16 research outputs found

    Controversies in acute kidney injury: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) conference

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    In 2012, Kidney Disease: Improving Global Outcomes (KDIGO) published a guideline on the classification and management of acute kidney injury (AKI). The guideline was derived from evidence available through February 2011. Since then, new evidence has emerged that has important implications for clinical practice in diagnosing and managing AKI. In April of 2019, KDIGO held a controversies conference entitled Acute Kidney Injury with the following goals: determine best practices and areas of uncertainty in treating AKI; review key relevant literature published since the 2012 KDIGO AKI guideline; address ongoing controversial issues; identify new topics or issues to be revisited for the next iteration of the KDIGO AKI guideline; and outline research needed to improve AKI management. Here, we present the findings of this conference and describe key areas that future guidelines may address

    Controversies in acute kidney injury : conclusions from a Kidney Disease : Improving Global Outcomes (KDIGO) Conference

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    In 2012, Kidney Disease: Improving Global Outcomes (KDIGO) published a guideline on the classification and management of acute kidney injury (AKI). The guideline was derived from evidence available through February 2011. Since then, new evidence has emerged that has important implications for clinical practice in diagnosing and managing AKI. In April of 2019, KDIGO held a controversies conference entitled Acute Kidney Injury with the following goals: determine best practices and areas of uncertainty in treating AKI; review key relevant literature published since the 2012 KDIGO AKI guideline; address ongoing controversial issues; identify new topics or issues to be revisited for the next iteration of the KDIGO AKI guideline; and outline research needed to improve AKI management. Here, we present the findings of this conference and describe key areas that future guidelines may address

    Enteric neuroimmunophysiology and pathophysiology 1,2 1The concepts for enteric neuroimmunophysiology in this article emerged, in part, from collaborative work with Professor Helen J. Cooke and several postdoctoral visitors and students in the author’s laboratories (including Fedias Christofi, Thomas Frieling, Jeffrey M. Palmer, Kenji Tamura, Paul R. Wade, Yu-Z. Wang, Yun Xia, Dimiter Zafirov, Hong-Zhen Hu, and Sumei Liu). 2The author is indebted to Professor Gilbert A. Castro of the University of Texas-Houston Health Science Center for introducing the author to the concept of a common mucosal immune system and for sending Jeffrey M. Palmer to the author for postdoctoral training in the early 1980s.

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