39 research outputs found

    A cross-national study on the antecedents of work–life balance from the fit and balance perspective

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    Drawing on the perceived work–family fit and balance perspective, this study investigates demands and resources as antecedents of work–life balance (WLB) across four countries (New Zealand, France, Italy and Spain), so as to provide empirical cross-national evidence. Using structural equation modelling analysis on a sample of 870 full time employees, we found that work demands, hours worked and family demands were negatively related to WLB, while job autonomy and supervisor support were positively related to WLB. We also found evidence that resources (job autonomy and supervisor support) moderated the relationships between demands and work–life balance, with high resources consistently buffering any detrimental influence of demands on WLB. Furthermore, our study identified additional predictors of WLB that were unique to some national contexts. For example, in France and Italy, overtime hours worked were negatively associated with WLB, while parental status was positively associated with WLB. Overall, the implications for theory and practice are discussed.Peer ReviewedPostprint (author's final draft

    Gender differences in the use of cardiovascular interventions in HIV-positive persons; the D:A:D Study

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    Development and Validation of a Risk Score for Chronic Kidney Disease in HIV Infection Using Prospective Cohort Data from the D:A:D Study

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    Ristola M. on työryhmien DAD Study Grp ; Royal Free Hosp Clin Cohort ; INSIGHT Study Grp ; SMART Study Grp ; ESPRIT Study Grp jäsen.Background Chronic kidney disease (CKD) is a major health issue for HIV-positive individuals, associated with increased morbidity and mortality. Development and implementation of a risk score model for CKD would allow comparison of the risks and benefits of adding potentially nephrotoxic antiretrovirals to a treatment regimen and would identify those at greatest risk of CKD. The aims of this study were to develop a simple, externally validated, and widely applicable long-term risk score model for CKD in HIV-positive individuals that can guide decision making in clinical practice. Methods and Findings A total of 17,954 HIV-positive individuals from the Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) study with >= 3 estimated glomerular filtration rate (eGFR) values after 1 January 2004 were included. Baseline was defined as the first eGFR > 60 ml/min/1.73 m2 after 1 January 2004; individuals with exposure to tenofovir, atazanavir, atazanavir/ritonavir, lopinavir/ritonavir, other boosted protease inhibitors before baseline were excluded. CKD was defined as confirmed (>3 mo apart) eGFR In the D:A:D study, 641 individuals developed CKD during 103,185 person-years of follow-up (PYFU; incidence 6.2/1,000 PYFU, 95% CI 5.7-6.7; median follow-up 6.1 y, range 0.3-9.1 y). Older age, intravenous drug use, hepatitis C coinfection, lower baseline eGFR, female gender, lower CD4 count nadir, hypertension, diabetes, and cardiovascular disease (CVD) predicted CKD. The adjusted incidence rate ratios of these nine categorical variables were scaled and summed to create the risk score. The median risk score at baseline was -2 (interquartile range -4 to 2). There was a 1: 393 chance of developing CKD in the next 5 y in the low risk group (risk score = 5, 505 events), respectively. Number needed to harm (NNTH) at 5 y when starting unboosted atazanavir or lopinavir/ritonavir among those with a low risk score was 1,702 (95% CI 1,166-3,367); NNTH was 202 (95% CI 159-278) and 21 (95% CI 19-23), respectively, for those with a medium and high risk score. NNTH was 739 (95% CI 506-1462), 88 (95% CI 69-121), and 9 (95% CI 8-10) for those with a low, medium, and high risk score, respectively, starting tenofovir, atazanavir/ritonavir, or another boosted protease inhibitor. The Royal Free Hospital Clinic Cohort included 2,548 individuals, of whom 94 individuals developed CKD (3.7%) during 18,376 PYFU (median follow-up 7.4 y, range 0.3-12.7 y). Of 2,013 individuals included from the SMART/ESPRIT control arms, 32 individuals developed CKD (1.6%) during 8,452 PYFU (median follow-up 4.1 y, range 0.6-8.1 y). External validation showed that the risk score predicted well in these cohorts. Limitations of this study included limited data on race and no information on proteinuria. Conclusions Both traditional and HIV-related risk factors were predictive of CKD. These factors were used to develop a risk score for CKD in HIV infection, externally validated, that has direct clinical relevance for patients and clinicians to weigh the benefits of certain antiretrovirals against the risk of CKD and to identify those at greatest risk of CKD.Peer reviewe

