“Bela escola de civismo”: o escotismo como elemento de transformação social no Brasil

O presente artigo tem por fito analisar a prática do escotismo no Brasil no início do século XX, problematizando como este método de educação extraescolar foi apropriado pelos intelectuais e autoridades políticas para o disciplinamento moral, cívico e físico da infância e juventude, associadas, neste momento, a “grandeza” da nação. Para alcançar o objetivo proposto, fizemos um cruzamento entre a análise das fontes impressas a saber: revistas O Tico-Tico e Ilustração Brasileira, leis e decretos com as contribuições de autores, tais como Foucault (1987), Nagle (2009), Nascimento (2004), Souza (2000, 2018), Nascimento (2008), entre outros. Destarte, constatamos que no Brasil o método de Baden-Powell foi convertido em uma escola de civismo para moldar o comportamento do futuro cidadão da Pátria brasileira.

BRASIL E MERCOSUL: ASPECTOS ECONÔMICOS E A RELEVÂNCIA DO BLOCO PARA O PAÍS

O objetivo geral deste estudo é abordar a situação econômica do MERCOSUL (Mercado Comum do Sul) e a atuação do bloco em meio ao contexto econômico brasileiro. Questiona-se se ainda é imprescindível a participação do Brasil no grupo sul-americano, visto que, devido a uma série de desvios e deturpações, o MERCOSUL atualmente está distante dos princípios que guiaram sua criação. Em seu desdobramento, o estudo compreende revisões de bibliografias envolvendo o tema da integração econômica regional, com análises voltadas à América Latina, com foco no MERCOSUL e sua relação com a economia brasileira. Utilizou-se da pesquisa descritiva, quanto aos objetivos, e da pesquisa bibliográfica e do estudo de caso quanto aos procedimentos técnicos, enquanto a análise seguiu abordagem qualitativa. Em relação aos resultados, avalia-se que a participação do Brasil no MERCOSUL, considerado unicamente o âmbito econômico, não se faz impreterível como outrora

European landscape changes between 2010 and 2050 under the EU Reference Scenario: EU Reference Scenario 2013 LUISA platform – Updated Configuration 2014

The ‘Land-Use-based Integrated Sustainability Assessment’ modelling platform (LUISA) is primarily used for the ex-ante evaluation of EC policies that have a direct or indirect territorial impact. It is based on the concept of ‘land function’ for cross-sector integration and for the representation of complex system dynamics. Beyond a traditional land use model, LUISA adopts a new approach towards activity-based modelling based upon the endogenous dynamic allocation of population, services and activities. LUISA has been applied to address the competition for land arising from the energy, transport and climate dimensions of EU policies and configured according to the EU Energy Reference scenario 2013 (updated configuration 2014) to produce high-resolution land use/cover projections up to 2050 and a related series of thematic indicators. This report describes the stocks and the main land cover/use flows (LCF) taking place in Europe in the period 2010-2050 and the processes that cause those flows, thus providing insight on how the European landscape might change if the future happens according to a reference scenario consistent with settings (economic and demographic in particular) and policies in place in 2013 (hence including in particular the 2020 renewable energy targets). Main findings: • The extent of the land for housing and leisure (urban) and industrial/commercial and services (ICS) increases, while the area of agriculture, forest and natural land decreases; • Urban and industrial land are expected to represent the highest share of net formation as % of the initial year (2010); • Energy crops appear in the model as of 2020 and are expected to reach 135,479 km2 across Europe in 2050; • Energy crops become the second most important land transformation in Europe (17%); approximately 90 % of the land consumed for energy purposes comes from land for food and feed, followed by forest and natural land; • While a large proportion of land dedicated to food and feed crops is expected to be converted into dedicated energy crops, the net land losses are very small as a results of the conversion from forest land into food and feed production; • New forest and natural land compensate in some way for quantity of losses or consumption by other uses; however the high value of the turnover indicator, reveal that those land-uses are unstable and vulnerable to the fast changes driven by economic development and climate changes, thus compromising the biodiversity and habitat conservation status; • The conversion between farming types represent 35% over the total land changes between 2010 and 2050; The results show the loss of natural and agricultural land because of ever-ongoing urbanisation and industrialization processes. The loss of natural and agricultural land for food production is even larger because of the advent of energy crops production incited by shifts in the European Energy supply system.JRC.H.8-Sustainability Assessmen

European cities: territorial analysis of characteristics and trends - An application of the LUISA Modelling Platform (EU Reference Scenario 2013 - Updated Configuration 2014)

