101 research outputs found
Polymorphismes du gène ABCB1 (MDR1) et impacts fonctionnels dans le transport de xénobiotiques - Particularités chez les sujets Noirs Subsahariens
- Publication venue
- 'African Journals Online (AJOL)'
- Publication date
- 31/08/2012
- Field of study
Les différences interindividuelles observées dans la réponse aux médicaments sont en partie dues aux polymorphismes du gène ABCB1 codant pour la glycoprotéine-P (P-gp), une protéine de transport des médicaments. Cette revue a pour but de faire le point des connaissances sur les polymorphismes du gène ABCB1, leur relevance fonctionnelle et clinique et de préciser les particularités au sein de la population noire subsharienne. Le rôle du gène (ABCB1)MDR1 dans la variabilité pharmacocinétique ou pharmacodynamique a été démontrée clairement in vitro, dans des modèles animaux et lors d’études cliniques. Le polymorphisme C3435T est associé à une diminution de l’expression protéique de la P-gp et, par voie de conséquence, de son activité. L’existence d’une forte association entre les polymorphismes C3435T et G2677T a suggéré alors que la différence fonctionnelle observée peut être attribuée également au deuxième polymorphisme i.e le G2677T (exon 21). Il a été identifié chez les noirs africains de nouveaux polymorphismes et des haplotypes particuliers. Différnts travaux ont démontré également que le gène ABCB1 intervient dans le suivi thérapeutique des patients mis sous immunosuppresseurs, anticancéreux, antidépresseurs, antirétroviraux ou antihypertenseurs. Des perspectives fort intéressantes en pharmacothérapie avec entre autres l’utilisation de modulateurs de la P-gp sont d’actualité.Mots clés: Pharmacogénétique, glycoprotéine-P, médicaments, substances exogènes, Noirs Subsaharien
HIV-1 Tat mimetic of VEGF correlates with increased microvessels density in AIDS-related diffuse large B-cell and Burkitt lymphomas
- Author
- A Albini
- A Albini
- A Brkovic
- A. Luzzi
- B Ensoli
- BJ Dezube
- C Ruch
- C. Bellan
- D Gratzinger
- D Zagury
- D. Spina
- G Barillari
- G Bergers
- G Falco De
- G Mazur
- G McMahon
- G Ranieri
- G. Cerino
- G. De Falco
- GH Fong
- HF Dvorak
- HF Dvorak
- I Dragoni
- IO Ng
- J Waltenberger
- J. Nyagol
- JL Gala
- JL Warner-Schmidt
- K Vermeulen
- L. Leoncini
- LF Brown
- LJ Reigstad
- LS Rosen
- M Bardelli
- M Morini
- M Rusnati
- N. Palummo
- P Scheidegger
- PP Claudio
- R Dell’Eva
- RC Gallo
- RO Pritchard-Jones
- S Lazzi
- S. Lazzi
- S. Shaheen
- SC Santos
- U Fearon
- W Petersen
- Y Aoki
- Y Takahashi
- Y Yamazaki
- Publication venue
- Springer-Verlag
- Publication date
- 01/07/2008
- Field of study
Angiogenic switch marks the beginning of tumor’s strategy to acquire independent blood supply. In some subtypes of non-Hodgkin’s lymphomas, higher local vascular endothelial growth factor (VEGF) expression correlates with increased microvessel density. However, this local VEGF expression is higher only in tumors with elevated expression of the receptors of the growth factor, suggesting an autocrine growth-promoting feedback loop. Several studies have indicated that VEGF receptors are also targeted by Tat protein from the HIV-1-infected cells. Given the similarity of the basic region of Tat to the angiogenic factors (basic fibroblast growth factor, VEGF), Tat mimics these proteins and binds to their receptors. We evaluated the role of HIV-1 Tat in regulating the level of VEGF expression and microvessel density in the AIDS-related diffuse large B-cell (DLBCL) and Burkitt lymphomas (BL). By luciferase assay, we showed that VEGF promoter activity was downregulated in vitro in cells transfected with Tat. Reduced VEGF protein expression in primary HIV-1 positive BL and DLBCL, compared to the negative cases, supported the findings of promoter downregulation from the cell lines. Microvascular density assessed by CD34 expression was, however, higher in HIV-1 positive than in HIV-1 negative tumors. These results suggest that Tat has a wider angiogenic role, besides the regulation of VEGF expression. Thus, targeting Tat protein itself and stabilizing transient silencing of VEGF expression or use of monoclonal antibodies against their receptors in the AIDS-associated tumors will open a window for future explorable pathways in the management of angiogenic phenotypes in the AIDS-associated non-Hodgkin’s lymphomas
Combination antiretroviral therapy and the risk of myocardial infarction
- Author
- Abbadesse V
- Abrams DI
- Abrescia N
- Akerlund B
- Alberici F
- Alessandrini A
- Anderson J
- Antinori A
- Antinori A
- Antunes F
- Arduino R
- Arici C
- Arici C
- Arlotti M
- Austin D
- Baker B
- Bal J
- Balestre E
- Ballardini G
- Banhegyi D
- Barton S
- Bartsch G
- Bartsch G
- Baxter J
- Bedini A
- Ben-Ishai Z
- Benfield T
- Beniowski M
- Bentwich Z
- Bentz L
- Bernard E
- Bernard N
- Bernasconi E
- Beylot C
- Beylot J
- Beylot J
- Bezian JH
- Bieckel M
- Blaizeau MJ
- Blaxhult A
- Blok W
- Bonarek M
- Bonasso M
- Bonnet F
- Borleffs J
- Boron-Kaczmarska A
- Bottari G
- Boulant B
- Brettle R
- Brevenboer B
- Brinkman K
- Bronsveld W
- Bruno R
- Bruun J
- Bucher H
- Burgisser P
- Cadafalch J
- Cadeo G
- Caggese L
- Caissotti C
- Calvo G
- Calvo G
- Calvo G
- Caramello P
- Cargnel A
- Carnevale G
- Carosi G
- Carr A
- Castelli F
- Castera L
- Cattacin S
- Chaillou S
- Chambon D
- Chene G
- Chiesi A
- Chiodo F
- Chiriann A
- Chirianni A
- Chossat I
- Chuah J
- Cioppi A
- Cipriano C
- Cipriano G
- Claessen F
- Clotet B
- Clumeck N
- Clumeck N
- Coadou B
- Codina C
- Cohn D
- Colangeli V
- Colebunders R
- Colomba A
- Conejero J
- Conri C
- Constans J
- Cooper D
- Coronado O
- Couzigou P
- Crane LR
- D'Alessandro M
- Dabis F
- Dabis F
- Danner S
- De La Taille C
- De Lalla F
- De Longis P
- De Luca A
- De Marco M
- de Marie S
- De Salvador-Guillouet F
- De Stefano C
- De Wit S
- De Wit S
- De Wit S
- de Wolf F
- Decoin M
- Del Cacho E
- Dellamonica P
- Delveaux S
- Diaz B
- Dietrich M
- Djossou F
- Domingo P
- Doutre MS
- Dupon M
- Dupon M
- Durant J
- Dutoit D
- Dutronc H
- Egger M
- El-Sadr WM
- El-Sadr WM
- El-Sadr WM
- Erb P
- Esposito R
- Esposito R
- Fankhauser W
- Faure I
- Ferrara S
- Ferraro T
- Fierz W
- Filandras A
- Filice G
- Finazzi R
- Fischer M
- Fisher E
- Fisher M
- Flamholc L
- Flepp M
- Fleury H
- Fontana A
- Fontas E
- Fontas E
- Formaggio AM
- Franci P
- Francioli P
- Francioli P
- Friedland G
- Friis-Moller N
- Friis-Moller N
- Frissen P
- Furrer H
- Furrer HJ
- Fuster M
- Gabbuti A
- Galloni D
- Galperine T
- Garcia-Benayas T
- Gargalianos P
- Gasiorowski J
- Gatell J
- Gatell JM
- Gelie P
- Gennero L
- Gerard M
- Gerstoft J
- Ghinelli F
- Godfried M
- Goebel FD
- Gonzalez-Lahoz J
- Gordin F
- Gorgievski M
- Gowers A
- Grima P
- Grisorio B
- Guttman R
- Gyssens I
- Hakangard C
- Hammer S
- Heidemann B
- Hemmer R
- Heripret L
- Hermans P
- Hildebrand M
- Hillbrand M
- Hirschel B
- Hirschel B
- Hoepelman I
- Horban A
- Houyez F
- Jacqmin-Gadda H
- Jaspers C
- Jaubert D
- Jeurissen F
- Johnson AM
- Johnson MA
- Jou A
- Juttmann J
- Kabeya K
- Kaiser L
- Karlsson A
- Karydis I
- Katlama C
- Katzenstein T
- Kauffmann R
- Keuter M
- Kind C
- Kirk O
