Evaluación de la transformación del matorral del Parque Nacional de Doñana como medida de gestión y su impacto sobre la comunidad de micromamíferos.

Una de las principales medidas de gestión que se realizan en el Parque Nacional de Doñana dentro del Plan de manejo del lince (Lynx pardina) y del águila imperial (Aquila adalberti) es el desbroce de matorral, con ob- jeto de crear zonas abiertas de alimentación para el conejo (Oryctolagus cuniculus). Esta medida de gestión está produciendo una profunda modificación en la estructura de la vegetación, y aunque afecta positiva- mente a los conejos, se desconoce su efecto sobre otras especies características de este hábitat como son los micromamíferos, cuya comunidad podría estar sufriendo importantes procesos de cambio. En concreto una de las especies más características de esta comunidad, el lirón careto atlántico, Eliomys quercinus lusitanicus, abundante en el pasado es ahora extremadamente rara, e incluso podría haber desparecido del área. Este estudio tiene como objetivo evaluar el efecto de la eliminación del matorral, mediante quema con- trolada, sobre la comunidad de micromamíferos. Para ello hemos analizado la riqueza y abundancia es- pecíficas y la evolución temporal de estos parámetros en parcelas quemadas de diferente antigüedad y en zonas no sometidas a tratamiento. La toma de datos se realizó mediante captura-recaptura en pe- riodos estacionales, desde el verano de 2005 a la primavera de 2007. Los resultados mostraron que la riqueza específica fue muy baja, con tan solo 4 especies capturadas (Mus spretus, Apodemus sylvaticus, Crocidura russula y Eliomys quercinus). La abundancia presentó valo- res muy variables dependiendo de la especie, la época del año y el tipo de parcela; aunque se observa que la especie más abundante es Mus spretus con mucha diferencia sobre las demás. En general, el otoño y el invierno fueron las estaciones con mayor abundancia, y ésta se hace muy escasa durante el verano. La quema controlada del matorral mediterráneo senescente en el Parque Nacional de Doñana favorece la presencia de especies y su abundancia, no tanto en la propia parcela sometida a tratamiento, como en el matorral que la bordea. Mus es la especie dominante en todos los ambientes. Apodemus muestra mecanis- mos de evitación espacial y temporal con Mus. Eliomys quercinus no ha desaparecido de Doñana, aunque su abundancia es escasísima y aparece asociada al borde de parcelas quemadas de cuatro años de antigüedad. El proceso de colonización de las parcelas quemadas parece alcanzar la abundancia más alta y la mayor riqueza específica a los tres-cuatro años tras la quema. Esta colonización no sigue una pauta regular en el tiempo, sino que se encuentra condicionada por otros factores, entre los que parece encontrarse la pre- cipitación anual.Peer Reviewe

Limitations and usefulness of maximum daily shrinkage (MDS) and trunk growth rate (TGR) indicators in the irrigation scheduling of table olive trees

8 páginas.-- 7 figuras.-- 2 tablas.-- 32 referenciasMaximum daily trunk shrinkage (MDS) is the most popular indicator derived from trunk diameter fluctuations in most fruit trees and has been reported to be one of the earliest signs in the detection of water stress. However, in some species such as olive trees (. Olea europaea L.), MDS does not usually change in water stress conditions and trunk growth rate (TGR) has been suggested as better indicator. Most of this lack of sensitivity to drought conditions has been related to the relationship between the MDS and the water potential. This curvilinear relationship produces an uncertain zone were great variations of water potential do not imply any changes of MDS. The MDS signal, the ratio between measured MDS and estimated MDS with full irrigation, has been thought to be a better indicator than MDS, as it reduces the effect of the environment. On the other hand, though literature results suggest an effect of environment in TGR values, there are not clear relationship between this indicator and meteorological data. The aims of this work are, on one hand, to study the improvements of the baseline approach in the MDS signal and, on the other, study the influence of several meteorological variables in TGR. Three years' data from an irrigation experiment were used in to carry out the MDS analysis and six years' data for full irrigated trees during pit hardening period were used for TGR study. The comparison between MDS vs. water potential and MDS signal vs. water potential presented a great scattering in both relationships. Values of MDS signal between 1.1 and 1.4 were always identified with moderate water stress conditions (-1.4 to -2. MPa of water potential). However, since this MDS signal values are around the maximum in the curvilineal relationship with water potential, greater values of MDS signal (in the range of 1.1-1.4) were not necessary lower values of water potential. In addition, during low fruit load seasons MDS signal was not an accurate indicator. On the other hand, absolute values of several climatological measurements were not significantly related with TGR. Only daily increments explain part of the variations of TGR in full irrigated trees. In all the data analysed, the daily increment of average vapour pressure deficit was the best indicator related with TGR. The increase of this indicator decreased TGR values. In addition, the agreement between this indicator and TGR was affected for fruit load. Great yield seasons decrease the influence of VPD increment in TGR.This research was supported by the Spanish Ministerio de Ciencia e Innovación (MICINN), (AGL2010-19201-CO4-03). Thanks are due to J. Rodriguez and A. Montero for help with field measurements.Peer reviewe

