12 research outputs found
Intraosseous Ameloblastoma â an aggressive lesion of the jaw
The ameloblastomas are the most common odontogenic benign tumours, locally aggressive and with clinical significance. We report a case of an old woman with a mixed cystic and solid ameloblastoma. We also review the clinical, imagiologic and surgical state of art of ameloblastomas
A propĂłsito de um caso clĂnico
A Doença de Machado-Joseph, ou ataxia espinocerebelosa tipo 3, Ă© uma doença neurodegenerativa autossĂłmica dominante, com uma expressĂŁo clĂnica e idade de inĂcio variĂĄveis, o que torna o diagnĂłstico difĂcil e raramente precoce.
A doença de Machado-Joseph, afeta maioritariamente descendentes de Açorianos, e estĂĄ dispersa a nĂvel mundial.
Esta dissertação parte da investigação alargada da literatura cientĂfica acerca da Doença de Machado-Joseph e do relato de um caso clĂnico exemplificativo da clĂnica da doença, revendo e salientando as novas descobertas nas caraterĂsticas clĂnicas, genĂ©ticas e patogenia da doença. SĂŁo, tambĂ©m, referidas as terapias atuais e, possivelmente, futuras para os doentes com Doença de Machado-Joseph.The Machado-Joseph disease, also known as spinocerebellar ataxia type
3 is an autosomal dominant neurodegenerative disorder, with a clinical
expression and age of onset variable, which makes the diagnosis difficult and
rarely early.
The Machado-Joseph disease, affects mostly the descendants of
Azorean, and is spread all over the world.
This dissertation consists in an extended investigation of the scientific
literature about the Machado-Joseph disease and reports a clinical case
example of the disease, reviewing and highlighting new findings on the
clinical features, genetics and pathogenesis of the disease. They are also
referred current therapies, and possibly future, for patients with MachadoJoseph disease
Fever and Rash: Revisiting Measles
Fever and rash are a common combination of symptoms in the young adult patient. The etiologic investigation is usually oriented towards the most common diseases, but atypical presentations of less frequent conditions should also be recalled. We describe the case of a 44 year-old Portuguese woman who presented with fever, conjunctivitis, cough and rash, rapidly evolving to hepatitis and extensive pneumonia with respiratory failure. Although she claimed to be vaccinated according to the national immunisation schedule, a final diagnosis of primary measles pneumonia was clinically made and confirmed by serology. However, some less typical features mislead us initially. Although the rare form of primary measles pneumonia is more prevalent among immunosuppressed patients, our patient was immunocompetent. Moreover, absence of contagiousness, as was the case, occurs more frequently in atypical measles. This case highlights the need to always confirm the alleged vaccination status in adults and raises attention to some unusual features of typical measles
Atypical presentation of colon cancer: perforation with hepatic fistulization
One of the known and rare complications of the colon cancer is perforation, with fistulas or abscesses formation. In this paper it is reported the case of a 61 year old man who presented himself with pain and a palpable mass in the right upper abdominal quadrant in association with fever and weight loss. The radiological investigation showed findings compatible with perforated colon cancer and hepatic fistulization. An emergent surgery was performed and confirmed the radiologic suspicion
Morgagni Hernia Associated with Hiatus Hernia, a Rare Case
The simultaneous occurrence of two separate non-traumatic diaphragmatic hernias is extremely rare. We report a case of an old man with two diaphragmatic hernias (Morgagni and Hiatal hernias) and we also review the clinical and imagiologic features (Radiographic and Computed Tomography) of Morgagni and hiatal herniation
The impact of surgical delay on resectability of colorectal cancer: An international prospective cohort study
AIM: The SARS-CoV-2 pandemic has provided a unique opportunity to explore the impact of surgical delays on cancer resectability. This study aimed to compare resectability for colorectal cancer patients undergoing delayed versus non-delayed surgery. METHODS: This was an international prospective cohort study of consecutive colorectal cancer patients with a decision for curative surgery (January-April 2020). Surgical delay was defined as an operation taking place more than 4âweeks after treatment decision, in a patient who did not receive neoadjuvant therapy. A subgroup analysis explored the effects of delay in elective patients only. The impact of longer delays was explored in a sensitivity analysis. The primary outcome was complete resection, defined as curative resection with an R0 margin. RESULTS: Overall, 5453 patients from 304 hospitals in 47 countries were