79 research outputs found
Exploring Factors that Influence Vehicle Purchase Decisions of Older Drivers:âš Where Does Safety Fit?
- Author
- Publication venue
- 'The University of Iowa'
- Publication date
- 01/01/2011
- Field of study
Vehicle design features that enhance safety can mitigate older driver frailty and declines in ability. We have investigated the older driverâs perception of vehicle safety and how this influences their vehicle purchase. Focus groups (n = 27) were conducted among drivers aged 70-90 in South-Western Ontario. Questions focused on participantsâ perceptions of vehicle safety and design, the vehicle purchasing process, and resources used therein. Participants emphasized the importance of a few standard safety features (e.g., seatbelt, reliable brakes) but de-emphasized the role of safety on their purchase decisions. Safety was superseded by other purchasing considerations, most notably price. Stressful dealer-buyer interactions and poor congruency of information created barriers. Purchasing aids for older drivers should be developed that speak to the spectrum of safety technologies and emphasize the relationship between safety and other design features on driving ability
Stereotactic body radiation therapy (SBRT) for patients with stage I non-small cell lung cancer is applicable to more tumors than sublobar resection
- Publication venue
- Jefferson Digital Commons
- Publication date
- 01/03/2021
- Field of study
Background: Virtually all patients with medically inoperable stage I non-small cell lung cancer (NSCLC) can receive stereotactic body radiation therapy. However, the percentage of such patients in whom sublobar resection is technically feasible is unknown. This discrepancy can confound clinical trial eligibility and designs comparing stereotactic body radiation therapy vs. sublobar resection.
Methods: A total of 137 patients treated with stereotactic body radiation therapy for lung lesions (3/2013-11/2017) underwent retrospective review. Diagnostic CT chest and PET/CT images, stereotactic body radiation therapy dates, and demographic data were collected on 100 of 137 patients. Two experienced board-certified thoracic surgeons independently reviewed anonymized patients\u27 pre-stereotactic body radiation therapy diagnostic imaging and completed a custom survey about the technical feasibility of sublobar resection for each patient. Interrater agreement was measured using Cohen\u27s kappa coefficient by bootstrap methodology. Summary statistics were performed for baseline demographics and tumor characteristics.
Results: Of the 100 patients, 57% were female, with median age of 75 years (range, 52-95 years) and Karnofsky Performance Status of 80 (range, 40-100). Most patients (61%) had Stage IA1, T1a tumors. For interrater agreement analysis, one patient was removed from each cohort due to inability to locate tumor on images, leaving 98 patients analyzed. Comparing Surgeon #1 vs. Surgeon #2, 64 (65.3%) vs. 69 (70.3%) of tumors were thought eligible for sublobar resection, respectively (Îș=0.414).
Conclusions: Stereotactic body radiation therapy for stage I NSCLC is applicable to more tumors than sublobar resection, with ~30-35% of stereotactic body radiation therapy patients unable to undergo sublobar resection assessed by pretreatment diagnostic imaging based on technical grounds. This study illustrates that clinical trials comparing stereotactic body radiation therapy vs. sublobar resection are limited to only a subpopulation of patients with stage I NSCLC
Toward a molecular pathogenic pathway for Yersinia pestis YopM
- Author
- Publication venue
- Publication date
- 01/01/2012
- Field of study
YopM is one of the six âeffector Yopsâ of the human-pathogenic Yersinia, but its mechanism has not been defined. After delivery to J774A.1 monocyte-like cells, YopM can rapidly bind and activate the serine/threonine kinases RSK1 and PRK2. However, in infected mice, effects of Y. pestis YopM have been seen only after 24â48 h post-infection (p.i.). To identify potential direct effects of YopM in-vivo we tested for effects of YopM at 1 h and 16â18 h p.i. in mice infected systemically with 106 bacteria. At 16 h p.i., there was a robust host response to both parent and ÎyopM-1 Y. pestis KIM5. Compared to cells from non-infected mice, CD11b+ cells from spleens of infected mice produced more than 100-fold greater IFNÎł. In the corresponding sera there were more than 100-fold greater amounts of IFNÎł, G-CSF, and CXCL9, as well as more than 10-fold greater amounts of IL-6, CXCL10, and CXCL1. The only YopM-related differences were slightly lower CXCL10 and IL-6 in sera from mice infected 16 h with parent compared to ÎyopM-1 Y. pestis. Microarray analysis of the CD11b+ cells did not identify consistent transcriptional differences of â„4-fold at 18 h p.i. However, at 1 h p.i. mRNA for early growth response transcription factor 1 (Egr1) was decreased when YopM was present. Bone marrow-derived macrophages infected for 1 h also expressed lower Egr1 message when YopM was present. Infected J774A.1 cells showed greater expression of Egr1 at 1 h p.i. when YopM was present, but this pattern reversed at 3 h. At 6 h p.i., Cxcl10 mRNA was lower in parent-strain infected cells. We conclude that decreased Egr1 expression is a very early transcriptional effect of YopM and speculate that a pathway may exist from RSK1 through Egr1. These studies revealed novel early transcriptional effects of YopM but point to a time after 18 h of infection when critical transitional events lead to later major effects on cytokine gene transcription
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
- Author
- Abraham Roby
- Alfredsson Lars
- Ardlie Kristin
- Aubin Cristin
- Baker Amie
- Baker Katharine
- Ban Maria
- Band Gavin
- Baranzini Sergio E
- Barcellos Lisa F
- Bellenguez CĂ©line
- Bergamaschi Laura
- Bergamaschi Roberto
- Bernstein Allan
- Berthele Achim
- Blackburn Hannah
- Blackwell Jenefer M
- Boggild Mike
- Bomfim Izaura Lima
- Booth David R
- Bradfield Jonathan P
- Bramon Elvira
- Brassat David
- Broadley Simon A
- Brown Matthew A
- Buck Dorothea
- Bumpstead Suzannah J
- Butzkueven Helmut
- Capra Ruggero
- Carroll William M
- Casas Juan P
- Cavalla Paola
- Celius Elisabeth G
- Cepok Sabine
- Chiavacci Rosetta
- Clerget-Darpoux Françoise
- Clysters Katleen
- Comabella Manuel
- Comi Giancarlo
- Compston Alastair
- Corvin Aiden
- Cossburn Mark
- Cournu-Rebeix Isabelle
- Cox Mathew B
- Cozen Wendy
- Cree Bruce AC
- Cross Anne H
- Cusi Daniele
- D'alfonso Sandra
- D'hooghe Marie Beatrice
- Daly Mark J
- Davis Emma
- de Bakker Paul IW
- De Jager Philip L
- Debouverie Marc
- Deloukas Panos
- Dilthey Alexander
- Dixon Katherine
- Dobosi Rita
- Donnelly Peter
- Dronov Serge
- Dubois Bénédicte
- Duncanson Audrey
- Edkins Sarah
- Ellinghaus David
- Elovaara Irina
- Esposito Federica
- Fontaine Bertrand
- Fontenille Claire
- Foote Simon
- Franke Andre
- Freeman Colin
- Galimberti Daniela
- Ghezzi Angelo
- Giannoulatou Eleni
- Gillman Matthew
- Glessner Joseph
- Gomez Refujia
- Goris An
- Gout Olivier
- Graham Colin
- Grant Struan FA
- Gray Emma
- Guerini Franca Rosa
- Gwilliam Rhian
- Hafler David A
- Haines Jonathan L
- Hakonarson Hakon
- Hall Per
- Hammond Naomi
- Hamsten Anders
- Harbo Hanne F
- Hartung Hans-Peter
- Hauser Stephen L
- Hawkins Clive
- Hawkins Stanley
- Heard Rob N
- Heath Simon
- Hellenthal Garrett
- Hemmer Bernhard
- Hillert Jan
- Hobart Jeremy
- Hoshi Muna
- Hunt Sarah E
- Infante-Duarte Carmen
- Ingram Gillian
- Ingram Wendy
- International Multiple Sclerosis Genetics Consortium
- Islam Talat
- Ivinson Adrian J
- Jagodic Maja
- Jankowski Janusz
- Jayakumar Alagurevathi
- Kabesch Michael
- Kemppinen Anu
- Kermode Allan G
- Kilpatrick Trevor J
- Kim Cecilia
- Klopp Norman
- Kockum Ingrid
- Koivisto Keijo
- Langford Cordelia
- Larsson Malin
- Lathrop Mark
- Lechner-Scott Jeannette S
- Leone Maurizio A
- LeppÀ Virpi
- Leslie Stephen
- Liddle Jennifer
- Liljedahl Ulrika
- Lincoln Robin R
- Link Jenny
- Liu Jianjun
- Lorentzen Aslaug R
- Lupoli Sara
- Macciardi Fabio
- Mack Thomas
- Markus Hugh S
- Marriott Mark
- Martin Roland
- Martinelli Boneschi Filippo
- Martinelli Vittorio
- Mason Deborah
- Mathew Christopher G
- McCann Owen T
- McCauley Jacob L
- McVean Gil
