P29 274. Indicaciones de la válvula aórtica ats 3f enable® sin sutura

La válvula ATS 3f Enable® (Medtronic) es una prótesis biológica de pericardio, diseñada como una válvula tubular para optimizar sus características hemodinámicas y disminuir el estrés.ObjetivosDescripción de las posibles indicaciones de la válvula aórtica 3f Enable® sin sutura seg?estra experiencia.Material y métodosDesde mayo de 2010 se han implantado 10 válvulas 3f Enable®, eligiendo pacientes con anillo aórtico pequeño (< 21mm) e índice de masa corporal (IMC) igual o superior a 30 o con estenosis protésica de 19mm. El tamaño de los implantes fue: 19mm: 5, 21mm: 4, y 23mm: 1. Perfil clínico de los pacientes: edad media: 72 años. Estenosis aórtica protésica: 2 pacientes. EuroSCORE medio: 6,3. El IMC medio de los pacientes con estenosis nativa: 32. En tres pacientes se realizaron injertos concomitantes.ResultadosTodos los implantes se realizaron con éxito. En dos pacientes fue necesaria la recolocación de la prótesis por insuficiencia antes de descontinuar la circulación extracorpórea. El tiempo medio de isquemia fue de 61 min, con un rango de 22–81 min. Los gradientes pico obtenidos fueron 21±6mmHg y los gradientes medios de 11±3mmHg. Un paciente requirió reintervención por insuficiencia grave debido a inframedición de la prótesis.ConclusionesLa prótesis 3f Enable® presenta un excelente comportamiento hemodinámico en pacientes con anillo aórtico pequeño y con un IMC igual o superior a 30 y consiguiente riesgo de mismatch. La estenosis protésica de 19mm también se podría considerar como indicación de implante de esta válvula

On the Variability of the Length Weight Relationship for Atlantic Bluefin Tuna, Thunnus thynnus (L.)

