Contribution for new genetic markers of rheumatoid arthritis activity and severity : sequencing of the tumor necrosis factor-alpha gene promoter

© 2007 Fonseca et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly citedThe objective of this study was to assess whether clinical measures of rheumatoid arthritis activity and severity were influenced by tumor necrosis factor-alpha (TNF-alpha) promoter genotype/haplotype markers. Each patient's disease activity was assessed by the disease activity score using 28 joint counts (DAS28) and functional capacity by the Health Assessment Questionnaire (HAQ) score. Systemic manifestations, radiological damage evaluated by the Sharp/van der Heijde (SvdH) score, disease-modifying anti-rheumatic drug use, joint surgeries, and work disability were also assessed. The promoter region of the TNF-alpha gene, between nucleotides -1,318 and +49, was sequenced using an automated platform. Five hundred fifty-four patients were evaluated and genotyped for 10 single-nucleotide polymorphism (SNP) markers, but 5 of these markers were excluded due to failure to fall within Hardy-Weinberg equilibrium or to monomorphism. Patients with more than 10 years of disease duration (DD) presented significant associations between the -857 SNP and systemic manifestations, as well as joint surgeries. Associations were also found between the -308 SNP and work disability in patients with more than 2 years of DD and radiological damage in patients with less than 10 years of DD. A borderline effect was found between the -238 SNP and HAQ score and radiological damage in patients with 2 to 10 years of DD. An association was also found between haplotypes and the SvdH score for those with more than 10 years of DD. An association was found between some TNF-alpha promoter SNPs and systemic manifestations, radiological progression, HAQ score, work disability, and joint surgeries, particularly in some classes of DD and between haplotypes and radiological progression for those with more than 10 years of DD.This work was supported by grant POCTI/SAU-ESP/59111/2004 from Fundação Ciência e Tecnologia.info:eu-repo/semantics/publishedVersio

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

Correction to: Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

The original version of this article unfortunately contained a mistake

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

Bullying e a criança com doença crónica Bullying y el niño con enfermedad crónica Bullying and children with chronic illness

Constatando-se que a doença crónica na criança apresenta uma prevalência bastante elevada realizou-se um levantamento bibliográfico sistematizado de estudos indexados nas bases de dados SciElo, LILACS, CINAHL, PubMed, Nursing Reference Center, PEPsic, Medline, PsycoInfo e ScienceDirect, publicados entre 2001 e 2010, relativos ao tema bullying nas crianças com doença crónica no qual se procurou verificar se as crianças portadoras de doença crónica são mais vítimas de bullying do que as crianças saudáveis. Para orientar a revisão utilizaram-se as palavras de pesquisa: “criança”, “bullying”, “necessidades especiais”, “doença crónica”, “vitimização”, “violência”, “agressão” e “danos psicológicos” tendo-se identificado 97 artigos, dos quais foram selecionados 40, localizados 10 e utilizados 6. Os resultados da pesquisa foram analisados de acordo com o tema investigado e os aspetos metodológicos categorizados. Os principais tópicos abordados nos estudos foram a incidência do bullying, as diferentes formas de bullying e a quebra de silêncio por parte da criança. Os estudos analisados fazem a relação entre o facto de a criança ser portadora de uma doença crónica e ser vítima de bullying fazendo a comparação com o grupo de controlo, o das crianças saudáveis. Os estudos revelaram que existem diferenças significativas entre ser ou não portador de doença crónica e ser vítima de bullying.Teniendo en cuenta que la enfermedad crónica mantiene una prevalencia bastante elevada, se realizó una búsqueda sistematizada de estudios indexados en las bases de datos SciElo, LILACS, CINAHL, PubMed, Nursing Reference Center, PEPsic, Medline, ScienceDirect y PsycoInfo, publicados entre 2001 y 2010, relacionados con el tema del bullying en niños con enfermedades crónicas en los que se procuró comprobar si los niños con enfermedades crónicas sufren más del bullying que los niños sanos. Para guiar la revisión se utilizaron las palabras de búsqueda: “niño”, “bullying”, “necesidades especiales”, “enfermedad crónica”, “victimización”, “violencia”, “agresión” y “daños psicológicos”, tras lo cual se identificaron 97 artículos de los cuales se seleccionaron 40, se localizaron 10 y se utilizaron 6. Los resultados de la búsqueda fueron analizados de acuerdo con el tema investigado y los aspectos metodológicos clasificados. Los principales tópicos tratados en los estudios fueron la incidencia del bullying, las distintas formas de bullying y la quiebra del silencio por parte del niño. Los estudios analizados muestran la relación entre el hecho de que el niño sea portador de enfermedad crónica y que sea víctima de bullying, tras compararlos con el grupo de niños sanos. Los estudios revelaron que existen diferencias significativas entre tener o no una enfermedad crónica y ser víctima de bullying.Awareness of the very high prevalence of chronic illness in children led us to carry out a systematic literature review of studies indexed in the databases SciElo, LILACS, CINAHL, PubMed, Nursing Reference Center, PepsiCo, Medline, PsycoInfo and ScienceDirect published between 2001 and 2010, related to the topic bullying in Children with Chronic Illness, in which we tried to determine whether children with a chronic illness are more likely to be victims of bullying than healthy children. To guide the review we used the search words “child,” “bullying”, “special needs”, “chronic disease”, “victimization,” “violence”, “aggression” and “psychological damage”, and identified 97 articles, 40 of which were selected, 10 were located and 6 were used. The results were analyzed according to the topic investigated and the methodological aspects were categorized. The main topics covered in the study were the incidence of bullying, different forms of bullying and breaking of silence by the child. The studies analyzed identified a relationship between the fact that the child has a chronic illness and being bullied by comparing a control group of healthy children. Studies have shown that there are significant differences between having chronic illness and being a victim of bullying

Comemoração dos 100 anos de Paulo Freire

Em 2021 celebramos o Centenário de Paulo Freire, ilustre educador, com atuação e reconhecimento internacionais e cuja trajetória deixa um legado para o mundo, de modo especial para a construção de saberes no diálogo entre o conhecimento acadêmico e o popular. A PROEC, no propósito de reconhecer e ressaltar a importante contribuição de Paulo Freire, abriu o Concurso “Comemoração dos 100 anos de Paulo Freire” que buscou valorizar, incentivar e dar visibilidade às ações de ensino, pesquisa, extensão e cultura da UNIFESP inspiradas no referencial teórico-metodológico freireano e realizadas por estudantes, docentes, técnicos(as) e terceirizados(as)

Characterisation of microbial attack on archaeological bone

As part of an EU funded project to investigate the factors influencing bone preservation in the archaeological record, more than 250 bones from 41 archaeological sites in five countries spanning four climatic regions were studied for diagenetic alteration. Sites were selected to cover a range of environmental conditions and archaeological contexts. Microscopic and physical (mercury intrusion porosimetry) analyses of these bones revealed that the majority (68%) had suffered microbial attack. Furthermore, significant differences were found between animal and human bone in both the state of preservation and the type of microbial attack present. These differences in preservation might result from differences in early taphonomy of the bones. © 2003 Elsevier Science Ltd. All rights reserved

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat