The first law of thermodynamics and 2d CFT descriptions for near-extremal and near-EVH black holes

In this thesis we investigate the quantum aspects of black holes near extremality. In particular we seek evidence that a near-extremal black hole has a microscopic description in terms of a two dimensional conformal field theory (CFT). We first demonstrate how the low temperature expansion of the first law of thermodynamics leads to an expression for the entropy of extremal black holes which can be recast as the Cardy formula for the entropy of a chiral two dimensional CFT, in agreement with the Extremal Black Hole/CFT correspondence. We apply Sen’s entropy function formalism to fortify this result by reproducing it in a gravitational setup. We extend our first law analysis to a class of near-Extremal Vanishing Horizon (near-EVH) black holes. These black holes have low entropy and temperature, and their geometries contain locally asymptotically AdS3 throats in the near horizon region. The low temperature expansion of the first law is compatible with the first law for a three dimensional BTZ black hole. As the BTZ black hole has an AdS/CFT description in terms of a non-chiral two dimensional CFT, our result can be viewed as thermodynamic evidence for the EVH/CFT correspondence, which states that gravity on the near horizon EVH geometry is described by a 2d CFT. A near-EVH black hole, or low energy excitation around an EVH black hole, is described by excitations of the dual 2d CFT. As case studies of our first law analysis and the EVH/CFT correspondence, we focus on two asymptotically AdS5× S5 classes of near-EVH black holes. The two cases have interesting individual properties and, by the AdS/CFT correspondence, dual descriptions as states in N = 4 super Yang-Mills theory . We can compare these (UV) pictures to the two dimensional descriptions that emerge from the near horizon, or low energy, dynamics. All EVH near horizon geometries have local AdS3 factors which become BTZ black holes when the configurations are excited from EVH to near-EVH. In the study of static black holes with three R-charges, we examine the non-BPS and near- BPS regimes separately. While the non-BPS near horizon limit is locally regular, in the near- BPS case the near horizon procedure requires focussing geometrically on a strip of the horizon, and the degrees of freedom of the dual CFT2 can be associated with stretched strings between giant gravitons in the transverse five-sphere. The near-EVH limit of non-BPS stationary charged black holes is obtained by taking the vanishing limit of one or both of the angular momenta. When one of the momenta is small, the AdS3 angle is a combination of azimuthal angles in the AdS5 and S5 regions of the geometry. Taking the vanishing limit of both of the angular momenta leads to a near horizon limit which contains a BTZ black hole that is non-trivially fibred by a three-sphere. For each of the case studies we use the AdS3/CFT2 dictionary to specify dual IR CFT2 descriptions of the black holes. We outline a map between the UV and IR near-EVH excitations and demonstrate how the first law reduces in the near-EVH limit to the first law of a BTZ black hole. As a consistency check we compare our results with those of the Kerr/CFT correspondence

Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study

Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods: This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings: This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (74·0%) had emergency surgery and 280 (24·8%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (26·1%) patients. 30-day mortality was 23·8% (268 of 1128). Pulmonary complications occurred in 577 (51·2%) of 1128 patients; 30-day mortality in these patients was 38·0% (219 of 577), accounting for 81·7% (219 of 268) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 1·75 [95% CI 1·28–2·40], p\textless0·0001), age 70 years or older versus younger than 70 years (2·30 [1·65–3·22], p\textless0·0001), American Society of Anesthesiologists grades 3–5 versus grades 1–2 (2·35 [1·57–3·53], p\textless0·0001), malignant versus benign or obstetric diagnosis (1·55 [1·01–2·39], p=0·046), emergency versus elective surgery (1·67 [1·06–2·63], p=0·026), and major versus minor surgery (1·52 [1·01–2·31], p=0·047). Interpretation: Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery. Funding: National Institute for Health Research (NIHR), Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research