- Mentch Frank
- Mero Inger-Lise
- Mihalova Tania
- Montalban Xavier
- Mottershead John
- Moutsianas Loukas
- Mycko Marcin P
- Myhr Kjell-Morten
- Naldi Paola
- Oksenberg Jorge R
- Ollier William
- Olsson Tomas
- Oturai Annette Bang
- Page Alison
- Palmer Colin NA
- Palotie Aarno
- Patsopoulos Nikolaos A
- Pelletier Jean
- Peltonen Leena
- Perez Marc L
- Pericak-Vance Margaret A
- Piccio Laura
- Pickersgill Trevor
- Piehl Fredrik
- Pirinen Matti
- Plomin Robert
- Pobywajlo Susan
- Potter Simon C
- Quach Hong L
- Ramsay Patricia P
- Rautanen Anna
- Ravindrarajah Rathi
- Reunanen Mauri
- Reynolds Richard
- Ricketts Michelle
- Rioux John D
- Robertson Neil
- Rodegher Mariaemma
- Roesner Sabine
- Rubio Justin P
- RĂŒckert Ina-Maria
- Saarela Janna
- Salvetti Marco
- Salvi Erika
- Santaniello Adam
- Sawcer Stephen
- Schaefer Catherine A
- Schreiber Stefan
- Schulze Christian
- Scott Rodney J
- Sellebjerg Finn
- Selmaj Krzysztof W
- Sexton David
- Shen Ling
- Simms-Acuna Brigid
- Skidmore Sheila
- Sleiman Patrick MA
- Smestad Cathrine
- Spencer Chris CA
- Spurkland Anne
- Stankovich Jim
- Stewart Graeme J
- Strange Amy
- Strange Richard C
- Su Zhan
- Sulonen Anna-Maija
- Sundqvist Emilie
- SyvÀnen Ann-Christine
- SĂžndergaard Helle Bach
- SĂžrensen Per Soelberg
- Taddeo Francesca
- Taylor Bruce
- Tienari Pentti
- Tourbah Ayman
- Trembath Richard C
- Tronczynska Ewa
- Tubridy Niall
- Vickery Jane
- Villoslada Pablo
- Viswanathan Ananth C
- Waller Matthew J
- Wang Kai
- Wason James
- Wellcome Trust Case Control Consortium 2
- Weston Paul
- Whittaker Pamela
- Wichmann H-Erich
- Widaa Sara
- Willoughby Ernest
- Winkelmann Juliane
- Wittig Michael
- Wood Nicholas W
- Yaouanq Jacqueline
- Zajicek John
- Zhang Haitao
- Zipp Frauke
- Zuvich Rebecca
- Publication venue
- Nature Research
- Publication date
- 01/01/2011
- Field of study
Multiple sclerosis is a common disease of the central nervous system in which the interplay between inflammatory and neurodegenerative processes typically results in intermittent neurological disturbance followed by progressive accumulation of disability. Epidemiological studies have shown that genetic factors are primarily responsible for the substantially increased frequency of the disease seen in the relatives of affected individuals, and systematic attempts to identify linkage in multiplex families have confirmed that variation within the major histocompatibility complex (MHC) exerts the greatest individual effect on risk. Modestly powered genome-wide association studies (GWAS) have enabled more than 20 additional risk loci to be identified and have shown that multiple variants exerting modest individual effects have a key role in disease susceptibility. Most of the genetic architecture underlying susceptibility to the disease remains to be defined and is anticipated to require the analysis of sample sizes that are beyond the numbers currently available to individual research groups. In a collaborative GWAS involving 9,772 cases of European descent collected by 23 research groups working in 15 different countries, we have replicated almost all of the previously suggested associations and identified at least a further 29 novel susceptibility loci. Within the MHC we have refined the identity of the HLA-DRB1 risk alleles and confirmed that variation in the HLA-A gene underlies the independent protective effect attributable to the class I region. Immunologically relevant genes are significantly overrepresented among those mapping close to the identified loci and particularly implicate T-helper-cell differentiation in the pathogenesis of multiple sclerosis
Meta-analysis of genome-wide association studies identifies novel loci that influence cupping and the glaucomatous process
- Author
- Abhishek Nag
- Adriana I. Iglesias
- Aiden Corvin
- Aiden Corvin
- Alagurevathi Jayakumar
- Albert Hofman
- Alex W. Hewitt
- Alireza Mirshahi
- Amy Strange
- Ananth C. Viswanathan
- Ananth C. Viswanathan
- Ananth Viswanathan
- Andrew J. Lotery
- André G. Uitterlinden
- Angela J. Cree
- Aniket Mishra
- Anna Rautanen
- Anthony Realini
- Arne Schillert
- Arthur A. B. Bergen
- Arthur J. Sit