- Kirk O
- Kirk O
- Kjaer J
- Klimkait T
- Knysz B
- Koger E
- Konopnicki D
- Koopmans P
- Koppel K
- Kosmidis J
- Kroon F
- Krum E
- Krum E
- La Gala A
- Labarerre S
- Lacoste D
- Lacut JY
- Lafarie S
- Lafarie S
- Lafon ME
- Lange J
- Lauper U
- Lavignolle V
- Lavignolle V
- Law G
- Law M
- Law MG
- Law MG
- Lawson-Ayayi S
- Lazzarin A
- Lazzarin A
- Le Bras M
- Le Bras M
- Ledergerber B
- Ledergerber B
- Leemhuis M
- Leng B
- Lichtner M
- Lo Caputo S
- Loeliger E
- Loiacono L
- Loveday C
- Lowe S
- Lundgren JD
- Lundgren JD
- Lundgren JD
- Lundgren JD
- Luskin-Hawk R
- Maayan S
- Machala L
- Maeland A
- Magnani G
- Mallal S
- Malvy D
- Manconi PE
- Mancuso S
- Manegold C
- Mannazzu M
- Mansinho K
- Markowitz N
- Martin-Carbonero L
- Martinelli C
- Masquelier B
- Mateau S
- Matute A
- Mazzotta F
- Mazzotta F
- McFarlane R
- Meenhorst P
- Meester R
- Meester R
- Menichetti F
- Mercey D
- Merchadou L
- Mercie P
- Merli S
- Mestre C
- Migliorino G
- Mijch A
- Miller V
- Minafra G
- Miro JM
- Mocroft A
- Moioli C
- Mondain-Miton V
- Monforte AD
- Monforte AD
- Monforte AD
- Monforte VO
- Monteforte AD
- Montesarchio E
- Montroni M
- Moreau F
- Moreau JF
- Morfeldt L
- Morfeldt L
- Morfeldt L
- Morlat P
- Moroni M
- Mulcahy F
- Mulder J
- Mura MS
- Mushatt D
- Mussini C
- Nappa S
- Narciso P
- Narciso P
- Nasti G
- Neaton J
- Neaton J
- Neau D
- Nellen F
- Nielsen J
- Noto P
- Nouts C
- Novati R
- Ochoa A
- Opravil M
- Ormaasen V
- Ortolani P
- Ortona L
- Paccaud F
- Pagano G
- Palmer G
- Panos G
- Pantaleo G
- Parkin J
- Pasquinucci S
- Pastecchia C
- Pastore G
- Payen MC
- Pedersen C
- Pehrson P
- Pellegrin I
- Pellegrin JL
- Pellegrin JL
- Perbost I
- Perdios J
- Pereira F
- Perenboom R
- Perez G
- Perrin L
- Petoumenos K
- Petoumenos K
- Petrelli E
- Petrosillo N
- Pezzotti P
- Pezzotti P
- Phillips AN
- Phillips AN
- Phillips AN
- Piano P
- Piazza M
- Piersantelli N
- Piffaretti JC
- Pinching A
- Piscopo R
- Pivetaud JP
- Pizzigallo E
- Pnyka M
- Pogany K
- Poggio A
- Poll B
- Poll B
- Pollack S
- Pradier C
- Pradier C
- Pradier C
- Pradier C
- Prestileo T
- Prins J
- Pristera R
- Proenca R
- Prokopowicz D
- Prouvost-Keller B
- Pugliese P
- Pusterla L
- Ragnaud JM
- Ragnaud JM
- Rahelinirina V
- Raise E
- Reiss P
- Reiss P
- Reiss P
- Reiss R
- Rhiebaut R
- Richter C
- Rickenbach M
- Rickenbach M
- Rispal P
- Rizzardini G
- Rockstroh J
- Roge B
- Roger PM
- Roth N
- Rudin C
- Ruggieri A
- Ruys T
- Sabin CA
- Sabin CA
- Saint-Marc T
- Salamon R
- Salcuni P
- Salzberger B
- Sambatakou H
- Sambeat MA
- Sampson J
- Santopadre P
- Santoro D
- Sawitz A
- Scasso A
- Scerbo A
- Schattenkerk JKE
- Schieveld S
- Schippers E
- Schneider M
- Schrey G
- Schupbach J
- Schurink C
- Sciandra M
- Scullard G
- Series C
- Sighinolfi L
- Sinicco A
- Sirera G
- Sjol A
- Sjol A
- Skett J
- Skinhoj P
- Soranzo ML
- Soravia-Dunand V
- Soriano V
- Soscia F
- Speck R
- Sprenger HG
- Staszewski S
- Staub T
- Sundstrom A
- Sunstrom A
- Suter F
- Tacconi L
- Taupin JL
- Taytard A
- Tchamgoue S
- Tedaldi E
- Telenti A
- Telenti A
- Telgt D
- Telzak E
- ten Kate RW
- ten Napel C
- ten Veen J
- Thiebaut R
- Thompson G
- Thulin G
- Tirelli U
- Torres F
- Torres F
- Tositti G
- Touchard D
- Tressler R
- Trimoulet P
- Trkola A
- Trocha H
- Tundo P
- Tural C
- Turner D
- Ursitti M
- Uwamaliya B
- van Dam P
- van der Ende M
- van der Geest S
- van der Heul C
- van der Meer J
- van der Poll T
- van der Valk M
- van der Ven A
- van der Ven E
- van Eeden A
- van Gorp E
- Van Laethem Y
- van Leusen R
- van Lunzen J
- Van Valkengoed L
- Vandenbos F
- Vangi D
- Vanhems P
- Vaque A
- Vella S
- Verbon A
- Vernazza P
- Vetter N
- Viallard JF
- Viard JP
- Vigevani GM
- Vimard E
- Vincenti A
- Vriesendorp R
- Vullo V
- Vullo V
- Watson K
- Weber J
- Weber R
- Weber R
- Weber R
- Weber R
- Weigel H
- Weller I
- Wentworth D
- Wit F
- Wood H
- Yerly S
- Yust I
- Zaccarelli M
- Zaheri S
- Zauli T
- Zoli A
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 20/11/2003
- Field of study
Comparison of glucosamine sulfate and a polyherbal supplement for the relief of osteoarthritis of the knee: a randomized controlled trial [ISRCTN25438351]
- Author
- A Liacini
- A Liacini
- AR Cappola
- BA Biggee
- BA Biggee
- CJL Murray
- DJ Graham
- DO Clegg
- DT Felson
- E Rahme
- EJ Uitterlinden
- F De Ceuninck
- G Herrero-Beaumont
- GA Laughlin
- GF Gonzales
- GF Gonzales
- GH Werstruck
- GX Qiu
- H Madry
- H Muller-Fassbender
- Harshad Thakur
- J Duke
- J Piscoya
- J-N Gouze
- Jayesh Gala
- JB Houpt
- JK Jackson
- JL Funk
- JL Haupt
- JY Reginster
- K Pavelka
- K Strle
- Komal Mehta
- L Denti
- L Fernandez-Celemin
- LG Ameye
- M Barbieri
- M Sandoval
- M Sandoval
- M Sandoval-Chacon
- M Shakibaei
- Mark JS Miller
- Millind Modak
- MJS Miller
- MJS Miller
- MJS Miller
- MS Hogenmiller
- Nivedita Deo
- NM Thie
- P Borgeois
- PC Schulze
- PJ Verschure
- PM Kraan
- PR Usha
- R Grainger
- R Hambrecht
- R Muniyappa
- R Vuppalanchi
- RD Altman
- RS Vasan
- S Christgau
- S Persiani
- S Persiani
- S-D Lee
- Sattayasheel Naik
- SC Vlad
- SE Kimmel
- Surendra Bhasale
- T Pham
- TE McAlindon
- W Hui
- Y Higashi
- Publication venue
- BioMed Central
- Publication date
- 01/01/2007
- Field of study
<p>Abstract</p> <p>Background</p> <p>The efficacy and safety of a dietary supplement derived from South American botanicals was compared to glucosamine sulfate in osteoarthritis subjects in a Mumbai-based multi-center, randomized, double-blind study.</p> <p>Methods</p> <p>Subjects (n = 95) were screened and randomized to receive glucosamine sulfate (n = 47, 1500 mg/day) or reparagen (n = 48, 1800 mg/day), a polyherbal consisting of 300 mg of vincaria (<it>Uncaria guianensis</it>) and 1500 mg of RNI 249 (<it>Lepidium meyenii</it>) administered orally, twice daily. Primary efficacy variable was response rate based on a 20% improvement in WOMAC pain scores. Additional outcomes were WOMAC scores for pain, stiffness and function, visual analog score (VAS) for pain, with assessments at 1, 2, 4, 6 and 8 weeks. Tolerability, investigator and subject global assessments and rescue medication consumption (paracetamol) were measured together with safety assessments including vital signs and laboratory based assays.</p> <p>Results</p> <p>Subject randomization was effective: age, gender and disease status distribution was similar in both groups. The response rates (20% reduction in WOMAC pain) were substantial for both glucosamine (89%) and reparagen (94%) and supported by investigator and subject assessments. Using related criteria response rates to reparagen were favorable when compared to glucosamine. Compared to baseline both treatments showed significant benefits in WOMAC and VAS outcomes within one week (P < 0.05), with a similar, progressive improvement over the course of the 8 week treatment protocol (45–62% reduction in WOMAC or VAS scores). Tolerability was excellent, no serious adverse events were noted and safety parameters were unchanged. Rescue medication use was significantly lower in the reparagen group (p < 0.01) at each assessment period. Serum IGF-1 levels were unaltered by treatments.</p> <p>Conclusion</p> <p>Both reparagen and glucosamine sulfate produced substantial improvements in pain, stiffness and function in subjects with osteoarthritis. Response rates were high and the safety profile was excellent, with significantly less rescue medication use with reparagen. Reparagen represents a new natural productive alternative in the management of joint health.</p> <p>Trial registration</p> <p>Current Controlled Trials ISRCTN25438351.</p
