59 research outputs found

    The RAP Net: A Geodetic Positioning Network for Andalusia (South Spain)

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    The Council of Public Works and Housing of the Government of Andalusia by means of the Andalusian Cartographic Institute has set a positioning geodetic network named Andalusian Positioning Network (RAP). The Laboratory of Astronomy, Geodesy and Cartography (LAGC) of the University of Cadiz is responsible for the design, development, quality checking, geodetic control and technical support of this network. The RAP network main goal is providing GPS data in RINEX format for post-processing operations, and broadcasting differential corrections (RTK or DGPS) from the stations for real-time operations. The RAP network is formed by 22 permanent stations distributed homogeneously as to solve the position problem along Andalusia, including the coast line. The network is referred to ETRF89 reference frame and it has become the geodetic reference frame to scientific and technologic applications, such as the geodynamic control of Andalusia; precise geoid determination; obtaining tropospheric and ionospheric models to regional climatological studies; setting photogrammetric points or marks for georeferencing of satellite images; establishing control points for reference networks in big civil works, for GIS applications, and for terrestrial, maritime and aerial navigation etc. In this paper we present the proceedings to design and set up of the network, to the organization and quality checking of data and the stations. Finally we explain the methodology established to calculate and adjust the RAP network.IECA (instituto de Estadística y Cartografía de Andalucía) Junta de Andalucía- Autor/es: Berrocoso M., Paez R., Jigena B. and Caturla C. - Título: The RAP Net: A Geodetic Positioning Network for Andalusia (South Spain) - Nombre de la revista: EUREF Publication No. 16 - Volumen: Publication No. 16 - Página inicial y final d

    Effects of the inclusion of oat hulls or sugar beet pulp in the diet on gizzard characteristics, apparent ileal digestibility of nutrients, and microbial count in the ceca in 36 day old broilers reared on floor

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    The effects of the inclusion of oat hulls (OH) and sugar beet pulp (SBP) in the diet on gizzard characteristics, apparent ileal nutrient digestibility (AID), and Clostridium perfringens, Enterobacteriaceae, and Lactobacillus proliferation in the ceca were studied in 36 d?old broilers. There were a control diet with a low CF content (1.61%) and 2 additional diets that resulted from the dilution of this feed with 5% of either OH or SBP

    The Coniacian–Santonian sedimentary record in southern Tanzania (Ruvuma Basin, East Africa): Planktonic foraminiferal evolutionary, geochemical and palaeoceanographic patterns

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    AbstractA 101 m thick stratigraphically complete late Coniacian–early Santonian (ca 89 to 83 Ma) sedimentary sequence drilled in Tanzania (Tanzania Drilling Project Site 39) allows, for the first time, examination of the planktonic foraminiferal biostratigraphy and evolution, the depositional history, and geochemical patterns of the subtropical–tropical Indian Ocean region. The sedimentary succession corresponds to an outer shelf to upper slope setting and is dominated by calcareous clayey siltstones and mudstones. The occurrences of Tethyan marker species enable application of the tropical biozonation including identification of the Dicarinella concavata and Dicarinella asymetrica Zones. In addition, Tanzania Drilling Project Site 39 is proposed as reference section for the Coniacian/Santonian boundary in the Indian Ocean with the boundary placed at the lowest occurrence of Globotruncana linneiana in agreement with the Global Stratotype Section and Point (Spain). The record at Tanzania Drilling Project Site 39 provides a unique opportunity to document the planktonic foraminiferal evolution in a subtropical marginal sea environment during a key period in their evolutionary history characterized by a major radiation among the deep‐dwelling taxa. Combined documentation of lithological and geochemical changes (%CaCO3, %Corg, δ13Ccarb and δ18Ocarb) reveals a setting influenced by continental‐derived nutrients in the Dicarinella concavata Zone (Lindi Formation) with a change to higher carbonate production and reduced surface water primary productivity in the overlying Dicarinella asymetrica Zone (Nangurukuru Formation). Planktonic foraminiferal assemblage changes mirror the depositional and geochemical trends and indicate a progressive shift from a more eutrophic to a more oligotrophic regime through time. At the local scale, this palaeoceanographic scenario is consistent with the deepening of coastal Tanzania in response to the Late Cretaceous marine transgression registered in south‐east Tanzania. Because the tectonic evolution and sea‐level rise along the East Africa continental margin is superimposed on the Coniacian–Campanian global long‐term sea‐level high, this study hypothesizes that the epicontinental invasion of blue waters may have favoured radiation among deep‐dwelling taxa