- Audrey Duncanson
- Ben A. Oostra
- Caroline C. W. Klaver
- Chiea-Chuen Khor
- Ching-Yu Cheng
- Chris C. A. Spencer
- Chris C. A. Spencer
- Christopher G. Mathew
- Christopher G. Mathew
- Christopher J. Hammond
- Colin Freeman
- Colin N. A. Palmer
- Cordelia Langford
- Cornelia M. van Duijn
- Cristina Venturini
- CĂ©line Bellenguez
- Damjan Vukcevic
- David A. Mackey
- David S. Friedman
- Dominiek D. G. Despriet
- Donald J. Zack
- Donald L. Budenz
- Douglas Gaasterland
- Douglas Vollrath
- E-Shyong Tai
- Elena Rochtchina
- Eleni Giannoulatou
- Elisabeth M. van Leeuwen
- Elizabeth G. Holliday
- Elvira Bramon
- Emma Gray
- Emmanuelle Souzeau
- Eranga Vithana
- Fernando Rivadeneira
- Fridbert Jonasson
- Gadi Wollstein
- Garrett Hellenthal
- Gavin Band
- Geeta Menon
- Grant W. Montgomery
- Gudmar Thorleifsson
- Hannah Blackburn
- Hans G. Lemij
- Henriët. Springelkamp
- Hugh S. Markus
- Ines Barroso
- Ines Barroso
- Jae H. Kang
- Jae Hee Kang
- Jamie E. Craig
- Jane Gibson
- Janey L. Wiggs
- Janey L. Wiggs
- Janusz Jankowski
- Jenefer M. Blackwell
- Jenefer M. Blackwell
- Jennifer Liddle
- Jenny E. Mountain
- Jessica N. Cooke Bailey
- Jessica N. Cooke Bailey
- Jie Jin Wang
- Jing Xie
- Joel S. Schuman
- Johannes R. Vingerling
- John Attia
- John Fingert
- John Landers
- Jonathan L. Haines
- Jonathan L. Haines
- Jost B. Jonas
- Juan P. Casas
- Julia E. Richards
- Kang Zhang
- Kar-Seng Sim
- Kari Stefansson
- Kathryn P. Burdon
- Kuldev Singh
- Lennart C. Karssen
- Leonieke M. E. van Koolwijk
- Liang Xu
- Louis R. Pasquale
- Louis R. Pasquale
- Margaret A. Pericak-Vance
- Matthew A. Brown
- Matthew A. Brown
- Matthew Gillman
- Matthew Waller
- Matti Pirinen
- Michael A. Hauser
- Michael A. Hauser
- Michael Inouye
- Michelle Ricketts
- Monisha E. Nongpiur
- Murray H. Brilliant
- Najaf Amin
- Naomi Hammond
- Nicholas W. Wood
- Nomdo M. Jansonius
- Norbert Pfeiffer
- null null
- null null
- null null
- Owen T. McCann
- Pamela Whittaker
- Panos Deloukas
- Panos Deloukas
- Paul G. Sanfilippo
- Paul Mitchell
- Paul N. Baird
- Paul R. Lichter
- Paul Weston
- Paulus T. V. M. de Jong
- Peter Donnelly
- Peter Donnelly
- Peter Kraft
- Pirro G. Hysi
- Puya Gharahkhani
- R. Rand Allingham
- Radhi Ravindrarajah
- René Höhn
- Rhian Gwilliam
- Richard C. Trembath
- Richard K. Lee
- Richard Pearson
- Robert N. Weinreb
- Robert N. Weinreb
- Robert Plomin
- Rodney Scott
- Roger C. W. Wolfs
- Sara Widaa
- Sarah E. Hunt
- Sarah Edkins
- Sarah Ennis
- Sarah F. Janssen
- Sayoko E. Moroi
- Seang-Mei Saw
- Seng-Chee Loon
- Serge Dronov
- Simon C. Potter
- Stephanie J. Loomis
- Stephanie J. Loomis
- Stephen J. Sawcer
- Stuart Macgregor
- Suzannah J. Bumpstead
- Terri L. Young
- Terry Gaasterland
- Tien-Yin Wong
- Tien-Yin Wong
- Timothy D. Spector
- Tin Aung
- Unnur Thorsteinsdottir
- Vesteinn Jonsson
- Virginie J. M. Verhoeven
- William G. Christen
- William K. Scott
- Wishal D. Ramdas
- Xiaoyan Luo
- Xueling Sim
- Yi Lu
- Yik-Ying Teo
- Yutao Liu
- Zhan Su
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2014
- Field of study
Glaucoma is characterized by irreversible optic nerve degeneration and is the most frequent cause of irreversible blindness worldwide. Here, the International Glaucoma Genetics Consortium conducts a meta-analysis of genome-wide association studies of vertical cup-disc ratio (VCDR), an important disease-related optic nerve parameter. In 21,094 individuals of European ancestry and 6,784 individuals of Asian ancestry, we identify 10 new loci associated with variation in VCDR. In a separate risk-score analysis of five case-control studies, Caucasians in the highest quintile have a 2.5-fold increased risk of primary open-angle glaucoma as compared with those in the lowest quintile. This study has more than doubled the known loci associated with optic disc cupping and will allow greater understanding of mechanisms involved in this common blinding condition
Finishing the euchromatic sequence of the human genome
- Author
- . Haifeng
- . Magner
- . Yin
- Abbott Scott
- Abbott-Ozersky Amanda
- Abdellah Zahra
- Abouelleil Amr
- Abrajano Anne
- Adachi Tamami
- Adam Catherine
- Adams Charles Q.