Pathogenic Huntingtin Repeat Expansions in Patients with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis.
- Author
- Aarsland D
- Abramzon Y
- Adams DJ
- Adeleye A
- Aguilar M
- Ahmed S
- Al-Chalabi A
- Al-Sarraj S
- Al-Sarraj S
- Alba C
- Alba C
- Albani D
- Albert MS
- Altschuler S
- Alvarez I
- Amar K
- Ambrose JC
- Archibald N
- Arcila-Londono X
- Arepalli S
- Aronica E
- Arumugam P
- Asress S
- Atassi N
- Attems J
- Auluck P
- Baas F
- Baas F
- Babu S
- Bacikova D
- Bacikova D
- Baloh RH
- Baloh RH
- Bandmann O
- Baple EL
- Barrett MJ
- Beach TG
- Bekris LM
- Bennett DA
- Benussi L
- Berry JD
- Bertolin C
- Besser LM
- Bigio EH
- Binetti G
- Black SE
- Blair IP
- Bleda M
- Boada M
- Boardman-Pretty F
- Boeve BF
- Bohannan RC
- Boissiere JM
- Borroni B
- Boustred CR
- Bowser R
- Bowser R
- Boylan KB
- Brady CB
- Brett F
- Brice A
- Brice A
- Brittain H
- Broach J
- Broach JR
- Broce I
- Brown RH
- Brunetti M
- Bruni A
- Butovsky O
- Calini D
- Calvo A
- Camu W
- Canosa A
- Capps E
- Caraway CA
- Caroppo P
- Castellotti B
- Caulfield MJ
- Cereda C
- Ceroni M
- Chan GC
- Chandran S
- Chia R
- Chiang H-H
- Chiò A
- Chiò A
- Church A
- Clarimon J
- Clarimon J
- Coebergh J
- Colombrita C
- Comi GP
- Cooper-Knock J
- Corcia P
- Corrado L
- Corti S
- Costantini A
- Cox GA
- Craig CEH
- Crary J
- Critchley P
- Dalgard CL
- Danek A
- Danielson EW
- Dardiotis E
- Daugherty LC
- De Belleroche J
- De Burca A
- Del Bo R
- Devereau A
- Dewan R
- Dickson D
- Diehl-Schimd J
- Diekstra FP
- Diez-Fairen M
- Diez-Fairen M
- Ding J
- Dols-Icardo O
- Drepper C
- Drory V
- Drory VE
- Dubnau J
- Duga S
- Dunckley TL
- Duyckaerts C
- D’Alfonso S
- Elgar G
- Esteban-Pérez J
- Faber K
- Faghri F
- Fallini C
- Farren J
- Feldman E
- Ferman T
- Ferrari R
- Ferrucci L
- Finkbeiner S
- Flanagan ME
- Floeter MK
- Floris G
- Foroud TM
- Fortea J
- Foulger RE
- Fowler T
- Fraenkel E
- Fratta P
- Fratta P
- Furió-Tarí P
- Gagliardi S
- Galimberti D
- Gan-Or Z
- García-Redondo A
- Gellera C
- Gentleman S
- Gerhard G
- Ghetti B
- Ghidoni R
- Ghosh BCP
- Gibbs JR
- Gibbs JR
- Gibson SB
- Gkazi AS
- Glass JD
- Goate A
- Goldstein D
- González-Aramburu I
- Gotkine M
- Goutman SA
- Graff C
- Graff-Radford NR
- Hackett JM
- Halai D
- Hamblin A
- Hammell MG
- Hardiman O
- Hardy JA
- Harms M
- Harms MB
- Harris B
- Heiman-Patterson T
- Heiman-Patterson TD
- Henderson S
- Hernandez DG
- Hernández I
- Hickman RA
- Hjermind LE
- Hodges AK
- Holman JE
- Hoover B
- Hornstein E
- Hu H-C
- Hu MTM
- Hubbard TJP
- Hupalo D
- Hupalo DN
- Ibáñez K
- Illán-Gala I
- Infante J
- Iranzo A
- Jabbari E
- Jackson R
- Jansson L
- Johansson PM
- Jones LJ
- Kaiser SM
- Kamel F
- Kasperaviciute D
- Kaufmann H
- Kayikci M
- Keagle P
- Keith J
- Kenna KP
- Khoshnood B
- Kim RC
- King A
- Kirby J
- Klein G
- Kobylecki C
- Kost J
- Kowal N
- Kowall NW
- Krüger R
- Kukull W
- Kuzma A
- Kwan J
- Laaksovirta H
- Lage C
- Lahnstein L
- Landers JE
- Landi F
- Lange DJ
- Lauria G
- Lawson K
- Le Ber I
- Leblond-Manry C
- Lee EB
- Leigh PN
- Leigh SEA
- Leong IUS
- Lesage S
- Leverenz JB
- Lewis EA
- Lleó A
- Lleó A
- Logroscino G
- Lopez G
- Lopez JF
- Love S
- Lumbroso S
- MacGowan DJ
- MacGowan DJL
- Malaspina A
- Maleady-Crowe F
- Mann C
- Mao Q
- Maragakis NJ
- Marti MJ
- Martinez EM
- Martinez-McGrath E
- Masellis M
- Masliah E
- Mason J
- Massey LA
- May P
- Mazzini L
- McDonagh EM
- McKeith I
- McKenna-Yasek D
- McLaughlin RL
- McMillan C
- Menon V
- Mesulam M-M
- Miller JW
- Miller TM
- Molina-Porcel L
- Monuki ES
- Mora G
- Moreno-Grau S
- Morris CM
- Morris CM
- Morris HR
- Morris HR
- Morrison KE
- Moutsianas L
- Mouzat K
- Mueller M
- Murugaesu N
- Muñoz-Blanco JL
- Myllykangas L
- Nacmias B
- Nalls MA
- Nath A
- Nath U
- Need AC
- Newell KL
- Nicholson GA
- Nielsen JE
- Nilsson CF
- Norcliffe-Kaufmann L
- Novelli V
- Odhams CA
- Orrell RW
- Ostrow LW
- Ostrow LW
- Padovani A
- Paganoni S
- Pal S
- Pall H
- Palma J-A
- Palmer L
- Pamphlett R
- Pastor P
- Pastor P
- Patch C
- Patsopoulos NA
- Pavese N
- Paviour D
- Pensato V
- Perez-Gil D
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- Zhang B
- Zhang X
- Zinman L
- Öijerstedt L
- Publication venue
- Neuron
- Publication date
- 01/01/2020
- Field of study
We examined the role of repeat expansions in the pathogenesis of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) by analyzing whole-genome sequence data from 2,442 FTD/ALS patients, 2,599 Lewy body dementia (LBD) patients, and 3,158 neurologically healthy subjects. Pathogenic expansions (range, 40-64 CAG repeats) in the huntingtin (HTT) gene were found in three (0.12%) patients diagnosed with pure FTD/ALS syndromes but were not present in the LBD or healthy cohorts. We replicated our findings in an independent collection of 3,674 FTD/ALS patients. Postmortem evaluations of two patients revealed the classical TDP-43 pathology of FTD/ALS, as well as huntingtin-positive, ubiquitin-positive aggregates in the frontal cortex. The neostriatal atrophy that pathologically defines Huntington's disease was absent in both cases. Our findings reveal an etiological relationship between HTT repeat expansions and FTD/ALS syndromes and indicate that genetic screening of FTD/ALS patients for HTT repeat expansions should be considered
Intraperitoneal drain placement and outcomes after elective colorectal surgery: international matched, prospective, cohort study
- Author
- Aba M
- Abdellatif M
- Abdelmahmoud S
- Abu Hassan F
- Acil C
- Adarkwah P
- Adarraga J
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- Akintunde A
- Akkaya YM
- Akram J
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- Zafer F
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- Ölmez M
- Özbalcı GS
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- Öztürk OU
- Čustović S
- Štefanová H
- Ευσταθίου Η
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2022
- Field of study
