Discovery of a new M32-like "Compact Elliptical" galaxy in the halo of the Abell 496 cD galaxy

Aims: ``Compact ellipticals'' are so rare that a search for M32 analogs is needed to ensure the very existence of this class. Methods: We report here the discovery of A496cE, a M32 twin in the cluster Abell 496, located in the halo of the central cD. Results: Based on CFHT and HST imaging we show that the light profile of A496cE requires a two component fit: a Sersic bulge and an exponential disc. The spectrum of A496cE obtained with the ESO-VLT FLAMES/Giraffe spectrograph can be fit by a stellar synthesis spectrum dominated by old stars, with high values of [Mg/Fe] and velocity dispersion. Conclusions: The capture of A496cE by the cD galaxy and tidal stripping of most of its disc are briefly discussed.Comment: 4 pages, 4 figures, accepted for publication in A&A Letter

The SAURON project. II. Sample and early results

Early results are reported from the SAURON survey of the kinematics and stellar populations of a representative sample of nearby E, S0 and Sa galaxies. The survey is aimed at determining the intrinsic shape of the galaxies, their orbital structure, the mass-to-light ratio as a function of radius, the age and metallicity of the stellar populations, and the frequency of kinematically decoupled cores and nuclear black holes. The construction of the representative sample is described, and its properties are illustrated. A comparison with long-slit spectroscopic data establishes that the SAURON measurements are comparable to, or better than, the highest-quality determinations. Comparisons are presented for NGC 3384 and NGC 4365 where stellar velocities and velocity dispersions are determined to a precision of 6 km/s, and the h3 and h4 parameters of the line-of-sight velocity distribution to a precision of better than 0.02. Extraction of accurate gas emission-line intensities, velocities and line widths from the datacubes is illustrated for NGC 5813. Comparisons with published line-strengths for NGC 3384 and NGC 5813 reveal uncertainties of < 0.1 A on the measurements of the Hbeta, Mgb and Fe5270 indices. Integral-field mapping uniquely connects measurements of the kinematics and stellar populations to the galaxy morphology. The maps presented here illustrate the rich stellar kinematics, gaseous kinematics, and line-strength distributions of early-type galaxies. The results include the discovery of a thin, edge-on, disk in NGC 3623, confirm the axisymmetric shape of the central region of M32, illustrate the LINER nucleus and surrounding counter-rotating star-forming ring in NGC 7742, and suggest a uniform stellar population in the decoupled core galaxy NGC 5813.Comment: 20 pages, 17 figures. To be published in MNRAS. Version with full resolution images available at http://www.strw.leidenuniv.nl/~dynamics/Instruments/Sauron/pub_list.htm

Quasars Probing Quasars III: New Clues to Feedback, Quenching, and the Physics of Massive Galaxy Formation

Galaxies hosting z~2 quasars are the high-$z$ progenitors of today's massive `red-and-dead' galaxies. With close pairs of quasars at different redshifts, a background quasar can be used to study a foreground quasar's halo gas in absorption, providing a wealth of information about feedback, quenching, and the physics of massive galaxy formation. We present a Keck/HIRES spectrum of the bright background quasar in a projected pair with angular separation 13.3" corresponding to 108kpc at the redshift of the foreground quasar z_fg=2.4360 +/- 0.0005, precisely determined from Gemini/GNIRS near-IR spectroscopy. Our echelle spectrum reveals optically thick gas (NHI~10^19.7), coincident with the foreground quasar redshift. The ionic transitions of associated metal-lines reveal the following properties of the foreground quasar's halo: (1) the kinematics are extreme with absorption extending to +780km/s relative to z_fg; (2) the metallicity is nearly solar; (3) the temperature of the predominantly ionized gas is T<~20,000K; (4) the electron density is n_e~1 cm^-3 indicating a characteristic size ~10 - 100pc for the absorbing `clouds'; (7) there is a negligible amount of warm gas 10^5K < T < 10^6K; (8) the gas is unlikely illuminated by the foreground quasar, implying anisotropic or intermittent emission. The mass of cold T~10^4K gas implied by our observations is significant, amounting to a few percent of the total expected baryonic mass density of the foreground quasar's dark halo at r~100kpc. The origin of this material is still unclear, and we discuss several possibilities in the context of current models of feedback and massive galaxy formation.Comment: Accepted to ApJ. 38 pages, 11 figure

Identification and localization of minimal MHC-restricted CD8+ T cell epitopes within the Plasmodium falciparum AMA1 protein

