Notas sobre al tratado de Dios Uno y Trino

Se describe aquí la situación del tratado de Dios Uno y Trino tanto en su estructuración general como en los temas que reciben mayor atención. Los autores estudian el itinerario seguido por el tratado desde los años sesenta hasta la entrada del siglo XXI. Al narrar la evolución de estos casi cincuenta años, enumeran las adquisiciones más relevantes y duraderas. El juicio de este proceso es muy positivo; se trata hasta de una auténtica renovación. La atención se centra en el campo católico, dejando para otro momento el análisis de la evolución del tratado en autores pertenecientes a la Ortodoxia y a otras confesiones cristianas. También aquí se debe hablar de un progreso altamente positivo.The treatise of God as One and Trine is described here, both its general structure and the themes that receive most attention. The authors study the itinerary followed by the treatise from the Sixties until the beginning of the twenty-first century. In our account of developments over these last fifty years, the most relevant and lasting acquisitions are enumerated. The overall judgment of this process is very positive, as we may even be witnessing a genuine renovation. Attention centers on the Catholic field, as we leave aside analysis of the evolution of this treatise in authors belonging to Orthodoxy and other Christian denominations. Here too, we must point out that the progress in this field has been extremely positive

Los juegos deportivos y su influencia en la gestión emocional en universitarios

Los objetivos de este estudio fueron identicar las intensidades emocionales (positivas, negativas y ambiguas) durante la práctica de jue- gos deportivos de oposición con y sin competición y comprobar la relación existente con el historial deportivo de los participantes. Participaron 147 estudiantes universitarios, los cuales cumplimentaron el cuestionario GES (Game and Emotions Scale) desarrollado y validado por Lavega, March y Filella (2013). Las ecuaciones de estimación generalizadas mostraron di- ferencias signicativas (p < .001) en las variables tipo de emoción, tipo de resultado y huella deportiva del participante. Las emociones positivas se vi- vieron con mayor intensidad en los juegos, mientras que las emociones nega- tivas y ambiguas fueron más bajas que las positivas. La huella deportiva fue determinante para las variaciones emocionales experimentadas, mostrando los jugadores con mayor experiencia y nivel competitivo puntuaciones me- nores en las emociones suscitadas durante la práctica de juegos deportivos de oposición. Los resultados contribuyen a orientar las intervenciones de futuros profesionales gracias a las experiencias prácticas vivenciadas.

Mental impact of Covid-19 among Spanish healthcare workers. A large longitudinal survey

Altres ajuts: Fondo Europeo de Desarrollo Regional (FEDER); Ministerio de Ciencia e Innovación; Gerencia Regional de Salud de Castilla y León (SACYL, GRS COVID 32/A/20).Aims Longitudinal data on the mental health impact of the coronavirus disease 2019 (Covid-19) pandemic in healthcare workers is limited. We estimated prevalence, incidence and persistence of probable mental disorders in a cohort of Spanish healthcare workers (Covid-19 waves 1 and 2) -and identified associated risk factors. Methods 8996 healthcare workers evaluated on 5 May-7 September 2020 (baseline) were invited to a second web-based survey (October-December 2020). Major depressive disorder (PHQ-8 ≥ 10), generalised anxiety disorder (GAD-7 ≥ 10), panic attacks, post-traumatic stress disorder (PCL-5 ≥ 7), and alcohol use disorder (CAGE-AID ≥ 2) were assessed. Distal (pre-pandemic) and proximal (pandemic) risk factors were included. We estimated the incidence of probable mental disorders (among those without disorders at baseline) and persistence (among those with disorders at baseline). Logistic regression of individual-level [odds ratios (OR)] and population-level (population attributable risk proportions) associations were estimated, adjusting by all distal risk factors, health care centre and time of baseline interview. Results 4809 healthcare workers participated at four months follow-up (cooperation rate = 65.7%; mean = 120 days s.d. = 22 days from baseline assessment). Follow-up prevalence of any disorder was 41.5%, (v. 45.4% at baseline, p < 0.001); incidence, 19.7% (s.e. = 1.6) and persistence, 67.7% (s.e. = 2.3). Proximal factors showing significant bivariate-adjusted associations with incidence included: work-related factors [prioritising Covid-19 patients (OR = 1.62)], stress factors [personal health-related stress (OR = 1.61)], interpersonal stress (OR = 1.53) and financial factors [significant income loss (OR = 1.37)]. Risk factors associated with persistence were largely similar. Conclusions Our study indicates that the prevalence of probable mental disorders among Spanish healthcare workers during the second wave of the Covid-19 pandemic was similarly high to that after the first wave. This was in good part due to the persistence of mental disorders detected at the baseline, but with a relevant incidence of about 1 in 5 of HCWs without mental disorders during the first wave of the Covid-19 pandemic. Health-related factors, work-related factors and interpersonal stress are important risks of persistence of mental disorders and of incidence of mental disorders. Adequately addressing these factors might have prevented a considerable amount of mental health impact of the pandemic among this vulnerable population. Addressing health-related stress, work-related factors and interpersonal stress might reduce the prevalence of these disorders substantially. Study registration number: NCT0455656

Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases

Central corneal thickness (CCT) is a highly heritable trait associated with complex eye diseases such as keratoconus and glaucoma. We perform a genome-wide association meta-analysis of CCT and identify 19 novel regions. In addition to adding support for known connective tissue-related pathways, pathway analyses uncover previously unreported gene sets. Remarkably, >20% of the CCT-loci are near or within Mendelian disorder genes. These included FBN1, ADAMTS2 and TGFB2 which associate with connective tissue disorders (Marfan, Ehlers-Danlos and Loeys-Dietz syndromes), and the LUM-DCN-KERA gene complex involved in myopia, corneal dystrophies and cornea plana. Using index CCT-increasing variants, we find a significant inverse correlation in effect sizes between CCT and keratoconus (r =-0.62, P = 5.30 × 10-5) but not between CCT and primary open-angle glaucoma (r =-0.17, P = 0.2). Our findings provide evidence for shared genetic influences between CCT and keratoconus, and implicate candidate genes acting in collagen and extracellular matrix regulation

Autoantibodies against type I IFNs in patients with life-threatening COVID-19

Interindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients with life-threatening coronavirus disease 2019 (COVID-19) pneumonia had neutralizing immunoglobulin G (IgG) autoantibodies (auto-Abs) against interferon-w (IFN-w) (13 patients), against the 13 types of IFN-a (36), or against both (52) at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not found in 663 individuals with asymptomatic or mild SARS-CoV-2 infection and were present in only 4 of 1227 healthy individuals. Patients with auto-Abs were aged 25 to 87 years and 95 of the 101 were men. A B cell autoimmune phenocopy of inborn errors of type I IFN immunity accounts for life-threatening COVID-19 pneumonia in at least 2.6% of women and 12.5% of men

Novel Loci for Adiponectin Levels and Their Influence on Type 2 Diabetes and Metabolic Traits : A Multi-Ethnic Meta-Analysis of 45,891 Individuals

J. Kaprio, S. Ripatti ja M.-L. Lokki työryhmien jäseniä.Peer reviewe