Despite current guidelines, intraperitoneal drain placement after elective colorectal surgery remains widespread. Drains were not associated with earlier detection of intraperitoneal collections, but were associated with prolonged hospital stay and increased risk of surgical-site infections.Background Many surgeons routinely place intraperitoneal drains after elective colorectal surgery. However, enhanced recovery after surgery guidelines recommend against their routine use owing to a lack of clear clinical benefit. This study aimed to describe international variation in intraperitoneal drain placement and the safety of this practice. Methods COMPASS (COMPlicAted intra-abdominal collectionS after colorectal Surgery) was a prospective, international, cohort study which enrolled consecutive adults undergoing elective colorectal surgery (February to March 2020). The primary outcome was the rate of intraperitoneal drain placement. Secondary outcomes included: rate and time to diagnosis of postoperative intraperitoneal collections; rate of surgical site infections (SSIs); time to discharge; and 30-day major postoperative complications (Clavien-Dindo grade at least III). After propensity score matching, multivariable logistic regression and Cox proportional hazards regression were used to estimate the independent association of the secondary outcomes with drain placement. Results Overall, 1805 patients from 22 countries were included (798 women, 44.2 per cent; median age 67.0 years). The drain insertion rate was 51.9 per cent (937 patients). After matching, drains were not associated with reduced rates (odds ratio (OR) 1.33, 95 per cent c.i. 0.79 to 2.23; P = 0.287) or earlier detection (hazard ratio (HR) 0.87, 0.33 to 2.31; P = 0.780) of collections. Although not associated with worse major postoperative complications (OR 1.09, 0.68 to 1.75; P = 0.709), drains were associated with delayed hospital discharge (HR 0.58, 0.52 to 0.66; P < 0.001) and an increased risk of SSIs (OR 2.47, 1.50 to 4.05; P < 0.001). Conclusion Intraperitoneal drain placement after elective colorectal surgery is not associated with earlier detection of postoperative collections, but prolongs hospital stay and increases SSI risk
Pooled analysis of WHO Surgical Safety Checklist use and mortality after emergency laparotomy
- Author
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- Publication venue
- Publication date
- 15/10/2018
- Field of study
Background The World Health Organization (WHO) Surgical Safety Checklist has fostered safe practice for 10 years, yet its place in emergency surgery has not been assessed on a global scale. The aim of this study was to evaluate reported checklist use in emergency settings and examine the relationship with perioperative mortality in patients who had emergency laparotomy. Methods In two multinational cohort studies, adults undergoing emergency laparotomy were compared with those having elective gastrointestinal surgery. Relationships between reported checklist use and mortality were determined using multivariable logistic regression and bootstrapped simulation. Results Of 12 296 patients included from 76 countries, 4843 underwent emergency laparotomy. After adjusting for patient and disease factors, checklist use before emergency laparotomy was more common in countries with a high Human Development Index (HDI) (2455 of 2741, 89.6 per cent) compared with that in countries with a middle (753 of 1242, 60.6 per cent; odds ratio (OR) 0.17, 95 per cent c.i. 0.14 to 0.21, P <0001) or low (363 of 860, 422 per cent; OR 008, 007 to 010, P <0.001) HDI. Checklist use was less common in elective surgery than for emergency laparotomy in high-HDI countries (risk difference -94 (95 per cent c.i. -11.9 to -6.9) per cent; P <0001), but the relationship was reversed in low-HDI countries (+121 (+7.0 to +173) per cent; P <0001). In multivariable models, checklist use was associated with a lower 30-day perioperative mortality (OR 0.60, 0.50 to 073; P <0.001). The greatest absolute benefit was seen for emergency surgery in low- and middle-HDI countries. Conclusion Checklist use in emergency laparotomy was associated with a significantly lower perioperative mortality rate. Checklist use in low-HDI countries was half that in high-HDI countries.Peer reviewe
Global variation in anastomosis and end colostomy formation following left-sided colorectal resection
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- de Leó
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- Diab A
- Diaconescu B
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- Dick L
- Dickfos M
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- Dijan E
- Dimech T
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- Dindyal S
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- Djivoh F
- Domini E
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- Donnelly P
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- Dorani Rmnr
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- Driscoll A
- Drungilas M
- Du Plessis D
- du Plooy F
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- Dueñ
- Duffy L
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- Ebidy M
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- Ekow M
- El Ashal G
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- El Salam YA
- El Sayed GS
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- El-Ma&apos
- El-Rabaa S
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- El-Sawy A
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- El-Sheemy H
- El-Taher E
- Elabdin Hz
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- Elazayem Aa
- Elazoul M
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- Elbanby Es
- Elbatahgy A
- Elbe P
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- Eldafrawy M
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- Eldeeb Az
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- Elebute O
- Elebute O
- Elena G
- Elfarargy A
- Elfeki H
- Elfeki H
- Elfiky M
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- Elgendy Fi
- Elgheriany M
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- Elkadsh I
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- Elkelany A
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- Elkholy A
- Elkholy Ss
- Elkolaly Ss
- Elkorashy Am
- Ellison Q
- Elmashala A
- Elmasry M
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- Elmihy S
- Elnagar A
- Elnajjar Ma
- Elnemr Ae
- Elrasoul Ya
- Elrazek Aa
- Elsabbagh N
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- Elsawahly Dme
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- Elsayed M
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- Elsemelawy R
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- Elsherbiney S
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- Elshobary M
- Elsiddig M
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- Elwan A
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- Elzahed N
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- Emadeldin D
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- Eng C
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- Essam A
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- Faturoti O
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- Feidantsis T
- Felipe Co
- Fergany A
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- Firdouse M
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- Fouad D
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- Gaignard E
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- Ghoneem M
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- Gudlaugsdottir K
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- Gulielmi A
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- Gunnarsson U
- Guo W
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- Gustafsson U
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- Habeeb O