    Energy use in the paper industry

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    The paper sector is affected by many challenges, especially related to increased competition for raw materials and energy. In this thesis several opportunities are identified that enable the sector to reduce its’ dependency on energy and resources, lower its energy costs and reduce its carbon footprint. Based on detailed energy benchmarks of different processes within the Dutch paper industry, significant energy efficiency improvement opportunities (15%) were identified by implementing existing best practices. The largest improvement potential is in the drying section. By means of a thermodynamic optimisation, it was shown that an increase in dew point decreases energy use of water evaporation and increases the heat recovery potential of exhaust air; applying additives in higher consistencies further decreases water evaporation. Combining best practices and retrofits in the drying section, an energy efficiency improvement potential of 22% was found to be possible for Dutch paper machines. Our results further show that increased recycling and enhanced recyclability of paper grades offer good improvement potentials for the sector. Current paper recycling rates in The Netherlands (75%) have led to 3 Mt avoided CO2 emissions per year, compared to a situation without recycling, equalling approximately 9% of the total Dutch industrial CO2 emissions in 2007. Only a few European countries have reached their limit in paper recycling, whereas in most countries there is still potential for growth. A 10% increase in recycling could bring 10% savings in primary energy and CO2 emissions over the total life cycle of paper. CHP could in many countries be an interesting improvement opportunity as the technology fits well to the paper industry and it can lead to 2-3 times lower primary energy demands. Biomass energy conversion technologies should be implemented when possible and feasible, as they are effective in reducing CO2 emissions, especially in cases that are currently based on carbon-intensive fuels. For the Dutch paper industry, due to the lack of domestically available biomass, most of the biomass based alternatives do not seem promising alternatives; for them improving energy efficiency and maintaining the high implementation level of CHP are the most feasible routes for improving its energetic performance. The variety of research methods applied, take into account the sector’s complexity in terms of variability of feedstock and product ranges and have contributed to a more detailed and nuanced analysis of energy efficiency improvement and CO2 reduction potentials compared to earlier studies. The work in this thesis stresses the importance of using non-aggregated data, especially when benchmarks are to be used in industrial target setting. We show that using a single indicator is often not sufficient to determine the sustainability or improvement potential of paper production chains. Also in policy making, trade-offs between various sustainability indicators are often not well reflected. While policy makers are nowadays focused on renewable energy targets, the deteriorating economic position of CHP is leading to several closures of CHP facilities, resulting in a consequent increases in primary energy demand. The methodologies applied in this thesis enable to account for these types of effects

    Trading biomass or GHG emission credits?

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    Global biomass potentials are considerable but unequally distributed over the world. Countries with Kyoto targets could import biomass to substitute for fossil fuels or invest in bio-energy projects in the country of biomass origin and buy the credits (Clean Development Mechanism (CDM) and Joint Implementation (JI)). This study analyzes which of those options is optimal for transportation fuels and looks for the key variables that influence the result. In two case studies (Mozambique and Brazil), the two trading systems are compared for the amount of credits generated, land-use and associated costs. We found costs of 17–30 euro per ton of carbon for the Brazilian case and economic benefits of 11 to 60 euros per ton of carbon avoided in the Mozambique case. The impact of carbon changes related to direct land-use changes was found to be very significant (both positive and negative) and can currently only be included in emission credit trading, which can largely influence the results. In order to avoid indirect land-use changes (leakage) and consequent GHG emissions, it is crucial that bioenergy crop production is done in balance with improvements of management of agriculture and livestock management. Whatever trading option is economically most attractive depends mainly on the emission baseline in the exporting (emission credit trading) or importing (physical trading) country since both bio- and fossil fuel prices are world market prices in large scale trading systems where transportation costs are low. Physical trading could be preferential since besides theGHGreduction one could also benefit from the energy. It could also generate considerable income sources for exporting countries. This study could contribute to the development of a methodology to deal with bio fuels for transport, in Emission Trading (ET), CDM and the certification of traded bio fuels

    Energy conversion strategies in the European paper industry : A case study in three countries

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    The pulp and paper industry both uses and produces large amounts of energy and rising fuel prices bring along significant challenges to the sector. Several strategies can be applied in order to remain competitive e.g. an increase in energy efficiency, a switch in fuel and/or a novel energy conversion technology. In this study, we investigate if improved energy conversion strategies can reduce energy costs, primary energy use and CO₂ emissions of paper mills within different European countries (The Netherlands, Poland and Sweden). Our results show that differences in history and availability of resources has led to different conversion strategies in the three countries. We found that a natural gas combined cycle, which is largely implemented in The Netherlands due to long term domestic availability of natural gas, has the lowest primary energy demand. Due to a long history of low electricity prices, CHP has not been common in Sweden. Many Swedish mills use biomass as an energy source and due to low CO₂ emissions of the national grid the CO₂ emission profile of the Swedish paper industry is very low. Our results imply that future conversion routes for the Swedish paper and board industry are again wood based; in case of increasing electricity prices these would be biomass gasification based CHP solutions. With a reduction of 800 kg CO₂/ton paper on average, a switch from coal to biomass would reduce CO₂ emissions in the Polish pulp and paper industry with approximately 0.6 Mton/year. A carbon price of 20–25 €/ton would, according to our results, be enough to provoke this switch. Due to the high share of natural gas, the CO₂ emission reduction potential of the Dutch paper industry (1.5 Mton/year) is even larger than in Poland. Due to high biomass prices and relative low CO₂ emission profile of natural gas, a carbon prices of more than 60 €/ton CO₂ would be needed to provoke a switch in The Netherlands. Provided with few alternatives, the most effective strategy in The Netherlands would be an increase in energy efficiency

    Benchmarking Energy Use in the Paper Industry- A benchmarking study on process-unit level

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    There are large differences between paper mills in, e.g. feedstock use and grades produced, but typical processes are similar in all mills. The aim of this study is to benchmark the specific energy consumption (SEC) of similar processes within different paper mills in order to identify energy improvement potentials at process level. We have defined improvement potentials as measures that can be taken at mill/ process level under assumed fixed inputs and outputs. We were able to use industrial data on detailed process level, and we conducted energy benchmarking comparisons in 23 Dutch paper mills. We calculated average SECs per process step for different paper grades, and we were able to identify ranges in SECs between mills producing the same grade. We found significant opportunities for energy efficiency improvement in the wire and press section as well as in the drying section. The total energy improvement potential based on identified best practices in these sections was estimated at 5.4 PJ (or 15 % of the total primary energy use in the selected mills). Energy use in the other processes was found to be too dependent on quality and product specifications to be able to quantify improvement potentials. Our results emphasise that even a benchmark on detailed process level does not lead to clear estimations of energy improvement potentials without accounting for structural effects and without having a decent understanding of the process
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