Expanding the Circle: Respecting the Past, Preparing for the Future: A Summer Program and Curriculum to Support American Indian Students in Transition

MS. PETERSON: It\u27s 1 :00 and I think that Jean and Jen have a lot to share today. So, I think we\u27ll get started. And I - my name is Kris Peterson and I work for the National Center on Secondary Transmission at the University of Minnesota. And I am just here to facilitate today and welcome all of you participants who are there and people who come on as time goes on

An Observational Study With the Janssen Autism Knowledge Engine (JAKE((R))) in Individuals With Autism Spectrum Disorder

Objective: The Janssen Autism Knowledge Engine (JAKE(R)) is a clinical research outcomes assessment system developed to more sensitively measure treatment outcomes and identify subpopulations in autism spectrum disorder (ASD). Here we describe JAKE and present results from its digital phenotyping (My JAKE) and biosensor (JAKE Sense) components. Methods: An observational, non-interventional, prospective study of JAKE in children and adults with ASD was conducted at nine sites in the United States. Feedback on JAKE usability was obtained from caregivers. JAKE Sense included electroencephalography, eye tracking, electrocardiography, electrodermal activity, facial affect analysis, and actigraphy. Caregivers of individuals with ASD reported behaviors using My JAKE. Results from My JAKE and JAKE Sense were compared to traditional ASD symptom measures. Results: Individuals with ASD (N = 144) and a cohort of typically developing (TD) individuals (N = 41) participated in JAKE Sense. Most caregivers reported that overall use and utility of My JAKE was easy (69%, 74/108) or very easy (74%, 80/108). My JAKE could detect differences in ASD symptoms as measured by traditional methods. The majority of biosensors included in JAKE Sense captured sizable amounts of quality data (i.e., 93-100% of eye tracker, facial affect analysis, and electrocardiogram data was of good quality), demonstrated differences between TD and ASD individuals, and correlated with ASD symptom scales. No significant safety events were reported. Conclusions: My JAKE was viewed as easy or very easy to use by caregivers participating in research outside of a clinical study. My JAKE sensitively measured a broad range of ASD symptoms. JAKE Sense biosensors were well-tolerated. JAKE functioned well when used at clinical sites previously inexperienced with some of the technologies. Lessons from the study will optimize JAKE for use in clinical trials to assess ASD interventions. Additionally, because biosensors were able to detect features differentiating TD and ASD individuals, and also were correlated with standardized symptom scales, these measures could be explored as potential biomarkers for ASD and as endpoints in future clinical studies. Clinical Trial Registration: https://clinicaltrials.gov/ct2/show/NCT02668991 identifier: NCT02668991

Expanding the Circle: Respecting the Past, Preparing for the Future—A Summer Program and Curriculum to Support American Indian Students in Transition (NCSET Teleconference)

A transcript summarizing a teleconference on Expanding the Circle—Respecting the Past, Preparing for the Future which was developed specifically for American Indian students.NCSET is supported through cooperative agreement #H326J000005 with the U.S. Department of Education, Office of Special Education Programs. Opinions expressed herein do not necessarily reflect the policy or position of the U.S. Department of Education, and no official endorsement should be inferred

Earlier Mother's Age at Menarche Predicts Rapid Infancy Growth and Childhood Obesity

Earlier age at menarche may be a transgenerational marker of faster growth, particularly during infancy, leading to taller childhood stature but earlier maturation and hence shorter adult stature