Following extensive review, a model of the Atlantic bluefin tuna (ABFT), Thunnus thynnus (L.), length–weight relationship for the eastern Atlantic and Mediterranean (RW = 0.0000188 SFL3.01247; Ec 1) is presented on the basis of samples of ABFT spawners, with an average value of index K = 2.03 ± 0.15SD, collected by the Atlantic traps of Portugal and Spain in the Strait of Gibraltar (1963; 1996–1998; 2000–2012), and a set of samples of juvenile fishes from ICCAT–GBYP (n = 707). The resulting model (Ec 1), together with the model used for the eastern stock assessment (RW = 0.000019607 SFL3.0092; Ec 2) and a recently adopted by ICCAT Standing Committee on Research and Statistics (SCRS) (RW = 0.0000315551 SFL2.898454; EAST) are analyzed in using a bi-variant sample [SFL (cm), RW (kg)] of 474 pairs of data with the aim of validating them and establishing which model(s) best fit the reality represented by the sample and, therefore, will have the greatest descriptive and predictive power. The result of the analysis indicates that the model EAST clearly underestimates the weight of spawning ABFT and that model Ec 2 overestimates it slightly, being model Ec 1 that best explains the data of the sample. The result of the classical statistical analysis is confirmed by means of the quantile regression technique, selecting the quantiles 5, 25, 50, 75, and 95%. Other fisheries and biological indicators also conclude that the model EAST gradually underestimates the weight of ABFT spawners (of 2–3 m) by 9–12.5 %, and does not meet the criterion that for RW = 725 kg (Wmax), SFL = 319.93 ± 11.3 cm (Lmax).Cort, JL.; Estruch Fuster, VD.; Neves Dos Santos, M.; Di Natale, A.; Abid, N.; De La Serna, JM. (2015). On the Variability of the Length Weight Relationship for Atlantic Bluefin Tuna, Thunnus thynnus (L.). Reviews in Fisheries Science & Aquaculture. 23(1):23-38. doi:10.1080/23308249.2015.1008625S2338231Aguado-Giménez, F., & García-García, B. (2005). Changes in some morphometric relationships in Atlantic bluefin tuna (Thunnus thynnus thynnus Linnaeus, 1758) as a result of fattening process. Aquaculture, 249(1-4), 303-309. doi:10.1016/j.aquaculture.2005.04.064Block, B. A., Teo, S. L. H., Walli, A., Boustany, A., Stokesbury, M. J. W., Farwell, C. J., … Williams, T. D. (2005). Electronic tagging and population structure of Atlantic bluefin tuna. Nature, 434(7037), 1121-1127. doi:10.1038/nature03463Chapman, E. W., Jørgensen, C., & Lutcavage, M. E. (2011). Atlantic bluefin tuna (Thunnus thynnus): a state-dependent energy allocation model for growth, maturation, and reproductive investment. Canadian Journal of Fisheries and Aquatic Sciences, 68(11), 1934-1951. doi:10.1139/f2011-109Cort, J. L., Arregui, I., Estruch, V. D., & Deguara, S. (2014). Validation of the Growth Equation Applicable to the Eastern Atlantic Bluefin Tuna,Thunnus thynnus(L.), UsingLmax, Tag-Recapture, and First Dorsal Spine Analysis. Reviews in Fisheries Science & Aquaculture, 22(3), 239-255. doi:10.1080/23308249.2014.931173Cort, J. L., Deguara, S., Galaz, T., Mèlich, B., Artetxe, I., Arregi, I., … Idrissi, M. (2013). Determination ofLmaxfor Atlantic Bluefin Tuna,Thunnus thynnus(L.), from Meta-Analysis of Published and Available Biometric Data. Reviews in Fisheries Science, 21(2), 181-212. doi:10.1080/10641262.2013.793284Fraser, K.Possessed. World Record Holder for Bluefin Tuna. Kingstown, Nova Scotia: T & S Office Essentials and printing, 243 pp. (2008).Fromentin, J.-M., & Powers, J. E. (2005). Atlantic bluefin tuna: population dynamics, ecology, fisheries and management. Fish and Fisheries, 6(4), 281-306. doi:10.1111/j.1467-2979.2005.00197.xHattour, A.Contribution a l’étude des Scombridés de Tunisie. Université de Tunis. Faculté des Sciences, 168 pp. (1979).Karakulak, S., Oray, I., Corriero, A., Deflorio, M., Santamaria, N., Desantis, S., & De Metrio, G. (2004). Evidence of a spawning area for the bluefin tuna (Thunnus thynnus L.) in the eastern Mediterranean. Journal of Applied Ichthyology, 20(4), 318-320. doi:10.1111/j.1439-0426.2004.00561.xKoenker, R., & Bassett, G. (1978). Regression Quantiles. Econometrica, 46(1), 33. doi:10.2307/1913643Koenker, R. (2005). Quantile Regression. doi:10.1017/cbo9780511754098Milatou, N., & Megalofonou, P. (2014). Age structure and growth of bluefin tuna (Thunnus thynnus, L.) in the capture-based aquaculture in the Mediterranean Sea. Aquaculture, 424-425, 35-44. doi:10.1016/j.aquaculture.2013.12.037Perçin, F., & Akyol, O. (2009). Lengthâ weight and lengthâ length relationships of the bluefin tuna,Thunnus thynnusL., in the Turkish part of the eastern Mediterranean Sea. Journal of Applied Ichthyology, 25(6), 782-784. doi:10.1111/j.1439-0426.2009.01288.xPercin, F., & Akyol, O. (2010). Some Morphometric Relationships in Fattened Bluefin Tuna, Thunnus thynnus L., from the Turkish Aegean Sea. Journal of Animal and Veterinary Advances, 9(11), 1684-1688. doi:10.3923/javaa.2010.1684.1688Rooker, J. R., Alvarado Bremer, J. R., Block, B. A., Dewar, H., de Metrio, G., Corriero, A., … Secor, D. H. (2007). Life History and Stock Structure of Atlantic Bluefin Tuna (Thunnus thynnus). Reviews in Fisheries Science, 15(4), 265-310. doi:10.1080/10641260701484135Sinovcic, G., Franicevic, M., Zorica, B., & Cikes-Kec, V. (2004). Length-weight and length-length relationships for 10 pelagic fish species from the Adriatic Sea (Croatia). Journal of Applied Ichthyology, 20(2), 156-158. doi:10.1046/j.1439-0426.2003.00519.xTičina, V., Grubišić, L., Šegvić Bubić, T., & Katavić, I. (2011). Biometric characteristics of small Atlantic bluefin tuna (Thunnus thynnus, Linnaeus, 1758) of Mediterranean Sea origin. Journal of Applied Ichthyology, 27(4), 971-976. doi:10.1111/j.1439-0426.2011.01752.