- Habeebullah A
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- Haddad N
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- Haffreingue A
- Hafiz S
- Hagan R
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- Hakim H
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- Halhouli O
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- Hamasaki J
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- Hany E
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- Hassan A
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- Hassan I
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- Hassanein Ab
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- Helguero-Santin Lm
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- Hemmila M
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- Iannone I
- Ibraheem Aa
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- Ibrahem Aa
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- Ibrahim A
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- Ibrahim I
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- Imoro O
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- Liew I
- Liew I
- Lilford R
- Lilford R
- Lilford Rj
- Lim G
- Lim H
- Lim J
- Lim Pj
- Lim Sj
- Lim Sj
- Lim Sy
- Limache S
- Limaye N
- Limoges B
- Lintin L
- Lipnickas V
- Litvin A
- Liu Q
- Liu Q
- Livesey A
- Livingston M
- Ljuhar D
- Lo Conte A
- Loaloa Mr
- Lockey J
- Lohse Has
- Lohse Has
- Loizides S
- Lokman Maa
- Longstaff L
- Lopez Ce
- Lopez Lip
- Lopez M
- Lopez M
- Lopez-Arevalo C
- Lorenzon L
- Lossius Wj
- Loughran D
- Low X
- Luc Ar
- Luck J
- Luck J
- Luck J
- Luglio G
- Lund J
- Lund J
- Lundgren Po
- Luque Gb
- Luque L
- Luque L
- Lytras D
- Lytras D
- Má
- Mé
- Mü
- Mañ
- Ma J
- Mabitsela Me
- Mabrouk M
- Macchiavello R
- Macchitella Y
- Macchitella Y
- Macdermid E
- Macdonald A
- Macdonald E
- Macdonald L
- Maceviciute K
- Macfarlane A
- Machaca M
- Maciejec L
- Madiba T
- Madkor Mh
- Maffioli A
- Maffioli A
- Magdy A
- Magdy B
- Magdy E
- Magdy H
- Magdy M
- Magdy S
- Magee C
- Maghrabi A
- Maghrabi Aa
- Magri D
- Mahamood Ab
- Mahanty S
- Maharaj G
- Mahdi A
- Mahdi S
- Mahdi S
- Maher Me
- Mahmoud B
- Mahmoud H
- Mahmoud M
- Mahmoud Ma
- Mahmoud Mi
- Mahmoud S
- Mahmoud Sme
- Mahmud K
- Maillot B
- Maimbo M
- Maimbo M
- Mairs Ng
- Maison K
- Maistry N
- Majauskyté
- Majbar A
- Majid Ahha
- Majid K
- Major Cp
- Major P
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- Mak T
- Mak T
- Makama J
- Makinde M
- Makupe A
- Malavenda M
- Malik K
- Malik P
- Malik Ta
- Mamdouh E
- Mamdouh R
- Manatakis Dk
- Manfreda S
- Mangan C
- Mangan C
- Mangiapane M
- Manipal Ce
- Maniscalco A
- Mann T
- Mannu Gs
- Manriquez-Reyes M
- Mansor Ey
- Mansour B
- Mansour S
- Mansuri A
- Mao P
- Mapasse D
- Maple N
- Maraie N
- Marey A
- Marey As
- Margaritis M
- Mariani A
- Marinkovic B
- Marinos C
- Marks E
- Marples L
- Marret Jb
- Marshall Dc
- Martian Bv
- Martin A
- Mas R
- Mason C
- Mata Lps
- Matheu A
- Mathew Sw
- Matos-Puig R
- Matta Jjh
- Mattar O
- Matter Sm
- Mauro L
- Mayasari M
- Mazelyte R
- Mazrimas P
- Mazzella A
- Mcaleer E
- Mcaleer S
- Mccarthy K
- Mccarthy M
- Mccarthy M
- McCullagh D
- Mcdonald R
- McGarvie S
- Mcguigan A
- McIntosh K
- Mcintosh R
- Mcintyre Cj
- Mcintyre N
- Mcintyre R
- Mckechnie D
- Mclachlan G
- Mclean Al
- Mclean K
- McMorran D
- Mcnish D
- Mcphee A
- Mealy K
- Mehdi A
- Mehrez S
- Mejia Agv
- Melo R
- Melo R
- Mendel H
- Mendez M
- Mendez N
- Mendizabal Caa
- Mendoza I
- Menegussi J
- Mensah E
- Menshawy A
- Mentula P
- Meqbil J
- Mericliler M
- Merlini D
- Merlini D
- Merlo Ms
- Mesbah N
- Meshref A
- Metwally Mm
- Migliore M
- Miguel Gps
- Mihaljevic Al
- Mihanovic J
- Mihanovic J
- Mijuskovic B
- Mikalauskas S
- Mikalauskas S
- Mikuckyte D
- Mikwar Z
- Milligan W
- Milligan W
- Mingrone P
- Minguez G
- Minocha A
- Minocha A
- Miranda C
- Mircea H
- Mirghani D
- Mironescu A
- Mironescu A
- Mironescu As
- Mironescu As
- Mirza A
- Mirza S
- Mistry A
- Mitrasinovic S
- Mitroudi M
- Mitroudis N
- Mittal A
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- Miyasato Hs
- Mizzi C
- Mizzi S
- Mlotshwa M
- Moaty M
- Mochet S
- Modolo Mm
- Modolo Mm
- Modolo Mm
- Moe Tt
- Mogan Yp
- Moghazy Me
- Mohamed A
- Mohamed A
- Mohamed Am
- Mohamed Ar
- Mohamed B
- Mohamed F
- Mohamed I
- Mohamed M
- Mohamed Ma
- Mohamed Maeh
- Mohamed Mm
- Mohamed O
- Mohamed Sr
- Mohameden A
- Mohammad A
- Mohammad A
- Mohammed A
- Mohammed A
- Mohammed Ae
- Mohammed Ar
- Mohammed H
- Mohammed Mm
- Mohammed Mmh
- Mohammed S
- Mohan H
- Mohan M
- Mohan M
- Mok Yt
- Mokhtar A
- Molina G
- Mollo Mc
- Monaghan E
- Monaghan E
- Monrad-Hansen Pw
- Montejo Msg
- Monteleone M
- Monteleone M
- Montes I
- Montes I
- Montrimaite M
- Montrimaite M
- Moodley Y
- Moore R
- Moore R
- Mora Jjv
- Morais Pab
- Morales C
- Moran Aer
- Morandi E
- Moreira G
- Moreno Sc
- Morgan C
- Morgan C
- Morshedy Em
- Morsi A
- Morsi M
- Morton D
- Morton D
- Morton R
- Mosad A
- Mosalum O
- Mostafa Ha
- Mostafa M
- Mostafa M
- Mousa M
- Moussa O
- Moustafa A
- Mouttalib S
- Mowafy B
- Mphatsoe Am
- Mshelbwala P
- Msiska N
- Msosa V
- Msosa V
- Muddebihal U
- Mukin Adf
- Muktar U
- Mukuzunga C
- Muller C
- Muller C
- Munera A
- Munhoz Mm
- Munipalle Pc
- Muntean L
- Muntean Li
- Muralha N
- Murphy J
- Murray A
- Murutoglu B
- Musa Aek
- Musleh A
- Musowoya J
- Mussad A
- Mustafa M
- Mustafa M
- Mustafa Ma
- Musyoka Ck
- Mutabazi Az
- Mutabazi Az
- Mutlu D
- Mutlu V
- Muzio E
- Myers J
- Mykoniatis I
- Næ
- Nabawi A
- Nada F
- Nadeem N
- Nadkarni S
- Nagy Gs
- Nahar Sn
- Nair H
- Nanthakumaran S
- Napolitano L
- Napolitano L
- Naqvi Sa
- Naqvi T
- Naranjo Aristizã
- Narayanan R
- Narayanan R
- Narvestad Jk
- Nashaat A
- Nashat M
- Nasher O
- Nashidengo P
- Nasir A
- Nasir Aa
- Nasr A
- Nasr M
- Nasr M
- Nassif D
- Nastri G
- Natalie H
- Nataraja R
- Natili A
- Navarro A
- Nawara C
- Nawawi A
- Nawawi A
- Nayel Ar
- Nazir M
- Ndajiwo A
- Ndajiwo A
- Ndegwa W
- Ndlovu Sr
- Ndwambi P
- Ne&apos
- Negida A
- Negoi I
- Nel D
- Nemeth K
- Neo Yn
- Neo Yt
- Neophytou C
- Nepogodiev D
- Nepogodiev D
- Nepogodiev D
- Nepogodiev D
- Nesaratnam A
- Nessa A
- Nestorovic M
- Nevieraite V
- Newton T
- Ng S
- Ng Yk
- Ng Zh
- Ngayu N
- Ngwa Te
- Niazi Ak
- Nicholson L
- Nighat B
- Nigo S
- Nikberg M
- Nikoloudis N
- Nikoloudis N
- Niragire A
- Niranjan N
- Nirumal Mk
- Niska K
- Nita Ge
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- Niyirera E
- Njokanma I
- Nnajiuba H
- Nocito A
- Nocito A
- Nofal E
- Noor F
- Normile C
- Normile C
- North As
- Notarnicola M
- Notarnicola M
- Nouh T
- Nouh T
- Noukpozounkou B
- Novak A
- Nowers J
- Nsengimana Vjp
- Nsengiyumva C
- Ntirenganya F
- Nur&apos
- Nurqistan Hd
- Nwabuoku E
- Nwinee V
- Nwokoro C
- Nyberg J
- Nymo L
- O&apos
- O&apos
- O&apos
- O&apos
- O&apos
- O&apos
- Obute Rd
- Occhionorelli S
- Odeyemi B
- Odeyemi B
- Odutola O
- Ogunsua O
- Ogunyemi A
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- Oh J
- Ohene-Yeboah M
- Ojeda Rrb
- Okenabirhie O
- Olajide To
- Olaolorun A
- Olivier J
- Olori S
- Olori S
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- Oludara M
