analysis of a prospective phase II trial

German Clinical Trials Register DRKS: DRKS0000011

Precision Measurement of the Mass of the h_c(1P1) State of Charmonium

A precision measurement of the mass of the h_c(1P1) state of charmonium has been made using a sample of 24.5 million psi(2S) events produced in e+e- annihilation at CESR. The reaction used was psi(2S) -> pi0 h_c, pi0 -> gamma gamma, h_c -> gamma eta_c, and the reaction products were detected in the CLEO-c detector. Data have been analyzed both for the inclusive reaction and for the exclusive reactions in which eta_c decays are reconstructed in fifteen hadronic decay channels. Consistent results are obtained in the two analyses. The averaged results of the present measurements are M(h_c)=3525.28+-0.19 (stat)+-0.12(syst) MeV, and B(psi(2S) -> pi0 h_c)xB(h_c -> gamma eta_c)= (4.19+-0.32+-0.45)x10^-4. Using the 3PJ centroid mass, Delta M_hf(1P)= - M(h_c) = +0.02+-0.19+-0.13 MeV.Comment: 9 pages, available through http://www.lns.cornell.edu/public/CLNS/, submitted to PR

J/psi and psi(2S) Radiative Transitions to eta_c

Using 24.5 million psi(2S) decays collected with the CLEO-c detector at CESR we present the most precise measurements of magnetic dipole transitions in the charmonium system. We measure B(psi(2S)->gamma eta_c) = (4.32+/-0.16+/-0.60)x10^-3, B(J/psi->gamma eta_c)/B(psi(2S)->gamma eta_c) = 4.59+/-0.23+/-0.64, and B(J/psi->gamma eta_c) = (1.98+/-0.09+/-0.30)%. We observe a distortion in the eta_c line shape due to the photon-energy dependence of the magnetic dipole transition rate. We find that measurements of the eta_c mass are sensitive to the line shape, suggesting an explanation for the discrepancy between measurements of the eta_c mass in radiative transitions and other production mechanisms.Comment: 11 pages, 3 figure

Measurement of the Absolute Branching Fraction of D_s^+ --> tau^+ nu_tau Decay

Using a sample of tagged D_s decays collected near the D^*_s D_s peak production energy in e+e- collisions with the CLEO-c detector, we study the leptonic decay D^+_s to tau^+ nu_tau via the decay channel tau^+ to e^+ nu_e bar{nu}_tau. We measure B(D^+_s to tau^+ nu_tau) = (6.17 +- 0.71 +- 0.34) %, where the first error is statistical and the second systematic. Combining this result with our measurements of D^+_s to mu^+ nu_mu and D^+_s to tau^+ nu_tau (via tau^+ to pi^+ bar{nu}_tau), we determine f_{D_s} = (274 +- 10 +- 5) MeV.Comment: 9 pages, postscript also available through http://www.lns.cornell.edu/public/CLNS/2007/, revise

Effect of different cytokines on mammaglobin and maspin gene expression in normal leukocytes: possible relevance to the assays for the detection of micrometastatic breast cancer

In cancer patients, the ability to detect disseminated tumour cells in peripheral blood or bone marrow could improve prognosis and consent both early detection of metastatic disease and monitoring of the efficacy of systemic therapy. These objectives remain elusive mainly due to the lack of specific genetic markers for solid tumours. The use of surrogate tissue-specific markers can reduce the specificity of the assays and give rise to a clinically unacceptable false-positive rate. Mammaglobin (MAM) and maspin are two putative breast tissue-specific markers frequently used for detection of occult tumour cells in the peripheral blood, bone marrow and lymph nodes of breast cancer patients. In this study, it was evaluated whether MAM and maspin gene expression may be induced in the normal blood and bone marrow cells exposed to a panel of cytokines, including chemotactic factors (C5a, interleukin (IL)-8), LPS, proinflammatory cytokines (TNF-α, IL-1β) and growth factors (IL-3, granulocyte-macrophage colony-stimulating factor, granulocyte colony-stimulating factor). The experimental data show that all cytokines included in the panel, except for IL-8, were able to induce maspin expression; on the contrary, MAM gene was never induced. These results suggest that MAM is more specific than maspin and that the possible interference of cytokines should be taken into account in interpreting molecular assays for detection of isolated tumour cells

Observation of associated near-side and away-side long-range correlations in √sNN=5.02 TeV proton-lead collisions with the ATLAS detector