<p>Abstract</p> <p>Background</p> <p><it>Plasmodium falciparum </it>apical membrane antigen-1 (AMA1) is a leading malaria vaccine candidate antigen that is expressed by sporozoite, liver and blood stage parasites. Since CD8+ T cell responses have been implicated in protection against pre-erythrocytic stage malaria, this study was designed to identify MHC class I-restricted epitopes within AMA1.</p> <p>Methods</p> <p>A recombinant adenovirus serotype 5 vector expressing <it>P. falciparum </it>AMA1 was highly immunogenic when administered to healthy, malaria-naive adult volunteers as determined by IFN-γ ELISpot responses to peptide pools containing overlapping 15-mer peptides spanning full-length AMA1. Computerized algorithms (NetMHC software) were used to predict minimal MHC-restricted 8-10-mer epitope sequences within AMA1 15-mer peptides active in ELISpot. A subset of epitopes was synthesized and tested for induction of CD8+ T cell IFN-γ responses by ELISpot depletion and ICS assays. A 3-dimensional model combining Domains I + II of <it>P. falciparum </it>AMA1 and Domain III of <it>P. vivax </it>AMA1 was used to map these epitopes.</p> <p>Results</p> <p>Fourteen 8-10-mer epitopes were predicted to bind to HLA supertypes A01 (3 epitopes), A02 (4 epitopes), B08 (2 epitopes) and B44 (5 epitopes). Nine of the 14 predicted epitopes were recognized in ELISpot or ELISpot and ICS assays by one or more volunteers. Depletion of T cell subsets confirmed that these epitopes were CD8+ T cell-dependent. A mixture of the 14 minimal epitopes was capable of recalling CD8+ T cell IFN-γ responses from PBMC of immunized volunteers. Thirteen of the 14 predicted epitopes were polymorphic and the majority localized to the more conserved front surface of the AMA1 model structure.</p> <p>Conclusions</p> <p>This study predicted 14 and confirmed nine MHC class I-restricted CD8+ T cell epitopes on AMA1 recognized in the context of seven HLA alleles. These HLA alleles belong to four HLA supertypes that have a phenotypic frequency between 23% - 100% in different human populations.</p

Elliptical Galaxies and Bulges of Disk Galaxies: Summary of Progress and Outstanding Issues

This is the summary chapter of a review book on galaxy bulges. Bulge properties and formation histories are more varied than those of ellipticals. I emphasize two advances: 1 - "Classical bulges" are observationally indistinguishable from ellipticals, and like them, are thought to form by major galaxy mergers. "Disky pseudobulges" are diskier and more actively star-forming (except in S0s) than are ellipticals. Theys are products of the slow ("secular") evolution of galaxy disks: bars and other nonaxisymmetries move disk gas toward the center, where it starbursts and builds relatively flat, rapidly rotating components. This secular evolution is a new area of galaxy evolution work that complements hierarchical clustering. 2 - Disks of high-redshift galaxies are unstable to the formation of mass clumps that sink to the center and merge - an alternative channel for the formation of classical bulges. I review successes and unsolved problems in the formation of bulges+ellipticals and their coevolution (or not) with supermassive black holes. I present an observer's perspective on simulations of dark matter galaxy formation including baryons. I review how our picture of the quenching of star formation is becoming general and secure at redshifts z < 1. The biggest challenge is to produce realistic bulges+ellipticals and disks that overlap over a factor of 10**3 in mass but that differ from each other as observed over that whole range. Second, how does hierarchical clustering make so many giant, bulgeless galaxies in field but not cluster environments? I argue that we rely too much on AGN and star-formation feedback to solve these challenges.Comment: 46 pages, 10 postscript figures, accepted for publication in Galactic Bulges, ed. E. Laurikainen, R. F. Peletier, & D. A. Gadotti (New York: Springer), in press (2015

A standardized protocol for blood and cerebrospinal fluid collection and processing for biomarker research in ataxia

The European Spinocerebellar Ataxia Type 3/Machado-Joseph Disease Initiative (ESMI) is a consortium established with the ambition to set up the largest European longitudinal trial-ready cohort of Spinocerebellar Ataxia Type 3/Machado Joseph disease (SCA3/MJD), the most common autosomal dominantly inherited ataxia worldwide. A major focus of ESMI has been the identification of SCA3/MJD biomarkers to enable future interventional studies. As biosample collection and processing variables significantly impact the outcomes of biomarkers studies, biosampling procedures standardization was done previously to study visit initiation. Here, we describe the ESMI consensus biosampling protocol, developed within the scope of ESMI, that ultimately might be translated to other neurodegenerative disorders, particularly ataxias, being the first step to protocol harmonization in the field

Kinematics and Stellar Populations of Low-Luminosity Early-Type Galaxies in the Abell 496 Cluster

The morphology and stellar populations of low-luminosity early-type galaxies in clusters have until now been limited to a few relatively nearby clusters such as Virgo or Fornax. Scenarii for the formation and evolution of dwarf galaxies in clusters are therefore not well constrained. We investigate here the morphology and stellar populations of low-luminosity galaxies in the relaxed cluster Abell 496 (z=0.0330). Deep multiband imaging obtained with the CFHT Megacam allowed us to select a sample of faint galaxies (-18.8<M_B<-15.1 mag). We observed 118 galaxies spectroscopically with the ESO VLT FLAMES/Giraffe spectrograph (R=6300). We present structural analysis and colour maps for the 48 galaxies belonging to the cluster. We fit the spectra of 46 objects with PEGASE.HR synthetic spectra to estimate the ages, metallicities, and velocity dispersions. We computed values of $\alpha$/Fe abundance ratios from the measurements of Lick indices. High-precision estimates of stellar population properties have been obtained for a large sample of faint galaxies in a cluster, allowing for the extension of relations between stellar populations and internal kinematics to the low-velocity dispersion regime. We have revealed a peculiar population of elliptical galaxies in the core of the cluster, resembling massive early-type galaxies by their stellar population properties and velocity dispersions, but having luminosities of about 2 mag fainter. External mechanisms of gas removal (ram pressure stripping and gravitational harassment) are more likely to have occurred than internal mechanisms such as supernova-driven winds. The violent tidal stripping of intermediate-luminosity, early-type galaxies in the cluster core can explain the properties of the peculiar elliptical galaxies surrounding the cD galaxy.Comment: Accepted to A&A, 48 pages, 62 figures, 3 tables. This version contains low-resolution figures. We encourage you to get the full-resolution PDF (16Mb) from http://voplus.obspm.fr/DataCollections/Abell0496

The SAURON project - III. Integral-field absorption-line kinematics of 48 elliptical and lenticular galaxies

We present the stellar kinematics of 48 representative elliptical and lenticular galaxies obtained with our custom-built integral-field spectrograph SAURON operating on the William Herschel Telescope. The data were homogeneously processed through a dedicated reduction and analysis pipeline. All resulting SAURON datacubes were spatially binned to a constant minimum signal-to-noise. We have measured the stellar kinematics with an optimized (penalized pixel-fitting) routine which fits the spectra in pixel space, via the use of optimal templates, and prevents the presence of emission lines to affect the measurements. We have thus generated maps of the mean stellar velocity, the velocity dispersion, and the Gauss-Hermite moments h3 and h4 of the line-of-sight velocity distributions. The maps extend to approximately one effective radius. Many objects display kinematic twists, kinematically decoupled components, central stellar disks, and other peculiarities, the nature of which will be discussed in future papers of this series.Comment: 23 pages, 18 figures. Accepted for publication in MNRAS. Version with full resolution images available at http://www.strw.leidenuniv.nl/sauron/papers/emsellem2004_sauron3.pd

Detecting Radio AGN Signatures in Red Geysers

A new class of quiescent galaxies harboring possible AGN-driven winds has been discovered using spatially resolved optical spectroscopy from the ongoing SDSS-IV MaNGA survey. These galaxies, termed "red geysers", constitute 5−10% of the local quiescent population and are characterized by narrow bisymmetric patterns in ionized gas emission features. Cheung et al. argued that these galaxies host large-scale AGN-driven winds that may play a role in suppressing star formation at late times. In this work, we test the hypothesis that AGN activity is ultimately responsible for the red geyser phenomenon. We compare the nuclear radio activity of the red geysers to a matched control sample with similar stellar mass, redshift, rest frame NUV−r color, axis ratio and presence of ionized gas. We have used the 1.4 GHz radio continuum data from VLA FIRST survey to stack the radio flux from the red geyser and control samples. In addition to a 3 times higher FIRST detection rate, we find that red geysers have a 5σ higher level of average radio flux than control galaxies. After restricting to rest-frame NUV−r color > 5 and checking mid-IR WISE photometry, we rule out star formation contamination and conclude that red geysers are associated with more active AGN. Red geysers and a possibly-related class with disturbed Hα emission account for 40\% of all radio-detected red galaxies with log (M⋆/M⊙)<11. Our results support a picture in which episodic AGN activity drives large-scale-relatively weak ionized winds that may provide a feedback mechanism for many early-type galaxies

The Toll→NFκB Signaling Pathway Mediates the Neuropathological Effects of the Human Alzheimer's Aβ42 Polypeptide in Drosophila

Alzheimer's (AD) is a progressive neurodegenerative disease that afflicts a significant fraction of older individuals. Although a proteolytic product of the Amyloid precursor protein, the Αβ42 polypeptide, has been directly implicated in the disease, the genes and biological pathways that are deployed during the process of Αβ42 induced neurodegeneration are not well understood and remain controversial. To identify genes and pathways that mediated Αβ42 induced neurodegeneration we took advantage of a Drosophila model for AD disease in which ectopically expressed human Αβ42 polypeptide induces cell death and tissue degeneration in the compound eye. One of the genes identified in our genetic screen is Toll (Tl). It encodes the receptor for the highly conserved Tl→NFkB innate immunity/inflammatory pathway and is a fly homolog of the mammalian Interleukin-1 (Ilk-1) receptor. We found that Tl loss-of-function mutations dominantly suppress the neuropathological effects of the Αβ42 polypeptide while gain-of-function mutations that increase receptor activity dominantly enhance them. Furthermore, we present evidence demonstrating that Tl and key downstream components of the innate immunity/inflammatory pathway play a central role in mediating the neuropathological activities of Αβ42. We show that the deleterious effects of Αβ42 can be suppressed by genetic manipulations of the Tl→NFkB pathway that downregulate signal transduction. Conversely, manipulations that upregulate signal transduction exacerbate the deleterious effects of Aβ42. Since postmortem studies have shown that the Ilk-1→NFkB innate immunity pathway is substantially upregulated in the brains of AD patients, the demonstration that the Tl→NFkB signaling actively promotes the process of Αβ42 induced cell death and tissue degeneration in flies points to possible therapeutic targets and strategies