- Olugbemi M
- Omar Aa
- Omar Me
- Omar Mfw
- Omara S
- Omer Oa
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- Onuoha C
- Oosterkamp A
- Opoku-Agyeman R
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- Ortega I
- Ortega-Vazquez I
- Ortiz N
- Orton P
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- Osei-Nketiah S
- Oshati O
- Oshodi O
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- Osinowo A
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- Osman O
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- Oswald D
- Otero-Dí
- Othman M
- Ots R
- Otten K
- Oumer R
- Owen C
- Owusu F
- Owusu F
- Ozben V
- Ozkan Bb
- Ozkan Bb
- Ozkan Bb
- Ozmen Bb
- Pé
- Paž
- Pabla G
- Pacheco Rda
- Padmore G
- Pagano G
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- Pagnozzi J
- Pahlsson Hi
- Pai S
- Palayan K
- Palkhi Eya
- Palliyil M
- Palliyil Mm
- Palma A
- Palma Af
- Paludi Ma
- Paludi Ma
- Panait N
- Panez Wr
- Panieri E
- Panteli C
- Papageorgiou D
- Papailia A
- Papandrea M
- Papaskarlatos Ia
- Pape J
- Parakh J
- Parakh J
- Paramasivan A
- Parasyris S
- Pardo G
- Parent V
- Park Eh
- Park J
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- Parkinson L
- Parmentier B
- Parpoudi S
- Parreno-Sacdalan Md
- Parseliunas A
- Parthiban S
- Pascale G
- Pascale Mm
- Pasini M
- Pasquali S
- Pastora J
- Pata D
- Pata D
- Pata F
- Pata F
- Pata F
- Pata F
- Pata F
- Pata F
- Pata G
- Pata G
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- Patel K
- Patel P
- Patel P
- Patel S
- Patel V
- Paterson-Brown S
- Patoulias I
- Paul M
- Paul S
- Paulouski D
- Peñ
- Peck Fs
- Pektaş
- Pellino G
- Peltrini R
- Pereira B
- Perenyei M
- Perera J
- Perera J
- Periasammy D
- Perino M
- Peros G
- Perrotta G
- Pesenti G
- Petrikenas S
- Peycelon M
- Peycelon M
- Pezas T
- Pezas T
- Pezelj N
- Phillips N
- Picardo A
- Picciariello A
- Pimenta Ml
- Pineñ
- Pinkney T
- Pinkney Td
- Pinnagoda K
- Pino W
- Pitt Sk
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- Pluke K
- Poš
- Podevin G
- Podevin G
- Poh Ks
- Popa M
- Popoola A
- Popoola A
- Porter J
- Poskus T
- Poskus T
- Poskus T
- Poskus T
- Post N
- Powell A
- Pozo Dar
- Prabhudesai A
- Pranevicius R
- Prasad Ss
- Preckailaite E
- Primavesi F
- Prins M
- Proctor Vk
- Pronin S
- Prudhomme T
- Psaila J
- Psarianos K
- Psarianos K
- Pugliesi Tb
- Pujol-Cano N
- Puma Cmh
- Punja V
- Purwaningsih Na
- Puttick M
- Puttick M
- Puyana J
- Puyana Jc
- Qadir Mrm
- Qaissieh A
- Qawasmi I
- Qenawy M
- Quayle J
- Quek R
- Quezada Jhj
- Qumbos Aa
- Qureshi Au
- Qureshi Au
- Qureshi Au
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- Rabie M
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- Rackauskas R
- Radic M
- Radkowiak D
- Radojkovic M
- Rahantasoa Fcfp
- Rahmah Df
- Rahmawati Fn
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- Rajan R
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- Rajmohan S
- Rakauskas R
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- Rakita I
- Ramadan Mt
- Ramazzini P
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- Rangarajan M
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- Rashwan H
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- Rasoaherinomenjanahary F
- Rath M
- Rausa E
- Ravishankar R
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- Rayne S
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- Raza A
- Raza I
- Raza I
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- Razmdjou S
- Razuri C
- Razzaque J
- Reali C
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- Recinos G
- Recinos G
- Recinos G
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- Reddy Y
- Redgrave N
- Redota Map
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- Rees Cm
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- Rekhis S
- Renaux-Petel M
- Restrepo Im
- Restrepo J
- Reunis E
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- Ripa M
- Riswan Nz
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- Robert E
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- Robertson N
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- Roche Mo
- Rocke A
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- Rodriguez X
- Roi D
- Rojas Adp
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- Roslani Ac
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- Rotunno G
- Rouse T
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- Rubinkiewicz M
- Rudzenskaite A
- Ruiz-Tovar J
- Rulie As
- Runigamugabo E
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- Ruzzenente A
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- Saad H
- Saad Ha
- Saad M
- Saad Mm
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- Saad S
- Saadeh R
- Saami M
- Saar S
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- Sabe Ak
- Sabeeh L
- Sabour Fa
- Sabry A
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- Sadig N
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- Safa H
- Sahbaz Na
- Sahel S
- Saidbadr A
- Sakr A
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- Salah A
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- Salah O
- Salah Om
- Salama M
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- Salamone G
- Salas Mdce
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- Saleh O
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- Salleh A
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- Sallinen V
- Sallinen V
- Salma M
- Salma M
- Salma U
- Salman A
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- Sam Zh
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- Samaniego Cs
- Samaraweera Di
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- Sammarco G
- Sammut K
- Sampson C
- Samson G
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- Samy M
- Samy S
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- Sandler S
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- Sanz S
- Sapci I
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- Sarafilovic H
- Saraste D
- Saravia F
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- Sasia D
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- Sayed F
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- Sayma Ea
- Scalabre A
- Scalabre A
- Schadde E
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- Schiavone R
- Schivo D
- Schmid R
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- Schuetz T
- Schultz Jk
- Scicluna R
- Scott M
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- Selvaggi F
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- Semeda N
- Semiz A
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- Senanayake Kj
- Senanayake Mkj
- Senanayake W
- Septiem Jg
- Servin Grp
- Setiawan J
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- Sfougaris D
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- Shaalan M
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- Shah A
- Shah J
- Shah R
- Shaharuddin S
- Shahbaz Ar
- Shaheen A
- Shahine A
- Shahzad N
- Shaikh N
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- Shalabi A
- Shalaby A