Two-particle correlations in relative azimuthal angle (Δϕ) and pseudorapidity (Δη) are measured in √sNN=5.02  TeV p+Pb collisions using the ATLAS detector at the LHC. The measurements are performed using approximately 1  μb-1 of data as a function of transverse momentum (pT) and the transverse energy (ΣETPb) summed over 3.1<η<4.9 in the direction of the Pb beam. The correlation function, constructed from charged particles, exhibits a long-range (2<|Δη|<5) “near-side” (Δϕ∼0) correlation that grows rapidly with increasing ΣETPb. A long-range “away-side” (Δϕ∼π) correlation, obtained by subtracting the expected contributions from recoiling dijets and other sources estimated using events with small ΣETPb, is found to match the near-side correlation in magnitude, shape (in Δη and Δϕ) and ΣETPb dependence. The resultant Δϕ correlation is approximately symmetric about π/2, and is consistent with a dominant cos⁡2Δϕ modulation for all ΣETPb ranges and particle pT

Observation of chi_cJ radiative decays to light vector mesons

Using a total of 2.74 x 10^7 decays of the psi(2S) collected with the CLEO-c detector, we present a study of chi_cJ -> gamma V, where V = rho^0, omega, phi. The transitions chi_c1 -> gamma rho^0 and chi_c1 -> gamma omega are observed with B(chi_c1 -> gamma rho^0) = (2.43 +- 0.19 +- 0.22) x 10^-4 and B(chi_c1 -> gamma omega) = (8.3 +- 1.5 +- 1.2) x 10^-5. In the chi_c1 -> gamma rho^0 transition, the final state meson is dominantly longitudinally polarized. Upper limits on the branching fractions of other chi_cJ states to light vector mesons are presented.Comment: 10 pages, available through http://www.lns.cornell.edu/public/CLNS

Determination of the Strong Phase in D0 -> K+pi- Using Quantum-Correlated Measurements

We exploit the quantum coherence between pair-produced D0 and D0bar in psi(3770) decays to study charm mixing, which is characterized by the parameters x and y, and to make a first determination of the relative strong phase \delta between D0 -> K+pi- and D0bar -> K+pi-. Using 281 pb^-1 of e^+e^- collision data collected with the CLEO-c detector at E_cm = 3.77 GeV, as well as branching fraction input and time-integrated measurements of R_M = (x^2+y^2)/2 and R_{WS} = Gamma(D0 -> K+pi-)/Gamma(D0bar -> K+pi-) from other experiments, we find \cos\delta = 1.03 +0.31-0.17 +- 0.06, where the uncertainties are statistical and systematic, respectively. By further including other mixing parameter measurements, we obtain an alternate measurement of \cos\delta = 1.10 +- 0.35 +- 0.07, as well as x\sin\delta = (4.4 +2.7-1.8 +- 2.9) x 10^-3 and \delta = 22 +11-12 +9-11 degrees.Comment: 5 pages, also available through http://www.lns.cornell.edu/public/CLNS/2007/. Incorporated referees' comment

Measurement of the eta'-meson mass using J/psi--> gamma eta'

We measure the mass of the eta' meson using psi(2S)--> pi+ pi- J/psi, J/psi--> gamma eta' events acquired with the CLEO-c detector operating at the CESR e+e- collider. Using three decay modes, eta'--> rho0 gamma, eta'--> pi+ pi- eta with eta--> gamma gamma, and eta'--> pi+ pi- eta with eta--> pi+ pi- pi0, we find M(eta') = 957.793 +- 0.054 +- 0.036 MeV, in which the first uncertainty is statistical and the second is systematic. This result is consistent with but substantially more precise than the current world average.Comment: 11 pages, available through http://www.lns.cornell.edu/public/CLNS

Absolute Branching Fractions of Cabibbo-Suppressed D --> K Kbar Decays

Using 281/pb of data collected with the CLEO-c detector at the psi(3770) resonance, we have studied Cabibbo-suppressed decays of D mesons to final states with two kaons. We present results for the absolute branching fractions of the modes D^0 --> K^+ K^-, D^0 --> K^0_S K^0_S, and D^+ --> K^+ K^0_S. We measure B(D^0 --> K^+ K^-) = (4.08 +- 0.08 +- 0.09) x 10^-3, B(D^0 --> K^0_S K^0_S) = (1.46 +- 0.32 +- 0.09) x 10^-4, and B(D^+ --> K^+ K^0_S) = (3.14 +- 0.09 +- 0.08) x 10^-3. We also determine the ratio B(D^0 --> K^+ K^-)/B(D^0 --> pi^+ pi^-) = 2.89 +- 0.05 +- 0.06. For each measurement, the first uncertainty is statistical and the second uncertainty is systematic.Comment: 7 pages, 3 figures, available through http://www.lns.cornell.edu/public/CLNS/, published in PRD Rapid Communication