Cities and towns are at the core of the European economy but they are often also the places where problems related to the quality of life of citizens such as unemployment, segregation and poverty are most evident. To curtail the negative impacts and foster the positive effects of ongoing urban processes in Europe, policies have to be adjusted and harmonised to accommodate future urbanization trends. Such an analysis of the evolution of European cities requires the evaluation of impacts of continent-wide drivers and, at the same time, assessment of the effect of national and local strategies. As a contribution to this analysis of the current and future evolution of European territories (countries, macro-regions, regions or urban areas), the Directorate-General Joint Research Centre (DG JRC) of the European Commission (EC) has developed the Land-Use-based Integrated Sustainability Assessment (LUISA) Modelling Platform. Based on the concept of ‘dynamic land functions’, LUISA has adopted a novel approach towards activity-based modelling and endogenous dynamic allocation of population, services and activities. This report illustrates how European cities could potentially evolve over the time period 2010-2050, according to the reference configuration of the LUISA modelling platform, on the basis of a collection of spatial indicators covering several thematic fields. These spatial indicators aim to improve our understanding of urbanization and urban development processes in Europe; explore territorial dimensions of projected demographic and economic changes, and finally examine some key challenges that urban areas are or may be exposed to. Some of the key findings of this report are given below: - The proportion of the population living in cities, towns and suburbs is higher in the EU than in the rest of the world. According to the LUISA forecasts, the urban proportion will continue to increase up to 2030; subsequently slow down, and reach a relatively steady state by 2050. - In 2010, 65% of the EU population were living in Functional Urban Areas (FUA, the city and its commuting zone). This figure is expected to reach 70% by 2050. The total EU-28 population is expected to grow by 4.6%. Most of this population growth will occur particularly in FUA which will grow by an average 14%. - As of 2010, the amount of artificial areas per inhabitant in the EU-28 was estimated as 498 m2: it becomes 539 m2 in 2050 with an 8% increase. Although there is not a unique spatial pattern, land take tends to start peak at 5 km distance from the city centre. This is due to the fact that land is often less available for development within city centres and that the majority of land take therefore will occur firstly in the suburbs and then in rural areas. - By 2050, potential accessibility – as measure of economic opportunities - will be higher in the urban areas of north-western Europe, while it will not improve in lagging European regions. Urban form has a considerable impact on average travelled distances and thus potentially on the energy dependence of transport. - Green infrastructure is mainly located at the periphery of urban areas. Its share per person is generally low or very low in most of the European cities, with few exceptions. Green infrastructure per capita in FUA shows a general trend towards a decrease across the EU-28 (by approximately 13%) between 2010 and 2050. - Larger cities tend to have higher average flood risk, especially due to the higher sensitivity in terms of potential human and physical losses. The analysis herein presented is part of a wider initiative of DG JRC and DG REGIO aiming to improve the management of knowledge and sharing of information related to territorial policies, such as those concerning urban development. In this framework, the work will be further developed, covering the following main elements: - Development of the European Urban Data Platform, providing a single access point for data and indicators on the status and trends of European urban areas; - Updates of the LUISA configuration, to account for new socio-economic projections; - Support to the development of the EU Urban Agenda and related initiatives; - Provision of evidence-based support for the evaluation of territorial policies in particular to proof the role of cities in the implementation of EU priorities.JRC.H.8-Sustainability Assessmen

LUISA Dynamic Land Functions: Catalogue of Indicators – Release I: EU Reference Scenario 2013 LUISA Platform - Updated Configuration 2014

The concept of ‘dynamic land function’ is a new notion for cross-sector integration and for the representation of complex system dynamics. A land function can be societal (e.g. provision of housing, leisure and recreation), economic (e.g. provision of production factors - employment, investments, energy – or provision of manufacturing products and services – food, fuels, consumer goods, etc.) or environmental (e.g. supply of ecosystem services). Land functions are temporally and spatially dynamic, and are constrained and driven by natural, socio-economic, and techno-economic processes. Based on the concept of ‘land function’ and beyond a traditional land use model, the Land-Use based Integrated Sustainability Assessment (LUISA) modelling platform adopts a new approach towards activity-based modelling based upon the endogenous dynamic allocation of population, services and activities. The ultimate product of LUISA is a set of territorial indicators that can be grouped and combined according to the ‘land function’ of interest and/or to the sector under assessment. The herein presented indicators measure the provision of land functions in the period 2010-2050, according to the EU Reference Scenario (LUISA, updated configuration 2014), consistent with settings (economic and demographic in particular) and policies in place in 2013 (hence including the 2020 renewable energy targets). The indicators are aggregated by Member States and Regions (Administrative Units NUTS-2) and can be employed as benchmark to monitor sectorial and territorial evolutions of alternative scenarios (e.g. to simulate policy options or specific measures), and for future updates of the reference scenario, to capture policy impacts (for example when changing energy targets) and their territorial effects. This catalogue aims to provide the description of the land functions and the list of related indicators and an indicator factsheet (metadata). 30 indicators, out of the more than 50 currently produced by LUISA, are included in the first release of the catalogue. The catalogue is periodically up-dated, following the updates of the configurations of the LUISA modelling platform and the definition, computation and validation of new indicators. Indicators and basic spatial layers used for the simulations will be made available in the frame of the framework for the management of knowledge and dissemination of information being set up by the Pilot Knowledge Centre on Territorial Policies.JRC.H.8-Sustainability Assessmen