- Adamson Aaron
- Adekoya Emmanuel
- Adio-Oduola Babajide
- Aerts Andrea
- Aggarwal Arun
- Ahmadi Alireza
- Ahmed Shahana
- Aimable Matthew
- Ainscough Rachael
- Ait-Zahra Mostafa
- Aizu Tomoyuki
- Alcivare Dana
- Alegria Michelle
- Ali Alla
- Ali Johar
- Allegria-hartmann Michelle
- Alleman Jennifer
- Allen Carlana C.
- Allen Heather
- Allen Nicole R.
- Allen Susan
- Allen Thaddeus
- Almeida Jeff
- Almond Claire
- Alsbrooks Stephen L.
- Altherr Michael R.
- Amaratunge Harshinie C.
- Ambler Andrew
- Ambrose Karen
- Ambrose Kerrie
- Amemiya Chris
- Amico-Keller Gina
- Amin Amita G.
- Anderson Mechele
- Anderson Scott
- Anderson Scott
- Andora Janice
- Andredesz Carol
- Andrew Robert
- Andrews Dan
- Andrews Daniel
- Andrews Neil
- Andrews Stephanie
- Andriese Tim
- Anthouard VĂ©ronique
- Antonarakis Stylianos E.
- Anyalebechi Vivian
- Aoki Norie
- Apostolou Sinoula
- Apweiler Eva
- Arachchi Harindra
- Arai Rie
- Arbery Hazel
- Arcaina Marlon
- Arcaina Terisita
- Archer Beth
- Arellano Andre
- Arellano-Jones Perry
- Armbruster Jeff
- Armstrong Jon
- Arredondo Dilrukshi P.
- Arredondo Heather Hope
- Artiguenave François
- Asakawa Shuichi
- Asakawa Teruyo
- Ash Gareth
- Ashcroft Kevin
- Ashurst Jennifer
- Ashwell Robert
- Ashworth Linda K.
- Aslanidis Cara
- Asomugha Chinwe O.
- Asuncion Lawreen
- Atkin Deborah
- Atkinson Andrea
- Atkinson Barry
- Attix Cristina
- Attwood John
- Aubin Keith
- Auger Katherine
- Austin Shannon Michelle
- Avila Aaron
- Avis Terry
- Ayele Mulu
- Babayan Primo
- Babbage Anne
- Babbage Sarah
- Bach Phil
- Bachatsang Pasang
- Bacon Joanne
- Badri Hummy
- Baertsch Robert
- Bagguley Claire
- Bailey Jonathan
- Bajorek Eva
- Baker Andrew
- Baker Dan
- Baker M.
- Baker Richard
- Bakis Michele
- Baldwin Jennifer
- Banda Michael
- Banerjee Ruby
- Bao Jingyue
- Bao Qiyu
- Bao Weidong
- Bao Weidong
- Baptiste Pertrice
- Barbaria Joseph A.
- Barbe Valérie
- Bardill Simon
- Barker Daniel
- Barker Darren
- Barker Gary
- Barlow Karen
- Baron Laurent
- Barrett Anika
- Bartlett Rebecca
- Basham Victoria
- Bashman David
- Basu Suba
- Bateman Alex
- Bates Karen
- Battles John
- Batzer Mark
- Baumgart Cornelia
- Baumohl Jason
- Baynes Caroline
- Bayul Tashi
- Beall Keith
- Beard Lisa
- Beard Susan
- Beare David
- Beasley Alastair
- Beasley Helen
- Beasley Oliver
- Beaucham Leslie
- Beaudet Arthur
- Beck Alfred
- Beck Stephen
- Becker Michael
- Bell Emma
- Bell George I.
- Bellard Terell M.
- Bellerby Damian
- Bellerby Tristram
- Belter Edward A., Jr.
- Bemrose Richard
- Benard Michael Anthony
- BenKahla Alia
- Benke J
- Benner William
- Bennett James
- Bensasson Douda
- Bentley Andrew
- Bentley Dan
- Bentley David
- Berardinis VĂ©ronique de
- Bercovitz John
- Berghoff Amy
- Bergmann Anne
- Berkowicz Nicolas
- Berks Mary
- Berks Michael
- Bethel Graeme
- Beugelsdijk Tony J.
- Bhakta Rita
- Bhuchar Venita
- Bi Shihua
- Bian Xuemeng
- Bieri Tamberlyn
- Bimage Kesha E.