included, of whom 6.6% (358/5453) did not receive their planned operation. Of the 4304 operated patients without neoadjuvant therapy, 40.5% (1744/4304) were delayed beyond 4âweeks. Delayed patients were more likely to be older, men, more comorbid, have higher body mass index and have rectal cancer and early stage disease. Delayed patients had higher unadjusted rates of complete resection (93.7% vs. 91.9%, PÂ =Â 0.032) and lower rates of emergency surgery (4.5% vs. 22.5%, Pâ<â0.001). After adjustment, delay was not associated with a lower rate of complete resection (OR 1.18, 95% CI 0.90-1.55, PÂ =Â 0.224), which was consistent in elective patients only (OR 0.94, 95% CI 0.69-1.27, PÂ =Â 0.672). Longer delays were not associated with poorer outcomes. CONCLUSION: One in 15 colorectal cancer patients did not receive their planned operation during the first wave of COVID-19. Surgical delay did not appear to compromise resectability, raising the hypothesis that any reduction in long-term survival attributable to delays is likely to be due to micro-metastatic disease
Brain Herniation into Giant Arachnoid Granulation: An Unusual Case
Arachnoid granulations are structures filled with cerebrospinal fluid (CSF) that extend into the venous sinuses through openings in the dura mater and allow the drainage of CSF from subarachnoid space into venous system. Usually they are asymptomatic but can be symptomatic when large enough to cause sinus occlusion. We report a rare case of a brain herniation into a giant arachnoid granulation in an asymptomatic elderly male patient, which was discovered incidentally
Sacral Myeloid Sarcoma Manifesting as Radiculopathy in a Pediatric Patient: An Unusual Form of Myeloid Leukemia Relapse
Myeloid sarcoma (MS), granulocytic sarcoma or chloroma, is defined as a localized extramedullary mass of blasts of granulocytic lineage with or without maturation, occurring outside the bone marrow. MS can be diagnosed concurrently with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). The authors report a case of sacral MS occurring as a relapse of myeloid leukemia in a 5-year-old girl who was taken to the emergency department with radiculopathy symptoms
Characterisation of microbial attack on archaeological bone
As part of an EU funded project to investigate the factors influencing bone preservation in the archaeological record, more than 250 bones from 41 archaeological sites in five countries spanning four climatic regions were studied for diagenetic alteration. Sites were selected to cover a range of environmental conditions and archaeological contexts. Microscopic and physical (mercury intrusion porosimetry) analyses of these bones revealed that the majority (68%) had suffered microbial attack. Furthermore, significant differences were found between animal and human bone in both the state of preservation and the type of microbial attack present. These differences in preservation might result from differences in early taphonomy of the bones. © 2003 Elsevier Science Ltd. All rights reserved
Outcomes from elective colorectal cancer surgery during the SARSâCoVâ2 pandemic
Aim
This study aimed to describe the change in surgical practice and the impact of SARS-CoV-2 on mortality after surgical resection of colorectal cancer during the initial phases of the SARS-CoV-2 pandemic.
Method
This was an international cohort study of patients undergoing elective resection of colon or rectal cancer without preoperative suspicion of SARS-CoV-2. Centres entered data from their first recorded case of COVID-19 until 19 April 2020. The primary outcome was 30-day mortality. Secondary outcomes included anastomotic leak, postoperative SARS-CoV-2 and a comparison with prepandemic European Society of Coloproctology cohort data.
Results
From 2073 patients in 40 countries, 1.3% (27/2073) had a defunctioning stoma and 3.0% (63/2073) had an end stoma instead of an anastomosis only. Thirty-day mortality was 1.8% (38/2073), the incidence of postoperative SARS-CoV-2 was 3.8% (78/2073) and the anastomotic leak rate was 4.9% (86/1738). Mortality was lowest in patients without a leak or SARS-CoV-2 (14/1601, 0.9%) and highest in patients with both a leak and SARS-CoV-2 (5/13, 38.5%). Mortality was independently associated with anastomotic leak (adjusted odds ratio 6.01, 95% confidence interval 2.58â14.06), postoperative SARS-CoV-2 (16.90, 7.86â36.38), male sex (2.46, 1.01â5.93), age >70 years (2.87, 1.32â6.20) and advanced cancer stage (3.43, 1.16â10.21). Compared with prepandemic data, there were fewer anastomotic leaks (4.9% versus 7.7%) and an overall shorter length of stay (6 versus 7 days) but higher mortality (1.7% versus 1.1%).
Conclusion
Surgeons need to further mitigate against both SARS-CoV-2 and anastomotic leak when offering surgery during current and future COVID-19 waves based on patient, operative and organizational risks