Data analysis from the Spanish Registry of Cardiac Surgery (RECC) 2021-2022

Cardiovascular surgery; Acquired cardiac disease; Aortic surgeryCirurgia cardiovascular; Cardiopaties adquirides; Cirurgia aòrticaCirugía cardiovascular; Cardiopatías adquiridas; Cirugía aórticaIntroducción Desde el 8 de febrero de 2021, la Sociedad Española de Cirugía Cardiovascular y Endovascular (SECCE) puso en marcha el Registro Español de Cirugía Cardiaca (RECC) que está disponible para las diferentes unidades de cirujanos cardiovasculares de nuestro país. Es una herramienta que permite recopilar datos de pacientes sometidos a cirugía cardiaca, vascular o endovascular. Tras dos años de desarrollo, hemos llevado a cabo un análisis de la calidad de la información obtenida para adquirir una visión general de su contenido. Métodos La información ha sido analizada de forma anónima a nivel de paciente, hospital y provincia. Para la estimación de la mortalidad ajustada por riesgo se utilizó la escala de estimación de riesgo preoperatorio EuroSCORE II. Resultados Se han incluido en el RECC un total de 7.087 intervenciones, de las cuales 6.267 se trataban de cirugías cardiacas mayores. Del total de intervenciones mayores, 53,9% eran cirugías valvulares, 25,2% de revascularización miocárdica y 14,9% de aorta. La mortalidad global de la serie fue de 5,0% y el índice de mortalidad ajustada al riesgo (IMAR) de 0,88. La calibración del EuroSCORE II en la muestra global fue buena en los pacientes de riesgo más bajo, aunque sobreestimó la mortalidad en los de alto riesgo. Conclusiones El RECC se trata de una base de datos clínica nacional que permite el análisis de datos de pacientes con el fin de evaluar de forma precisa el volumen de la actividad, riesgo y resultados. A nivel local, podría utilizarse como una herramienta para mejorar la calidad de la atención y el desarrollo de programas correctivos.Introduction Since February 8, 2021, the Spanish Society of Cardiovascular and Endovascular Surgery got under way the Spanish Registry of Cardiac Surgery (RECC), which is available for the different units of cardiovascular surgeons in our country. It is a tool that allows collect patient-level data of patients undergoing cardiac, vascular or endovascular surgery. After two years of development, we have carried out an analysis of the quality of the information obtained in order to acquire an overview of its content. Methods The information has been analyzed anonymously at patient, hospital and province level. For risk-adjusted mortality estimation, the EuroSCORE II preoperative risk estimation scale was used. Results A total of 7087 interventions have been included. Six thousand two hundred and sixty-seven were major cardiac surgeries: 53.9% valvular, 25.2% coronary artery bypass grafting, and 14.9% aortic procedures. The overall mortality was 5.0% and the risk-adjusted mortality rate was 0.88. The EuroSCORE II calibration in the overall sample was good in the lowest-risk patients, although it overestimated mortality in high-risk patients. Conclusions RECC is a nationally defined clinical database in the field of cardiovascular surgery. RECC allows a patient-level data analysis in order to perform an accurate analysis of the volumen of activity, risk adjustment and results. Locally, it could be used as a tool to improve the quality of care and development of corrective programs

EPDR1 up-regulation in human colorectal cancer is related to staging and favours cell proliferation and invasiveness