- Bird Christine
- Birditt Brian
- Birney Ewan
- Birney Ewan
- Birren Bruce
- Bissell Helen
- Biswalo Kaneza
- Bituin Aleksandr
- Black Stacey
- Blackburne-Maze Suzanne
- Blair Jessica Anne
- Blakey Sarah
- Blanks Tia
- Blasiar Darin
- Blazej Robert
- Blitshsteyn Berta
- Blomstrom David B.
- Bloom Scott
- Bloom Toby
- Blumer Heather
- Blye Jason
- Blyth Peter R.
- Blöcker Helmut
- Boatright Elizabeth
- Boehm John
- Boen Juanan
- Boguslavskiy Leonid
- Bolton Christel
- Bolund Lars
- Bondoc Marnel
- Bonfield James
- Bonnett Ralph
- Bonnin David
- Border Richard
- Borowsky Mark
- Borzym Katja
- Boukhgalter Boris
- Bowen Eric
- Bradley Amanda
- Bradshaw-Cordum Holly
- Brady Nicola
- Brandriff Brigitte F.
- Brannon Wade
- Branscomb Elbert
- Bray Jason
- Bray-Allen Sarah
- Brettin Thomas
- Bridgeman Anne
- Bridgers Michael
- Brimhall Angela K.
- Brokstein Peter
- Brook Jonathan
- Brooking Shane
- Brottier Philippe
- Brown Andrew
- Brown Clive
- Brown Jacqui
- Brown Margaret
- Brown Mary
- Brown Mary J.
- Brown Michael
- Brown Nancy C.
- Bruce David D.
- Bruce Robert
- Bruno William J.
- Bruskiewich Richard
- Bryant Jackie
- Bryant Jennifer E.
- Bryant Nathaniel P.
- BrĂŒls Thomas
- Buatsi Delali
- Buck David
- Buckingham Judith M.
- Buckle Veronica
- Buczek Donald
- Budd Claire
- Buhay Christian J.
- Bulbul Kerem
- Buller Sarah
- Bunker Nathan
- Burberry Jill
- Burch Paula Ellen
- Burford Deborah
- Burgess Joanne
- Burgin Matt
- Burkett Carrie E.
- Burkhart-Schultz Karolyn
- Burrell Kevin L.
- Burrill Wayne
- Burrows Christine
- Burton Christine
- Burton John
- Butcher Phil
- Butler Adam
- Butler Jon
- Butler Paul
- Caenepeel Sean
- Cahill Patrick
- Cai Tianjing
- Cai Zhen
- Cairns Murray
- Calderon Eliana
- Callen David F.
- Camarata Jody
- Camire David
- Camm Nick
- Campbell Christopher
- Campbell Connie S.
- Campbell Evelyn W.
- Campbell Mary I.
- Campbell Mary L.
- Campo Kevin
- Canning Bruno
- Cao Ting
- Cao Yuzhu
- Caoile Chenier
- Cardenas Faviola
- Cardenas Lolo
- Cardenas Veronica
- Carder Carol
- Carder Paul
- Carpenter Kelly
- Carrano Anthony V.
- Carriere Jason
- Carter Jason
- Carter Kelvin
- Carter Nigel
- Caruso Lauren
- Casias Kristal
- Cattolico Laurence
- Cavanna Tamara
- Cavazos Iracema
- Cavazos Sandra R.
- Ceasar Heather
- Cedroni Maria
- Cepeda Mario
- Chacko Joseph
- Chain Patrick
- Chalk Shani
- Challacombe Jean F.
- Chan Ka
- Chan Sheryl N.
- Chan Yee Man
- Chang Jean L.
- Chapman Jarrod
- Chapman Joanna
- Chapple Jeffrey
- Charles Rachel
- Chasteen Leslie A.
- Chavarria Simeon
- Chazaro Bruno
- Chen Baoxian
- Chen Bin
- Chen Chira
- Chen Chong
- Chen Chong
- Chen Chun-Nan
- Chen Cong
- Chen Ellson
- Chen Hsiu-Chuan
- Chen Jianlong
- Chen Jie
- Chen Jin
- Chen Junbao
- Chen Lihong
- Chen Lixia
- Chen Ray
- Chen Shu
- Chen Tong
- Chen Xiaoyun
- Chen Xinyi
- Chen Yanjiong
- Chen Yiyu
- Chen Zhu
- Chen Zhu
- Chen Zhu
- Cheng Jan-Fang
- Cheng Zhihua
- Chertkov Olga
- Cheshatsang Yama
- Chi Cheng
- Chi Han C.
- Chillingworth Neil
- Chin Sylvia
- Chinn Corey
- Chinwalla Asif
- Chissoe Stephanie
- Chiu Sally
- Chothia Tom
- Christensen Mari
- Christopoulos Constantine
- Chu Joseph
- Chui Connie
- Chung A
- Cinkowsky Michael J.
- Citroen Mieke
- Clack Rob
- Clamp Michele
- Clark Anthea
- Clark Graham
- Clark Kevin
- Clark Lynn
- Clark Lynn M.