PRISM (Polarized Radiation Imaging and Spectroscopy Mission): A White Paper on the Ultimate Polarimetric Spectro-Imaging of the Microwave and Far-Infrared Sky

PRISM (Polarized Radiation Imaging and Spectroscopy Mission) was proposed to ESA in response to the Call for White Papers for the definition of the L2 and L3 Missions in the ESA Science Programme. PRISM would have two instruments: (1) an imager with a 3.5m mirror (cooled to 4K for high performance in the far-infrared---that is, in the Wien part of the CMB blackbody spectrum), and (2) an Fourier Transform Spectrometer (FTS) somewhat like the COBE FIRAS instrument but over three orders of magnitude more sensitive. Highlights of the new science (beyond the obvious target of B-modes from gravity waves generated during inflation) made possible by these two instruments working in tandem include: (1) the ultimate galaxy cluster survey gathering 10e6 clusters extending to large redshift and measuring their peculiar velocities and temperatures (through the kSZ effect and relativistic corrections to the classic y-distortion spectrum, respectively) (2) a detailed investigation into the nature of the cosmic infrared background (CIB) consisting of at present unresolved dusty high-z galaxies, where most of the star formation in the universe took place, (3) searching for distortions from the perfect CMB blackbody spectrum, which will probe a large number of otherwise inaccessible effects (e.g., energy release through decaying dark matter, the primordial power spectrum on very small scales where measurements today are impossible due to erasure from Silk damping and contamination from non-linear cascading of power from larger length scales). These are but a few of the highlights of the new science that will be made possible with PRISM.Comment: 20 pages Late

PTPA variants and impaired PP2A activity in early-onset parkinsonism with intellectual disability

The protein phosphatase 2A complex (PP2A), the major Ser/Thr phosphatase in the brain, is involved in a number of signalling pathways and functions, including the regulation of crucial proteins for neurodegeneration, such as alpha-synuclein, tau and LRRK2. Here, we report the identification of variants in the PTPA/PPP2R4 gene, encoding a major PP2A activator, in two families with early-onset parkinsonism and intellectual disability. We carried out clinical studies and genetic analyses, including genome-wide linkage analysis, whole-exome sequencing, and Sanger sequencing of candidate variants. We next performed functional studies on the disease-associated variants in cultured cells and knock-down of ptpa in Drosophila melanogaster. We first identified a homozygous PTPA variant, c.893T&gt;G (p.Met298Arg), in patients from a South African family with early-onset parkinsonism and intellectual disability. Screening of a large series of additional families yielded a second homozygous variant, c.512C&gt;A (p.Ala171Asp), in a Libyan family with a similar phenotype. Both variants co-segregate with disease in the respective families. The affected subjects display juvenile-onset parkinsonism and intellectual disability. The motor symptoms were responsive to treatment with levodopa and deep brain stimulation of the subthalamic nucleus. In overexpression studies, both the PTPA p.Ala171Asp and p.Met298Arg variants were associated with decreased PTPA RNA stability and decreased PTPA protein levels; the p.Ala171Asp variant additionally displayed decreased PTPA protein stability. Crucially, expression of both variants was associated with decreased PP2A complex levels and impaired PP2A phosphatase activation. PTPA orthologue knock-down in Drosophila neurons induced a significant impairment of locomotion in the climbing test. This defect was age-dependent and fully reversed by L-DOPA treatment. We conclude that bi-allelic missense PTPA variants associated with impaired activation of the PP2A phosphatase cause autosomal recessive early-onset parkinsonism with intellectual disability. Our findings might also provide new insights for understanding the role of the PP2A complex in the pathogenesis of more common forms of neurodegeneration.</p

Nrf2-interacting nutrients and COVID-19 : time for research to develop adaptation strategies