The finding of novel molecular markers for prediction or prognosis of invasiveness in colorectal cancer (CRC) constitutes an appealing challenge. Here we show the up-regulation of EPDR1 in a prospective cohort of 101 CRC patients, in a cDNA array of 43 patients and in in silico analyses. EPDR1 encodes a protein related to ependymins, a family of glycoproteins involved in intercellular contacts. A thorough statistical model allowed us to conclude that the gene is significantly up-regulated in tumour tissues when compared with normal mucosa. These results agree with those obtained by the analysis of three publicly available databases. EPDR1 up-regulation correlates with the TNM staging parameters, especially T and M. Studies with CRC cell lines revealed that the methylation of a CpG island controls EPDR1 expression. siRNA knocking-down and overexpression of the gene following transient plasmid transfection, showed that EPDR1 favours cell proliferation, migration, invasiveness and adhesion to type I collagen fibres, suggesting a role in epithelial to mesenchymal transition. Both statistical and functional analysis correlated EPDR1 overexpression with invasiveness and dissemination of tumour cells, supporting the inclusion of EPDR1 in panels of genes used to improve molecular subtyping of CRC. Eventually, EPDR1 may be an actionable target.Fil: Gimeno Valiente, F.. No especifíca;Fil: Riffo Campos, Á. L.. Universidad de La Frontera; ChileFil: Ayala, G.. Universidad de Valencia; EspañaFil: Tarazona, N.. Universidad de Valencia; EspañaFil: Gambardella, V.. Universidad de Valencia; EspañaFil: Rodríguez, Fernanda Mariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Ciencias Veterinarias del Litoral. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Instituto de Ciencias Veterinarias del Litoral; ArgentinaFil: Huerta, M.. Universidad de Valencia; EspañaFil: Martínez-Ciarpaglini, C.. Universidad de Valencia; EspañaFil: Montón Bueno, J.. Universidad de Valencia; EspañaFil: Roselló, S.. Universidad de Valencia; EspañaFil: Roda, D.. Universidad de Valencia; EspañaFil: Cervantes, A.. Universidad de Valencia; EspañaFil: Franco, L.. Universidad de Valencia; EspañaFil: López Rodas, G.. Universidad de Valencia; EspañaFil: Castillo, J.. Universidad de Valencia; Españ

Measurement of the cross-section and charge asymmetry of WW bosons produced in proton-proton collisions at s=8\sqrt{s}=8 TeV with the ATLAS detector

This paper presents measurements of the $W^+ \rightarrow \mu^+\nu$ and $W^- \rightarrow \mu^-\nu$ cross-sections and the associated charge asymmetry as a function of the absolute pseudorapidity of the decay muon. The data were collected in proton--proton collisions at a centre-of-mass energy of 8 TeV with the ATLAS experiment at the LHC and correspond to a total integrated luminosity of 20.2~\mbox{fb^{-1}}. The precision of the cross-section measurements varies between 0.8% to 1.5% as a function of the pseudorapidity, excluding the 1.9% uncertainty on the integrated luminosity. The charge asymmetry is measured with an uncertainty between 0.002 and 0.003. The results are compared with predictions based on next-to-next-to-leading-order calculations with various parton distribution functions and have the sensitivity to discriminate between them.Comment: 38 pages in total, author list starting page 22, 5 figures, 4 tables, submitted to EPJC. All figures including auxiliary figures are available at https://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/STDM-2017-13

Oxigenación con membrana extracorpórea en el paciente COVID-19: resultados del Registro Español ECMO-COVID de la Sociedad Española de Cirugía Cardiovascular y Endovascular (SECCE)

Background and aim: COVID-19 patients with severe heart or respiratory failure are potential candidates for extracorporeal membrane oxygenation (ECMO). Indications and management of these patients are unclear. Our aim is to describe the results of a prospective registry of COVID-19 patients treated with ECMO. Methods: An anonymous prospective registry of COVID-19 patients treated with veno-arterial (V-A) or veno-venous (V-V) ECMO was created on march 2020. Clinical, analytical and respiratory preimplantation variables, implantation data and post-implantation course data were recorded. The primary endpoint was all cause in-hospital mortality. Secondary events were functional recovery and the combined endpoint of mortality and functional recovery in patients followed at least 3 months after discharge. Results: Three hundred and sixty-six patients from 25 hospitals were analyzed, 347 V-V ECMO and 18 V-A ECMO patients (mean age 52.7 and 49.5 years respectively). Patients with V-V ECMO were more obese, had less frequently organ damage other than respiratory failure and needed less inotropic support; Thirty three percent of V-A ECMO and 34.9% of V-A ECMO were discharged (P = NS). Hospital mortality was non-significantly different, 56.2% versus 50.9% respectively, mainly during ECMO therapy and mostly due to multiorgan failure. Other 51 patients (14%) remained admitted. Mean follow-up was 196 +/- 101.7 days (95%CI: 170.8-221.6). After logistic regression, body weight (OR 0.967, 95%CI: 0.95-0.99, P = 0.004) and ECMO implantation in the own centre (OR 0.48, 95%CI: 0.27-0.88, P = 0.018) were protective for hospital mortality. Age (OR 1.063, 95%CI: 1.005-1.12, P = 0.032), arterial hypertension (3.593, 95%CI: 1.06-12.19, P = 0.04) and global (2.44, 95%CI: 0.27-0.88, P = 0.019), digestive (OR 4,23, 95%CI: 1.27-14.07, P = 0.019) and neurological (OR 4.66, 95%CI: 1.39-15.62, P = 0.013) complications during ECMO therapy were independent predictors of primary endpoint occurrence. Only the post-discharge day at follow-up was independent predictor of both secondary endpoints occurrence. Conclusions: Hospital survival of severely ill COVID-19 patients treated with ECMO is near 50%. Age, arterial hypertension and ECMO complications are predictors of hospital mortality, and body weight and implantation in the own centre are protective. Functional recovery is only predicted by the follow-up time after discharge. A more homogeneous management of these patients is warranted for clinical results and future research optimization. (C) 2022 Sociedad Espanola de Cirugia Cardiovascular y Endovascular. Published by Elsevier Espana, S.L.U