- Clark Richard
- Clark Sarah
- Clark Sue
- Clarke Adrian
- Clarke Betty
- Clarke Eddie
- Clarke Kay
- Clarke Laura
- Clawson Hiram
- Clee Chris
- Clegg Shelia
- Clerc Blankenburg Kerstin Petra
- Cleveland David
- Clifford Karen
- Clifton Sandra W.
- Coates Julia
- Cobley Victoria
- Cockrell Raynard
- Coffey Alison
- Cofield Jackie
- Coggill Penelope
- Cohn Judith D.
- Colayco Rick
- Cole Lotte
- Collier Rachael
- Collings Simon
- Collins Francis S.
- Collins John
- Collins Philip
- Collymore Al
- Colman Louise
- Combs Jessie
- Comstock Robin
- Cong Bin
- Conner Richard
- Connolly Anthony
- Connolly Karen
- Conquer Jennie
- Conrad Ansgar
- Conroy Donald
- Considine Tony
- Constance Doug
- Cook April
- Cook Leanna
- Cooke Patrick
- Cooper Jonathan
- Cooper Rachel
- Cooper Robert
- Copeland Alex
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- Crawley Matt
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- Crew Victor
- Critchlow Terrance
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- Culley Karl
- Cummings Auli
- Cummings Kirsti
- Cummings Paul
- Cummings Stephanie
- Cuomo Christina A.
- Curran Adam
- Curwen Valery
- Cutts Jeffrey
- Czubayko Martin
- D\u27Souza Lisa Marie
- Da Silva Corinne
- Dai Li
- Dalin Eillen
- Dang Michelle
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- Daniels Rachael
- Dathorne Stephanie R.
- Daum Christopher
- David Robert
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- Davies Jonathon
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- Davis Cheryl
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- Dawoe Tenzin
- Dawson Elisabeth
- De Anda Claudia
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- Deaven Larry I.
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- DeGray Stewart
- Degusta David
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- Dehal Paramvir
- Delgado Marcos
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- Devlin Laurie
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- Dong Hui
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- Evans Gareth
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- Zembeck Lisa
- Zeng Yixin
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- Zhang Guangyu
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- Zhang Guohua
- Zhang Haiqing
- Zhang Haiqing
- Zhang Haiqing
- Zhang Hongbo
- Zhang Hongbo
- Zhang Jingjing
- Zhang Jingjing
- Zhang Jingkun
- Zhang Jiuchun
- Zhang Jiuchun
- Zhang Lanzhi
- Zhang Li
- Zhang Li
- Zhang Meihua
- Zhang Meng
- Zhang Ming
- Zhang Qing
- Zhang Ruhua
- Zhang Shaojie
- Zhang Tiezhen
- Zhang Wei
- Zhang Wei
- Zhang Xianglin
- Zhang Xianglin
- Zhang Xiaoliang
- Zhang Xiuqing
- Zhang Yan
- Zhang Yi
- Zhang Yilin
- Zhang Yilin
- Zhang Ying
- Zhang Yuansen
- Zhang Yuzhi
- Zhang Zhengdong
- Zhao Hongmei
- Zhao Lijian
- Zhao Shenru
- Zhao Zhijing
- Zhen Zhicheng
- Zheng Haibo
- Zhong Ming
- Zhou Carol
- Zhou Haixia
- Zhou Jianling
- Zhou Nannan
- Zhou Xinfeng
- Zhou Yan
- Zhou Yang
- Zhou Yi
- Zhu Bingying
- Zhu Bofeng
- Zhu Fenghua
- Zhu Genfeng
- Zhu Genfeng
- Zhu Miao
- Zhu Ning
- Zhu Yongge
- Zhu Zhen
- Zhuang Shitao
- Zierten Deborah
- Zimmer Andrew
- Zody Michael C.
- Zollo Massimo
- Zorrilla Sara E.
- Zuo Lin
- Publication venue
- LSU Digital Commons
- Publication date
- 21/10/2004
- Field of study
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers âŒ99% of the euchromatic genome and is accurate to an error rate of âŒ1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.