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- Shamasneh A
- Shamsedine Aw
- Shamsi G
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- Siguantay M
- Sigurdadottir J
- Sii Ssy
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- Silvestri V
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- Snyder E
- Sobnach S
- Sodde P
- Soeselo Da
- Sokratous A
- Solaini L
- Soldevila-Verdeguer C
- Soley R
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- Sollazzo V
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- Souaibou Yi
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- Spence R
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- Srinivasan R
- Sriram A
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- Stefanopoulos A
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- Summerour V
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- Sundstrom Sm
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- Tade A
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- Tahboub H
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- Taiwo A
- Taiwo O
- Taiwo O
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- Tan Yk
- Tan Yw
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- Tanase A
- Tang A
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- Tani Si
- Tansoker I
- Tarek A
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- Tawfik G
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- Taylor F
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- Tedeschi U
- Tedjaatmadja C
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- Thomas E
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- Thomson P
- Thorarinsdottir H
- Thorarinsdottir H
- Thorell A
- Thorell A
- Thorsen K
- Thurairaja R
- Ticona Wa
- Tierney G
- Tilston Tw
- Timothy Ok
- Ting Jrs
- To K
- To K
- Todd O
- Toeema Ag
- Tolba H
- Tolg C
- Tolonen M
- Tolotra Tec
- Tori Sa
- Torrance Hd
- Torrance Hd
- Torres Cpg
- Torres Sg
- Toto Ö
- Tou S
- Townsend D
- Tracy J
- Trompetto M
- Tselos A
- Tshisola Sk
- Tugnoli G
- Tugnoli G
- Tun Ak
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- Tun M
- Turati L
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- Turkustani S
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- Tutino R
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- Tyler R
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- Tze Rge
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- Uš
- Ubhi Hk
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- Ukwenya Y
- Uluş
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- Urbanavicius L
- Urbonas T
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- Urniež
- Urniezius Z
- Urquizu Mc
- Usaityte A
- Utter M
- Uzabumwana N
- Vaicius A
- Valcarcel-Saldañ
- Valioulis I
- Van Der Naald N
- Van Duren B
- Van Niekerk M
- Van Straten S
- Varcada M
- Vargas M
- Varkalys K
- Vartanoglu T
- Vartic M
- Vartic M
- Vasquez G
- Vasquez I
- Veen T
- Vega Gmm
- Vega Gmm
- Velá
- Velá
- Velasquez R
- Vella-Baldacchino M
- Venclauskas L
- Vendramin E
- Venskutonis D
- Venskutonis D
- Venskutonis D
- Venskutonis D
- Venugopal C
- Verbeek A
- Vergara Alc
- Verjee A
- Vermaas M
- Veronese E
- Viš
- Vianna P
- Vicario E
- Vico Td
- Vida Lc
- Vida Lc
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- Villa R
- Villalobos S
- Villegas Mi
- Vimalachandran D
- Vincent J
- Violi P
- Vivekanantham S
- Vlachogiorgos A
- Voulgaris E
- Vth Le
- Wael N
- Wagener M
- Wakefield R
- Walę
- Waleed H
- Walker M
- Walker N
- Walls L
- Walsh M
- Walsh U
- Waqar M
- Ward Ae
- Ward S
- Warda M
- Warren O
- Warren O
- Warwick Am
- Waterman A
- Watson Nf
- Watts A
- Weber B
- Weber P
- Weber P
- Weinstein Ms
- Werder G
- Wheeler J
- Whewell H
- Whitaker J
- White R
- White T
- Whitehurst K
- Wiborg J
- Widiastini Ta
- Widmer Lw
- Wijayarathna Ls
- Wild Jrl
- Williams E
- Williams G
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- Williamson A
- Wilson A
- Wilson L
- Wilson M
- Wilson M
- Wilson Ms
- Wilson Msj
- Wimalge Pmsn
- Winstanley J
- Witherspoon P
- Wogensen F
- Wogensen F
- Wogensen F
- Woin E
- Wold Tb
- Wolf B
- Wolf B
- Wondimu S
- Wondoh P
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- Wong Cs
- Wong Cy
- Wong F
- Wong Hy
- Wood G
- Woodward H
- Worku M
- Worku M
- Worku T
- Wredberg C
- Wright N
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- Xerri T
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- Yahaya Mt
- Yakubu M
- Yallop L
- Yam Sy
- Yang J
- Yap S
- Yaseen T
- Yaseen Tm
- Yau Jd
- Yavuz Ma
- Ye J
- Yeang Lj
- Yee J
- Yeo Ls
- Yeung En
- Yeung Mha
- Yifieyeh A
- Yildirim R
- Yip C
- Yip Sbs
- Ymeri S
- Yoganathan P
- Yolcu S
- Yong Co
- Yong Gl
- Younis A
- Youssef D
- Youssef H
- Youssef M
- Youssif Jh
- Yuksek Ma
- Yusufali T
- Zaa&apos
- Zachariades Dc
- Zadoroznas A
- Zahran D
- Zakaria E
- Zakaria M
- Zakaria Y
- Zaki A
- Zakir M
- Zalabia Mf
- Zamarin K
- Zammit S
- Zampitis N
- Zani A
- Zani A
- Zani A
- Zanini N
- Zanini N
- Zapata F
- Zarb C
- Zardab A
- Zegarra S
- Zeidan S
- Zerihun Ab
- Zhang Z
- Zheng F
- Zidan H
- Zidan H
- Zidan M
- Zielinski M
- Ziff O
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- Zil-E-Ali A
- Zilinskas J
- Zilinskas J
- Zilinskas J
- Zilinskas J
- Zilinskiene R
- Zimmermann Ef
- Zohair A
- Zorrilla Cd
- Zuber M
- Zuber M
- Zuk G
- Zulkifli A
- Zumbü
- Publication venue
- 'Wiley'
- Publication date
- 27/11/2018
- Field of study
Background
End colostomy rates following colorectal resection vary across institutions in high-income settings, being influenced by patient, disease, surgeon and system factors. This study aimed to assess global variation in end colostomy rates after left-sided colorectal resection.
Methods
This study comprised an analysis of GlobalSurg-1 and -2 international, prospective, observational cohort studies (2014, 2016), including consecutive adult patients undergoing elective or emergency left-sided colorectal resection within discrete 2-week windows. Countries were grouped into high-, middle- and low-income tertiles according to the United Nations Human Development Index (HDI). Factors associated with colostomy formation versus primary anastomosis were explored using a multilevel, multivariable logistic regression model.
Results
In total, 1635 patients from 242 hospitals in 57 countries undergoing left-sided colorectal resection were included: 113 (6·9 per cent) from low-HDI, 254 (15·5 per cent) from middle-HDI and 1268 (77·6 per cent) from high-HDI countries. There was a higher proportion of patients with perforated disease (57·5, 40·9 and 35·4 per cent; P < 0·001) and subsequent use of end colostomy (52·2, 24·8 and 18·9 per cent; P < 0·001) in low- compared with middle- and high-HDI settings. The association with colostomy use in low-HDI settings persisted (odds ratio (OR) 3·20, 95 per cent c.i. 1·35 to 7·57; P = 0·008) after risk adjustment for malignant disease (OR 2·34, 1·65 to 3·32; P < 0·001), emergency surgery (OR 4·08, 2·73 to 6·10; P < 0·001), time to operation at least 48 h (OR 1·99, 1·28 to 3·09; P = 0·002) and disease perforation (OR 4·00, 2·81 to 5·69; P < 0·001).