    Campanian-Maastrichtian ocean circulation in the tropical Pacific

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    The Pacific Ocean is the largest water body on Earth, and circulation in the Pacific contributed significantly to climate evolution in the latest Cretaceous, the culmination of a period of long-term cooling. Here, we present new high-resolution late Campanian to Maastrichtian benthic and planktic foraminiferal stable isotope data and a neodymium (Nd) isotope record obtained from sedimentary ferromanganese oxide coatings of Ocean Drilling Program Hole 1210B from the tropical Pacific Ocean (Shatsky Rise). These new records resolve 13 million years in the latest Cretaceous, providing insights into changes in surface and bottom water temperatures and source regions of deep to intermediate waters covering the carbon isotope excursions of the Campanian-Maastrichtian Boundary Event (CMBE) and the Mid-Maastrichtian event (MME). Our new benthic foraminiferal δ18O and Nd isotope records together with published Nd isotope data show markedly parallel trends across the studied interval over a broad range of bathyal to abyssal water depths interpreted to reflect changes in the intensity of deep-ocean circulation in the tropical Pacific. In particular, we observe a three-million-year-long period of cooler conditions in the early Maastrichtian (72.5 to 69.5 Ma) when a concomitant change toward less radiogenic seawater Nd isotope signatures probably marks a period of enhanced admixture and northward flow of deep waters with Southern Ocean provenance. We suggest this change to have been triggered by intensified formation and convection of deep waters in the high southern latitudes, a process that weakened during the MME (69.5 to 68.5 Ma). The early Maastrichtian cold interval is closely related to the negative and positive carbon isotope trends of the CMBE and MME. The millions-of-years long duration of these carbon cycle perturbations suggests a tectonic forcing of climatic cooling, possibly related to changes in ocean basin geometry and bathymetry

    A longitudinal study of gene expression in first-episode schizophrenia; exploring relapse mechanisms by co-expression analysis in peripheral blood

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    Little is known about the pathophysiological mechanisms of relapse in first-episode schizophrenia, which limits the study of potential biomarkers. To explore relapse mechanisms and identify potential biomarkers for relapse prediction, we analyzed gene expression in peripheral blood in a cohort of first-episode schizophrenia patients with less than 5 years of evolution who had been evaluated over a 3-year follow-up period. A total of 91 participants of the 2EPs project formed the sample for baseline gene expression analysis. Of these, 67 provided biological samples at follow-up (36 after 3 years and 31 at relapse). Gene expression was assessed using the Clariom S Human Array. Weighted gene co-expression network analysis was applied to identify modules of co-expressed genes and to analyze their preservation after 3 years of follow-up or at relapse. Among the 25 modules identified, one module was semi-conserved at relapse (DarkTurquoise) and was enriched with risk genes for schizophrenia, showing a dysregulation of the TCF4 gene network in the module. Two modules were semi-conserved both at relapse and after 3 years of follow-up (DarkRed and DarkGrey) and were found to be biologically associated with protein modification and protein location processes. Higher expression of DarkRed genes was associated with higher risk of suffering a relapse and early appearance of relapse (p = 0.045). Our findings suggest that a dysregulation of the TCF4 network could be an important step in the biological process that leads to relapse and suggest that genes related to the ubiquitin proteosome system could be potential biomarkers of relapse. © 2021, The Author(s)

    The polygenic basis of relapse after a first episode of schizophrenia

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    Little is known about genetic predisposition to relapse. Previous studies have linked cognitive and psychopathological (mainly schizophrenia and bipolar disorder) polygenic risk scores (PRS) with clinical manifestations of the disease. This study aims to explore the potential role of PRS from major mental disorders and cognition on schizophrenia relapse. 114 patients recruited in the 2EPs Project were included (56 patients who had not experienced relapse after 3 years of enrollment and 58 patients who relapsed during the 3-year follow-up). PRS for schizophrenia (PRS-SZ), bipolar disorder (PRS-BD), education attainment (PRS-EA) and cognitive performance (PRS-CP) were used to assess the genetic risk of schizophrenia relapse.Patients with higher PRS-EA, showed both a lower risk (OR=0.29, 95% CI [0.11–0.73]) and a later onset of relapse (30.96± 1.74 vs. 23.12± 1.14 months, p=0.007. Our study provides evidence that the genetic burden of neurocognitive function is a potentially predictors of relapse that could be incorporated into future risk prediction models. Moreover, appropriate treatments for cognitive symptoms appear to be important for improving the long-term clinical outcome of relapse

    PATJ Low Frequency Variants Are Associated with Worse Ischemic Stroke Functional Outcome: A Genome-Wide Meta-Analysis

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    RATIONALE: Ischemic stroke is among the leading causes of adult disability. Part of the variability in functional outcome after stroke has been attributed to genetic factors but no locus has been consistently associated with stroke outcome. OBJECTIVE: Our aim was to identify genetic loci influencing the recovery process using accurate phenotyping to produce the largest GWAS (genome-wide association study) in ischemic stroke recovery to date. METHODS AND RESULTS: A 12-cohort, 2-phase (discovery-replication and joint) meta-analysis of GWAS included anterior-territory and previously independent ischemic stroke cases. Functional outcome was recorded using 3-month modified Rankin Scale. Analyses were adjusted for confounders such as discharge National Institutes of Health Stroke Scale. A gene-based burden test was performed. The discovery phase (n=1225) was followed by open (n=2482) and stringent joint-analyses (n=1791). Those cohorts with modified Rankin Scale recorded at time points other than 3-month or incomplete data on previous functional status were excluded in the stringent analyses. Novel variants in PATJ (Pals1-associated tight junction) gene were associated with worse functional outcome at 3-month after stroke. The top variant was rs76221407 (G allele, β=0.40, P=1.70×10-9). CONCLUSIONS: Our results identify a set of common variants in PATJ gene associated with 3-month functional outcome at genome-wide significance level. Future studies should examine the role of PATJ in stroke recovery and consider stringent phenotyping to enrich the information captured to unveil additional stroke outcome loci

    Geogaceta.

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    Ponencia presentada en la 34a Sesión Científica de la Sociedad Geológica de España, celebrada en la Facultad de Ciencias de la Universidad del País Vasco, Campus de Leioa (Bilbao) el día 30 de mayo de 200
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