Coronal Structure of Low-Mass Stars

We investigate the change in stellar magnetic topology across the fully-convective boundary and its effects on coronal properties. We consider both the magnitude of the open flux that influences angular momentum loss in the stellar wind and X-ray emission measure. We use reconstructed maps of the radial magnetic field at the stellar surface and the potential-field source surface method to extrapolate a 3D coronal magnetic field for a sample of early-to-mid M dwarfs. During the magnetic reconstruction process it is possible to force a solution towards field geometries that are symmetric or antisymmetric about the equator but we demonstrate that this has only a modest impact on the coronal tracers mentioned above. We find that the dipole component of the field, which governs the large-scale structure, becomes increasingly strong as the stellar mass decreases, while the magnitude of the open (wind-bearing) magnetic flux is proportional to the magnitude of the reconstructed magnetic flux. By assuming a hydrostatic and isothermal corona we calculate X-ray emission measures (in magnitude and rotational modulation) for each star and, using observed stellar densities as a constraint, we reproduce the observed X-ray saturation at Ro < 0.1. We find that X-ray rotational modulation is not a good indicator of magnetic structure as it shows no trend with Rossby number but can be useful in discriminating between different assumptions on the field geometry.Comment: 12 pages, 10 figures, Published in MNRA

Swift observations of the 2006 outburst of the recurrent nova RS Ophiuchi: I. Early X-ray emission from the shocked ejecta and red giant wind

RS Ophiuchi began its latest outburst on 2006 February 12. Previous outbursts have indicated that high velocity ejecta interact with a pre-existing red giant wind, setting up shock systems analogous to those seen in Supernova Remnants. However, in the previous outburst in 1985, X-ray observations did not commence until 55 days after the initial explosion. Here we report on Swift observations covering the first month of the 2006 outburst with the Burst Alert (BAT) and X-ray Telescope (XRT) instruments. RS Oph was clearly detected in the BAT 14-25 keV band from t=0 to $t\sim6$ days. XRT observationsfrom 0.3-10 keV, started at 3.17 days after outburst. The rapidly evolving XRT spectra clearly show the presence of both line and continuum emission which can be fitted by thermal emission from hot gas whose characteristic temperature, overlying absorbing column, $[N_H]_W$, and resulting unabsorbed total flux decline monotonically after the first few days. Derived shock velocities are in good agreement with those found from observations at other wavelengths. Similarly, $[N_H]_W$ is in accord with that expected from the red giant wind ahead of the forward shock. We confirm the basic models of the 1985 outburst and conclude that standard Phase I remnant evolution terminated by $t\sim10$ days and the remnant then rapidly evolved to display behaviour characteristic of Phase III. Around t=26 days however, a new, luminous and highly variable soft X-ray source began to appear whose origin will be explored in a subsequent paper.Comment: 20 pages, 4 figures (2 updated), accepted by Ap

The Fourteenth Data Release of the Sloan Digital Sky Survey: First Spectroscopic Data from the extended Baryon Oscillation Spectroscopic Survey and from the second phase of the Apache Point Observatory Galactic Evolution Experiment

The fourth generation of the Sloan Digital Sky Survey (SDSS-IV) has been in operation since July 2014. This paper describes the second data release from this phase, and the fourteenth from SDSS overall (making this, Data Release Fourteen or DR14). This release makes public data taken by SDSS-IV in its first two years of operation (July 2014-2016). Like all previous SDSS releases, DR14 is cumulative, including the most recent reductions and calibrations of all data taken by SDSS since the first phase began operations in 2000. New in DR14 is the first public release of data from the extended Baryon Oscillation Spectroscopic Survey (eBOSS); the first data from the second phase of the Apache Point Observatory (APO) Galactic Evolution Experiment (APOGEE-2), including stellar parameter estimates from an innovative data driven machine learning algorithm known as "The Cannon"; and almost twice as many data cubes from the Mapping Nearby Galaxies at APO (MaNGA) survey as were in the previous release (N = 2812 in total). This paper describes the location and format of the publicly available data from SDSS-IV surveys. We provide references to the important technical papers describing how these data have been taken (both targeting and observation details) and processed for scientific use. The SDSS website (www.sdss.org) has been updated for this release, and provides links to data downloads, as well as tutorials and examples of data use. SDSS-IV is planning to continue to collect astronomical data until 2020, and will be followed by SDSS-V.Comment: SDSS-IV collaboration alphabetical author data release paper. DR14 happened on 31st July 2017. 19 pages, 5 figures. Accepted by ApJS on 28th Nov 2017 (this is the "post-print" and "post-proofs" version; minor corrections only from v1, and most of errors found in proofs corrected