El futuro de las revistas científicas españolas: un esfuerzo científico, social e institucional

In spite of the increasingly high level of scientific production by Spanish researchers on terrestrial vertebrate biology, Spanish journals on this topic are, paradoxically, in a delicate situation that seriously threatens their future. This paper surnrnarises the results obtained in an analysis of the current situation of these journals and their perspectives for the near future: Such results are fully applicable to most scientific journals edited both in Spain and in countries in a similar situation. The international status of a journal determines the quality and quantity of original works that receives and publishes. The quality of the published papers was, in turn, the rnain deterrnining factor of this international status until the appearance of the "impact factors" elaborated by a private company, the North American lnstitute for Scientific lnformation (ISI), The ISI also elaborates a list of journals classified according to their irnpact factors, as well as to a nurnber of inclusion criteria. In spite of the fact that both the irnpact factors and the criteria for inclusion of journals are now under close scrutiny by the scientific cornrnunity, journals not included on this list are considered "non-prestigious". The future of such journals is thus threatened as this " label" prevents scientists frorn subrnitting their good quality papers to thern. Few Spanish scientific journals are included on the list, and the ISI is reluctant to lengthen it unless the journals are new, published in English and, usually, supported by the major publishing houses which monopolise the international rnarket of scientific publications. Most Spanish scientific journals, especially those focused on terrestrial vertebrates, are published by scientific societies integrated by both professional scientists and naturalists interested in the study of these organisrns. The Spanish Administration partially supported some of them in the past through specific funding. In addition, sorne journals were fully supported by public funds, but they have either disappeared or are not published periodically. This situation contradicts the governrnent's objectives to prornote the Spanish language and to obtain returns on the investment in training high-level scientists. On this basis, one way to ensure the long-term rnaintenance of Spanish journals would be to enhance alternatives such as the publication of local studies or the support and training of novel scientists. This option may be carried out by scientific societies thernselves without institutional aid by means of ¡.e. reducing the subscription cost, as far as some disagreernents between the scientific and non-scientific partners were solved properly. However, this would limit the international projection of the Spanish journals. The only alternative would be a social, institutional and political agreement aimed at promoting those Spanish journals, either already established or new, with the best perspectives for international diffusion. The final goal should be the inclusion of these journals on the ISI list. The co-ordinated efforts of scientists, scientific societies and the administration would thus eventually reach the objective of maintaining high-quality scientific journals, one of the main mid-term returns on the investment in science. Key words: Problems for long-term maintenance, Scientific journals, Scientific policy, Scientific societies, Social and institutional support, Terrestrial vertebrates.In spite of the increasingly high level of scientific production by Spanish researchers on terrestrial vertebrate biology, Spanish journals on this topic are, paradoxically, in a delicate situation that seriously threatens their future. This paper surnrnarises the results obtained in an analysis of the current situation of these journals and their perspectives for the near future: Such results are fully applicable to most scientific journals edited both in Spain and in countries in a similar situation. The international status of a journal determines the quality and quantity of original works that receives and publishes. The quality of the published papers was, in turn, the rnain deterrnining factor of this international status until the appearance of the "impact factors" elaborated by a private company, the North American lnstitute for Scientific lnformation (ISI), The ISI also elaborates a list of journals classified according to their irnpact factors, as well as to a nurnber of inclusion criteria. In spite of the fact that both the irnpact factors and the criteria for inclusion of journals are now under close scrutiny by the scientific cornrnunity, journals not included on this list are considered "non-prestigious". The future of such journals is thus threatened as this " label" prevents scientists frorn subrnitting their good quality papers to thern. Few Spanish scientific journals are included on the list, and the ISI is reluctant to lengthen it unless the journals are new, published in English and, usually, supported by the major publishing houses which monopolise the international rnarket of scientific publications. Most Spanish scientific journals, especially those focused on terrestrial vertebrates, are published by scientific societies integrated by both professional scientists and naturalists interested in the study of these organisrns. The Spanish Administration partially supported some of them in the past through specific funding. In addition, sorne journals were fully supported by public funds, but they have either disappeared or are not published periodically. This situation contradicts the governrnent's objectives to prornote the Spanish language and to obtain returns on the investment in training high-level scientists. On this basis, one way to ensure the long-term rnaintenance of Spanish journals would be to enhance alternatives such as the publication of local studies or the support and training of novel scientists. This option may be carried out by scientific societies thernselves without institutional aid by means of ¡.e. reducing the subscription cost, as far as some disagreernents between the scientific and non-scientific partners were solved properly. However, this would limit the international projection of the Spanish journals. The only alternative would be a social, institutional and political agreement aimed at promoting those Spanish journals, either already established or new, with the best perspectives for international diffusion. The final goal should be the inclusion of these journals on the ISI list. The co-ordinated efforts of scientists, scientific societies and the administration would thus eventually reach the objective of maintaining high-quality scientific journals, one of the main mid-term returns on the investment in science. Key words: Problems for long-term maintenance, Scientific journals, Scientific policy, Scientific societies, Social and institutional support, Terrestrial vertebrates.In spite of the increasingly high level of scientific production by Spanish researchers on terrestrial vertebrate biology, Spanish journals on this topic are, paradoxically, in a delicate situation that seriously threatens their future. This paper surnrnarises the results obtained in an analysis of the current situation of these journals and their perspectives for the near future: Such results are fully applicable to most scientific journals edited both in Spain and in countries in a similar situation. The international status of a journal determines the quality and quantity of original works that receives and publishes. The quality of the published papers was, in turn, the rnain deterrnining factor of this international status until the appearance of the "impact factors" elaborated by a private company, the North American lnstitute for Scientific lnformation (ISI), The ISI also elaborates a list of journals classified according to their irnpact factors, as well as to a nurnber of inclusion criteria. In spite of the fact that both the irnpact factors and the criteria for inclusion of journals are now under close scrutiny by the scientific cornrnunity, journals not included on this list are considered "non-prestigious". The future of such journals is thus threatened as this " label" prevents scientists frorn subrnitting their good quality papers to thern. Few Spanish scientific journals are included on the list, and the ISI is reluctant to lengthen it unless the journals are new, published in English and, usually, supported by the major publishing houses which monopolise the international rnarket of scientific publications. Most Spanish scientific journals, especially those focused on terrestrial vertebrates, are published by scientific societies integrated by both professional scientists and naturalists interested in the study of these organisrns. The Spanish Administration partially supported some of them in the past through specific funding. In addition, sorne journals were fully supported by public funds, but they have either disappeared or are not published periodically. This situation contradicts the governrnent's objectives to prornote the Spanish language and to obtain returns on the investment in training high-level scientists. On this basis, one way to ensure the long-term rnaintenance of Spanish journals would be to enhance alternatives such as the publication of local studies or the support and training of novel scientists. This option may be carried out by scientific societies thernselves without institutional aid by means of ¡.e. reducing the subscription cost, as far as some disagreernents between the scientific and non-scientific partners were solved properly. However, this would limit the international projection of the Spanish journals. The only alternative would be a social, institutional and political agreement aimed at promoting those Spanish journals, either already established or new, with the best perspectives for international diffusion. The final goal should be the inclusion of these journals on the ISI list. The co-ordinated efforts of scientists, scientific societies and the administration would thus eventually reach the objective of maintaining high-quality scientific journals, one of the main mid-term returns on the investment in science. Key words: Problems for long-term maintenance, Scientific journals, Scientific policy, Scientific societies, Social and institutional support, Terrestrial vertebrates