There are large between- and within-country variations in COVID-19 death rates. Some very low death rate settings such as Eastern Asia, Central Europe, the Balkans and Africa have a common feature of eating large quantities of fermented foods whose intake is associated with the activation of the Nrf2 (Nuclear factor (erythroid-derived 2)-like 2) anti-oxidant transcription factor. There are many Nrf2-interacting nutrients (berberine, curcumin, epigallocatechin gallate, genistein, quercetin, resveratrol, sulforaphane) that all act similarly to reduce insulin resistance, endothelial damage, lung injury and cytokine storm. They also act on the same mechanisms (mTOR: Mammalian target of rapamycin, PPAR gamma:Peroxisome proliferator-activated receptor, NF kappa B: Nuclear factor kappa B, ERK: Extracellular signal-regulated kinases and eIF2 alpha:Elongation initiation factor 2 alpha). They may as a result be important in mitigating the severity of COVID-19, acting through the endoplasmic reticulum stress or ACE-Angiotensin-II-AT(1)R axis (AT(1)R) pathway. Many Nrf2-interacting nutrients are also interacting with TRPA1 and/or TRPV1. Interestingly, geographical areas with very low COVID-19 mortality are those with the lowest prevalence of obesity (Sub-Saharan Africa and Asia). It is tempting to propose that Nrf2-interacting foods and nutrients can re-balance insulin resistance and have a significant effect on COVID-19 severity. It is therefore possible that the intake of these foods may restore an optimal natural balance for the Nrf2 pathway and may be of interest in the mitigation of COVID-19 severity

Cabbage and fermented vegetables : From death rate heterogeneity in countries to candidates for mitigation strategies of severe COVID-19

Large differences in COVID-19 death rates exist between countries and between regions of the same country. Some very low death rate countries such as Eastern Asia, Central Europe, or the Balkans have a common feature of eating large quantities of fermented foods. Although biases exist when examining ecological studies, fermented vegetables or cabbage have been associated with low death rates in European countries. SARS-CoV-2 binds to its receptor, the angiotensin-converting enzyme 2 (ACE2). As a result of SARS-CoV-2 binding, ACE2 downregulation enhances the angiotensin II receptor type 1 (AT(1)R) axis associated with oxidative stress. This leads to insulin resistance as well as lung and endothelial damage, two severe outcomes of COVID-19. The nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is the most potent antioxidant in humans and can block in particular the AT(1)R axis. Cabbage contains precursors of sulforaphane, the most active natural activator of Nrf2. Fermented vegetables contain many lactobacilli, which are also potent Nrf2 activators. Three examples are: kimchi in Korea, westernized foods, and the slum paradox. It is proposed that fermented cabbage is a proof-of-concept of dietary manipulations that may enhance Nrf2-associated antioxidant effects, helpful in mitigating COVID-19 severity.Peer reviewe

Why Are Outcomes Different for Registry Patients Enrolled Prospectively and Retrospectively? Insights from the Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF).

Background: Retrospective and prospective observational studies are designed to reflect real-world evidence on clinical practice, but can yield conflicting results. The GARFIELD-AF Registry includes both methods of enrolment and allows analysis of differences in patient characteristics and outcomes that may result. Methods and Results: Patients with atrial fibrillation (AF) and ≥1 risk factor for stroke at diagnosis of AF were recruited either retrospectively (n = 5069) or prospectively (n = 5501) from 19 countries and then followed prospectively. The retrospectively enrolled cohort comprised patients with established AF (for a least 6, and up to 24 months before enrolment), who were identified retrospectively (and baseline and partial follow-up data were collected from the emedical records) and then followed prospectively between 0-18 months (such that the total time of follow-up was 24 months; data collection Dec-2009 and Oct-2010). In the prospectively enrolled cohort, patients with newly diagnosed AF (≤6 weeks after diagnosis) were recruited between Mar-2010 and Oct-2011 and were followed for 24 months after enrolment. Differences between the cohorts were observed in clinical characteristics, including type of AF, stroke prevention strategies, and event rates. More patients in the retrospectively identified cohort received vitamin K antagonists (62.1% vs. 53.2%) and fewer received non-vitamin K oral anticoagulants (1.8% vs . 4.2%). All-cause mortality rates per 100 person-years during the prospective follow-up (starting the first study visit up to 1 year) were significantly lower in the retrospective than prospectively identified cohort (3.04 [95% CI 2.51 to 3.67] vs . 4.05 [95% CI 3.53 to 4.63]; p = 0.016). Conclusions: Interpretations of data from registries that aim to evaluate the characteristics and outcomes of patients with AF must take account of differences in registry design and the impact of recall bias and survivorship bias that is incurred with retrospective enrolment. Clinical Trial Registration: - URL: http://www.clinicaltrials.gov . Unique identifier for GARFIELD-AF (NCT01090362)