Conclusion
Global differences existed in the proportion of patients receiving end stomas after left-sided colorectal resection based on income, which went beyond case mix alone
Human plasma protein N-glycosylation
- Author
- A Adam
- A Audfray
- A Bharti
- A Bondt
- A Bondt
- A Gonzalez-Quintela
- A Halim
- A Harazono
- A Harazono
- A Henschen
- A Johs
- A Klein
- A Kobata
- A Kobata
- A Kondo
- A Larkin
- A Larsson
- A Mackiewicz
- A Navarro
- A Okazaki
- A Plematl
- A Tanaka
- A Torano
- A Vahlquist
- A Varki
- A Varki
- AC Haglund
- AD Attie
- AG Morell
- AJ Hulsmeier
- AK Chauhan
- AK Powell
- AL Jones
- Albert Bondt
- AN Koterov
- AP Kaplan
- AS Gounni
- B Adamczyk
- B Adamczyk
- B Belloir
- B Garner
- B Garner
- B Laat de
- B Turk
- B Weeke
- Bas C. Jansen
- BB Haab
- BC Hennis
- BG Langer
- BJ Zegers
- C Ferrara
- C Fuss
- C Grimstein
- C Huhn
- C Montaldo
- C Ordonez
- C Panzironi
- CB Peterson
- CF Tseng
- CH Zeng
- CR Chitambar
- CV Dang
- CY Yang
- CY Yang
- D Dill
- D Kolarich
- D Leger
- D Reusch
- D Seiffert
- D Wang
- DA Bergin
- DB Borza
- DD Slyke Van
- DH Hogg
- DH Perlmutter
- DH Perlmutter
- DH Perlmutter
- DJ Lefeber
- DM Czajkowsky
- DR Collins
- DS Rowe
- DS Rowe
- DT Drayna
- E Levy
- E Maverakis
- E Polz
- E Rassart
- E Tolosano
- EC Brinkman-van der Linden
- EC Havenaar
- EN Debruyne
- F Blanco-Vaca
- F Dall’Olio
- F Gejyo
- F Kanakoudi
- F Lottspeich
- F Nimmerjahn
- FA Gala
- FE Geijn van de
- FJ Raal
- Florent Clerc
- FW Putnam
- G Boskovic
- G Kostner
- G Lauc
- G Opdenakker
- G Perdomo
- G Raugei
- G Zauner
- G Zauner
- GN Rogentine
- Guinevere S. M. Kammeijer
- H Hwang
- H Kontro
- H Kurokawa
- H Ogawa
- H Saito
- H Stockmann
- H Vlierberghe Van
- H Wang
- H Watzlawick
- H Yin
- H-J Lee
- HH Freeze
- HJ Gould
- HL Spiegelberg
- HL Spiegelberg
- HS Margolius
- I Filipovic
- I Kushner
- I Martínez-Martínez
- I Perdivara
- I Ryden
- I Schvartz
- I Schwab
- IK Poon
- IS Trowbridge
- J Benicky
- J Bones
- J Bunkenborg
- J Conard
- J Huang
- J Jaeken
- J Jaeken
- J Jaeken
- J Kristic
- J Kroll
- J Lozier
- J Martinez
- J Moretti
- J Nilsson
- J Rainio
- J Stadlmann
- J Stenflo
- J Vukmirica
- J Zhu
- JA Boxel Van
- JE Huffman
- JE Huffman
- JEM Björklund
- JG Flanagan
- JH Griffin
- JH Ix
- JH Lee
- JJ Corrigan Jr
- JJM Rooijen van
- JK Boyles
- JL Dage
- JL Woodhead
- JM Kollman
- JM Wieruszeski
- JM Woof
- JM Woof
- JN Arnold
- JN Arnold
- JN Arnold
- JN Arnold
- JN Arnold
- JP Lebreton
- JR Day
- JR Delanghe
- JS Moore
- JS Rosenberg
- JS Tsai
- JW Tams
- JW Weisel
- K Beatty
- K Caidahl
- K Carter
- K Chen
- K Marino
- K Mills
- K Mills
- K Ohtsubo
- K Saigo
- K Schmid
- K Thorstensen
- K Yamashita
- K Yamazumi
- K-TC Shade
- Karli R. Reiding
- KB Chandler
- KB Reid
- KJ Dorrington
- KR Reiding
- KT Preissner
- KT Preissner
- KT Preissner
- L Brylka
- L Kasturi
- L Kesner
- L Kesner
- L Pol-Fachin
- L Sottrup-Jensen
- L Udby
- LE Franzén
- LL Johnson
- LL Leung
- LM Sanchez
- LR Ruhaak
- LR Ruhaak
- M Balbin
- M Balbin
- M Cnop
- M Dalziel
- M Dalziel
- M Egmond van
- M Endo
- M Gunnarsson
- M Hammel
- M Kuwana
- M Mele
- M Molinari
- M Nakano
- M Pieters
- M Schubert
- M Sperandio
- M Thaysen-Andersen
- M Tian
- M Wuhrer
- M Wuhrer
- Manfred Wuhrer
- MB Smeets
- MC Carlsson
- MC Carlsson
- MC Thurnheer
- MD Curry
- MH Coan
- MH Selman
- MH Selman
- MI Hassan
- MI Hassan
- MJ Flick
- MJ McQueen
- MJ Waxdal
- MM Gomes
- MM Patnaik
- MR Ehrenstein
- MR Langlois
- MS Carling
- N Ishioka
- N Kalsheker
- N Piyaphanee
- N Takahashi
- N Takahashi
- N Takahashi
- N Takahashi
- N Taniguchi
- NE Simister
- NL Wilson
- O Gornik
- O Kassaar
- P Chames
- P Kreunin
- P Li
- P Pompach
- P Pompach
- P Quartier
- P Ramachandran
- P Tarugi
- PA Schindler
- PG Blain
- PG Groot De
- PJ Twomey
- PM Rudd
- PS Maclean
- PT Gomme
- R Bajo-Graneras
- R Camato
- R Carrell
- R Chen
- R Furth van
- R Huttenhain
- R Jefferis
- R Parekh
- R Parekh
- R Plomp
- R Plomp
- R Thieme
- R Tofik
- RA Clark
- RB Parekh
- RC Monteiro
- RD Rosenberg
- RE Morton
- RE Morton
- RE Thompson
- RF Doolittle
- RJ Mandle
- RL Shields
- RM Anthony
- RW Carrell
- S Bailey
- S Biswas
- S Bohm
- S Futakawa
- S Grünewald
- S Herrick
- S Kaptoge
- S Kochl
- S Ray
- S Reddigari
- S Zhang
- S-H Chen
- SC Bock
- SC Klapoetke
- SG Johansson
- SG Young
- SJ Mellis
- SL Delker
- SL Gonias
- SO Olofsson
- SO Olofsson
- SS Twining
- ST Mathews
- SY Yoon
- T Araki
- T Chandra
- T Drasin
- T Fournier
- T Kibe
- T Koide
- T Koide
- T Kristensen
- T Lang
- T Liu
- T Mega
- T Mizuochi
- T Sugo
- T Sugo
- T Takayasu
- T Wei
- T Zaidi
- TD Randall
- TR Daniels
- TR Daniels
- TS Mattu
- TS Raju
- TZ Kristiansen
- U Lewandrowski
- U Schauer
- UM Demelbauer
- UM Demelbauer
- UM Demelbauer
- V Frantikova
- V Picard
- W Borth
- W Burgi
- W Dijk Van
- W Dobryszycka
- W Jahnen-Dechent
- W Jia
- W Kutteh
- W Weis
- W Yuan
- WM Brown
- WR Lagor
- X Wang
- Y Chen
- Y Fujioka
- Y Satomi
- Y Satomi
- Y Yoshioka
- YK Lim
- Z Lin
- Z Zeng
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Lack of Bcl-2 Expression At Presentation Characterizes Burkitts Leukemia Carrying the Typical T(8 14) Or the Variant T(8 22), and Caucasian Burkitts-lymphoma
- Publication venue
- W B Saunders Co
- Publication date
- 01/01/1993
- Field of study
- …