Early vascular endothelial complications after hematopoietic cell transplantation: Role of the endotheliopathy in biomarkers and target therapies development

This work aims to review the role of endothelial dysfunction underlying the main complications appearing early after autologous and allogeneic hematopoietic cell transplantation (HCT). The endothelial damage as the pathophysiological substrate of sinusoidal obstruction syndrome (SOS) is well established. However, there is growing evidence of the involvement of endothelial dysfunction in other complications, such as acute graft-versus-host disease (aGVHD) and transplant-associated thrombotic microangiopathy (TA-TMAs). Moreover, HCT-related endotheliopathy is not only limited to the HCT setting, as there is increasing evidence of its implication in complications derived from other cellular therapies. We also review the incidence and the risk factors of the main HCT complications and the biological evidence of the endothelial involvement and other linked pathways in their development. In addition, we cover the state of the art regarding the potential use of the biomarkers of endotheliopathy in the prediction, the early diagnosis, and the follow-up of the HCT complications and summarize current knowledge points to the endothelium and the other linked pathways described as potential targets for the prevention and treatment of HCT-complications. Lastly, the endothelium-focused therapeutic strategies that are emerging and might have a potential impact on the survival and quality of life of post-HCT-patients are additionally reviewed.Copyright © 2022 Moreno-Castaño, Salas, Palomo, Martinez-Sanchez, Rovira, Fernández-Avilés, Martínez, Cid, Castro, Escolar, Carreras and Diaz-Ricart