Increased risk of miscarriage among women experiencing physical or sexual intimate partner violence during pregnancy in Guatemala City, Guatemala: cross-sectional study

<p>Abstract</p> <p>Background</p> <p>Violence against women by their male intimate partners (IPV) during pregnancy may lead to negative pregnancy outcomes. We examined the role of IPV as a potential risk factor for miscarriage in Guatemala. Our objectives were: (1) To describe the magnitude and pattern of verbal, physical and sexual violence by male intimate partners in the last 12 months (IPV) in a sample of pregnant Guatemalans; (2) To evaluate the influence of physical or sexual IPV on miscarriage as a pregnancy outcome.</p> <p>Methods</p> <p>All pregnant women reporting to the maternity of a major tertiary care public hospital in Guatemala City from June 1st to September 30th, 2006 were invited to participate in this cross-sectional study. The admitting physician assessed occurrence of miscarriage, defined as involuntary pregnancy loss up to and including 28 weeks gestation. Data on IPV, social and demographic characteristics, risk behaviours, and medical history were collected by interviewer-administered questionnaire. Laboratory testing was performed for HIV and syphilis. The relationship between IPV and miscarriage was assessed through multivariable logistic regression.</p> <p>Results</p> <p>IPV affected 18% of the 1897 pregnant Guatemalan women aged 15-47 in this sample. Verbal IPV was most common (16%), followed by physical (10%) and sexual (3%) victimisation. Different forms of IPV were often co-prevalent. Miscarriage was experienced by 10% of the sample (<it>n </it>= 190). After adjustment for potentially confounding factors, physical or sexual victimisation by a male intimate partner in the last 12 months was significantly associated with miscarriage (ORadj 1.1 to 2.8). Results were robust under a range of analytic assumptions.</p> <p>Conclusions</p> <p>Physical and sexual IPV is associated with miscarriage in this Guatemalan facility-based sample. Results cohere well with findings from population-based surveys. IPV should be recognised as a potential cause of miscarriage. Reproductive health services should be used to screen for spousal violence and link to assistance.</p

Hmgcr in the Corpus Allatum Controls Sexual Dimorphism of Locomotor Activity and Body Size via the Insulin Pathway in Drosophila

The insulin signaling pathway has been implicated in several physiological and developmental processes. In mammals, it controls expression of 3-Hydroxy-3-Methylglutaryl CoA Reductase (HMGCR), a key enzyme in cholesterol biosynthesis. In insects, which can not synthesize cholesterol de novo, the HMGCR is implicated in the biosynthesis of juvenile hormone (JH). However, the link between the insulin pathway and JH has not been established. In Drosophila, mutations in the insulin receptor (InR) decrease the rate of JH synthesis. It is also known that both the insulin pathway and JH play a role in the control of sexual dimorphism in locomotor activity. In studies here, to demonstrate that the insulin pathway and HMGCR are functionally linked in Drosophila, we first show that hmgcr mutation also disrupts the sexual dimorphism. Similarly to the InR, HMGCR is expressed in the corpus allatum (ca), which is the gland where JH biosynthesis occurs. Two p[hmgcr-GAL4] lines were therefore generated where RNAi was targeted specifically against the HMGCR or the InR in the ca. We found that RNAi-HMGCR blocked HMGCR expression, while the RNAi-InR blocked both InR and HMGCR expression. Each RNAi caused disruption of sexual dimorphism and produced dwarf flies at specific rearing temperatures. These results provide evidence: (i) that HMGCR expression is controlled by the InR and (ii) that InR and HMGCR specifically in the ca, are involved in the control of body size and sexual dimorphism of locomotor activity