Brillouin frequency shift of standard optical fibers set in water vapor medium

The dependence of the Brillouin frequency shift (BFS) on UV-cured acrylate coating and uncoated fibers for media that have different water vapor concentrations is experimentally investigated. The BFS is proportional to the temperature within the fiber, but it also depends on the water vapor contained in the surroundings of the fiber. A hypothesis based on the efficiency of the heat transfer due to the different humidity concentration in the media is proposed, and the temperature difference that depends on the heat transfer is quantified in standard fibers. A shift of ∼0.22 MHz for relative humidity change between 60% and 98% at 20°C is measure

Efficient dynamic events discrimination technique for fiber distributed Brillouin sensors

A technique to detect real time variations of temperature or strain in Brillouin based distributed fiber sensors is proposed and is investigated in this paper. The technique is based on anomaly detection methods such as the RX-algorithm. Detection and isolation of dynamic events from the static ones are demonstrated by a proper processing of the Brillouin gain values obtained by using a standard BOTDA system. Results also suggest that better signal to noise ratio, dynamic range and spatial resolution can be obtained. For a pump pulse of 5 ns the spatial resolution is enhanced, (from 0.541 m obtained by direct gain measurement, to 0.418 m obtained with the technique here exposed) since the analysis is concentrated in the variation of the Brillouin gain and not only on the averaging of the signal along the time

Canagliflozin and renal outcomes in type 2 diabetes and nephropathy

BACKGROUND Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium–glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes. METHODS In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to <90 ml per minute per 1.73 m2 of body-surface area and albuminuria (ratio of albumin [mg] to creatinine [g], >300 to 5000) and were treated with renin–angiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of <15 ml per minute per 1.73 m2), a doubling of the serum creatinine level, or death from renal or cardiovascular causes. Prespecified secondary outcomes were tested hierarchically. RESULTS The trial was stopped early after a planned interim analysis on the recommendation of the data and safety monitoring committee. At that time, 4401 patients had undergone randomization, with a median follow-up of 2.62 years. The relative risk of the primary outcome was 30% lower in the canagliflozin group than in the placebo group, with event rates of 43.2 and 61.2 per 1000 patient-years, respectively (hazard ratio, 0.70; 95% confidence interval [CI], 0.59 to 0.82; P=0.00001). The relative risk of the renal-specific composite of end-stage kidney disease, a doubling of the creatinine level, or death from renal causes was lower by 34% (hazard ratio, 0.66; 95% CI, 0.53 to 0.81; P<0.001), and the relative risk of end-stage kidney disease was lower by 32% (hazard ratio, 0.68; 95% CI, 0.54 to 0.86; P=0.002). The canagliflozin group also had a lower risk of cardiovascular death, myocardial infarction, or stroke (hazard ratio, 0.80; 95% CI, 0.67 to 0.95; P=0.01) and hospitalization for heart failure (hazard ratio, 0.61; 95% CI, 0.47 to 0.80; P<0.001). There were no significant differences in rates of amputation or fracture. CONCLUSIONS In patients with type 2 diabetes and kidney disease, the risk of kidney failure and cardiovascular events was lower in the canagliflozin group than in the placebo group at a median follow-up of 2.62 years

Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study

Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods: This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings: This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (74·0%) had emergency surgery and 280 (24·8%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (26·1%) patients. 30-day mortality was 23·8% (268 of 1128). Pulmonary complications occurred in 577 (51·2%) of 1128 patients; 30-day mortality in these patients was 38·0% (219 of 577), accounting for 81·7% (219 of 268) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 1·75 [95% CI 1·28–2·40], p\textless0·0001), age 70 years or older versus younger than 70 years (2·30 [1·65–3·22], p\textless0·0001), American Society of Anesthesiologists grades 3–5 versus grades 1–2 (2·35 [1·57–3·53], p\textless0·0001), malignant versus benign or obstetric diagnosis (1·55 [1·01–2·39], p=0·046), emergency versus elective surgery (1·67 [1·06–2·63], p=0·026), and major versus minor surgery (1·52 [1·01–2·31], p=0·047). Interpretation: Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery. Funding: National Institute for Health Research (NIHR), Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research

Influence of Size on the Microstructure and Mechanical Properties of an AISI 304L Stainless Steel—A Comparison between Bulk and Fibers

In this work, the mechanical properties and microstructural features of an AISI 304L stainless steel in two presentations, bulk and fibers, were systematically studied in order to establish the relationship among microstructure, mechanical properties, manufacturing process and effect on sample size. The microstructure was analyzed by XRD, SEM and TEM techniques. The strength, Young’s modulus and elongation of the samples were determined by tensile tests, while the hardness was measured by Vickers microhardness and nanoindentation tests. The materials have been observed to possess different mechanical and microstructural properties, which are compared and discussed