The avoidance of G-CSF and the addition of prophylactic corticosteroids after autologous stem cell transplantation for multiple myeloma patients appeal for the at-home setting to reduce readmission for neutropenic fever

Background Autologous stem cell transplantation (ASCT) remains the standard of care for young multiple myeloma (MM) patients; indeed, at-home ASCT has been positioned as an appropriate therapeutic strategy. However, despite the use of prophylactic antibiotics, neutropenic fever (NF) and hospital readmissions continue to pose as the most important limitations in the outpatient setting. It is possible that the febrile episodes may have a non-infectious etiology, and engraftment syndrome could play a more significant role. The aim of this study was to analyze the impact of both G-CSF withdrawal and the addition of primary prophylaxis with corticosteroids after ASCT. Methods Between January 2002 and August 2018, 111 MM patients conditioned with melphalan were managed at-home beginning +1 day after ASCT. Three groups were established: Group A (n = 33) received standard G-CSF post-ASCT; group B (n = 32) avoided G-CSF post-ASCT; group C (n = 46) avoided G-CSF yet added corticosteroid prophylaxis post-ASCT. Results The incidence of NF among the groups was reduced (64%, 44%, and 24%; P2 (OR 6.1; P = 0.002) and G-CSF avoidance plus corticosteroids (OR 0.1; P60 years (OR 14.6; P = 0.04) and G-CSF avoidance plus corticosteroids (OR 0.07; P = 0.05). Conclusions G-CSF avoidance and corticosteroid prophylaxis post ASCT minimize the incidence of NF in MM patients undergoing at-home ASCT. This approach should be explored in a prospective randomized clinical trial

What to consider when pseudohypoparathyroidism is ruled out: IPPSD and differential diagnosis

Background: Pseudohypoparathyroidism (PHP) is a rare disease whose phenotypic features are rather difficult to identify in some cases. Thus, although these patients may present with the Albright''s hereditary osteodystrophy (AHO) phenotype, which is characterized by small stature, obesity with a rounded face, subcutaneous ossifications, mental retardation and brachydactyly, its manifestations are somewhat variable. Indeed, some of them present with a complete phenotype, whereas others show only subtle manifestations. In addition, the features of the AHO phenotype are not specific to it and a similar phenotype is also commonly observed in other syndromes. Brachydactyly type E (BDE) is the most specific and objective feature of the AHO phenotype, and several genes have been associated with syndromic BDE in the past few years. Moreover, these syndromes have a skeletal and endocrinological phenotype that overlaps with AHO/PHP. In light of the above, we have developed an algorithm to aid in genetic testing of patients with clinical features of AHO but with no causative molecular defect at the GNAS locus. Starting with the feature of brachydactyly, this algorithm allows the differential diagnosis to be broadened and, with the addition of other clinical features, can guide genetic testing. Methods: We reviewed our series of patients (n = 23) with a clinical diagnosis of AHO and with brachydactyly type E or similar pattern, who were negative for GNAS anomalies, and classify them according to the diagnosis algorithm to finally propose and analyse the most probable gene(s) in each case. Results: A review of the clinical data for our series of patients, and subsequent analysis of the candidate gene(s), allowed detection of the underlying molecular defect in 12 out of 23 patients: five patients harboured a mutation in PRKAR1A, one in PDE4D, four in TRPS1 and two in PTHLH. Conclusions: This study confirmed that the screening of other genes implicated in syndromes with BDE and AHO or a similar phenotype is very helpful for establishing a correct genetic diagnosis for those patients who have been misdiagnosed with "AHO-like phenotype" with an unknown genetic cause, and also for better describing the characteristic and differential features of these less common syndromes

Multiplicity dependence of jet-like two-particle correlations in p-Pb collisions at sNN\sqrt{s_{NN}} = 5.02 TeV