Consensus on complementary feeding from the Latin American Society for Pediatric Gastroenterology, Hepatology and Nutrition: COCO 2023

Abstract Complementary feeding (CF) is defined as infant feeding that complements breastfeeding or, alternatively, breastfeeding with a breast milk substitute, and is a process that goes beyond simply providing guidance on what and how to introduce foods. The information provided by health professionals should be up-to-date and evidence-based. There are different guidelines or position papers at the international level, which, although most of the recommendations may be applicable, there are some others that require regionalization or adaptation to the conditions and reality of each area. The Nutrition working group of the Latin American Society of Pediatric Gastroenterology, Hepatology and Nutrition convened a group of experts, representatives from each of the countries that make up the society, with the objective of developing a consensus on CA, incorporating, when possible, local information that adapts to the reality of the region. The purpose of this document is to show the results of this work. Through Delphi methodology, a total of 34 statements or statements regarding relevant aspects of CA were evaluated, discussed and voted upon.Resumen La alimentación complementaria (AC) se define como la alimentación de los lactantes que complementa a la lactancia materna o en su defecto, a la lactancia con un sucedáneo de la leche materna, y es un proceso que va más allá de simplemente una guía sobre qué y cómo introducir los alimentos. La información brindada por parte de los profesionales de la salud debe ser actualizada y basada en evidencia. Existen diferentes guías o documentos de posición a nivel internacional, que, aunque la mayoría de las recomendaciones pueden ser aplicables, hay algunas otras que requieren una regionalización o adecuación a las condiciones y realidad de cada zona. El grupo de trabajo de Nutrición de la Sociedad Latinoamericana de Gastroenterología, Hepatología y Nutrición Pediátrica convocó a un grupo de expertos, representantes de cada uno de los países que conforman la sociedad, con el objetivo de desarrollar un consenso sobre la AC, que incorporó cuando así fue posible, información local que se adapte a la realidad de la región. El objetivo de este documento es mostrar los resultados de dicho trabajo. A través de metodología Delphi, se evaluaron, discutieron y votaron un total de 34 declaraciones o enunciados con respecto a aspectos relevantes de la AC

Low exposure long-baseline neutrino oscillation sensitivity of the DUNE experiment

The Deep Underground Neutrino Experiment (DUNE) will produce world-leading neutrino oscillation measurements over the lifetime of the experiment. In this work, we explore DUNE's sensitivity to observe charge-parity violation (CPV) in the neutrino sector, and to resolve the mass ordering, for exposures of up to 100 kiloton-megawatt-years (kt-MW-yr). The analysis includes detailed uncertainties on the flux prediction, the neutrino interaction model, and detector effects. We demonstrate that DUNE will be able to unambiguously resolve the neutrino mass ordering at a 3$\sigma$ (5$\sigma$) level, with a 66 (100) kt-MW-yr far detector exposure, and has the ability to make strong statements at significantly shorter exposures depending on the true value of other oscillation parameters. We also show that DUNE has the potential to make a robust measurement of CPV at a 3$\sigma$ level with a 100 kt-MW-yr exposure for the maximally CP-violating values \delta_{\rm CP}} = \pm\pi/2. Additionally, the dependence of DUNE's sensitivity on the exposure taken in neutrino-enhanced and antineutrino-enhanced running is discussed. An equal fraction of exposure taken in each beam mode is found to be close to optimal when considered over the entire space of interest