- Author
- Abdel-Aziz AK
- Abdelfatah S
- Abdellatif M
- Abdoli A
- Abel S
- Abeliovich H
- Abildgaard MH
- Abudu YP
- Acevedo-Arozena A
- Adamopoulos IE
- Adeli K
- Adolph TE
- Adornetto A
- Aflaki E
- Agam G
- Agarwal A
- Aggarwal BB
- Agnello M
- Agostinis P
- Agrewala JN
- Agrotis A
- Aguilar PV
- Ahmad ST
- Ahmed ZM
- Ahumada-Castro U
- Aits S
- Aizawa S
- Akkoc Y
- Akoumianaki T
- Akpinar HA
- Al-Abd AM
- Al-Akra L
- Al-Gharaibeh A
- Alaoui-Jamali MA
- Alberti S
- Alcocer-GĂłmez E
- Alessandri C
- Ali M
- Alim Al-Bari MA
- Aliwaini S
- Alizadeh J
- Almacellas E
- Almasan A
- Alonso A
- Alonso GD
- Altan-Bonnet N
- Altieri DC
- Alves da Costa C
- Alves S
- Alzaharna MM
- Amadio M
- Amantini C
- Amaral C
- Ambrosio S
- Amer AO
- Ammanathan V
- An Z
- Andersen SU
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- Ănal G
- ĂstĂŒn S
- ÄoliÄ M
- ÄokiÄ J
- Ćœerovnik E
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
- Author
- A. -G. Wu
- A. C. Ma
- A. K. Au
- Abdel-Aziz A. K.
- Abdelfatah S.
- Abdellatif M.
- Abdoli A.
- Abel S.
- Abeliovich H.
- Abildgaard M. H.
- Abudu Y. P.
- Acevedo-Arozena A.
- Adamopoulos I. E.
- Adeli K.
- Adolph T. E.
- Adornetto A.
- Aflaki E.
- Agam G.
- Agarwal A.
- Aggarwal B. B.
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- Al-Abd A. M.
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- Al-Gharaibeh A.
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- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
Shaping 3D root system architecture
- Author
- Agata Golebiowska
- Ahmed
- Atkinson
- Atkinson
- Atkinson
- Avramova
- Babe
- Baldwin
- Balzergue
- Band
- Bao
- Bates
- Brian Atkinson
- Brisson
- Brundrett
- Bucksch
- Canamero
- Casero
- Casimiro
- Casper
- Castrillo
- Chen
- Clark
- Colombi
- Craig J. Sturrock
- Daly
- Daniel von Wangenheim
- Darren M. Wells
- Dathe
- De Smet
- Depuydt
- Dietrich
- Digby
- Dolan
- Downie
- Drew
- Dudley
- Emily C. Morris
- Fageria
- Fang
- Feng
- Flavel
- Forde
- Franche
- Fusconi
- Galen
- Galvan-Ampudia
- Gao
- Gao
- Ge
- Gersani
- Giehl
- Gioia
- Godfray
- Granato
- Gruber
- Gruntman
- Gutjahr
- Gutjahr
- Guyomarc'h
- Hamer
- Hangarter
- Harrison
- Helber
- Hodge
- Hodge
- Hodge
- Hofhuis
- Hooker
- Iwata
- Jasmine Burr-Hersey
- Jenny
- Jonathan P. Lynch
- Karl Ritz
- Kawa
- King
- Kirkham
- Kleine-Vehn
- Kolesnikov
- Kris Vissenberg
- Laxmi
- Lee
- Lev-Yadun
- Lopez-Bucio
- Luxmoore
- Lynch
- Lynch
- Ma
- Ma
- Maina
- Mairhofer
- Mairhofer
- Malcolm J. Bennett
- Mangalassery
- Marcus Griffiths
- Mo
- Molas
- Moriwaki
- Mullen
- Mullen
- Nestler
- Nord
- O'Brien
- Olah
- Ozcoban
- Passot
- Paszkowski
- Peret
- Popova
- Raghothama
- Rath
- Rellan-Alvarez
- Remans
- Rich
- Ritz
- Robbins
- Rosquete
- Roychoudhry
- Roychoudhry
- Rubio
- Ruppel
- Sacha J. Mooney
- Schenk
- Schmid
- Sebastian
- Shane
- Smith
- Smith
- Sprent
- Stefan Mairhofer
- Steffens
- Strack
- Swarup
- Tatsuaki Goh
- Tian
- Tinker
- Trachsel
- Trachsel
- Tracy
- Tracy
- Tracy
- Uga
- Valentine
- van Dusschoten
- Wan
- Wang
- Wang
- Weligama
- White
- Wilkinson
- Yu
- Yuan
- Zhan
- Zhan
- Zhang
- Zhang
- Zou
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2017
- Field of study
Plants are sessile organisms rooted in one place. The soil resources that plants require are often distributed in a highly heterogeneous pattern. To aid foraging, plants have evolved roots whose growth and development are highly responsive to soil signals. As a result, 3D root architecture is shaped by myriad environmental signals to ensure resource capture is optimised and unfavourable environments are avoided. The first signals sensed by newly germinating seeds â gravity and light â direct root growth into the soil to aid seedling establishment. Heterogeneous soil resources, such as water, nitrogen and phosphate, also act as signals that shape 3D root growth to optimise uptake. Root architecture is also modified through biotic interactions that include soil fungi and neighbouring plants. This developmental plasticity results in a âcustom-madeâ 3D root system that is best adapted to forage for resources in each soil environment that a plant colonises
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