Two-particle angular correlations between unidentified charged trigger and associated particles are measured by the ALICE detector in p-Pb collisions at a nucleon-nucleon centre-of-mass energy of 5.02 TeV. The transverse-momentum range 0.7 $< p_{\rm{T}, assoc} < p_{\rm{T}, trig} <$ 5.0 GeV/$c$ is examined, to include correlations induced by jets originating from low momen\-tum-transfer scatterings (minijets). The correlations expressed as associated yield per trigger particle are obtained in the pseudorapidity range $|\eta|<0.9$. The near-side long-range pseudorapidity correlations observed in high-multiplicity p-Pb collisions are subtracted from both near-side short-range and away-side correlations in order to remove the non-jet-like components. The yields in the jet-like peaks are found to be invariant with event multiplicity with the exception of events with low multiplicity. This invariance is consistent with the particles being produced via the incoherent fragmentation of multiple parton--parton scatterings, while the yield related to the previously observed ridge structures is not jet-related. The number of uncorrelated sources of particle production is found to increase linearly with multiplicity, suggesting no saturation of the number of multi-parton interactions even in the highest multiplicity p-Pb collisions. Further, the number scales in the intermediate multiplicity region with the number of binary nucleon-nucleon collisions estimated with a Glauber Monte-Carlo simulation.Comment: 23 pages, 6 captioned figures, 1 table, authors from page 17, published version, figures at http://aliceinfo.cern.ch/ArtSubmission/node/161

Multi-particle azimuthal correlations in p-Pb and Pb-Pb collisions at the CERN Large Hadron Collider

Measurements of multi-particle azimuthal correlations (cumulants) for charged particles in p-Pb and Pb-Pb collisions are presented. They help address the question of whether there is evidence for global, flow-like, azimuthal correlations in the p-Pb system. Comparisons are made to measurements from the larger Pb-Pb system, where such evidence is established. In particular, the second harmonic two-particle cumulants are found to decrease with multiplicity, characteristic of a dominance of few-particle correlations in p-Pb collisions. However, when a $|\Delta \eta|$ gap is placed to suppress such correlations, the two-particle cumulants begin to rise at high-multiplicity, indicating the presence of global azimuthal correlations. The Pb-Pb values are higher than the p-Pb values at similar multiplicities. In both systems, the second harmonic four-particle cumulants exhibit a transition from positive to negative values when the multiplicity increases. The negative values allow for a measurement of $v_{2}\{4\}$ to be made, which is found to be higher in Pb-Pb collisions at similar multiplicities. The second harmonic six-particle cumulants are also found to be higher in Pb-Pb collisions. In Pb-Pb collisions, we generally find $v_{2}\{4\} \simeq v_{2}\{6\}\neq 0$ which is indicative of a Bessel-Gaussian function for the $v_{2}$ distribution. For very high-multiplicity Pb-Pb collisions, we observe that the four- and six-particle cumulants become consistent with 0. Finally, third harmonic two-particle cumulants in p-Pb and Pb-Pb are measured. These are found to be similar for overlapping multiplicities, when a $|\Delta\eta| > 1.4$ gap is placed.Comment: 25 pages, 11 captioned figures, 3 tables, authors from page 20, published version, figures at http://aliceinfo.cern.ch/ArtSubmission/node/87

Charge separation relative to the reaction plane in Pb-Pb collisions at sNN=2.76\sqrt{s_{\rm NN}}= 2.76 TeV

Measurements of charge dependent azimuthal correlations with the ALICE detector at the LHC are reported for Pb-Pb collisions at $\sqrt{s_{\rm NN}} = 2.76$ TeV. Two- and three-particle charge-dependent azimuthal correlations in the pseudo-rapidity range $|\eta| < 0.8$ are presented as a function of the collision centrality, particle separation in pseudo-rapidity, and transverse momentum. A clear signal compatible with a charge-dependent separation relative to the reaction plane is observed, which shows little or no collision energy dependence when compared to measurements at RHIC energies. This provides a new insight for understanding the nature of the charge dependent azimuthal correlations observed at RHIC and LHC energies.Comment: 12 pages, 3 captioned figures, authors from page 2 to 6, published version, figures at http://aliceinfo.cern.ch/ArtSubmission/node/286

A note on comonotonicity and positivity of the control components of decoupled quadratic FBSDE

In this small note we are concerned with the solution of Forward-Backward Stochastic Differential Equations (FBSDE) with drivers that grow quadratically in the control component (quadratic growth FBSDE or qgFBSDE). The main theorem is a comparison result that allows comparing componentwise the signs of the control processes of two different qgFBSDE. As a byproduct one obtains conditions that allow establishing the positivity of the control process.Comment: accepted for publicatio