Bildterapi – en väg till inre förändring och förbättrad hälsa

Avhandlingens övergripande syfte var att undersöka bildterapins möjlighet att bidra till inre förändring och förbättrad hälsa hos individen. Med inre förändring avses en strukturell och varaktig förändring som sker på ett psykologiskt djupare plan, till skillnad mot en yttre och mer tillfällig förändring. Den bildterapeutiska behandlingen bygger på en kombination av bildskapande och olika grad av reflekterande, bearbetande samtal. En triangulär relation, patient – bild – terapeut, är det som på ett avgörande sätt skiljer bildterapi från andra verbala behandlingsmetoder. Avhandlingens design var främst kvalitativ, med undantag för delstudie I som var en review. I delstudie I granskades studier om bildterapi för tre olika patientgrupper. En kvalitetsbedömning genomfördes med två olika system för evidens. I delstudie II djupintervjuades kvinnor om upplevelser av inre förändring och om den visat sig i utvalda målade bilder. Intervjuerna analyserades med deduktiv och induktiv innehållsanalys. I delstudie III ställdes via e-post två öppna enkätfrågor till bildterapeuter om vad de uppfattade som en inre förändring hos patienten. Data analyserades med tematisk analys. I delstudie IV genomfördes en sekundäranalys av intervjuerna från delstudie II. Utifrån ett teoretiskt perspektiv undersöktes förekomst av vitalitetsaffekter och grundaffekter samt deras betydelse för inre förändring. En deduktiv innehållsanalys genomfördes. I avhandlingen beskrivs inre förändring och förbättrad hälsa ur tre olika perspektiv; en grupp kvinnliga patienters upplevelser, en grupp bildterapeuters uppfattningar samt ur ett teoretiskt perspektiv. Resultatet visar att bildterapi kan bidra till en varaktig inre förändring som innebär identitetsförändring, förändrat beteende och förbättrad hälsa. Kvinnor som inte upplevt en inre förändring fann att bildterapin var ett stöd i vardagen. Existentiella frågor om meningen med livet var centrala både i kvinnornas och i bildterapeuternas utsagor. Resultatet visar att den terapeutiska alliansen och förmågan att utveckla en reflektiv distans till bilden är avgörande för om en individuell inre förändring är möjlig. Vidare är det viktigt med ett utforskande förhållningssätt och samtal om bildens betydelse för att en inre förändring skall kunna ske. En bildterapeutisk förändringsprocess innehåller vitalitetsaffekter och grundaffekter. Den leder till ökad insikt och medvetenhet om känslor. Den förbättrar självbilden, ökar autenticitet och autonomi, samt ger vidgade perspektiv. Avhandlingen bidrar till ökad kunskap om inre förändring och förbättrad hälsa genom behandling med bildterapi. Genom att beskriva och visa på att inre förändringar sker, beskriva vad i terapin som upplevs och bedöms som en inre förändring och att bekräfta inre förändring utifrån bakomliggande teorier, kan avhandlingen bidra till att avmystifiera den konstnärsmyt som ofta omger bildterapin och göra den mer förklarbar. Avhandlingen kan bidra till förbättrad kommunikationen mellan bildterapeuter och vårdgivare avseende metodens möjligheter och begränsningar. Vården kan därigenom överväga att använda bildterapi både som ett komplement eller ett alternativ till annan behandling. The overall aim of the dissertation was to investigate the ability of art therapy to contribute to inner change and improved health in the individual. Inner change refers to a structural and lasting change that occurs on a psychologically deeper level, as opposed to an external and more temporary change. Art therapy treatment is based on a combination of image creation and a different degree of reflective, processing dialogue. Art therapy is distinguished from other verbal therapies by a triangular relationship, patient – image – art therapist. The thesis design was primarily qualitative, except for study I, which was a review. Study I involved examination of studies of art therapy for three different patient groups. A quality assessment was carried out using two different evidence systems. In study II, interviews were carried out with women about their experiences of inner change and whether these were exhibited in selected painted images. The interviews were analysed using deductive and inductive content analysis. In study III, two open questions were sent to art therapists about what they perceived as an inner change in the patient. Data was analysed using thematic analysis. Study IV entailed a secondary analysis of the interviews from study II. Based on a theoretical perspective, the occurrence of vitality affects and basic affects and their importance for inner change were investigated. A deductive content analysis was conducted. This thesis describes inner change and improved health from three different perspectives: a group of female patients, a group of art therapists and a theoretical perspective. The results show that art therapy can contribute to a lasting inner change that involves identity change, changed behavior and improved health. Women who did not experience an inner change found that art therapy provided support in everyday life. Existential questions about the meaning of life were central to both the women's and the art therapists’ statements. The results show that therapeutic alliance, attachment and the ability to develop a reflective distance to the image is crucial to whether an individual inner change is possible. Furthermore, an exploratory approach and reflective dialogue about the importance of the image is important for an internal change to occur. An art therapeutic process of change contains vitality affects and basic affects. It leads to increased insight and awareness of feelings. It improves self-esteem, increases authenticity and autonomy, and provides widening perspectives. The thesis contributes to increased knowledge of inner change and improved health through treatment with art therapy. By showing that inner change occurs, describing what, is experienced and perceived as inner change, and by confirming inner change by theories, the thesis may demystify the myth of artistry that often surrounds art therapy and make it clearer. The thesis may contribute to improved communication between art therapists and caregivers with regard to the method’s possibilities and limitations. Caregivers can therefore consider using art therapy as a complement or as an alternative to other treatments.